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PubMed Journals Articles About "Change Mice Research Could Help Humans Scientists Guardian" RSS

15:40 EST 22nd January 2019 | BioPortfolio

Change Mice Research Could Help Humans Scientists Guardian PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Change Mice Research Could Help Humans Scientists Guardian articles that have been published worldwide.

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Showing "change mice research could help humans scientists Guardian" PubMed Articles 1–25 of 37,000+

Comprehensive analysis of hippocampal miRNAomes in humans and mice.

This study aims to explore the similarity and difference of hippocampal miRNAomes between humans and mice.


Development of a measure to evaluate competence perceptions of natural and social science.

Interdisciplinary scientific research teams are essential for responding to society's complex scientific and social issues. Perceptual barriers to collaboration can inhibit the productivity of teams crossing traditional disciplinary boundaries. To explore these perceptual barriers, survey measures related to perceived competence were developed and validated with a population of earth scientists (n = 449) ranging from undergraduates through professionals. Resulting competence scales included three factors th...

Smombie Guardian: We watch for potential obstacles while you are walking and conducting smartphone activities.

With the growing dependence on smartphones for everyday activities, a large number of pedestrians nowadays are constantly fixated on their smartphone screens, and hence are susceptible to walking off pavements or colliding with other pedestrians. Reduced attention and situational awareness can render smartphone-occupied users, or smombies, oblivious to potential risks when using their smartphones while walking or driving. In this paper, we introduce a smartphone application, called Smombie Guardian, that de...


The role of DNA methylation in epigenetics of aging.

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG sites, can accurately predict chronological age in a variety of species, including humans. These clocks are currently the best biomarkers for predicting mortality in humans. Additionally, several studies have characterized the effects of aging across the methylome in a wide variety of tissues from humans and mice. A small fraction (~...

Standardizing protocols dealing with growth hormone receptor gene disruption in mice using the Cre-lox system.

Mice and humans with reduced growth hormone (GH) action before birth are conferred positive health- and life-span advantages. However, little work has been performed to study the effect of conditional disruption of GH action in adult life. With this as our objective, we sought to elucidate a reproducible protocol that allows generation of adult mice with a global disruption of the GH receptor (Ghr) gene, using the tamoxifen (TAM)-inducible Cre-lox system, driven by the ROSA26 enhancer/promoter. Here we repo...

Magel2 Modulates Bone Remodeling and Mass in Prader-Willi Syndrome by Affecting Oleoyl Serine Levels and Activity.

Among a multitude of hormonal and metabolic complications, individuals with Prader-Willi syndrome (PWS) exhibit significant bone abnormalities, including decreased BMD, osteoporosis, and subsequent increased fracture risk. Here we show in mice that loss of Magel2, a maternally imprinted gene in the PWS critical region, results in reduced bone mass, density, and strength, corresponding to that observed in humans with PWS, as well as in individuals suffering from Schaaf-Yang syndrome (SYS), a genetic disorder...

Hydrolysis of di(2-ethylhexyl) phthalate in humans, monkeys, dogs, rats, and mice: An in vitro analysis using liver and intestinal microsomes.

Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer that is rapidly metabolized to mono(2-ethylhexyl) phthalate (MEHP), an active metabolite, in mammals. In the present study, the hydrolysis of DEHP by the liver and intestinal microsomes of humans, monkeys, dogs, rats, and mice was examined. The kinetics of liver microsomes fit the Michaelis-Menten model for humans, monkeys, and rats, and the Hill model for dogs and mice. K or S values were similar among species, whereas V exhibited species diffe...

Applying art to scientific research: reasons for using an original method.

Art, by virtue of its symbolic power, may function as a cognitive instrument and even as an aid in the scientific research process, especially in the phase of hypothesis generation and data analysis given its ability to induce creative and intuitive thinking. In this article, we propose a method to put such concept into practice based on the exposure of scientists to collective artistic activities in protected settings, a methodology developed from the experiences described by renowned artists and scientist...

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

A major mystery of many types of neurological and psychiatric disorders, such as Alzheimer's disease (AD), remains the underlying, disease-specific neuronal damage. Because of the strong interconnectivity of neurons in the brain, neuronal dysfunction necessarily disrupts neuronal circuits. In this article, we review evidence for the disruption of large-scale networks from imaging studies of humans and relate it to studies of cellular dysfunction in mouse models of AD. The emerging picture is that some forms...

Pharmacodynamics of regulatory T cells in mice and humans treated with low-dose interleukin-2.

We have developed and validated a mathematical model depicting and predicting the effect of low-dose interleukin-2 on Treg expansion in mice and humans. This model should help in the design of optimal therapeutic schemes for the long-term treatment of various chronic autoimmune, inflammatory or allergic diseases.

Monopoiesis in humans and mice.

Monocytes are a widely conserved cell population in vertebrates with important roles in both inflammation and homeostasis. Under both settings, monocytes continuously arise from hematopoietic progenitors in the bone marrow and, on demand, migrate into tissues through the bloodstream. Monocytes are classified into three subsets - classical, intermediate and non-classical - based on their cell-surface expression of CD14 and CD16 in humans and Ly6C, CX3CR1 and CCR2 in mice. In tissues, monocytes differentiate ...

Navigating the path to a biomedical science career.

The number of biomedical PhD scientists undergoing training and graduating far exceeds the number of academic faculty positions and academic research jobs. This trend compels biomedical PhD scientists to increasingly seek career paths outside of academia. Prior studies have used quantitative methodology to determine trends and outcomes of single factors contributing to this shift, but there is a literature gap in studies considering multiple factors and in qualitative work focusing on biomedical PhD scienti...

