PubMed Journals Articles About "Xencor Host First Quarter 2019 Financial Results Webcast" RSS

17:22 EDT 21st September 2019 | BioPortfolio

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Showing "Xencor Host First Quarter 2019 Financial Results Webcast" PubMed Articles 1–25 of 43,000+

The Gut Feeling: GPCRs Enlighten the Way.

Host-microbiome interactions affect host physiology, but the underlying mechanisms are not well understood. Recent papers from Chen et al. (2019) and Colosimo et al. (2019) in this issue of Cell Host & Microbe demonstrate that metabolites produced by several members of the gut microbiota can efficiently activate host G protein-coupled receptors and influence host physiology.

Malassezia: The Forbidden Kingdom Opens.

Malassezia yeast exist on all humans and have long been associated with healthy and diseased skin. In this issue of Cell Host & Microbe, Sparber et al. (2019) and Limon et al. (2019) present murine models for Malassezia/host interaction and describe a role for Malassezia in inflammatory skin and gut disease.

You don't have to be rich to save money: On the relationship between objective versus subjective financial situation and having savings.

Saving is an important financial behavior that provides an individual with psychological security and boosts his/her overall sense of well-being. For this reason, scientists and practitioners have attempted to understand why some people save when others do not. One of the most common explanations for this phenomenon is that those individuals who earn more should be more willing to save their money. In line with this logic, people who have more money should be more likely to have savings. Considering the res...

Moderating role of financial ratios in corporate social responsibility disclosure and firm value.

This study investigates the link between corporate social responsibility (CSR) disclosure for multi-stakeholders and financial performance of a firm through accounting-based activities for CSR. A dataset of Chinese non-financial firms listed on the Shanghai Stock Exchange from 2008 to 2012 is taken from the China Stock Market & Accounting Research database. The study compares different financial ratios of CSR disclosure and non-disclosure firms. Moreover, the financial ratios of CSR disclosure firms also co...

The Financial Life of Aspiring Veterinarians.

The stress of veterinary students ranges from the financial stress associated with high student loan debt combined with possible credit card debt, to relational stress due to lack of time to commit to social activities, to uncertainty regarding the ability to perform at the highest level. While this study considers a multifaceted approach to veterinary student stress and ultimate depressive symptoms, the focus is on the financial stress. A common strategy for reducing debt is to increase financial literacy....

HIV-1 Envelope FRETted Over by Antibodies.

The HIV-1 Envelope (Env) is a metastable protein that displays several conformational states. In recent works, Lu et al. (2019) in Nature and Alsahafi et al. (2019) in Cell Host & Microbe show that antibodies displaying neutralization or antibody-dependent cellular cytotoxicity (ADCC) target different conformations of the viral glycoprotein.

Exciting Contributions to the Cryptosporidium Renaissance.

In this issue of Cell Host & Microbe, Wilke et al. (2019) describe an air liquid interface culture system supporting the complete life cycle of Cryptosporidium, while Sateriale et al. (2019) report an immunocompetent mouse model facilitating vaccination-induced protection. Together, these studies represent a powerful toolbox for Cryptosporidium research.

Crowd Controlled-Host Quorum Sensing Drives Phage Decision.

In the January issue of Cell, Silpe and Bassler (2019) characterize a phage that looks beyond the boundaries of infected host cells by directly wiretapping their intercellular communication. This information influences the phage's decision of when to kill the host, likely in order to optimize the ecological prospects of phage progeny.

Financial Toxicity Is Associated With Worse Physical and Emotional Long-term Outcomes After Traumatic Injury.

Increasing healthcare costs and high deductible insurance plans have shifted more responsibility for medical costs to patients. After serious illnesses, financial responsibilities may result in lost wages, forced unemployment, and other financial burdens, collectively described as financial toxicity. Following cancer treatments, financial toxicity is associated with worse long-term health related quality of life outcomes (HRQOL). The purpose of this study was to determine the incidence of financial toxicity...

Building Complexity: Making and Breaking Synthetic Subunits of the HIV Capsid.

In this issue of Cell Host & Microbe, Summers et al. (2019) use protein engineering to generate a toolbox of HIV-1 capsid oligomers. In an accompanying Cell Reports paper, Huang et al. (2019) use these oligomers to determine how the capsid engages the kinesin-1 adaptor protein FEZ1.

Precision Engineers: Bacteriophages Modulate the Gut Microbiome and Metabolome.

The precise and rational manipulation of the gut microbiome may enable new therapies for gut health and disease. In this issue of Cell Host & Microbe, Hsu et al. (2019) reveal that bacteriophage predation reduces target bacteria and results in cascading interactions that alter non-target species and the gut metabolome.

Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

In this issue of Cell Host & Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a universal influenza vaccine.

