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PubMed Journals Articles About "Building Pipeline∨derfield=score∨derval=desc" RSS

10:40 EDT 16th July 2019 | BioPortfolio

Building Pipeline∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Building Pipeline∨derfield=score∨derval=desc articles that have been published worldwide.

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Showing "building pipeline derfield score derval desc" PubMed Articles 1–25 of 4,100+

Anti-androgenic therapy with finasteride in patients with chronic heart failure - a retrospective propensity score based analysis.

Sex hormones influence the prevalence and the outcome of heart diseases. The conversion of testosterone to its more active metabolite dihydrotestosterone drives cardiac growth and dysfunction, while inhibition of this step by the anti-androgenic drug finasteride counteracts these pathological processes in preclinical models. In this retrospective, observational study, we aim to investigate whether finasteride, which is in clinical use mainly for prostate disease, might ameliorate cardiac hypertrophy and hea...


The Associations Between Maladaptive Personality Traits, Craving, Alcohol Use, and Adolescent Problem Gambling: An Italian Survey Study.

Although gambling disorder (GD) criteria do not explicitly address craving, it has received increased attention because it has been found to be a significant predictor of gambling severity. Furthermore, recent findings have suggested that both alcohol consumption and maladaptive personality traits may be risk factors among adult GD. To date, no study has evaluated the relative contribution of these factors in adolescent gambling behavior. Consequently, the present study investigated the relationship between...

Use of Continuous Metabolic Syndrome Score in Overweight and Obese Children.

To assess the utility of continuous metabolic syndrome score (cMetS) for predicting metabolic syndrome (MS) and determine the cut-off values in overweight and obese children.


Incidence, Risk Factors, and Outcomes of Ventilator-Associated Pneumonia Traumatic Brain Injury: A Meta-analysis.

Ventilator-associated pneumonia (VAP) is one of the most severe complications in patients with traumatic brain injury (TBI) and is considered a risk factor for poor outcomes. However, the incidence of VAP among patients with TBI reported in studies varies widely. What is more, the risk factors and outcomes of VAP are controversial. This study estimates the incidence, risk factors, and outcomes of VAP in patients with TBI and provides evidence for prevention and treatment. PubMed, EMBASE, Cochrane Library, a...

Evaluation of Safety and Efficacy of Growth Hormone Therapy by IGF-1 Z Score in Children with Short Stature.

This study aims to explore the safety and efficacy of growth hormone (GH) therapy by retrospectively analyzing the changes of insulin-like growth factor-1 (IGF-1) Z-scores in children with short stature after treatment with GH.

Longitudinal Associations of Identity Processing Styles With Prodiversity and Proequality Values in Adolescence.

In adolescence, the formation of personal identity and values may be intertwined, since values are among the main issues considered when building one's identity. This study examined how sociocognitive strategies used in the process of identity formation were related with adoption of prodiversity and proequality values, which are critically important for socially diverse contemporary societies. Participants were 916 adolescents (51.4% females, M  = 15.65, SD  = 0.73 at baseline) involved in a three-wave ...

Identification ofendogenous small peptides involved in rice immunity through transcriptomics- and proteomics-based screening.

Small signaling peptides, generated from larger protein precursors, are important components to orchestrate various plant processes such as development and immune responses. However, small signaling peptides involved in plant immunity remain largely unknown. Here, we developed a pipeline using transcriptomicsand proteomics-based screening to identify putative precursors of small signaling peptides:small secreted proteins (SSPs) in rice, induced by rice blast fungus Magnaportheoryzaeand its elicitor, chitin....

Alopecia areata predictive score: A new trichoscopy-based tool to predict treatment outcome in patients with patchy alopecia areata.

There are no evidence-based data how to predict response to therapy in patients with alopecia areata.

The VALID-CRT risk score reliably predicts response and outcome of cardiac resynchronization therapy in a real-world population.

The aim of the study was to confirm the value of the VALID-cardiac resynchronization therapy (CRT) risk score in predicting outcome and to assess its association with clinical response (CR) in an unselected real-world CRT population.

