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02:11 EDT 20th June 2018 | BioPortfolio

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Showing "Your Daily Pharma Scoop Heron Undervalued Theravance Submits" PubMed Articles 1–25 of 2,700+

Letter: Enrollment-To-Screening Ratio: An Undervalued Data in Randomized Clinical Trials.

The Cost-Effectiveness of Screening in the Community to Reduce Osteoporotic Fractures in Older Women in the UK: Economic Evaluation of the SCOOP Study.

The SCOOP study was a two-arm randomized controlled trial conducted in the UK in 12,483 eligible women aged 70 to 85 years. It compared a screening program using the FRAX® risk assessment tool in addition to bone mineral density (BMD) measures versus usual management. The SCOOP study found a reduction in the incidence of hip fractures in the screening arm, but there was no evidence of a reduction in the incidence of all osteoporosis-related fractures. To make decisions about whether to implement any screen...

Never, non-daily, and daily smoking status and progression to daily cigarette smoking as correlates of major depressive episode in a national sample of youth: Results from the National Survey of Drug Use and Health 2013 to 2015.

Cigarette smoking is associated with depression, and new initiates who progress more quickly to daily smoking may be at enhanced risk. In a nationally representative sample of youth, this study examined the association between daily, non-daily, and never smoking with past-year and lifetime major depressive episode (MDE) and, among daily smokers, whether faster progression to daily smoking was associated with increased MDE risk.

Moving pharma contracting into the era of accountability.

Cerebrospinal Fluid Abacavir Concentrations in HIV-positive Patients Following Once-daily Administration.

Abacavir is a widely used nucleotide reverse transcriptase inhibitor whose cerebrospinal fluid (CSF) exposure has been previously assessed in twice-daily recipients. We studied abacavir CSF concentrations in 61 and 9 HIV-positive once-daily and twice-daily abacavir intakers. Patients on once-daily abacavir had higher plasma and CSF concentrations (96 vs. 22 ng/mL, p=0.038 and 123 vs. 49 ng/mL, p=0.038) but similar CSF-to-plasma ratios (0.8 vs. 0.5, p=0.500). CSF abacavir concentrations were adequate in once...

Intensity of Daily Drinking and its Relation to Alcohol Use Disorders.

Daily drinking is an important public health concern and informative for evaluating diagnostic classification. In particular, daily binge drinkers might be considered as the prototype of some forms of alcoholism, as this drinking pattern may drive many alcohol use disorder (AUD) symptoms. However, daily drinking potentially captures a wide range of drinkers, including light-moderate daily drinkers who exhibit presumed control over their drinking behavior and might benefit from salutary effects on health. Th...

Assessing adherence to inhaled medication in asthma: Impact of once-daily versus twice-daily dosing frequency. The ATAUD study.

This study was aimed at evaluating whether once-daily regimens (od-r) show benefits in adherence when compared to twice-daily (td-r).

Adding value to daily chest X-rays in the ICU through education, restricted daily orders and indication-based prompting.

Chest X-rays (CXRs) are traditionally obtained daily in all patients on invasive mechanical ventilation (IMV) in the intensive care unit (ICU). We sought to reduce overutilisation of CXRs obtained in the ICU, using a multifaceted intervention to eliminate automated daily studies.

Clinical Acceptability Of Trimetazidine Modified-Release 80 mg Once Daily Versus Trimetazidine Modified-Release 35 mg Twice Daily In Stable Angina Pectoris.

Trimetazidine (TMZ) is an anti-ischemic metabolic agent that has been shown to be efficacious in angina treatment, both in monotherapy and in combination. A new formulation of TMZ modified-release (MR) 80 mg was developed, which is to be taken once daily (od), instead of twice daily (bid) for the currently available TMZ MR 35 mg, with the aim of simplifying the medication regimen.

Malnutrition in Heart Failure: Important But Undervalued Issue.

Life Course Socioeconomic Status, Daily Stressors, and Daily Well-Being: Examining Chain of Risk Models.

This article models the chain of risk that links life course socioeconomic status (SES), daily stressor exposure and severity, and daily well-being.

Australian Hospital-Based Nurse Educators' Perceptions of Their Role.

This article presents the findings from a phenomenological study that explored the understandings of Australian hospital-based nurse educators' experiences of their role. Purposive sampling resulted in 11 nurse educators from four large metropolitan hospitals within an Australian jurisdiction. The participants were asked how they understand their role and translate that understanding into practice. Thematic analysis identified four themes representative of nurse educators' understanding of their role: Becom...

What Did You Do Today? Variability in Daily Activities is Related to Variability in Daily Cognitive Performance.

Are the activities we do each day related to fluctuations in our daily cognitive performance? Positive longitudinal associations between cognitive, physical, and social activities and cognitive ability in adulthood are well established. However little is known about how this relationship may operate at the daily level.

Dynamic, not stable: Daily variations in subjective age bias and age group identification predict daily well-being in older workers.

This work examines the hypothesis that older workers' responses to negative events at work depend, in part, on daily fluctuations of subjective age bias (SAB; how old people feel compared to their actual age) and age group identification (age GI). We tested whether SAB and age GI fluctuate over time, whether they influence attributions of negative daily work events as age-related, and thereby predict older workers' daily affect and cognitive engagement in their work. A diary study with 169 older workers (ag...

