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PubMed Journals Articles About "DeCode" RSS

17:48 EDT 20th October 2017 | BioPortfolio

DeCode PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest DeCode articles that have been published worldwide.

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Showing "deCode" PubMed Articles 1–25 of 31

The Importance of Being Modified: The Role of RNA Modifications in Translational Fidelity.

The posttranscriptional modifications of tRNA's anticodon stem and loop (ASL) domain represent a third level, a third code, to the accuracy and efficiency of translating mRNA codons into the correct amino acid sequence of proteins. Modifications of tRNA's ASL domain are enzymatically synthesized and site specifically located at the anticodon wobble position-34 and 3'-adjacent to the anticodon at position-37. Degeneracy of the 64 Universal Genetic Codes and the limitation in the number of tRNA species requir...


Categorical perception of facial expressions in individuals with non-clinical social anxiety.

According to the well-established categorical perception (CP) of facial expressions, we decode complicated expression signals into simplified categories to facilitate expression processing. Expression processing deficits have been widely described in social anxiety (SA), but it remains to be investigated whether CP of expressions are affected by SA. The present study examined whether individuals with SA had an interpretation bias when processing ambiguous expressions and whether the sensitivity of their CP ...

Dual-page reproduction to increase the data transfer rate in holographic memory.

To increase the reproduced data transfer rate in holographic memory, we have investigated simultaneous reproduction of two data pages. By irradiating s- and p-polarization reference beams whose angle gap is equal to the angle between the neighboring data pages in angle-multiplexed holograms, two different data pages can simultaneously be reproduced with a bit error rate low enough to decode. This technology is effective to double the data transfer rate in holographic memory.


The spacing effect for structural synaptic plasticity provides specificity and precision in plastic changes.

In contrast to trials of training without intervals (massed training), training trials spaced over time (spaced training) induce a more persistent memory identified as long-term memory (LTM). This phenomenon known as "the spacing effect for memory" is poorly understood. LTM is supported by structural synaptic plasticity; however, how synapses integrate spaced stimuli remains elusive. Here, we analyzed events of structural synaptic plasticity at the single synapse level after distinct patterns of stimulation...

Harnessing plant metabolic diversity.

Advances in DNA sequencing and synthesis technologies in the twenty-first century are now making it possible to build large-scale pipelines for engineering plant natural product pathways into heterologous production species using synthetic biology approaches. The ability to decode the chemical potential of plants by sequencing their transcriptomes and/or genomes and to then use this information as an instruction manual to make drugs and other high-value chemicals is opening up new routes to harness the vast...

Relationship between Dental Procedures and Shunt Infections in Hydrocephalic Patients: A Narrative Review.

Oral physicians frequently encounter medically compromised patients in their everyday practice and a sizable number of these patients are in urgent need of specialized care. One such medically specialized category is that of patients suffering from hydrocephalus. A large number of medical reports and citations in support of surgical care of the hydrocephalic disorder are available in literature. However, reports on dental studies offer contradictory statements on the relationship between hydrocephalic shunt...

Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene.

The extensive genetic regulatory flows underlying specification of different neuronal subtypes are not well understood at the molecular level. The Nplp1 neuropeptide neurons in the developing Drosophila nerve cord belong to two sub-classes; Tv1 and dAp neurons, generated by two distinct progenitors. Nplp1 neurons are specified by spatial cues; the Hox homeotic network and GATA factor grn, and temporal cues; the hb -> Kr -> Pdm -> cas -> grh temporal cascade. These spatio-temporal cues combine into two disti...

Commonalities and differences in the neural representations of English, Portuguese, and Mandarin sentences: When knowledge of the brain-language mappings for two languages is better than one.

This study extended cross-language semantic decoding (based on a concept's fMRI signature) to the decoding of sentences across three different languages (English, Portuguese and Mandarin). A classifier was trained on either the mapping between words and activation patterns in one language or the mappings in two languages (using an equivalent amount of training data), and then tested on its ability to decode the semantic content of a third language. The model trained on two languages was reliably more accura...

Simultaneous Indoor Tracking and Activity Recognition Using Pyroelectric Infrared Sensors.

