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PubMed Journals Articles About "Genes Found That Determine Heart Responds Exercise" RSS

00:16 EST 17th January 2019 | BioPortfolio

Genes Found That Determine Heart Responds Exercise PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Genes Found That Determine Heart Responds Exercise articles that have been published worldwide.

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Showing "genes found that determine heart responds exercise" PubMed Articles 1–25 of 39,000+

Exercise training workloads in cardiac rehabilitation are associated with clinical outcomes in patients with heart failure.

In patients with coronary heart disease, the exercise workload (i.e., metabolic equivalents of task, METs) at which patients exercise train upon entry and completion of cardiac rehabilitation (CR) are independently related to prognosis. Unknown is the association between exercise training workloads in CR and clinical outcomes in patients with heart failure (HF).


Exercise testing and spirometry as predictors of mortality in congenital heart disease: Contrasting Fontan physiology with repaired tetralogy of Fallot.

Risk prediction using cardiopulmonary exercise testing (CPET) in complex congenital heart disease tends to either focus on single diagnoses or complete cohorts. We aimed to evaluate patients with two distinct anatomies cared for at a single institution over the same time period to determine CPET variables associated with mortality.

Impact of a Graded Exercise Program on VO2peak and Survival in Heart Failure Patients.

Although exercise therapy has the potential to improve health outcomes of patients with Chronic Heart Failure (CHF), less than 50% of patients adhere to prescribed physical activity guidelines one year after Cardiac Rehabilitation (CR). We aimed to assess the effects of an extended CR program with 12-months of Graded Exercise Therapy (GET) and resistance exercise training (RT) on exercise capacity and long-term survival in patients with CHF.


Alveolar air and O uptake during exercise in patients with heart failure.

Peak exercise V̇O is a primary marker of prognosis in heart failure (HF). The pathophysiology of impaired peak V̇O is unclear in patients. To what extent alveolar airway function impacts V̇O during cardiopulmonary exercise testing (CPET) has not been fully elucidated. This study aimed to phenotype how changes in alveolar ventilation (V̇), volume (V), and related parameters couple with exercise V̇O in HF.

Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets.

Exercise-induced heart growth provides protection against cardiovascular disease, whereas disease-induced heart growth leads to heart failure. These distinct forms of growth are associated with different molecular profiles (e.g., mRNAs, non-coding RNAs, and proteins), and targeting differentially regulated genes has therapeutic potential for heart failure. The effects of exercise on the cardiac and circulating lipidomes in comparison to disease are unclear. Lipidomic profiling was performed on hearts and pl...

An acute bout of aerobic exercise reduces movement time in a Fitts' task.

Movement time (MT) is one of the most important variables influencing the way we control our movements. A few previous studies have generally found that MT reduces with reaction time testing during exercise. However, limited evidence exists concerning change in MT following an acute bout of exercise. Our purpose was to investigate the effect of an acute bout of aerobic exercise on movement time as assessed by a Fitts' Law task. We also sought to determine if exercise would further lower MT during the more d...

Echocardiographic predictors of exercise intolerance in patients with heart failure with severely reduced ejection fraction.

Decreased exercise capacity (EC) is an established predictor of cardiac and all-cause mortality in patients with chronic heart failure (HF). No correlation has been found between EC and left ventricular (LV) ejection fraction. Moreover, data about the effect of right ventricular (RV) function on EC in HF with severe LV dysfunction are limited and contradictory. In this study, we aimed to investigate the relationship between EC and myocardial mechanics in patients with HF with reduced ejection fraction.Conse...

Heart rate recovery after maximal exercise is impaired in healthy young adults born preterm.

The long-term implications of premature birth on autonomic nervous system (ANS) function are unclear. Heart rate recovery (HRR) following maximal exercise is a simple tool to evaluate ANS function and is a strong predictor of cardiovascular disease. Our objective was to determine whether HRR is impaired in young adults born preterm (PYA).

Ischaemic aetiology predicts exercise dyssynchrony in patients with heart failure with reduced ejection fraction.