Scientists on the Spot: Carol Ann Remme on her research and career.

Contemporary global perspectives of medical students on research during undergraduate medical education: a systematic literature review.

The need for increased expertise in evidence-based medicine and concerns about the decreasing numbers of physician-scientists have underscored the need for promoting and encouraging research in medical education. The critical shortage of physician-scientists has assumed a dimension demanding a coordinated global response. This systematic review examined the perceptions of medical students regarding research during undergraduate medical school from a global perspective.

Researchers' attitudes to the 3Rs-An upturned hierarchy?

Animal use in biomedical research is generally justified by its potential benefits to the health of humans, or other animals, or the environment. However, ethical acceptability also requires scientists to limit harm to animals in their research. Training in laboratory animal science (LAS) helps scientists to do this by promoting best practice and the 3Rs. This study evaluated scientists' awareness and application of the 3Rs, and their approach to other ethical issues in animal research. It was based on an o...

Sex bias in preclinical research and an exploration of how to change the status quo.

There has been a revolution within clinical trials to include females in the research pipeline. However, there has been limited change in the preclinical arena; yet the research here lays the ground work for the subsequent clinical trials. Sex bias has been highlighted as one of the contributing factors to the poor translation and replicability issues undermining preclinical research. There have been multiple calls for action and the funders of biomedical research are actively pushing the inclusion of sex a...

Ultra-rapid near universal TB drug regimen identified via parabolic response surface platform cures mice of both conventional and high susceptibility.

As current treatment of tuberculosis is burdensomely long, provoking non-adherence and drug resistance, effective short-course treatments are needed. Using the output-driven parabolic response surface (PRS) platform, we have identified drug regimens that treat tuberculosis more rapidly in mice than the current Standard Regimen used in humans. We show that PRS Regimen III, comprising clofazimine, SQ109, bedaquiline and pyrazinamide, rapidly sterilizes the lung both in conventionally studied BALB/c mice and i...

The clinician-scientist track: an approach addressing Australia's need for a pathway to train its future clinical academic workforce.

Clinician-scientist training represents the epitome of preparation for biomedical scientific discovery. The significance of, and need for, clinician-scientists is universally recognised as essential to progress medical research across what is regarded as the 'translational gap'. Despite a rich history of cutting-edge biomedical research, Australia has no infrastructure or career pathway for training clinician-scientists.

p53-Sensitive Epileptic Behavior and Inflammation in Hypomorphic Mice.

Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practical limitations, for this reason model systems are mostly preferred. Among animal models, mouse mutants are particularly valuable since they allow conjoint behavioral, organismal, and genetic analyses. Along with this, since aging has been associated with higher f...

Establishment and comparison of Actinobacillus pleuropneumoniae experimental infection model in mice and piglets.

Actinobacillus pleuropneumoniae (APP) causes porcine pleuropneumonia, a disease responsible for substantial losses in the worldwide pig industry. In this study, outbred Kunming (KM) and Institute of Cancer Research (ICR) mice were evaluated as alternative mice models for APP research. After intranasal infection of serotype 5 reference strain L20, there was less lung damage and a lower clinical sign score in ICR compared to KM mice. However, ICR mice showed more obvious changes in body weight loss, the amoun...

Differential effects of metformin glycinate and hydrochloride in glucose production, AMPK phosphorylation and insulin sensitivity in hepatocytes from non-diabetic and diabetic mice.

The liver is a main target tissue of the biguanide metformin which activates AMP-activated protein kinase (AMPK). We have previously reported that administration of metformin glycinate showed a greater decrease in glycated hemoglobin A1c than placebo in patients with type 2 diabetes mellitus (T2DM). Herein, we have compared the effects of metformin hydrochloride, the oral antidiabetic drug of first choice, with those of metformin glycinate in hepatocytes from non-diabetic, diabetic mice and humans. Both for...

Shared Platform for Antibiotic Research and Knowledge: A Collaborative Tool to SPARK Antibiotic Discovery.

The discovery of urgently needed antibiotics is hindered by challenges to information sharing. To help address this challenge, The Pew Charitable Trusts launched SPARK: the Shared Platform for Antibiotic Research and Knowledge. SPARK is an online, publicly available, interactive database designed to help scientists build on previous research and generate new insights to advance the field's understanding of Gram-negative permeability. This Viewpoint details how data are selected and integrated into the plat...

Welcoming Deaf Students into STEM: Recommendations for University Science Education.

Scientists are shaped by their unique life experiences and bring these perspectives to their research. Diversity in life and cultural experiences among scientists, therefore, broadens research directions and, ultimately, scientific discoveries. Deaf individuals, for example, have successfully contributed their unique perspectives to scientific inquiry. However, deaf individuals still face challenges in university science education. Most deaf students in science, technology, engineering, and mathematics (STE...

A didactic approach to presenting verbal and visual information to children participating in research protocols: the comic book informed assent.

When children participate in research protocols, consent (by a parent or legal guardian) and assent (by the children) must be given. Understanding research protocols can be challenging for an adult and even more difficult for a child. The aim of this study was to describe the development of a comic book created to facilitate children's understanding of informed assent with clear and simple language.

Promoting scientist-advocate collaborations in cancer research: why and how.

Advocates bring unique and important viewpoints to the cancer research process, ensuring that scientific and medical advances are patient-centered and relevant. In this article, we discuss the benefits of engaging advocates in cancer research and underscore ways in which both the scientific and patient communities can facilitate this mutually beneficial collaboration. We discuss how to establish and nurture successful scientist-advocate relationships throughout the research process. We review opportunities ...


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