PubMed Journals Articles About "Zimbabwe Industrialization Hinge Biotech" RSS

23:00 EST 18th January 2019 | BioPortfolio

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Showing "Zimbabwe Industrialization Hinge Biotech" PubMed Articles 1–25 of 154

HIV infection in patients with sexually transmitted infections in Zimbabwe - Results from the Zimbabwe STI etiology study.

HIV and other sexually transmitted infections (STI) frequently co-occur. We conducted HIV diagnostic testing in an assessment of the etiologies of major STI syndromes in Zimbabwe.

90-90-90 by 2020? Estimation and projection of the adult HIV epidemic and ART programme in Zimbabwe - 2017 to 2020.

The 90-90-90 targets set by the United Nations aspire to 73% of people living with HIV (PLHIV) being virally suppressed by 2020. Using the HIV Synthesis Model, we aim to mimic the epidemic in Zimbabwe and make projections to assess whether Zimbabwe is on track to meet the 90-90-90 targets and assess whether recently proposed UNAIDS HIV transition metrics are likely to be met.

Comparison of platelet activation through hinge vs bulk flow in bileaflet mechanical heart valves.

Bileaflet mechanical heart valves (BMHVs) are prone to thromboembolic complications which are believed to be initiated by platelet activation. Platelets are activated by non-physiologic shear stresses in the bulk flow or the leakage/hinge flow, whose contributions has yet to be quantified. Here, the contribution of bulk and hinge flows to the activation of platelets in BMHVs is quantified for the first time by performing simulations of the flow through a BMHV and resolving the hinge by overset grids (one gr...

Factors associated with home births in a selected ward in Mberengwa District, Zimbabwe.

Despite many efforts put by the Government to ensure that women give birth in health facilities under trained personnel supervision; statistics suggest that ward 2 in Mberengwa District in Zimbabwe has the highest home births. This study sought to assess factors that are associated with home births in ward 2 of Mberengwa District in Zimbabwe.

Identification of a new European rabbit IgA with a serine-rich hinge region.

In mammals, the most striking IgA system belongs to Lagomorpha. Indeed, 14 IgA subclasses have been identified in European rabbits, 11 of which are expressed. In contrast, most other mammals have only one IgA, or in the case of hominoids, two IgA subclasses. Characteristic features of the mammalian IgA subclasses are the length and amino acid sequence of their hinge regions, which are often rich in Pro, Ser and Thr residues and may also carry Cys residues. Here, we describe a new IgA that was expressed in N...

Towards UNAIDS Fast-Track goals: targeting priority geographic areas for HIV prevention and care in Zimbabwe.

Zimbabwe has made substantial progress towards the Joint United Nations Programme on HIV/AIDS (UNAIDS) targets of 90-90-90 by 2020, with 73% of people living with HIV diagnosed, 87% of those diagnosed on antiretroviral therapy (ART) and 86% of those on ART virally suppressed. Despite this exceptional response, more effort is needed to completely achieve the UNAIDS targets. Here, we conducted a detailed spatial analysis of the geographical structure of the HIV epidemic in Zimbabwe to include geographical pri...

Hinge-linker elements in the AAA+ protein unfoldase ClpX mediate intersubunit communication, assembly, and mechanical activity.

The ClpXP protease plays important roles in protein homeostasis and quality control. ClpX is a ring-shaped AAA+ homohexamer that unfolds target proteins and translocates them into the ClpP peptidase for degradation. AAA+ modules in each ClpX subunit - consisting of a large AAA+ domain, a short hinge-linker, and a small AAA+ domain - mediate the mechanical activities of the ring hexamer. Here, we investigate the roles of these hinge-linkers in ClpX function. Deleting one hinge-linker in a single-chain ClpX p...

The emerging health impact of voluntary medical male circumcision in Zimbabwe: An evaluation using three epidemiological models.

Zimbabwe adopted voluntary medical male circumcision (VMMC) as a priority HIV prevention strategy in 2007 and began implementation in 2009. We evaluated the costs and impact of this VMMC program to date and in future.

The forkhead domain hinge-loop plays a pivotal role in DNA binding and transcriptional activity of FOXP2.

Forkhead box (FOX) proteins are a ubiquitously expressed family of transcription factors that regulate the development and differentiation of a wide range of tissues in animals. The FOXP subfamily members are the only known FOX proteins capable of forming domain-swapped forkhead domain (FHD) dimers. This is proposed to be due to an evolutionary mutation (P539A) that lies in the FHD hinge loop, a key region thought to fine-tune DNA sequence specificity in the FOX transcription factors. Considering the import...