Left ventricular (LV) dyssynchrony is common in patients with heart failure with reduced ejection fraction (HFREF). However, various conditions including exercise may alter its presence. LV dyssynchrony at exercise (ExDYS) has been associated with lower cardiac performance and exercise capacity but with higher cardiac resynchronization therapy (CRT) response. Therefore, understanding mechanisms underlying ExDYS may improve patient selection for CRT.

AAV9-mediated Rbm24 overexpression induces fibrosis in the mouse heart.

The RNA-binding protein Rbm24 has recently been identified as a pivotal splicing factor in the developing heart. Loss of Rbm24 in mice disrupts cardiac development by governing a large number of muscle-specific splicing events. Since Rbm24 knockout mice are embryonically lethal, the role of Rbm24 in the adult heart remained unexplored. Here, we used adeno-associated viruses (AAV9) to investigate the effect of increased Rbm24 levels in adult mouse heart. Using high-resolution microarrays, we found 893 differ...

Predictive Value of Exercise Testing in Athletes with Ventricular Ectopy Evaluated by Cardiac Magnetic Resonance.

Exercise-induced ventricular arrhythmias (EIVA) in young athletes raise the suspect of an underlying heart disease at risk of sudden death.

Exercise-induced shift in right ventricular contraction pattern: novel marker of athlete's heart?

Data is limited about the functional adaptation of the right ventricle (RV) to intense exercise. Our aim was to characterize the RV mechanical pattern in top-level athletes using 3D echocardiography.

Dietary nitrate's effects on exercise performance in heart failure with reduced ejection fraction (HFrEF).

Heart failure with reduced ejection fraction (HFrEF) is a deadly and disabling disease. A key derangement contributing to impaired exercise performance in HFrEF is decreased nitric oxide (NO) bioavailability. Scientists recently discovered the inorganic nitrate pathway for increasing NO. This has advantages over organic nitrates and NO synthase production of NO. Small studies using beetroot juice as a source of inorganic nitrate demonstrate its power to improve exercise performance in HFrEF. A larger-scale ...

Which Cut-offs for Secondary VCombining Dot AboveO2max Criteria Are Robust to Diurnal Variations?

The aim was to determine the minimum secondary exhaustion criteria cut-offs (i.e. max respiratory exchange ratio [RERmax], max heart rate [HRmax], max rating of perceived exertion [RPEmax], and max blood lactate concentration [BLmax]) necessary to determine maximum oxygen uptake (VO2max) during cardiopulmonary exercise tests (CPET), by balancing type I and type II errors. A further aim was to investigate if the defined cut-offs would be robust to diurnal and to day-to-day variations.

Lymphocytes and monocytes egress peripheral blood within minutes after cessation of steady state exercise: A detailed temporal analysis of leukocyte extravasation.

Acute exercise evokes an almost instantaneous lymphocytosis, followed by sustained lymphopenia that occurs within just 30-60 min after exercise cessation. The aim of this study was to characterize the immediate (order of minutes) post-exercise kinetics of lymphocyte and monocyte egress, and to determine whether this egress is associated with heart rate recovery following a single bout of steady state dynamic exercise. Eleven healthy subjects cycled for 30-min at ~70% of their estimated peak power. Blood s...

Pulmonary artery wedge pressure at rest and during exercise in healthy adults: a systematic review and meta-analysis.

The pulmonary artery wedge pressure (PAWP) response to exercise may unmask latent heart failure with preserved ejection fraction. There remains a lack of consensus over threshold values for PAWP during exercise. A systematic review of studies examining PAWP by right heart catheterization at rest and during exercise in healthy individuals was performed.

Exercise alarms the immune system: A HMGB1 perspective.

The "danger" model of immunology states that the immune system detects and responds to danger by releasing endogenous molecules called alarmins. Strenuous exercise perturbs physiological homeostasis, increasing circulating alarmins to drive the inflammatory response. We describe a working concept of exercise-induced High Mobility Group Box (HMGB)1, a prototypical alarmin, in modulating immune responses and adaptations.