Positive genetic associations among fitness traits support evolvability of a reef-building coral under multiple stressors.

Climate change threatens organisms in a variety of interactive ways that requires simultaneous adaptation of multiple traits. Predicting evolutionary responses requires an understanding of the potential for interactions among stressors and the genetic variance and covariance among fitness-related traits that may reinforce or constrain an adaptive response. Here we investigate the capacity of Acropora millepora, a reef-building coral, to adapt to multiple environmental stressors: rising sea surface temperatu...

Molecular Markers of Prognosis in Canine Cortisol-Secreting Adrenocortical Tumours.

Hypercortisolism is caused by a cortisol-secreting adrenocortical tumour (ACT) in approximately 15-20% of cases in dogs. Little is known about which molecular markers are associated with malignant behaviour of canine ACTs. The objective of this study was to identify molecular markers of prognosis, which could be useful to refine prognostic prediction and to identify potential treatment targets. Cortisol-secreting ACTs were included from 40 dogs, of which follow-up information was available. The ACTs were cl...

Clinical prediction score of non-alcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index).

Non-alcoholic fatty liver disease (NAFLD) is common in obese adolescents with Polycystic ovary syndrome (PCOS), but there are no inexpensive ways to accurately identify NAFLD in PCOS. The objective was to develop a simple clinical score to screen for NAFLD risk in obese adolescents with PCOS.

The Diagnosis, Outcome, and Management of Chylous Ascites Following Pediatric Liver Transplantation.

Data on postoperative chylous ascites (CA) after pediatric liver transplantation (LT) are scarce. This retrospective study was conducted to identify the incidence, risk factors, management, and outcome of postoperative CA in a large single-center pediatric LT cohort (2000-2016). The study cohort comprised 317 LTs (153 living donors and 164 deceased donors) in 310 recipients with a median age of 2.71 years. The incidence of CA was 5.4% (n = 17), diagnosed after a median time of 10 days after LT. Compared to ...

Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson's disease.

Recently, it has been demonstrated that microRNA-137 (miR-137) plays a vital role in the induction of oxidative stress of neurons in Parkinson's disease (PD). Herein, the study aimed to investigate the effects of serum exosomal miR-137 on oxidative stress injury of neurons in PD. Microarray analysis was adopted to screen the PD-related differential expressed genes and predict the interaction between OXR1 and miR-137 in PD. It was found that OXR1 was down-regulated while miR-137 was up-regulated in PD. Addit...

A robust multi-variability model based liver segmentation algorithm for CT-scan and MRI modalities.

Developing methods to segment the liver in medical images, study and analyze it remains a significant challenge. The shape of the liver can vary considerably from one patient to another, and adjacent organs are visualized in medical images with similar intensities, making the boundaries of the liver ambiguous. Consequently, automatic or semi-automatic segmentation of liver is a difficult task. Moreover, scanning systems and magnetic resonance imaging have different settings and parameters. Thus the images o...

Visual search does not always predict performance in tasks that require finding targets among distractors: The case of line-ending illusory contours.

The standard visual search task is integral to the study of selective attention and in search tasks target present slopes are the primary index of attentional demand. However, there are times when similarities in slopes may obscure important differences between conditions. To demonstrate this point, we used the case of line-ending illusory contours, building on a study by Li, Cave, and Wolfe (2008) where orientation-based search for figures defined by line-ending illusory contours was compared to that for t...

Tunneling Nanotubes Mediate the Expression of Senescence Markers in Mesenchymal Stem/Stromal Cell Spheroids.

The therapeutic potential of mesenchymal stem/stromal cells (MSCs) is limited by acquired senescence following prolonged culture expansion and high passage numbers. However, the degree of cell senescence is dynamic, and cell-cell communication is critical to promote cell survival. MSC spheroids exhibit improved viability compared to monodispersed cells, and actin-rich tunneling nanotubes (TNTs) may mediate cell survival and other functions through the exchange of cytoplasmic components. Building upon our pr...

Porpholactone Chemistry: An Emerging Approach to Bioinspired Photosensitizers with Tunable Near-Infrared Photophysical Properties.

