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23:08 EST 20th November 2018 | BioPortfolio

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Showing "adds more tenants Venture Accelerator" PubMed Articles 1–25 of 313

Theory-driven formative research on on-site, shared sanitation quality improvement among landlords and tenants in peri-urban Lusaka, Zambia.

Rapid, unplanned urbanization in low-income countries is leading to increasing problems of dealing with human waste. On-site sanitation systems are often rudimentary, unhygienic, and poorly maintained. In-depth, on-site interactive interviews were conducted with 33 landlords and 33 tenants in a neighborhood in peri-urban Lusaka to understand on-site, shared sanitation quality improvement behaviors and preferences. Respondents were asked about housing characteristics, toilet histories, and financial decision...

Housing for People with Substance Use Disorders: One Size Does Not Fit All Tenants-Assessment of 16 Housing Services and Suggestions for Improvement Based on Real World Experience.

Housing is an important factor for individuals addressing substance use disorders (SUD). This work compared aims and outcomes for new housing services and made suggestions for improvement. 16 new services were assessed over 6 months activity against factors identified as important. Services defined expected standards including (1) engagement with treatment for SUD, (2) restrictions on continuing substance use by tenants. After 6 months, 9 (56%) housing projects did not achieve planned standards and lowere...

A photon source model based on particle transport in a parameterized accelerator structure for Monte Carlo dose calculations.

An accurate source model of a medical linear accelerator is essential for Monte Carlo (MC) dose calculations. This study aims to propose an analytical photon source model based on particle transport in parameterized accelerator structures, focusing on a more realistic determination of linac photon spectra compared to existing approaches.

An ultrasensitive electrochemiluminescence biosensor for detection of MicroRNA by in-situ electrochemically generated copper nanoclusters as luminophore and TiO as coreaction accelerator.

Herein, we constructed an ultrasensitive electrochemiluminescence (ECL) biosensor for detecting microRNA-21 (miR-21) based on in-situ generation of copper nanoclusters (Cu NCs) as luminophore and titanium dioxide (TiO) as coreaction accelerator. First, numerous AT-rich double-stranded DNA (dsDNA) was produced from the conversion of a small amount of target miR-21 via the combination of exonuclease III (Exo III)-assisted amplification and hybridization chain reaction (HCR), which could reduce the aggregation...

Design considerations for a Pulse Line Ion Accelerator (PLIA)-based PET isotope generator.

Positron emission tomography (PET) imaging remains limited by the cost associated with on-site production of short half-life, positron emitting isotopes. In this work, we examine the use of a pulse line ion accelerator (PLIA) to accelerate protons for single-dose PET isotope production.

Dialysis-Facility Joint-Venture Ownership - Hidden Conflicts of Interest.

Dedicated linear accelerator radiosurgery for classical trigeminal neuralgia: a single-center experience with long term follow-up.

During the past decades, stereotactic radiosurgery (SRS) and Gamma Knife in particular have proven its safety and efficacy for drug-resistant classical trigeminal neuralgia (CTN). However, few large series exist using linear accelerator (LINAC), reporting long-term follow-up.

First Six Dimensional Phase Space Measurement of an Accelerator Beam.

This Letter presents the first complete six dimensional phase space measurement of a beam in an accelerator. The measurement was made on the Spallation Neutron Source Beam Test Facility. The data reveal previously unknown correlations in the six dimensional phase space distribution that are not visible in lower dimensionality measurements. The correlations are shown to be intensity dependent.

Towards femtosecond-level intrinsic laser synchronization at fourth generation light sources.

In this Letter, the proof of principle for a scheme providing intrinsic femtosecond-level synchronization between an external laser system and fourth generation light sources is presented. The scheme is applicable at any accelerator-based light source that is based on the generation of coherent radiation from ultrashort electron bunches such as superradiant terahertz (THz) facilities or X-FELs. It makes use of a superradiant THz pulse generated by the accelerator as an intrinsically synchronized gate signal...

Observation of Laser Power Amplification in a Self-Injecting Laser Wakefield Accelerator.

We report on the depletion and power amplification of the driving laser pulse in a strongly driven laser wakefield accelerator. Simultaneous measurement of the transmitted pulse energy and temporal shape indicate an increase in peak power from 187±11  TW to a maximum of 318±12  TW after 13 mm of propagation in a plasma density of 0.9×10^{18}  cm^{-3}. The power amplification is correlated with the injection and acceleration of electrons in the nonlinear wakefield. This process is modeled by ...

PrEP Communications Accelerator: a digital demand creation tool for sub-Saharan Africa.

Strategic communications are critical for successful market introduction of oral pre-exposure prophylaxis (PrEP). This paper focuses on the OPTIONS Consortium's approach to developing the PrEP Communications Accelerator, a digital tool that provides communication strategies and tools for generating demand for PrEP across sub-Saharan Africa. The PrEP Communications Accelerator was developed through needs assessment, communications landscape and gap analysis, market research and content development and testi...

Assessment of Mn deposition on Earth via accelerator mass spectrometry.

The Mn flux onto Earth is a quantity relevant for different extraterrestrial and astrophysical questions. It is a proxy for related fluxes, such as supernova-produced material or interplanetary dust particles. In this work, we performed a first attempt to assess the Mn flux by measuring the Mn/Be isotopic ratio in a 1400 L sample of molten Antarctic snow by AMS (Accelerator Mass Spectrometry). Using the Be production rate in the atmosphere, an upper limit of 5.5 × 10 atoms cm yr was estimated for the...

Hardware acceleration of BWA-MEM genomic short read mapping for longer read lengths.

