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PubMed Journals Articles About "Scientists Develop Laboratory Model Study Tickborne Flaviviruses" RSS

14:54 EST 14th December 2018 | BioPortfolio

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Showing "scientists develop laboratory model study tickborne flaviviruses" PubMed Articles 1–25 of 76,000+

Development of a saphenous vein harvest model for simulation-based assessment.

There is a need to develop a realistic model of open saphenous vein harvesting for simulation training and assessment. The purpose of this study was to develop a novel simulated model of this procedure and to examine its viability by examining participants' performance and feedback on this model.


Flaviviruses and the Central Nervous System: Revisiting Neuropathological Concepts.

Flaviviruses are major emerging human pathogens on a global scale. Some flaviviruses can infect the central nervous system of the host and therefore are regarded as neurotropic. The most clinically relevant classical neurotropic flaviviruses include Japanese encephalitis virus, West Nile virus, and tick-borne encephalitis virus. In this review, we focus on these flaviviruses and revisit the concepts of flaviviral neurotropism, neuropathogenicity, neuroinvasion, and resultant neuropathogenesis. We attempt to...

Career Satisfaction in the Profession of Medical Laboratory Science.

The purpose of this research was to determine which job features create motivation and career satisfaction to retain personnel in the medical laboratory profession. Four research questions based on Wlodkowski's theory of motivation guided the study: Is there a difference in perceived career satisfaction among medical laboratory scientists who: a) feel included by practitioners in other healthcare professions, b) have choices on the job that are personally relevant, c) feel more challenged, and d) feel more ...


Detection of Arbovirus Transmission via Sugar Feeding in a Laboratory Setting.

Most species of mosquitoes consume sugar to survive and during sugar feeding can expectorate virus. Scientists have used this behavior to develop novel methods of mosquito control and arbovirus surveillance. In this study, we use sugar feeding and corresponding viral expectoration to develop an affordable method of monitoring individual mosquitoes for longitudinal data collection. Female Culex tarsalis Coquillett (Diptera: Culicidae) that consumed an infectious bloodmeal of West Nile virus were placed into ...

Antigenic relationship among zoonotic flaviviruses from Italy.

Here we report studies of the antigenic relationships of West Nile virus (WNV) and Usutu virus (USUV), two zoonotic flaviviruses from Italy, together with a Japanese encephalitis virus (JEV) strain and compared them with their genetic relationships using the immunodominant viral E protein. Thirty-nine isolates and reference strains were inactivated and used to immunize rabbits to produce hyper immune sera. Serum samples were tested by neutralization against all isolates and results visualized by generating ...

A Reflex Protocol for Creatinine Testing Reduces Costs and Maintains Patient Safety.

The Jaffe and enzymatic methods are the 2 most common methods for creatinine measurement. The Jaffe method is less expensive but subject to interferences. Some laboratory scientists have called for the Jaffe method to be retired.

Ilheus and Saint Louis encephalitis viruses elicit cross-protection against a lethal Rocio virus challenge in mice.

Rocio virus (ROCV) was the causative agent of an unprecedented outbreak of encephalitis during the 1970s in the Vale do Ribeira, Sao Paulo State, in the Southeast region of Brazil. Surprisingly, no further cases of ROCV infection were identified after this outbreak; however, serological surveys have suggested the circulation of ROCV among humans and animals in different regions of Brazil. Cross-protective immunity among flaviviruses is well documented; consequently, immunity induced by infections with other...

Tickborne Diseases - Confronting a Growing Threat.

Dental age estimation in Somali children using the Willems et al. model.

The aim of the current study was to retrospectively collect dental panoramic radiographs from Somali children living in Finland, to use the radiographic data to develop a new age estimation model based on the model established by Willems et al. (J Forensic Sci 46(4):893-895, 2001), and to compare the age prediction performances of the Willems et al. model (WM) and the newly developed model.

High-throughput neutralization assay for multiple flaviviruses based on single-round infectious particles using dengue virus type 1 reporter replicon.

Diseases caused by the genus Flavivirus, including dengue virus (DENV) and Zika virus (ZIKV), have a serious impact on public health worldwide. Due to serological cross-reactivity among flaviviruses, current enzyme-linked immunosorbent assay (ELISA) for IgM/G cannot reliably distinguish between infection by different flaviviruses. In this study, we developed a reporter-based neutralization assay using single-round infectious particles (SRIPs) derived from representative flaviviruses. SRIPs were generated by...

Building flux capacity: Citizen scientists increase resolution of soil greenhouse gas fluxes.

Though citizen science programs have been broadly successful in diverse scientific fields, their adoption has lagged in some disciplines, including soil science and ecosystem ecology. Collaborations with citizen scientists may be viewed as a conundrum in these disciplines, which often require substantial labor and technical experience; citizen scientists could improve sampling capacity but may reduce sample quality or require training and oversight prior to and while performing specialized tasks. To demonst...

Narrative and "anti-narrative" in science: How scientists tell stories, and don't.

Narratives are common to all branches of science, not only to the humanities. Scientists tell stories about how the things we study work, develop, and evolve, and about how we come to be interested in them. Here I add a third domain (Secularity) to Gould's two "non-overlapping magisteria" of Science and Religion, and I review previous work on the parallels in elements between story-telling in literature and science. The stories of each domain have different criteria for judging them valid or useful. In scie...

Machine learning model combining features from algorithms with different analytical methodologies to detect laboratory-event-related adverse drug reaction signals.

