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PubMed Journals Articles About "Zynerba Pharmaceuticals Reports First Quarter 2018 Financial Results" RSS

21:12 EST 23rd January 2019 | BioPortfolio

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Showing "Zynerba Pharmaceuticals Reports First Quarter 2018 Financial Results" PubMed Articles 1–25 of 47,000+

Life sciences licensing deals in the second quarter of 2018: updates and trends.

During the second quarter of 2018, Cortellis Competitive Intelligence registered 985 new deals (excluding mergers and acquisitions) with a total disclosed deal value of USD 19.5 billion as part of its ongoing coverage of licensing activity in the life sciences sector compared to 964 and USD 35.6 billion in the first quarter and 1,104 and USD 13.6 billion in the second quarter of 2017. Total deal value in the second quarter did not quite reach the peak of 2014 (paced by Novartis' USD 16 billion purchase of G...


Too soon to worry? Longitudinal examination of financial planning for retirement among Spanish aged workers.

The present study analyzes the relationship between three distal antecedents-financial literacy, confidence in retirement, and economic well-being-and financial planning for retirement evaluated at two different times. We used longitudinal data with repeated measures of financial planning for retirement obtained from a sample (N = 269) of active Spanish workers aged 45-62 years. The results confirm that self-perceived financial knowledge, confidence in retirement, and economic well-being are associated with...

Swimming activity in zebrafish larvae exposed to veterinary antiparasitic pharmaceuticals.

Veterinary antiparasitic pharmaceuticals have been detected in surface waters and several of these pharmaceuticals act on the nervous system on the target organisms implying that neurological effects also might be of concern in non-target animals such as fish. We tested if exposure to antiparasitic pharmaceuticals affect swimming activity in 6 days old zebrafish larvae. The results revealed that most pharmaceuticals did not cause any effects in swimming activity. However, larvae exposed to 0.58 mg/L doram...


Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: Hourly variation.

The removal efficiency of pharmaceuticals in wastewater treatment plants (WWTPs) is variable and some of these compounds pass these plants almost intact and others presenting a removal efficiency close to 100%. Their incomplete removal results in a continuous discharge of pharmaceuticals into the environment. To assess the profile of contamination of influents and effluents over a day, a set of 83 pharmaceuticals were evaluated hourly in a WWTP in Leiria, Portugal. The composite samples of the influent and ...

Insight into the distribution of pharmaceuticals in soil-water-plant systems.

Pharmaceuticals in agricultural soils originating from irrigation with treated wastewater and land-applied biosolids can enter field crops. However, little is known about the role of pore water in plant uptake of pharmaceuticals from soils. In this study, the fate, uptake and distribution of fifteen commonly used pharmaceuticals in soil-water-radish systems were investigated to examine the relationship between the accumulation and their physicochemical processes in soils. The results indicate that the distr...

Optimization Approach for Estimating the Required Amount of Pharmaceuticals in the Russian Federation.

To propose an algorithm that relates the effectiveness of drugs for a wide range of diseases with the financial capabilities of patients.

Exposure and ecotoxicological risk assessment of mixtures of top prescribed pharmaceuticals in Swedish freshwaters.

Surface water concentrations of 54 pharmaceuticals were predicted for seven major Swedish rivers and the Stockholm City area basins using the STREAM-EU model. These surface water concentrations were used to predict the ecotoxicological impact resulting from the exposure of aquatic organisms to this mixture of 54 pharmaceuticals. STREAM-EU model results indicated that

Chiral pharmaceuticals: Environment sources, potential human health impacts, remediation technologies and future perspective.

Chiral pharmaceuticals (CPs), including non-steroid anti-inflammatory drugs (NSAIDs), β-blockers and some herbicide and pesticides, are widely used in aquaculture, clinical treatment and many other fields. However, people are increasingly concerned about such ubiquitous pollutants, which can frequently be detected in contaminated soil and water. In large part, the significant sources of chiral pharmaceuticals stem from industrial processes, such as the direct discharge of untreated or incompletely treated ...