We present our work on hardware accelerated genomics pipelines, using either FPGAs or GPUs to accelerate execution of BWA-MEM, a widely-used algorithm for genomic short read mapping. The mapping stage can take up to 40% of overall processing time for genomics pipelines. Our implementation offloads the Seed Extension function, one of the main BWA-MEM computational functions, onto an accelerator. Sequencers typically output reads with a length of 150 base pairs. However, read length is expected to increase in...

Technical Note: Characterization of Clinical Linear Accelerator Triggering Latency for Motion Management System Development.

Latencies for motion management systems have previously been presented as guidelines for system development and implementation. These guidelines consider the overall system latency, including data acquisition, algorithm processing, and linac triggering time. However, during system development, the triggering latency of the clinical linear accelerator is often considered fixed. This paper presents a method to decouple the linac-only triggering latency from the total system latency such that latency can be co...

Grant Funding Needs Parallel the Start-Up Venture: An Analogy for Translational Research Success.

This editorial offers some ways to think about how best to position a research group for funding, by examining the parallels between what is needed for translational grants versus industry start-ups.


The first Radioactive Ion Beam Line in Lanzhou was a projectile fragment separator located in the HIRFL. The process of production and separation of radioactive ion beams can induce a strong and complex radiation field. The neutron dose equivalent rates were measured in four positions with a 70 MeV/u 40Ar18+ beam. The results were compared with that simulated by the FLUKA code. New shielding walls were installed to reduce the neutron background for spectroscopy measurement in the experimental terminal. In a...

Correction: Lung density change after SABR: A comparative study between tri-Co-60 magnetic resonance-guided system and linear accelerator.

[This corrects the article DOI: 10.1371/journal.pone.0195196.].

Stellar ^{36,38}Ar(n,γ)^{37,39}Ar Reactions and Their Effect on Light Neutron-Rich Nuclide Synthesis.

The ^{36}Ar(n,γ)^{37}Ar (t_{1/2}=35  d) and ^{38}Ar(n,γ)^{39}Ar (269 yr) reactions were studied for the first time with a quasi-Maxwellian (kT∼47  keV) neutron flux for Maxwellian average cross section (MACS) measurements at stellar energies. Gas samples were irradiated at the high-intensity Soreq applied research accelerator facility-liquid-lithium target neutron source and the ^{37}Ar/^{36}Ar and ^{39}Ar/^{38}Ar ratios in the activated samples were determined by accelerator mass spectrometry ...

CuS as co-reaction accelerator in PTCA-KSO system for enhancing electrochemiluminescence behavior of PTCA and its application in detection of amyloid-β protein.

In this work, 3,4,9,10-perylenetetracar-boxylic acid (PTCA) as luminophor was grafted on the surface of graphene oxide (PTCA-GO) directly. GO exhibited large specific surface area and excellent electrical conductivity which can immobilize large amounts of PTCA to improve the electrochemiluminescence (ECL) efficiency. Moreover, gold nanoparticles (Au NPs) were anchored on the surface of PTCA-GO to immobilize primary antibodies (Ab) via Au-NH bond and enhance the electron transport of PTCA-GO. CuS was used as...

BRAF Adds an Additional Piece of the Puzzle to Precision Oncology-Based Treatment Strategies in Lung Cancer.

Beam shaping assembly design of Li(p,n)Be neutron source for boron neutron capture therapy of deep-seated tumor.

The development of a medical facility for boron neutron capture therapy at Budker Institute of Nuclear Physics is under way. The neutron source is based on a tandem accelerator with vacuum insulation and lithium target. The proposed accelerator is conceived to deliver a proton beam around 10 mA at 2.3 MeV proton beam. To deliver a therapeutic beam for treatment of deep-seated tumors a typical Beam Shaping Assembly (BSA) based on the source specifications has been explored. In this article, an optimized ...

Skin Stem Cells in Silence, Action, and Cancer.

In studying how stem cells make and maintain tissues, nearly every chapter of a cell biology textbook takes on special interest. The field even allows us to venture where no chapters have yet been written. In studying this basic problem, we are continually bombarded by nature's surprises and challenges. Stem cell biology has captured my interest for nearly my entire scientific career. Below, I focus on my laboratory's contributions to this fascinating field, to which so many friends and colleagues have made...

Ultrafast Imaging of Laser Driven Shock Waves using Betatron X-rays from a Laser Wakefield Accelerator.

Betatron radiation from laser wakefield accelerators is an ultrashort pulsed source of hard, synchrotron-like x-ray radiation. It emanates from a centimetre scale plasma accelerator producing GeV level electron beams. In recent years betatron radiation has been developed as a unique source capable of producing high resolution x-ray images in compact geometries. However, until now, the short pulse nature of this radiation has not been exploited. This report details the first experiment to utilize betatron ra...

The role of Ca and BK channels of locus coeruleus (LC) neurons as a brake to the CO chemosensitivity response of rats.

The cellular mechanisms by which LC neurons respond to hypercapnia are usually attributed to an "accelerator" whereby hypercapnic acidosis causes an inhibition of K channels or activation of Na and Ca channels to depolarize CO-sensitive neurons. Nevertheless, it is still unknown if this "accelerator" mechanism could be controlled by a brake phenomenon. Whole cell patch clamping, fluorescence imaging microscopy and plethysmography was used to study the chemosensitive response of the LC neurons. Hypercapnic a...

DKG Certification of Paediatric Cancer Centres.

The new certification module will continue to foster the development of interdisciplinary networks and a centralised commitment to high quality of care in paediatric oncology. The new module was initiated in a joint venture of the German Society of Paediatric Oncology and Haematology (GPOH) and the German Cancer Society (DKG) in 2016. The comprehensive Catalogue of Requirements is based on the directive for paediatric oncology by the Federal Joint Committee (G-BA) and has been successfully implemented into ...

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