PubMed Journals Articles About "Scientists Recognized Transforming Wound Therapy" RSS

07:49 EST 20th January 2020 | BioPortfolio

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Showing "scientists recognized transforming wound therapy" PubMed Articles 1–25 of 15,000+

Fluorescence imaging guided dressing change frequency during negative pressure wound therapy: a case series.

Knowledge of wound bioburden can guide selection of therapies, for example, the use of negative pressure wound therapy (NPWT) devices with instillation in a heavily contaminated wound. Wound and periwound bacteria can be visualised in real-time using a novel, non-contact, handheld fluorescence imaging device that emits a safe violet light. This device was used to monitor bacterial burden in patients undergoing NPWT.

Benefits of a Patient-centered Remote Therapy Monitoring Program Focusing on Increased Adherence to Wound Therapy.

Patient nonadherence to wound care protocols may impact the efficacy of modalities, such as negative pressure wound therapy (NPWT). Recently, a remote therapy monitoring (RTM) system has been devised for use with NPWT for home care patients.

Temporary, Customized Negative Pressure Wound Therapy (t-NPWT) to Assist Wound Closure in Selected Patients: A Practical Solution or a Bridge to Advanced Care.

Negative pressure wound therapy in elective stoma reversal surgery: results of a UK district general hospital pilot.

The role of negative pressure wound therapy in stoma reversal surgery remains unknown. To evaluate this, a retrospective, non-randomised, single-institution, pilot study was conducted. Surgeon preference determined type of wound closure and application of the single-brand negative wound pressure device. No patient in the intervention group suffered wound complications, but five of the thirty-six patients in the control group suffered surgical site infection-related complications. Primary closure and negativ...

Use of a transforming powder dressing in the lower leg wounds of two older patients: case studies.

This report describes the use of a transforming powder dressing to treat lower leg surgical wounds occurring in two older patients. Wounds in this location are difficult and slow to heal. Both of these wounds exhibited complete granulation within two weeks of powder application and total healing in under four weeks, all while requiring no patient or nursing wound care.

Communication with patients using negative wound pressure therapy and their adherence to treatment.

The purpose of this study was to explore the challenges of communication between patients and health professionals, and patient adherence to treatment for hard-to-heal wounds when using negative wound pressure therapy (NPWT).

Wound-Healing Following Negative-Pressure Wound Therapy with Use of a Locally Developed AquaVac System as Compared with the Vacuum-Assisted Closure (VAC) System.

Negative-pressure wound therapy (NPWT) gained widespread clinical use after its introduction in the 1990s because of its many beneficial effects on the wound environment. However, high treatment costs have limited its use in third-world countries. The present study compares a low-cost, locally developed NPWT system with a commercially available system in terms of efficacy, reliability, ease of application, and safety.

Comparing the Therapeutic Value of Negative Pressure Wound Therapy and Negative Pressure Wound Therapy With Instillation and Dwell Time in Bilateral Leg Ulcers: A Case Report.

Several reports state that negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d) is useful in the management of intractable ulcers. However, reports comparing the effects of NPWT and NPWTi-d in the same patient are lacking.

Some observations on negative pressure wound therapy in acute soft tissue trauma.

Current Wound Care Education in Entry-Level Doctor of Physical Therapy Curricula.

To investigate how wound care instruction is currently delivered within entry-level doctor of physical therapy (DPT) educational curricula.

Quercetin Promotes Diabetic Wound Healing via Switching Macrophages From M1 to M2 Polarization.

For patients with diabetes mellitus, excessive and long-lasting inflammatory reactions at the wound site commonly lead to the delayed refractory wound healing. The polarization of macrophages in terms of M1 and M2 phenotypes is closely related to the production of inflammatory cytokines. Quercetin is traditionally recognized to have anti-inflammatory effect; however, whether quercetin modulates macrophage polarization from M1 to M2 and thus promotes diabetic wound healing remain unknown.

Fat grafting associated with negative pressure wound therapy.

To describe a case report of FG associated with NPWT in the treatment of complex wound on the distal third of the lower limb with bone exposure.

Combination application of ultrasonic debridement, methylene blue staining, and negative pressure wound therapy for severe pressure ulcers.

Prophylactic Negative Pressure Wound Therapy for Closed Laparotomy Incisions: A Meta-analysis of Randomized Controlled Trials.

The aim of this study was to determine whether negative pressure wound therapy (NPWT) applied to primarily closed incisions decreases surgical site infections (SSIs) following open abdominal surgery.

Topical antimicrobial peptide formulations for wound healing: Current developments and future prospects.

Antimicrobial peptides (AMPs) are the natural antibiotics recognized for their potent antibacterial and wound healing properties. Bare AMPs have limited activity following topical application attributable to their susceptibility to environment (hydrolysis, oxidation, photolysis), and wound (alkaline pH, proteolysis) related factors as well as minimal residence time. Therefore, the formulation of AMPs is essential to enhance stability, prolong delivery, and optimize effectiveness at the wound site. Different...