Indoor human tracking and activity recognition are fundamental yet coherent problems for ambient assistive living. In this paper, we propose a method to address these two critical issues simultaneously. We construct a wireless sensor network (WSN), and the sensor nodes within WSN consist of pyroelectric infrared (PIR) sensor arrays. To capture the tempo-spatial information of the human target, the field of view (FOV) of each PIR sensor is modulated by masks. A modified partial filter algorithm is utilized t...

The Code for Facial Identity in the Primate Brain.

Primates recognize complex objects such as faces with remarkable speed and reliability. Here, we reveal the brain's code for facial identity. Experiments in macaques demonstrate an extraordinarily simple transformation between faces and responses of cells in face patches. By formatting faces as points in a high-dimensional linear space, we discovered that each face cell's firing rate is proportional to the projection of an incoming face stimulus onto a single axis in this space, allowing a face cell ensembl...

Using comparative genomics to decode the genetics of acaricide resistance.

The availability of genome assemblies and other genomic resources is facilitating investigations of complex genetic traits for several species of ticks. Understanding the genetics of acaricide resistance is a priority for tick and tick-borne disease control. The synaptic enzyme acetylcholinesterase (ACE) is recognized as the target of organophosphates (OPs) and carbamates, and mutations in ACE have been tied to resistance. Multiple studies support three ACE (ace) loci in R. microplus but the molecular basis...

Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.

mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in 206 mRNA splicing-related genes with lung cancer risk by using the summary data from six published genome-wide association studies (GWASs) of Transdisciplinary Research in Cancer of the Lung (TRICL) (12,160 cases and 16,838 controls) and another two lung cancer GWASs of Harvard University (...

The Face of Fear and Anger: Facial Width-to-Height Ratio Biases Recognition of Angry and Fearful Expressions.

The ability to rapidly and accurately decode facial expressions is adaptive for human sociality. Although judgments of emotion are primarily determined by musculature, static face structure can also impact emotion judgments. The current work investigates how facial width-to-height ratio (fWHR), a stable feature of all faces, influences perceivers' judgments of expressive displays of anger and fear (Studies 1a, 1b, & 2), and anger and happiness (Study 3). Across 4 studies, we provide evidence consistent with...

Neural signatures of attention: insights from decoding population activity patterns.

Understanding brain function and the computations that individual neurons and neuronal ensembles carry out during cognitive functions is one of the biggest challenges in neuroscientific research. To this end, invasive electrophysiological studies have provided important insights by recording the activity of single neurons in behaving animals. To average out noise, responses are typically averaged across repetitions and across neurons that are usually recorded on different days. However, the brain makes deci...

An essential domain of an early-diverged RNA polymerase II functions to accurately decode a primitive chromatin landscape.

A unique feature of RNA polymerase II (RNA pol II) is its long C-terminal extension, called the carboxy-terminal domain (CTD). The well-studied eukaryotes possess a tandemly repeated 7-amino-acid sequence, called the canonical CTD, which orchestrates various steps in mRNA synthesis. Many eukaryotes possess a CTD devoid of repeats, appropriately called a non-canonical CTD, which performs completely unknown functions. Trypanosoma brucei, the etiologic agent of African Sleeping Sickness, deploys an RNA pol II ...

Identification of Candidate Odorant-Binding Protein and Chemosensory Protein Genes in Cyrtorhinus lividipennis (Hemiptera: Miridae), a Key Predator of the Rice Planthoppers in Asia.

Cyrtorhinus lividipennis Reuter (Hemiptera: Miridae) is an important predatory natural enemy of planthopper and leafhopper eggs in Asian rice paddy fields. Cyrtorhinus lividipennis is known to rely largely on herbivore-induced plant volatiles to identify eggs embedded in rice stem tissues for feeding and on pheromones for mating. However, exactly how C. lividipennis decode these chemical information is unclear. In most insects, the odorant-binding proteins (OBPs) and the chemosensory proteins (CSPs) are ess...

Electroencephalogram-based decoding cognitive states using convolutional neural network and likelihood ratio based score fusion.

Electroencephalogram (EEG)-based decoding human brain activity is challenging, owing to the low spatial resolution of EEG. However, EEG is an important technique, especially for brain-computer interface applications. In this study, a novel algorithm is proposed to decode brain activity associated with different types of images. In this hybrid algorithm, convolutional neural network is modified for the extraction of features, a t-test is used for the selection of significant features and likelihood ratio-bas...