Daily exceedance concentration hours: A novel indicator to measure acute cardiovascular effects of PM2.5 in six Chinese subtropical cities.

Daily mean concentration cannot fully address the hourly variations of air pollution within one day. As such, we proposed a new indicator, daily exceedance concentration hours (DECH), to explore the acute cardiovascular effects of ambient PM2.5 (particles with aerodynamic diameters less than 2.5μm). The DECH in PM2.5 was defined as daily total concentration-hours >25μg/m3.

Daily stem diameter variations can predict the canopy water status of mature temperate trees.

Direct evidence for the link between stem diameter variations (SDV) and the daily canopy water status, i.e., daily water potentials (Ψ), is rare, particularly for tall trees. It thus remains unclear up to what degree SDV readings are useful to estimate daily canopy Ψ. We measured SDV with point dendrometers at the stem base of tall, mature individuals of six European forest tree species in a near-natural temperate forest and compared them with daily canopy Ψ during the growing seasons of 2014 (wet) and 2...

Inverse correlation between daily outdoor temperature and blood pressure in six US cities.

This study aims to evaluate the relationship between mean outdoor temperature and mean daily blood pressure (BP) and heart rate (HR) among six, large, geographically and climatically diverse US cities. We collected BP and HR data from Higi stations, located in a wide range of neighborhood grocery stores and retail pharmacies, from six US cities (Houston, Los Angeles, Miami, Boise, Chicago, and New York City). Outdoor daily temperature data were collected from the National Centers for Environmental Informati...

A guide to manufacturing CAR T cell therapies.

In recent years, chimeric antigen receptor (CAR) modified T cells have been used as a treatment for haematological malignancies in several phase I and II trials and with Kymriah of Novartis and Yescarta of KITE Pharma, the first CAR T cell therapy products have been approved. Promising clinical outcomes have yet been tempered by the fact that many therapies may be prohibitively expensive to manufacture. The process is not yet defined, far from being standardised and often requires extensive manual handling ...

Daily Stress Reactivity Across the Lifespan: Longitudinal and Cross-Sectional Effects of Age.

Exploration of development requires the use of research designs and process-oriented methodologies that can capture daily fluctuations within individuals, systematic changes within individuals, and differences between individuals (Nesselroade, 1991). We examine the stress-affect relationship in this way to assess how the relationship between daily stress and negative affect (NA) as well as the relationship between daily stress and positive affect (PA) differs between individuals and changes over time depend...

Comparing daily drivers of problem drinking among older and younger adults: An electronic daily diary study using smartphones.

By 2030, numbers and proportions of older adults with substance-use problems are expected to increase. While risk factors for problem drinking in late life have been identified, it remains unknown whether these factors drive daily drinking among older problem drinkers. This study examined the daily drivers of drinking among problem drinkers, moderated by age, utilizing ecological momentary assessment (EMA).

The short-term impact of economic uncertainty on motor vehicle collisions.

Stress and anxiety lead to attention loss and sleep deprivation and may reduce driving performance, increasing the risk of motor vehicle collision. We used evidence from a natural experiment to examine whether daily changes in economic uncertainty, potentially leading to attention or sleep loss, are associated with collisions in Great Britain. Daily data from the economic policy uncertainty index, derived from analysis of daily UK newspapers, were linked to the daily number of motor vehicle collisions in Gr...

Raltegravir 1200 mg once daily vs 400 mg twice daily, with emtricitabine and tenofovir disoproxil fumarate, for previously untreated HIV-1 infection: Week 96 results from ONCEMRK, a randomized, double-blind, non-inferiority trial.

Raltegravir 1200mg (2x600mg tablets) once daily (QD) demonstrated non-inferior efficacy and similar safety to raltegravir 400mg BID at Week 48 of the ONCEMRK trial. Here we report the Week 96 results from this study.

Short-term changes in daily movement behaviour influence salivary C-reactive protein in healthy women.

This study assessed the effect of changing daily movement behaviour on C-reactive protein (CRP) measured in saliva. Two groups of women either reduced daily movement or increased physical activity for 10 days. Salivary CRP increased by 31% in the sedentary group (0.378±0.596 to 0.487±0.793 µg·L-1) and decreased by 22% in the active group (0.414±0.640 to 0.259±0.284 µg·L-1). These results suggest short-term changes in daily movement behaviour can affect salivary CRP, a marker of systemic inflammation...

Validation of adapted daily dose definitions for hospital antibacterial drug use evaluation: a multicentre study.

The WHO/ATC (Anatomical Therapeutic Chemical) index DDD (WHO-DDD) is commonly used for drug consumption measurement. Discrepancies between WHO-DDD and actual prescribed daily doses (PDD) in hospitals have prompted alternative dose definitions adapted to doses recommended in hospital practice guidelines [recommended daily doses (RDD)].

Associations between ambient air pollution and daily mortality in a cohort of congestive heart failure: Case-crossover and nested case-control analyses using a distributed lag nonlinear model.

Persons with congestive heart failure may be at higher risk of the acute effects related to daily fluctuations in ambient air pollution. To meet some of the limitations of previous studies using grouped-analysis, we developed a cohort study of persons with congestive heart failure to estimate whether daily non-accidental mortality were associated with spatially-resolved, daily exposures to ambient nitrogen dioxide (NO2) and ozone (O3), and whether these associations were modified according to a series of in...

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