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16:30 EDT 20th August 2018 | BioPortfolio

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Showing "expands label Amgen Repatha" PubMed Articles 1–25 of 1,100+

Letter--Incorporating Real-World Evidence and Patient Value Criteria into Value-Based Frameworks for Relapsed/Refractory Multiple Myeloma.

Orlowski has received research funding from Amgen, BioTheryX, Bristol-Myers Squibb, Celgene Corporation, and Takeda Pharmaceuticals; honoraria from Amgen, Bristol-Myers Squibb, Celgene Corporation, Janssen, Millennium Pharmaceuticals, and Onyx Pharmaceuticals; and is a member of advisory boards for Amgen, Bristol-Myers Squibb, Celgene Corporation, Incyte, Kite, Legend Biotech, Sanofi-Aventis, and Takeda Pharmaceuticals.

Labelling fashion magazine advertisements: Effectiveness of different label formats on social comparison and body dissatisfaction.

The experiment investigated the impact on women's body dissatisfaction of different forms of label added to fashion magazine advertisements. Participants were 340 female undergraduate students who viewed 15 fashion advertisements containing a thin and attractive model. They were randomly allocated to one of five label conditions: no label, generic disclaimer label (indicating image had been digitally altered), consequence label (indicating that viewing images might make women feel bad about themselves), inf...

The Urgent Need for Optimal Monitoring of Metabolic Adverse Effects in Children and Youngsters Who Take On-label or Off-label Antipsychotic Medication.

Prevention of Colony Establishment by the West Indian Drywood Termite Using Reduced Rates of Borate and Silica Dust or Solution.

Imago dispersal by the West Indian drywood termite, Cryptotermes brevis (Walker) (Isoptera: Kalotermitidae) potentially initiates or expands structural infestations by the establishment of incipient colonies. The prevention of drywood termite colonization in structures is difficult, but a substantial reduction may be obtainable. In this experiment, seasonal dispersal of C. brevis imagos commenced from infested wood in a laboratory building. A bioassay was developed to determine the efficacy of 100, 50, and ...

Dual inhibition of tumour necrosis factor and interleukin-17A with ABT-122: open-label long-term extension studies in rheumatoid arthritis or psoriatic arthritis.

To evaluate the safety and maintenance of efficacy with ABT-122, a bi-specific monoclonal antibody targeting TNF and IL-17A, in patients with RA or PsA in open-label, 24-week extensions [open-label extensions (OLEs)] of 12-week, randomized, double-blind studies.

An Open-Label Discontinuation Trial of Long-Term, Off-Label Antipsychotic Medication in People With Intellectual Disability: Determinants of Success and Failure.

Although physicians are aware of the risks of prescribing long-term off-label antipsychotics in people with intellectual disability, attempts to discontinue often fail. This study aimed to identify potential determinants of successful and failed discontinuation. Long-term off-label antipsychotics were tapered in 14 weeks, with 12.5% of baseline dose every 2 weeks. Participants living in facilities offered by intellectual disability service providers, ≥6 years, with an IQ

Unlicensed and Off-Label Medication Use in Pediatric and Neonatal Intensive Care Units: No Change Over a Decade.

Many of the medications prescribed to children are off-label and/or unlicensed because pharmacologic evaluations have not been performed in this age group.

Evaluation of medical prescriptions and off-label use on board ships to improve healthcare quality.

This study analyzed the appropriateness of drug therapies prescribed for a particular category of patients: the seafarers. We investigated an important problem of this area: the off-label use of drugs, which resulted to be a consequence of major shortcomings in the on-board pharmacies of ships. The off-label use of drugs is allowed, but can lead to some not negligible ethical and health problems, compromising the quality of provided healthcare.

Off-label antidepressant prescription in pediatric outpatients based on China Food and Drug Administration and Food and Drug Administration regulations: a Chinese retrospective study.

The objective of this study was to evaluate the prevalence and relative risk of off-label prescription of antidepressants in Chinese pediatric outpatients according to China Food and Drug Administration (C-FDA) and USFDA regulations. Medical records of 18 459 pediatric outpatients were identified between 2013 and 2015. Patient characteristics, prevalence of off-label antidepressant prescriptions, and relative risk factors associated with off-label prescribing were analyzed. The results indicate that patie...

Quantitative Peptidomics with Isotopic and Isobaric Tags.

In differential peptidomics, peptide profiles are compared between biological samples and the resulting expression levels are correlated to a phenotype of interest. This, in turn, allows us insight into how peptides may affect the phenotype of interest. In quantitative differential peptidomics, both label-based and label-free techniques are often employed. Label-based techniques have several advantages over label-free methods, primarily that labels allow for various samples to be pooled prior to liquid chro...

Sequence requirements of intrinsically fluorescent G-quadruplexes.

G-quadruplexes are four-stranded nucleic acid structures typically stabilized by GGGG tetrads. These structures are intrinsically fluorescent, which expands the known scope of nucleic acid function and raises the possibility that they could eventually be used as signaling components in label-free sensors constructed from DNA or RNA. In this study we systematically investigated the effects of mutations in tetrads, loops, and overhanging nucleotides on the fluorescence intensity and emission wavelength of mor...