Decoding the infant mind: Multivariate pattern analysis (MVPA) using fNIRS.

The MRI environment restricts the types of populations and tasks that can be studied by cognitive neuroscientists (e.g., young infants, face-to-face communication). FNIRS is a neuroimaging modality that records the same physiological signal as fMRI but without the constraints of MRI, and with better spatial localization than EEG. However, research in the fNIRS community largely lacks the analytic sophistication of analogous fMRI work, restricting the application of this imaging technology. The current paper...

Pattern classification of EEG signals reveals perceptual and attentional states.

Pattern classification techniques have been widely used to differentiate neural activity associated with different perceptual, attentional, or other cognitive states, often using fMRI, but more recently with EEG as well. Although these methods have identified EEG patterns (i.e., scalp topographies of EEG signals occurring at certain latencies) that decode perceptual and attentional states on a trial-by-trial basis, they have yet to be applied to the spatial scope of attention toward global or local features...

Topological Interference Management for K-User Downlink Massive MIMO Relay Network Channel.

In this paper, we study the emergence of topological interference alignment and the characterizing features of a multi-user broadcast interference relay channel. We propose an alternative transmission strategy named the relay space-time interference alignment (R-STIA) technique, in which a K -user multiple-input-multiple-output (MIMO) interference channel has massive antennas at the transmitter and relay. Severe interference from unknown transmitters affects the downlink relay network channel and degrades t...

A Novel Cross-Layer Routing Protocol Based on Network Coding for Underwater Sensor Networks.

Underwater wireless sensor networks (UWSNs) have attracted increasing attention in recent years because of their numerous applications in ocean monitoring, resource discovery and tactical surveillance. However, the design of reliable and efficient transmission and routing protocols is a challenge due to the low acoustic propagation speed and complex channel environment in UWSNs. In this paper, we propose a novel cross-layer routing protocol based on network coding (NCRP) for UWSNs, which utilizes network co...

Darwin revisited: The vagus nerve is a causal element in controlling recognition of other's emotions.

Charles Darwin proposed that via the vagus nerve, the tenth cranial nerve, emotional facial expressions are evolved, adaptive and serve a crucial communicative function. In line with this idea, the later-developed polyvagal theory assumes that the vagus nerve is the key phylogenetic substrate that regulates emotional and social behavior. The polyvagal theory assumes that optimal social interaction, which includes the recognition of emotion in faces, is modulated by the vagus nerve. So far, in humans, it has...

Revisiting chemoaffinity theory: Chemotactic implementation of topographic axonal projection.

Neural circuits are wired by chemotactic migration of growth cones guided by extracellular guidance cue gradients. How growth cone chemotaxis builds the macroscopic structure of the neural circuit is a fundamental question in neuroscience. I addressed this issue in the case of the ordered axonal projections called topographic maps in the retinotectal system. In the retina and tectum, the erythropoietin-producing hepatocellular (Eph) receptors and their ligands, the ephrins, are expressed in gradients. Accor...

Structure Based Energetics of Stop Codon Recognition by Eukaryotic Release Factor.

In translation termination, eukaryotic release factor (eRF1) recognizes mRNA stop codons (UAA, UAG or UGA) in ribosomal A-site and triggers release of the nascent polypeptide chain from P-site tRNA. eRF1 is highly selective for U in the first position and a combination of purines (except two consecutive guanines, i.e., GG) in the 2nd and 3rd positions. Eukaryotes decode all the three stop codons with a single release factor eRF1, instead of two (RF1 and RF2) in bacteria. Furthermore, unlike bacterial RF1/RF...

Magnetic resonance imaging for characterizing myocardial diseases.

The National Institute of Health defined cardiomyopathy as diseases of the heart muscle. These myocardial diseases have different etiology, structure and treatment. This review highlights the key imaging features of different myocardial diseases. It provides information on myocardial structure/orientation, perfusion, function and viability in diseases related to cardiomyopathy. The standard cardiac magnetic resonance imaging (MRI) sequences can reveal insight on left ventricular (LV) mass, volumes and regio...


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