Pressure distribution and flow characteristics during negative pressure wound therapy.

Negative pressure wound therapy is thought to improve wound healing by altering capillary perfusion. However, despite many theories, the underlying mechanism of action remains controversial. Recent evidence suggests an increased tissue pressure and a temporary decreased microvascular blood flow as the main reasons for the good clinical results [1]. In an attempt to further explain the mechanism of action, we investigated the pressure distribution on the foam interface, and the influence on perfusion in a pr...

Early-stage Management of Complex Wounds Using Negative Pressure Wound Therapy With Instillation and a Dressing With Through Holes.

An early-stage decision clinicians often make in the management of complex wounds is which method of wound preparation will be appropriate for the patient. This decision can be affected by numerous wound and patient risk factors that present challenges and may make surgical debridement difficult in patients with complex wounds. Recently, negative pressure wound therapy with instillation and dwell time (NPWTi-d) using a novel reticulated open-cell foam dressing with through holes (ROCF-CC) was shown to aid i...

The Efficacy of Prophylactic Negative Pressure Wound Therapy for Closed Incisions in Breast Surgery: A Systematic Review and Meta-Analysis.

Negative pressure wound therapy (NPWT) is a promising advance in the management of closed surgical incisions. NPWT application induces several effects locally within the wound including reduced lateral tension and improving lymphatic drainage. As a result, NPWT may improve wound healing and reduce surgical site complications. We aim to evaluate the efficacy of prophylactic application of NPWT in preventing surgical site complications for closed incisions in breast surgery.

Securing split-thickness skin grafts using negative-pressure wound therapy without suture fixation.

Negative-pressure wound therapy (NPWT) is generally applied as a bolster for split-thickness skin grafts (STSG) after the graft has been secured with sutures or skin staples. In this study, NPWT was applied to secure STSGs without any sutures or staples. Surgical outcomes of using NPWT without sutures was compared with a control group.

Closed Incisional Negative Pressure Wound Therapy Sponge Width and Tension Off-Loading: A Laboratory Model.

Closed incisional negative pressure wound therapy (ciNPWT) has become commonplace in surgery. One mechanism ciNPWT may prevent incision site complications is by off-loading tension. This study aimed to find what width sponge using ciNPWT provides the most tension off-loading.A model was designed to test tension off-loading of a wound using ciNPWT. An incision was made in an anatomy model and closed with single stitch at the central axis. Force was applied tangentially using a force gauge at a steady rate un...

Phytochemical analysis and wound healing studies on ethno medicinally important plant Malva neglecta Wallr.

The use of herbal medicines is increasing in developed countries as alternative and/or supportive therapy to conventional health care medicines. Malva neglecta Wallr. (Family: Malvaceae) has been reported as wound healing remedy in traditional medicines, however no experimental data is available on its wound healing potentials. The aim of this study was to explore phytochemistry and validate wound healing potentials of the plant using animal models.

lncRNA MALAT1 Accelerates Wound Healing of Diabetic Mice Transfused with Modified Autologous Blood via the HIF-1α Signaling Pathway.

Impaired wound healing is a debilitating complication of diabetes. The long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been recognized to be differentially expressed in various diseases. However, its underlying mechanism in diabetes has not been fully understood. Notably, we aim to examine the expression of MALAT1 in diabetic mice and its role in wound healing involving the hypoxia-inducible factor-1α (HIF-1α) signaling pathway with a modified autologous bl...

Secularism in science: The role of religious affiliation in assessments of scientists' trustworthiness.

With controversies surrounding numerous science topics, including vaccinations and climate change, science skepticism in the United States is of growing concern. Some skepticism of science may stem from the perceived association between science and atheism, as well as stereotypes of religious individuals as prosocial. Three studies examine how scientists' religious affiliation (or lack thereof) influences perceptions of their warmth and trustworthiness among Christian participants. (Study 1 also includes at...

CCL2-mediated reversal of impaired skin wound healing in diabetic mice by normalization of neovascularization and collagen accumulation.

Patients with diabetes frequently present complications such as impaired skin wound healing. Skin wound sites display a markedly enhanced expression of CCL2, a potent macrophage chemoattractant, together with macrophage infiltration during the early inflammatory phase in skin wound sites of healthy normal individuals, but it remains elusive on the association of CCL2 with delayed skin wound healing in diabetic patients. Compared to control mice, streptozotocin (STZ)-induced diabetic mice displayed impaired ...

Impact of negative-pressure wound therapy on bacterial behaviour and bioburden in a contaminated full-thickness wound.

The use of negative-pressure wound therapy (NPWT) has displayed significant clinical benefits in the healing of infected wounds. However, the effects of NPWT on bacterial colonisation and infection of traumatic wounds has been controversial. The aim of this study is to evaluate the impact of NPWT treatment in rabbits with a contaminated full-thickness wound on bacterial behaviour, including colony morphology, spatial distribution, fissional proliferation, and bacterial bioburden. Full-thickness wounds were ...

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