Chlorophylls, known as the key building blocks of natural light-harvesting antennae, are essential to utilize solar energy from visible to near-infrared (NIR) region during the photosynthesis process. The fundamental studies for the relationship between structure and photophysical properties of chlorophylls disclosed the importance of -peripheral modification and thus boosted the fast growth of NIR absorbing/emissive porphyrinoids via altering the extent of π-conjugation and the degree of distortion from t...

Introduction of a fixed-charge, photolabile derivative for enhanced structural elucidation of fatty acids.

Fatty acids are a structurally diverse category of lipids with a myriad of biochemical functions, which includes their role as building blocks of more complex lipids (e.g., glycerophospholipids and triacyl-glycerols). Increasingly, the analysis of fatty acids is undertaken using liquid chromatography-mass spectrometry (LC-MS), due to its versatility in the detection of lipids across a wide range of concen-trations and diversity of molecular structures and masses. Previous work has shown that fixed-charge py...

Determinant Formula for the Octagon Form Factor in N=4 Supersymmetric Yang-Mills Theory.

We present a closed expression for the octagon form factor which appears as a building block in a class of four-point correlation functions in N=4 supersymmetric Yang-Mills theory considered recently by Coronado. The octagon form factor is expressed, to all loop orders, as the determinant of a semi-infinite matrix. We find that perturbatively at weak coupling the entries of this matrix are linear combinations of ladder functions with simple rational coefficients.

Starting to Talk at Age 10 Years: Lessons About the Acquisition of English Speech Sounds in a Rare Case of Severe Congenital But Remediated Motor Disease of Genetic Origin.

Purpose This study was conducted to observe speech development in a child whose onset of oral communication was extremely delayed. In rare cases, children are born with physical limitations that temporarily interfere with speech sound production. Whether the development of speech sound production follows the same trajectory as that in typical children at younger ages is not well understood. Method We present a child who was wheelchair-bound and communicated nearly exclusively via augmentative and alternativ...

Revisiting the Cutoff Criteria of Intelligibility in Context Scale-Traditional Chinese.

Background This study evaluated the validity of the Intelligibility in Context Scale-Traditional Chinese (ICS-TC) and explored its potential as a screening tool for speech sound disorder (SSD) in Cantonese-speaking children in Hong Kong. Method The parents of 789 Cantonese-speaking children aged between 2;4 (years;months) and 6;9 completed the ICS-TC. Children were categorized into 2 groups: (a) an SSD group whose initial consonant scores in a standardized assessment were equal to or lower than -1.33 SD and...

Age-Dependent Resistance to in Sugar Beet.

Rhizoctonia crown and root rot of sugar beet ( L.), caused by , continues to be one of the important concerns for the beet industry in Minnesota and North Dakota. Use of resistant cultivars is an important strategy in the management of in combination with seed treatment and timely fungicide application during the growing season. The objective of this greenhouse study was to determine how sugar beet plants responded to increasing age in resistance to . Each of three seed companies provided three commercial ...

The Pediatric Toronto Extremity Salvage Score (pTESS): Validation of a Self-reported Functional Outcomes Tool for Children with Extremity Tumors.

The physical function of children with sarcoma after surgery has not been studied explicitly. This paucity of research is partly because of the lack of a sufficiently sensitive pediatric functional measure. The goal of this study was to establish and validate a standardized measure of physical function in pediatric patients with extremity tumors.

Delivering Cas9/sgRNA ribonucleoprotein (RNP) by lentiviral capsid-based bionanoparticles for efficient 'hit-and-run' genome editing.

Transient expression of the CRISPR/Cas9 machinery will not only reduce risks of mutagenesis from off-target activities, but also decrease possible immune response to Cas9 protein. Building on our recent developing of a system able to package up to 100 copies of Cas9 mRNA in each lentivirus-like particle (LVLP) via the specific interaction between aptamer and aptamer-binding proteins (ABP), here we develop a lentiviral capsid-based bionanoparticle system, which allows efficient packaging of Cas9/sgRNA ribonu...


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