Effects of pharmaceuticals on microbial communities and activity of soil enzymes in mesocosm-scale constructed wetlands.

Cyperus alternifolius based mesocosm-scale constructed wetland was employed to remove pharmaceuticals. We investigated the microbial community composition using phosphor lipid fatty acids (PFLAs) analysis and substrate enzyme activity during long-term exposure to pharmaceuticals in mesocosm-scale constructed wetlands. The results showed that there was no visible inhibition effect of pharmaceuticals on CW substrate enzymes activities in the experimental range (0-500 μg/L). Microbial communities, as reveal...

Does financial openness increase environmental degradation? Fresh evidence from MERCOSUR countries.

This article researches the impact of financial openness on environmental degradation in the MERCOSUR countries over the time spanning from 1980 to 2014. The Panel Autoregressive Distributed Lag (PARDL), in the form of Unrestricted Error Correction Model (UECM), was computed with the purpose of decomposing the total effects of variables in their short- and long-run ones. The results of short-run impacts and elasticities of PARDL model showed that the financial openness increases the CO emissions both in the...

Financial hardship and risk of suicide among U.S. Army personnel.

Financial stress has been frequently identified as a risk factor for suicidal behavior, both in military and civilian groups. However, it remains unclear to what degree financial stress may be associated independently with suicide behavior when accounting for other risk factors. This study examined data on suicide and suicide attempt cases in the Department of Defense Suicide Event Report compared with service members who did not have recent suicide behavior. The resulting multinomial regression analysis fo...

Objective and subjective financial status and mortality among older adults in China.

The association between financial status and mortality in older adults is well documented. However, it is unclear whether the association may vary by objective and subjective indicators of financial status. To examine this issue, we used the latest four waves (2005, 2008/2009, 2011/2012, and 2014) of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) of community-residing adults aged 65 and older (n = 25,954). Financial status was assessed using eight objective, subjective, and culturally-oriente...

The quantification of pharmaceutical related biological activity in effluents from wastewater treatment plants in UK and Japan.

Whilst pharmaceuticals are now routinely detected in aquatic environments, we know little of the biological activity their presence might provoke. It is estimated that nearly 40% of all marketed pharmaceuticals are G protein-coupled receptors (GPCRs)-acting pharmaceuticals. Here, we applied an in vitro assay, called the TGFα shedding assay, to measure the biological activities of GPCRs-acting pharmaceuticals present in effluents from municipal wastewater treatment plants in the United Kingdom (UK) and Japa...

Adsorptive interaction of cationic pharmaceuticals on activated charcoal: Experimental determination and QSAR modelling.

Due to high mobility and specific toxic actions of the ionizable pharmaceuticals in surface water with a normal range of pH, the pharmaceuticals should be removed before being discharged. Therefore, this study investigated the adsorptive interactions between cationic pharmaceuticals and a popular adsorbent (i.e., activated charcoal) frequently used in water treatment processes. For that, we performed isotherm experiments and then the results were plotted by Langmuir model to determine the adsorption affinit...

Establishing financial literacy: what every resident needs to know.

Financial literacy is a skill that requires an ongoing investment of time and often is overlooked throughout medical training. Physicians are facing an unprecedented student loan burden upon graduation from medical school, coupled with stagnant and decreasing salaries and few financial skills to help navigate this terrain. The purpose of this article is to address several specific steps every resident should take during training to establish good financial practices.

A heterogeneous artificial stock market model can benefit people against another financial crisis.

This paper presents results of an artificial stock market and tries to make it more consistent with the statistical features of real stock data. Based on the SFI-ASM, a novel model is proposed to make agents more close to the real world. Agents are divided into four kinds in terms of different learning speeds, strategy-sizes, utility functions, and level of intelligence; and a crucial parameter has been found to ensure system stability. So, some parameters are appended to make the model which contains zero-...

