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PubMed Journals Articles About "Sprinkle Platinum Nanoparticles Onto Graphene Makes Brain Probes" RSS

06:41 EST 23rd January 2019 | BioPortfolio

Sprinkle Platinum Nanoparticles Onto Graphene Makes Brain Probes PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Sprinkle Platinum Nanoparticles Onto Graphene Makes Brain Probes articles that have been published worldwide.

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Showing "sprinkle platinum nanoparticles onto graphene makes brain probes" PubMed Articles 1–25 of 14,000+

Ultrasensitive graphene optoelectronic probes for recording electrical activities of individual synapses.

The complex neuronal circuitry connected by sub-micron synapses in our brain calls for technologies that can map neural networks with ultrahigh spatiotemporal resolution to decipher the underlying mechanisms for multiple aspects of neuroscience. Here we show that through combining graphene transistor arrays with scanning photocurrent microscopy, we can detect the electrical activities of individual synapses of primary hippocampal neurons. Through measuring the local conductance change of graphene optoelectr...


Ethanol, O, and CO adsorption on Pt nanoparticles: effects of nanoparticle size and graphene support.

Pt nanoparticles dispersed over carbonaceous supports are widely used as catalysts for different applications, making studies on the interplay between size and support effects indispensable for rational catalyst design. Here, we use DFT calculations to simulate the interaction between O, CO, and ethanol with free platinum cuboctahedral nanoparticles with up to 147 atoms and with the same Pt nanoparticles supported on a single layer of graphene with up to 720 carbon atoms. We compute adsorption energies for ...

Electrochemiluminescent immunosensor for prostate specific antigen based upon luminol functionalized platinum nanoparticles loaded on graphene.

A novel label-free electrochemiluminescent (ECL) immunosensor based upon luminol functionalized platinum nanoparticles loaded on graphene sheets (Lu-Pt@GS) as sensing platform was fabricated for highly sensitive and selective determination of prostate specific antigen (PSA). In this work, for the first time luminol was employed as both ECL luminescence reagent and reductants to in-situ reduce HPtCl forming Pt NPs on surface of GS. A great deal of luminol could be attached onto the surface of Pt NPs within t...


FRET probes for measuring sphingolipid metabolizing enzyme activity.

Förster resonance energy transfer (FRET) probes are unique tools in biology, as they allow for a non-destructive monitoring of a certain state of a biomolecule or of an artificial substrate within living cells in real time. FRET substrates indicate their relative cleavage rate and thus the in situ activity of a given enzyme. In contrast to quenched probes or turn-on probes, one of the two separate signals of the FRET probes can be used as internal reference, which makes ratio-imaging and quantitation of cl...

Antioxidant efficacy of chitosan/graphene functionalized superparamagnetic iron oxide nanoparticles.

The antioxidant potential of superparamagnetic iron oxide nanoparticles functionalized with chitosan and graphene were examined in the present work. Coprecipitation technique was followed for the synthesis of iron oxide nanoparticles. Graphene-iron oxide nanocomposites were synthesized by mechanical mixing followed by the heat treatment at moderate temperature. The chitosan coated iron oxide nanoparticles were prepared by dispersing nanoparticles in chitosan solution. The nanoparticles/nanocomposites were c...

Platinum-doped carbon nanoparticles inhibit cancer cell migration under mild laser irradiation: Multi-organelle-targeted photothermal therapy.

Tumor growth and metastasis are two main causes of cancer-related deaths. Here, we simultaneously investigated the effects of nanoparticles on cancer cell viability and migration using polyethylene glycol (PEG)-modified, platinum-doped (

One stone with two birds: Phytic acid-capped platinum nanoparticles for targeted combination therapy of bone tumors.

Targeted drug delivery to malignant bone lesions remains a challenging task in the treatment of bone tumors. In this article, we reported a naturally occurring phytic acid (PA) with both bone-targeting capability and anticancer activity. The PA-capped platinum nanoparticles showed high affinity to hydroxyapatite in vitro and in vivo, and maintained both the inherent anticancer ability of PA and photothermal effect of platinum nanoparticles. PA-capped nanoparticles displayed a 4-fold higher accumulation in t...

Insight of holey-graphene in the enhancing of electrocatalytic activity as supporting material.

An ideal supporting material improves both activity and durability of noble-metal nanoparticles in electrocatalytic reactions. Graphene possesses a high transport rate of electrons in-plane, a low cost, and stability, but, the restacking of graphene layers trap noble-metal nanoparticles and make them inaccessible to reactants and results in reduced catalytic activity. Here, holey-graphene as the supporting materials for Pt nanoparticle catalysts is deeply investigated in the electrocatalytic reaction of met...