The effect of a tactile-to-visual shift on young children's tendency to map novel labels onto novel objects.

When taught a label for an object and then asked whether an exemplar of that object or a novel object is the referent of a novel label, children favor the novel object. Preschool-aged children tend not to show this so-called disambiguation effect, however, when the test objects are presented in a different sense modality than the original object. The current experiments used a touch-to-vision paradigm to test two explanations for this unexpected pattern. Experiment 1 asked whether children might fail to ret...

Effects of lexical ambiguity on perception: A test of the label feedback hypothesis using a visual oddball paradigm.

We used a visual oddball paradigm to investigate whether a shared verbal label makes two objects belonging to different conceptual categories less perceptually distinct. In Experiment 1, the critical images shared a label as well as some perceptual features referring to the color and the fruit), and in Experiment 2, the critical images shared a label but no perceptual features referring to the animal and the sports equipment). In both experiments comparison images were similar to each of the critical imag...

Patterns and predictors of off-label prescription of psychiatric drugs.

Off-label prescribing of psychiatric drugs is common, despite lacking strong scientific evidence of efficacy and potentially increasing risk for adverse events. The goal of this study was to characterize prevalence of off-label prescriptions of psychiatric drugs and examine patient and clinician predictors of off-label use. This manuscript presents a retrospective, cross-sectional study using data from the 2012 and 2013 National Ambulatory Medical Care Surveys (NAMCS). The study examined all adult outpatien...

A Deep Multi-Modal CNN for Multi-Instance Multi-Label Image Classification.

Deep Convolutional Neural Networks (CNNs) have shown superior performance on the task of single-label image classification. However, the applicability of CNNs to multilabel images still remains an open problem, mainly because of two reasons. First, each image is usually treated as an inseparable entity and represented as one instance, which mixes the visual information corresponding to different labels. Second, the correlations amongst labels are often overlooked. To address these limitations, we propose a ...

Publisher Correction: NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.

In the version of this Article originally published, in Fig. 2c, the '+' sign and 'OSKM' were superimposed in the label '+OSKM'. In Fig. 4e, in the labels, all instances of 'Ant' should have been 'Anti-'. And, in Fig. 7a, the label '0.0' was misplaced; it should have been on the colour scale bar. These figures have now been corrected in the online versions.

Why do open-label placebos work? A randomized controlled trial of an open-label placebo induction with and without extended information about the placebo effect in allergic rhinitis.

Several studies demonstrated that placebo treatment may have a significant impact on many different symptoms. While in the traditional view concealment of the placebo is essential, recent studies report intriguing evidence that placebos may work even without deception. For example, it has been demonstrated that open-label placebos can improve symptoms in allergic rhinitis. However, the mechanisms of how placebos without concealment work remain unknown.

Publisher Correction: A new fundamental type of conformational isomerism.

In the version of this Article originally published, the word 'stereoisomerism' was erroneously included in the label of the upper-right box of Fig. 1. The label within the box has been corrected and it now reads: "Constitutional isomerism (same formula, different connectivity)". This has been corrected in the online version of the Article.

Robust Distance Metric Learning via Bayesian Inference.

Distance metric learning (DML) has achieved great success in many computer vision tasks. However, most existing DML algorithms are based on point estimation, and thus are sensitive to the choice of training examples and tend to be over-fitting in the presence of label noise. In this paper, we present a robust DML algorithm based on Bayesian inference. In particular, our method is essentially a Bayesian extension to a previous classic DML method - LMNN [1] and we use stochastic variational inference (SVI) to...

Evaluating off-label uses of acetazolamide.

Current off-label uses of acetazolamide in hospitalized patients are reviewed.

Manifold regularized matrix completion for multi-label learning with ADMM.

Multi-label learning is a common machine learning problem arising from numerous real-world applications in diverse fields, e.g, natural language processing, bioinformatics, information retrieval and so on. Among various multi-label learning methods, the matrix completion approach has been regarded as a promising approach to transductive multi-label learning. By constructing a joint matrix comprising the feature matrix and the label matrix, the missing labels of test samples are regarded as missing values of...

Juvenile Animal Testing: Assessing Need and Use in the Drug Product Label.

Juvenile animal testing has become an established part of drug development to support safe clinical use in the human pediatric population and for eventual drug product label use.

Use of cholera vaccines expands, raising hopes.

Seeing More: A Future of Augmented Microscopy.

Microscope images are information rich. In this issue of Cell, Christiansen et al. show that label-free images of cells can be used to predict fluorescent labels representing cell type, state, and organelle distribution using a deep-learning framework. This paves the way for computationally multiplexed assays derived from inexpensive label-free microscopy.

South African Men Who Have Sex With Both Men and Women and How They Differ From Men Who Have Sex With Men Exclusively.

The label "men who have sex with men" (MSM) is used to categorize a diverse population exclusively on the basis of its sexual behavior. Understanding the diversity that this label comprises is critical for the development of health interventions that effectively reach the various populations subsumed under this label. In this cross-sectional study of South African MSM (N = 480) recruited through respondent-driven sampling (RDS), we explored differences between men who had sex with both men and women (MSMW...

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