A meeting Report on the 2018 annual meeting of ASBMR-Clinical practice of the osteoporosis-.

In the 2018 ASBMR annual meeting, many important results were reported, showing the effects of anti-osteoporotic drugs already focusing on bone quality and the concept of "treat-to-target", although there were few big topics on novel drugs. However, some reports on new drugs, such as probiotics and SARM(selective androgen receptor modulator), did draw attention.

New toxicogenetic insights and ranking of the selected pharmaceuticals belong to the three different classes: A toxicity estimation to confirmation approach.

Tetracycline hydrochloride (TH), indomethacin (IM), and bezafibrate (BF) belong to the three different important classes of pharmaceuticals, which are well known for their toxicity and environmental concerns. However, studies are still elusive to highlight the mechanistic toxicity of these pharmaceuticals and rank them using both, the toxicity prediction and confirmation approaches. Therefore, we employed the next generation toxicity testing in 21st century (TOX21) tools and estimated the in vitro/vivo toxi...

A Short Review of the Treatment of Headaches Using Osteopathic Manipulative Treatment.

This review highlights the importance of osteopathic manipulative treatment (OMT) in headache sufferers. OMT is a viable option for patients who either do not wish to use pharmaceuticals or who have contraindications to pharmaceuticals. Patients with headaches that are refractory to other treatment options may also be candidates for OMT. Multiple headache etiologies are amenable to this non-invasive treatment option and they will be reviewed here. Although there are advantages to using this treatment method...

Financial toxicity in cancer care: Prevalence, causes, consequences, and reduction strategies.

Financial toxicity is the adverse impact of a cancer diagnosis on a patient's financial well-being resulting from direct or indirect costs. Potential consequences of financial toxicity include material loss, psychological distress, and/or maladaptive coping strategies. This review will summarize the prevalence, causes, and consequences of financial toxicity, with an emphasis on strategies to anticipate and reduce its burden. Improvement will require multilevel, coordinated efforts between stakeholders inclu...

A novel financial risk assessment model for companies based on heterogeneous information and aggregated historical data.

The financial risk not only affects the development of the company itself, but also affects the economic development of the whole society; therefore, the financial risk assessment of company is an important part. At present, numerous methods of financial risk assessment have been researched by scholars. However, most of the extant methods neither integrated fuzzy sets with quantitative analysis, nor took into account the historical data of the past few years. To settle these defects, this paper proposes a n...

Relationships between Financial Toxicity and Symptom Burden in Cancer Survivors: A Systematic Review.

Financial toxicity (FT) is used to describe the financial distress/hardship associated with cancer and its treatment.

Transport of platinum-based pharmaceuticals in water-saturated sand and natural soil: Carboplatin and cisplatin species.

This study reports the transport characteristics of the pharmaceutical compounds carboplatin and cisplatin, and their respective derivatives, in saturated sand and soil columns. Pharmaceuticals are recognized as emerging pollutants of soil and water resources, but studies of the transport characteristics of organometallic pharmaceuticals in soil-water environments are rare. A recent study of oxaliplatin transport in natural soil raises the question of whether or not its behavior is representative of all Pt-...

Dynamics of investor spanning trees around dot-com bubble.

We identify temporal investor networks for Nokia stock by constructing networks from correlations between investor-specific net-volumes and analyze changes in the networks around dot-com bubble. The analysis is conducted separately for households, financial, and non-financial institutions. Our results indicate that spanning tree measures for households reflected the boom and crisis: the maximum spanning tree measures had a clear upward tendency in the bull markets when the bubble was building up, and, even ...

Asymmetrical endothelial cell migration from in vitro Quarter-Descemet membrane endothelial keratoplasty grafts.

To investigate in vitro central and peripheral corneal endothelial cell (EC) migration from Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK) grafts.


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