Long segment detection of HTLV-1 genome based on the fluorescence quenching technique.

Detecting fluorescence changes due to energy transfer between a quencher and fluorophore is a common method used for the fluorescence-based biosensors. In the present report, a new biosensor for long segment detection of the human T cell-lymphotropic virus 1 genome was constructed based on the fluorescence quenching of graphene oxide by gold nanoparticles. The fluorescence signal of unmodified graphene oxide was measured before and after hybridization of target and probes functionalized with gold nanoparti...

"Just Carbon": Ideas About Graphene Risks by Graphene Researchers and Innovation Advisors.

Graphene is a nanomaterial with many promising and innovative applications, yet early studies indicate that graphene may pose risks to humans and the environment. According to ideas of responsible research and innovation, all relevant actors should strive to reduce risks related to technological innovations. Through semi-structured interviews, we investigated the idea of graphene as a risk (or not) held by two types of key actors: graphene researchers and innovation advisors at universities, where the latte...

Neuro-Regenerative Choline Functionalized Injectable Graphene Oxide Hydrogel Repairs Focal Brain Injury.

Brain damage is associated with spatial imbalance of cholinergic system, which makes severe impact in recovery of damaged neurons of brain. Therefore, maintenance of cholinergic system is extremely important. Here, we fabricated an injectable hydrogel with acetylcholine functionalized graphene oxide and polyacrylic acid. Results revealed that this hydrogel is non-cytotoxic, promotes neurite outgrowth, stabilizes microtubule networks, and enhances the expression of some key neural markers in rat cortical pri...

Preparation of multifunctional Janus nanoparticles on the basis of SPIONs as targeted drug delivery system.

Passing the Blood-Brain-Barrier (BBB) is a challenging aspect in nanomedicine. Utilizing surfactant particles is reported to be a potent strategy for easier BBB penetration. On the other hand, loading different functional molecules on a single particle is therapeutically and economically beneficial. In this study, multifunctional amphiphilic Janus nanoparticles have been prepared on the basis of superparamagnetic iron oxide nanoparticles. This Janus platform is armed with folic acid targeting agent and Doxo...

High photocatalytic activity of ZnO-graphene composite.

In this work, ZnO nanoparticles-reduced graphene oxide (rGO) composites were fabricated via a novel one-step photochemical method. The developed nanocomposite offered high photodegradation efficiency of methylene blue (MB) under UV and visible light. In the proposed route, the reduction of graphene oxide (GO) and formation of ZnO nanoparticles occurred simultaneously, which results in high synthesis efficiency of ZnO/rGO nanocomposites. The electron microscopy confirmed that the ZnO nanoparticles were unifo...

Platinum Nanosheets between Graphite Layers.

Two-dimensional platinum nanosheets were obtained by the hydrogen reduction of platinum tetrachloride intercalated between graphite layers, the latter was prepared by the treatment of the mixture of platinum tetrachloride and graphite powder under chlorine atmosphere. The size of platinum nanosheets was 1-3 nm in thickness with a width in the range of 5-300 nm. These nanosheets contain a number of hexagonal holes and edges with an angle of 120°. This review discusses the reduction and oxidation behavio...

A perspective on biogenic synthesis of platinum nanoparticles and their biomedical applications.

In recent era, the interest on inorganic nanoparticles is augmenting due to their engrossing and uncanny properties. Among them, platinum nanoparticles (PtNPs) are highly remarkable owing to their intrinsic physicochemical and biological properties making them an effective candidate towards catalytic and biomedical applications. Nevertheless, conventional physical and chemical methodologies of PtNPs synthesis are among the most prevalent protocols to synthesize PtNPs of desired shape and size. However, the ...

Metal (Au, Pt) Nanoparticle-Latex Nanocomposites as Probes for Immunochromatographic Test Strips with Enhanced Sensitivity.

The development of a sensitive and rapid diagnostic test for early detection of infectious viruses is urgently required to defend against pandemic and infectious diseases including seasonal influenza. In this study, we developed noble metal (Au, Pt) nanoparticle-latex nanocomposite particles for use as probes for immunochromatographic test (ICT) strips. The nanocomposite particles were conjugated with monoclonal antibody (mAb) to detect an influenza A (H1N1) antigen. For comparison, Au nanoparticles conjuga...

Trabectedin for reversing platinum resistance and resensitization to platinum in patients with recurrent ovarian cancer.

We evaluated trabectedin in patients with platinum-resistant/refractory and partially platinum-sensitive recurrent ovarian cancer and the outcomes after reintroduction of platinum.

pH-sensitive and magnetically separable Fe/Cu bimetallic nanoparticles supported by graphene oxide (GO) for high-efficiency removal of tetracyclines.