The importance of identifying and evaluating adverse drug reactions (ADRs) has been widely recognized. Many studies have developed algorithms for ADR signal detection using electronic health record (EHR) data. In this study, we propose a machine learning (ML) model that enables accurate ADR signal detection by integrating features from existing algorithms based on inpatient EHR laboratory results.

The use of the chick embryo chorioallantoic membrane as experimental model to study virus growth and to test the clonal selection hypothesis. The contribution of Sir Mac Farlane Burnet.

Sir Mac Farlane Burnet was the most honored of all Australian scientists. In 1960, Burnet shared the Nobel Prize for Medicine with Peter Medawar of Britain for the discovery of acquired immunological tolerance, He developed techniques for growing influenza viruses in the chorioallantoic membrane of the chick embryo. This became standard laboratory practice. He continued to work with chick embryos long after the use of cell cultures had become general. His virology research resulted in significant discoverie...

A Clinical Model for the Early Diagnosis of Acute Pancreatitis in the Emergency Department.

This study aimed to develop a diagnostic model that predicts acute pancreatitis (AP) risk before imaging.

Beyond the Brown Bag: Designing Effective Professional Development for Informal Educators.

Most researchers are keenly interested in disseminating their work beyond traditional publication routes. With an eye to increasing broader impacts, scientists can benefit from partnerships with informal educators who interact daily with the public and see their role as translating science to increase the public's intellectual and emotional connections with the natural world. Typically, researchers give a one-time lunch hour talk, generally a modified version of a presentation aimed at scientific peers. Tal...

Nonlinear saturation of the large scale flow in a laboratory model of the quasibiennial oscillation.

The quasibiennial oscillation (QBO) is the nearly periodic reversal of the large scale flow generated by internal waves in the equatorial stratosphere. Using a laboratory model experiment, we study the instability that generates the QBO and investigate its nonlinear regime. We report the first quantitative measurements of the nonlinearly saturated velocity of the flow. We show that the QBO is generated by a bifurcation that is either supercritical or subcritical depending on the dominant dissipative process...

Use of the logic model to develop and implement an interprofessional module for undergraduate healthcare students at a University in South Africa: A study protocol.

Interprofessional education and collaborative practice, supported by the World Health Organisation and the local Health Professions Council is not fully established at all universities and for all health professions in South Africa (HPCSA, 2014). In this study protocol, the logic model is proposed as a framework for the development of a module for final year healthcare students. The logic model will guide planning and implementation following the steps of situational analysis, input and processes, output a...

Infection with flaviviruses requires BCLXL for cell survival.

BCL2 family proteins including pro-survival proteins, BH3-only proteins and BAX/BAK proteins control mitochondria-mediated apoptosis to maintain cell homeostasis via the removal of damaged cells and pathogen-infected cells. In this study, we examined the roles of BCL2 proteins in the induction of apoptosis in cells upon infection with flaviviruses, such as Japanese encephalitis virus, Dengue virus and Zika virus. We showed that survival of the infected cells depends on BCLXL, a pro-survival BCL2 protein due...

A new laboratory-based algorithm to predict microvascular invasion and survival in patients with hepatocellular carcinoma.

Preoperative serum inflammatory markers have been correlated with survival outcomes after resection of hepatocellular carcinoma (HCC). Whether they can predict microvascular invasion (MVI) in HCC is still unknown. This study aimed to evaluate the association of inflammatory markers with MVI, and develop a simple and inexpensive preoperative prediction model for MVI.

Predicting in-hospital mortality and unanticipated admissions to the intensive care unit using routinely collected blood tests and vital signs: development and validation of a multivariable model.

The National Early Warning System (NEWS) is based on vital signs; the Laboratory Decision Tree Early Warning Score (LDT-EWS) on laboratory test results. We aimed to develop and validate a new EWS (the LDTEWS:NEWS risk index) by combining the two and evaluating the discrimination of the primary outcome of unanticipated intensive care unit (ICU) admission or in-hospital mortality, within 24 hours.

Evaluation of Percutaneous Intradiscal Amniotic Suspension Allograft in a Rabbit Model of Intervertebral Disc Degeneration.

Laboratory study using a rabbit annular puncture model of intervertebral disc degeneration (IDD).

CD4 T cell responses to flaviviruses.

Flaviviruses pose an increasing threat to global health with their potential to cause severe disease in millions of people. Protective and long-lived immunity is closely linked to the generation of CD4 T cells, which provide B cell help and support high affinity neutralizing antibody responses. Research performed during the last years revealed important new insights into the antigen specificities and diverse effector functions of CD4 T cell responses to flaviviruses. Moreover, the identification of mechanis...

Structural Equation Model for Sleep Quality of Female Shift Work Nurses.

This study aimed to develop and test a structural model for sleep quality in female shift work nurses. The hypothetical model was constructed on the basis of Spielman's 3P model of insomnia and previous research related to the sleep quality of shift nurses.

Pre-validation study of alternative developmental toxicity test using mouse embryonic stem cell-derived embryoid bodies.

The embryoid body test (EBT) is a developmental toxicity test method that assesses the half inhibitory concentrations of substances in the area of embryoid bodies (EBs), and in the viability of mouse embryonic stem cells (ESCs) and fibroblasts (3T3 cells) following chemical exposure for three and four days, respectively. In the previous study, the EBT showed more advanced than the embryonic stem cell test (EST) from the European Centre for the Validation of Alternative Methods (ECVAM) applying cardiac diffe...


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