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Launches Open Science Alzheimer Initiative PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Launches Open Science Alzheimer Initiative articles that have been published worldwide.
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Comparison of retinal microvasculature within the macula and the optic nerve head in the eyes of patients with Alzheimer's disease (AD), primary open-angle glaucoma (POAG), and in a healthy control (HC) group, using optical coherence tomography angiography (OCTA).
In this research work, machine learning techniques are used to classify magnetic resonance imaging brain scans of people with Alzheimer's disease. This work deals with binary classification between Alzheimer's disease and cognitively normal. Supervised learning algorithms were used to train classifiers in which the accuracies are being compared. The database used is from The Alzheimer's Disease Neuroimaging Initiative (ADNI). Histogram is used for all slices of all images. Based on the highest performance, ...
: Funding for product development for neglected diseases fell from 2009-2015, other than a short-term injection of Ebola funding. One impediment to mobilizing resources is a lack of information on product candidates, the estimated costs to move them through the pipeline, and the likelihood of specific launches. This study aimed to help fill these information gaps. : We conducted a pipeline portfolio review to identify current candidates for 35 neglected diseases. Using an adapted version of the Portfolio ...
The usage of controlled biomedical vocabularies is the cornerstone that enables seamless interoperability when using a common data model across multiple data sites. The Observational Health Data Science and Informatics (OHDSI) initiative combines over 100 controlled vocabularies into its own. However, the OHDSI vocabulary is limited in the sense that it combines multiple terminologies and does not provide a direct way to link them outside of their own self-contained scope. This issue makes the tasks of enri...
Atrial fibrillation (AF) is a growing problem internationally and a recognised cause of cardiovascular morbidity and mortality. The London borough of Hounslow has a lower than expected prevalence of AF, suggesting poor detection and associated undertreatment. To improve AF diagnosis and management, a quality improvement (QI) initiative was set up in 48 general practices in Hounslow. We aimed to study whether there was evidence of a change in AF diagnosis and management in Hounslow following implementation o...
The Open Researcher and Contributor ID (ORCID) is a globally trending initiative for author name disambiguation and serves as a 'digital curriculum vitae' for displaying an individual's research output. Although there are several other tools similar to ORCID, the collaborative efforts by ORCID make it the most attractive option. Most of the organizations and publishers are increasingly adopting ORCID in their systems, and authors from West and other parts of the world have attempted to create awareness abou...
The National Institutes of Health (NIH) has joined the movement of big data by establishing a new research initiative to collect comprehensive health data from over 1 million U.S. citizens to better understand and address the health of the nation. As part of a focus supporting the Precision Medicine Initiative, the NIH aims to accelerate health and medical science and deliver on the promise for more personalized care and treatment. [J Contin Educ Nurs. 2019;50(10):442-443.].
Artificial Intelligence (AI) offers significant potential for improving healthcare. This paper discusses how an "open science" approach to AI tool development, data sharing, education, and research can support the clinical adoption of AI systems.
Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to have great efficacy in this domain. These algorithms often use neurological imaging data such as MRI and FDG PET, but a comprehensive and balanced comparison of the MRI and amyloid PET modalities has not been performed. In order to accurately determine the relative stren...
Relationship between age and dementia at extreme old ages is still an open question, yet population-based studies in this high-risk age segment are rare.
Preclinical studies suggest that amylin has a U-shaped dose-response association with risk of Alzheimer disease (AD). The association of plasma amylin with AD in humans is unknown.
If someone unintentionally breaks the rules, do they break the rules? In the abstract, the answer is obviously "yes." But, surprisingly, when considering specific examples of unintentional, blameless rule-breaking, approximately half of people judge that no rule was broken. This effect, known as excuse validation, has previously been observed in American adults. Outstanding questions concern what causes excuse validation, and whether it is peculiar to American moral psychology or cross-culturally robust. Th...
This report examines and evaluates pharmacogenomics as an emerging science as it relates to the Practice Advancement Initiative and its predecessor the Pharmacy Practice Model Initiative's consensus statements for optimal pharmacy practice models.
Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways.
[This corrects the article DOI: 10.1136/rmdopen-2018-000738.].
Outbreaks of emerging plant diseases and insect pests are increasing at an alarming rate threatening the food security needs of a booming world population. The role of plant pathologists in addressing these threats to plant health is critical. Here, we share our personal experience with the appearance in Bangladesh of a destructive new fungal disease called wheat blast and stress the importance of open-science platforms and crowdsourced community responses in tackling emerging plant diseases. Benefits of th...
The prevalence, mortality, and healthcare impact of Alaska Native and American Indian (ANAI) people with Alzheimer's disease and related dementias (ADRD) are unknown.
A lack of transparency and reporting standards in the scientific community has led to increasing and widespread concerns relating to reproduction and integrity of results. As an omics science, which generates vast amounts of data and relies heavily on data science for deriving biological meaning, metabolomics is highly vulnerable to irreproducibility. The metabolomics community has made substantial efforts to align with FAIR data standards by promoting open data formats, data repositories, online spectral l...
Recently, cerebrospinal fluid (CSF) YKL-40 levels were reported to be a promising candidate biomarker of glial inflammation in Alzheimer's disease (AD). To detect how APOE ε4 affects CSF YKL-40 levels in cognitively normal (CN) states, mild cognitive impairment (MCI) and AD dementia, data from 35 CN subjects, 63 patients with MCI, and 11 patients with AD from a cross-sectional study in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database were investigated. The results showed that CSF YKL-40 conc...