TESTING THE VAGAL WITHDRAWAL HYPOTHESIS DURING LIGHT EXERCISE UNDER AUTONOMIC BLOCKADE: A HEART RATE VARIABILITY STUDY.

We performed the first analysis of heart rate variability (HRV) at rest and exercise under full autonomic blockade on the same subjects, to test the conjecture that vagal tone withdrawal occurs at exercise onset. We hypothesized that, between rest and exercise: i) no differences in total power (PTOT) under parasympathetic blockade; ii) a PTOT fall under β1-sympathetic blockade; iii) no differences in Ptot under blockade of both ANS branches.

Exercise Training Mitigates Multi-System Deconditioning during Bed Rest.

This study investigated the safety and effectiveness of a new integrated aerobic and resistance exercise training prescription (SPRINT) using two different sets of exercise equipment: a suite of large ISS-like exercise equipment similar to what is found on the International Space Station (ISS) and a single device with aerobic and resistance exercise capability in the spaceflight analog of bed rest (BR).

Non-linear dynamics of heart rate variability during incremental cycling exercise.

Within the last years complex models of cardiovascular regulation and exercise fatigue have implemented heart rate variability (HRV) as a measure of autonomic nervous system. Using detrended fluctuation analysis (DFA) to assess heart rate correlation properties, the present study examines the influence of exercise intensity on total variability and complexity in non-linear dynamics of HRV. Sixteen cyclists performed a graded exercise test on a bicycle ergometer. HRV time domain measures and fractal correlat...

Acute aerobic exercise improves memory across intensity and fitness levels.

The present study was designed to examine the impact of exercise intensity and aerobic fitness on free recall, judgments of learning (JOLs), and metacognitive accuracy. In Experiment 1, 30 college students engaged in either (1) no exercise, (2) light exercise (55% of predicted maximal heart rate), or (3) moderate exercise (75% of predicted maximal heart rate) on three different days. In Experiment 2, 29 high-fit students (VO max ≥ 70th percentile) and 28 low-fit students (VO max ≤ 50th percentil...

Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury.

Physical exercise provides benefits for various organ systems, and some of systemic effects of exercise are mediated through modulation of muscle-derived secreted factors, also known as myokines. Myonectin/C1q (complement component 1q)/TNF (tumor necrosis factor)-related protein 15/erythroferrone is a myokine that is upregulated in skeletal muscle and blood by exercise.

Dynamics of cardiorespiratory response during and after the six-minute walk test in patients with heart failure.

The six-minute walk test (6MWT) is a useful measure to evaluate exercise capacity with a simple method. The kinetics of oxygen uptake ([Formula: see text]O) throughout constant-load exercise on cardiopulmonary exercise testing (CPX) are composed of three phases and the [Formula: see text]O kinetics are delayed in patients with heart failure (HF). This study aimed to investigate the kinetics of the cardiorespiratory response during and after the 6MWT according to exercise capacity.

Critical Genes in White Adipose Tissue Based on Gene Expression Profile Following Exercise.

Exercise is recognized as an effective method to prevent obesity and alleviate metabolic diseases. Browning of white adipose has the advantage of decreasing insulin resistance. We aim to identify critical differentially expressed genes (DEGs) in white adipose tissue after exercise. We downloaded the gene dataset GSE68161 of C57BL/6 mice from the Gene Expression Omnibus (GEO) database. Then, we analyzed the effect of exercise on up-regulated and down-regulated DEGs by GEO2R and performed protein-protein inte...

Non-ischemic heart preconditioning.

Ischemic heart conditioning has been shown to protect the organ against ischemia/reperfusion injury. Animal studies have revealed that the heart can also be conditioned by non-ischemic procedures, namely physical exercise and tachycardia. Long and short term endurance training, sprint training, resistance or interval training and even one bout of exercise induce cardiac preconditioning, which is manifested by a reduction in post ischemia/reperfusion infarct size, ventricular arrhythmia and improved heart fu...


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