Nanoscale zero-valent iron (nZVI) has been recognized as one of the most promising materials for the removal of a wide range of pharmaceuticals in water; however, aggregation and instability of nZVI in aqueous media reduces its efficacy. In this study, graphene oxide (GO) supported nZVI/copper bimetallic-nanoparticles (BNPs) were fabricated for high-efficiency removal of tetracyclines (TCs). In comparison to pure nZVI, the addition of Cu to the nano-adsorbents enhanced the efficacy of TC removal by 13%. The...

Electrical homogeneity mapping of epitaxial graphene on silicon carbide.

Epitaxial graphene is a promising route to wafer scale production of electronic graphene devices. Chemical vapor deposition of graphene on silicon carbide offers epitaxial growth with layer control, but is subject to significant spatial and wafer-to-wafer variability. We use terahertz time-domain spectroscopy and micro four-point probes to analyze the spatial variations of quasi-free-standing bi-layer graphene grown on 4 inch silicon carbide (SiC) wafers, and find significant variations in electrical proper...

Self-Assembly Precursor-Derived MoP Supported on N,P-Codoped Reduced Graphene Oxides as Efficient Catalysts for Hydrogen Evolution Reaction.

The design and synthesis of high-activity earth-abundant material-based electrocatalysts for hydrogen evolution reaction (HER) are of great significance. Here we develop a novel method to prepare a MoP nanoparticle supported on N,P-codoped reduced graphene oxides (MoP/N,P-rGO) by pyrolysis of the self-assembled precursor. Benefiting from the selected components of the assembly, P and N atoms are mixed at the molecular level, which leads to MoP nanoparticles uniformly attaching to the graphene substrate and ...

How to Study the Uptake and Toxicity of Nanoparticles in Cultured Brain Cells: The Dos and Don't Forgets.

Due to their exciting properties, engineered nanoparticles have obtained substantial attention over the last two decades. As many types of nanoparticles are already used for technical and biomedical applications, the chances that cells in the brain will encounter nanoparticles have strongly increased. To test for potential consequences of an exposure of brain cells to engineered nanoparticles, cell culture models for different types of neural cells are frequently used. In this review article we will discuss...

Rhodium Nanoparticles/F-Doped Graphene Composites as Multifunctional Electrocatalyst Superior to Pt/C for Hydrogen Evolution and Formic Acid Oxidation Reaction.

High-efficient electrocatalysis for clean, efficient and sustainable energy supply, such as hydrogen evolution reaction (HER) and formic acid oxidation reaction (FAOR), has drawn enthusiastic and worldwide attention. Universal and efficient electrocatalysts for these reactions are essential elements for the development of renewable and clean energy technologies. Herein, we show the design and fabrication of the rhodium nanoparticles modified fluorine-doped graphene (Rh/F-graphene) catalyst using silicon nan...

Graphite Wrapped Fe Core-shell Nanoparticles Anchored on Graphene as pH-Universal Electrocatalyst for Oxygen Reduction Reaction.

Development of high-performance non-precious metals and their nanocomposites as oxygen reduction electrocatalysts is critical but still challenging for fuel cells and metal-air batteries. Here, we introduce a synthetic strategy to fabricate graphite-wrapped Fe core-shell nanoparticles anchored on graphene as an efficient and stable pH-universal electrocatalyst for oxygen reduction reaction (ORR). The coordination among Fe3+, ellagic acid and graphene oxide would drive the formation of a sandwich-like assemb...

Amino acid conjugated chitosan nanoparticles for the brain targeting of a model dipeptidyl peptidase-4 inhibitor.

Saxagliptin (SAX) is dipeptidyl peptidase-4 enzyme inhibitor molecule now explored for its activity in the therapy of Alzheimer's disease. Being extremely hydrophilic, it is unable to permeate the blood-brain barrier by the conventional therapy modalities. Further repurposing the drug, SAX is associated with a reduction in the blood sugar level in the periphery. In the present study, the chitosan-L-valine conjugate was synthesized by carbodiimide chemistry. The conjugate was then used to prepare nanoparticl...

Tuning density of Si nanoparticles on graphene sheets in graphene-Si aerogels for stable lithium ion batteries.

Silicon is one of the most promising candidates for anodes of lithium ion batteries attributed to the highest theoretical specific capacity (4200 mAh/g). However, the conductivity and structural integrity during the lithiation-delithiation process are very poor, which seriously affect the actual electrochemical performance. To address these issues, we introduce graphene framework as both structural skeletons and conductive networks for silicon in this work. Through a facile freeze-drying approach, Si nano...


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