Dietary patterns and colorectal cancer risk in Zimbabwe: A population based case-control study.

The rising incidence of colorectal cancer in sub-Saharan Africa may be partly caused by changing dietary patterns. We sought to establish the association between dietary patterns and colorectal cancer in Zimbabwe.

Where, when and how many tuberculosis patients are lost from presumption until treatment initiation? A step by step assessment in a rural district in Zimbabwe.

To describe the pre-diagnosis and pre-treatment loss to follow-up (LTFU) in the TB care cascade in Guruve (2015-16), a rural district in Zimbabwe.

Predictive Factors for and Detection of Lateral Hinge Fractures Following Open Wedge High Tibial Osteotomy: Plain Radiography Versus Computed Tomography.

To compare the accuracy of plain radiography and computed tomography (CT) in detecting lateral hinge fractures and to identify predictive factors of the lateral hinge fractures after open wedge high tibial osteotomy (HTO).

The association of puerperal sepsis with HIV infection at two tertiary hospitals in Zimbabwe.

To evaluate the association between HIV infection and puerperal sepsis among women in Zimbabwe.

Antiretroviral adverse drug reactions pharmacovigilance in Harare City, Zimbabwe, 2017.

Key to pharmacovigilance is spontaneously reporting all Adverse Drug Reactions (ADR) during post-market surveillance. This facilitates the identification and evaluation of previously unreported ADR's, acknowledging the trade-off between benefits and potential harm of medications. Only 41% Antiretroviral (ARV) ADR's documented in Harare city clinical records for January to December 2016 were reported to Medicines Control Authority of Zimbabwe (MCAZ). We investigated reasons contributing to underreporting of ...

How well does the process of screening and diagnosis work for HIV-infected persons identified with presumptive tuberculosis who are attending HIV care and treatment clinics in Harare city, Zimbabwe?

Intensified TB case finding is recommended for all HIV-infected persons regularly attending HIV care and treatment clinics. The authors aimed to determine how well this system worked among HIV-infected patients diagnosed with presumptive TB in 14 health facilities of Harare province, Zimbabwe, between January and December 2016.

Third-quarter biotech job picture.

Second-quarter biotech job picture.

Characterization of disulfide linkages at the hinge region of IgG antibodies by HPLC mass spectrometry.

There are two types of disulfide linkages in IgG antibodies at the hinge region: intra- and inter-disulfide linkage. Characterization of intra-disulfide linked isomer will provide important information on the stability of the antibodies and better understanding of the mechanism of Fab-arm exchange. In this report, HPLC coupled with high resolution mass spectrometry was applied for characterization of disulfide linkages in IgG antibodies at the hinge region. We were able to accurately identify both inter- an...

The survivorship of the link endo-rotational hinge total knee arthroplasty: 5-12-year follow-up of 100 patients.

There is a paucity of survival data reporting the medium to long-term outcome of the LINK® Endo-Model rotational hinge total knee arthroplasty (ERH-TKA). Such information is essential when counselling patients and predictors of survival would help inform patients of their likely outcome.

Gates unveils biotech-within-a-charity.

Public biotech in 2017-the numbers.

New Nonprofit Biotech From Bill and Melinda Gates.

Biotech leaders call for free press.

Screening tool to identify adolescents living with HIV in a community setting in Zimbabwe: A validation study.

A simple cost-effective strategy to pre-screen for targeted HIV testing can have substantial benefit in high burden and resource limited settings. A 4-item (previous hospitalisation, orphanhood, poor health status, and recurring skin problems) screening tool to identify adolescents living with HIV has previously shown high sensitivity in healthcare facility settings. We validated this screening tool in a community setting, in Harare, Zimbabwe in a community-based HIV prevalence survey.

Time taken to link newly identified HIV positive clients to care following a home-base index case HIV testing: Experience from two provinces in Zimbabwe.

Homebased index case HIV testing (HHTC) has shown higher uptake and good yield than traditional HIV testing methods. World Health Organization has called for increased operational research to evaluate HIV care processes particularly linkage to care. In this paper, we present project results of the time taken to link newly identified PLHIV to care after HHTC in the Manicaland and Midlands provinces of Zimbabwe.

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