Typhoid Fever: The More We Learn, the Less We Know (Apologies, Albert Einstein).

In this issue of Cell Host & Microbe, Karlinsey et al. (2019) combine TraDIS with humanized mice to identify genes required for early replication of Salmonella Typhi in vivo. Surprisingly, some expected virulence traits and genes appear dispensable in the replication of S. Typhi, supporting findings from a recent human challenge study by Gibani et al. (2019).

Seeing Is Believing: Vitamin A Promotes Skin Health through a Host-Derived Antibiotic.

In this issue of Cell Host & Microbe, Harris et al. (2019) show that members of the resistin-like molecule (RELM) family are bactericidal, antimicrobial peptides that promote skin defenses in a vitamin-A-dependent manner. Administration of vitamin A analogs triggers RELM, which improves host resistance against skin pathogens in mice.

The effect of financial crises on air pollutant emissions: An assessment of the short vs. medium-term effects.

This paper empirically investigates the impact of financial crises on air pollutant emissions (CO, SO, NO and PM). A panel data approach is used, including 419 financial crisis episodes in >150 countries over the period 1970-2014. The short- and medium-term effects of crises are estimated, using a GMM specification (for short-term) and the estimation of impulse response functions (for medium-term). Results show that in the short-term, as a consequence financial crises, emissions decrease for all gases excep...

The Personal Financial Burden Associated with Musculoskeletal Trauma.

Little is known about the effect of orthopaedic trauma on the financial health of patients. We hypothesized that some patients who sustain musculoskeletal trauma experience considerable financial hardship during treatment, and we also assessed for factors associated with increased personal financial burden.

Prospective Survey of Financial Toxicity Measured by the Comprehensive Score for Financial Toxicity in Japanese Patients With Cancer.

We previously reported on the pilot study assessing the feasibility of using the Japanese translation of the Comprehensive Score for Financial Toxicity (COST) tool to measure financial toxicity (FT) among Japanese patients with cancer. In this study, we report the results of the prospective survey assessing FT in Japanese patients with cancer using the same tool.

Targeting Malaria in Flight.

In recent work, Paton et al. (2019) report that mosquitoes exposed to atovaquone, a known antimalarial, are resistant to infection by the malaria parasite Plasmodium. Their results may be the foundation for the discovery of a new arsenal of antimalarials.

Mast Cell Eavesdropping on Bacterial Communications.

Bacteria communicate through quorum sensing, which enables bacterial coordination of collective behaviors and environment-induced adaptations. In this issue of Cell Host & Microbe, Pundir et al. (2019) report that connective-tissue-type mast cells spy on bacterial communication by detecting the messenger molecules via their receptor Mrgprb2-MRGPRX2 to the host benefit.

Host Genetics, Diet, and Microbiome: The Role of AMY1.

Host gene variants selected by diet adaptation have been associated with the microbiome. Poole et al. (Cell Host Microbe 2019;25;553-564.E7) reported that AMY1 copy number, associated with obesity, also impacts microbiome composition and function. Complex genetics-diet-microbiome interactions and their effect on obesity could eventually translate into personalized nutrition.

Commensal Strains of Neisseria Use DNA to Poison Their Pathogenic Rivals.

Commensal bacteria can interfere with colonization of the host by infiltrating pathogens. In this issue of Cell Host & Microbe, Kim et al. (2019) describe an intriguing mechanism of colonization resistance driven by the mismatching of methylation patterns following uptake of commensal-derived DNA by pathogenic strains of Neisseria.

Financial Support Models: A Case for Use of Financial Navigators in the Oncology Setting.

Financial toxicity causes significant psychological and practical distress for patients and can affect their ability and willingness to undertake optimal treatment. Although different models of financial support are typically available to patients undergoing cancer treatments, not all models can offer equal amounts of support and effective solutions, particularly to those patients at the highest levels of risk for this toxicity.

Cancer survivorship care plans, financial toxicity, and financial planning alleviating financial distress among cancer survivors.

Concomitant with the increasing use of cancer care plans has been an increasing awareness of the potential for oncology care to result in long-term financial burdens and financial toxicity. Cancer survivors can benefit from information on support and resources to help them navigate the challenges after acute cancer treatment. While cancer survivorship plans could be a vehicle for patients to receive information on how to mitigate financial toxicity, cancer survivorship plans have typically not dealt with th...

Should Trolleys Be Scared of Mice? Replies to Evans and Brandt (2019); Białek, Turpin, and Fugelsang (2019); Colman, Gold, and Pulford (2019); and Plunkett and Greene (2019).

Patient Assistance Programs: Easing the Burden of Financial Toxicity During Cancer Treatment.

As the cost of cancer treatment escalates, patients with cancer are facing an increased financial burden because of their financial obligations for coinsurance, deductibles, and co-payments.

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