Topics

PubMed Journals Articles About "Arete Pharmacy Network" RSS

08:59 EDT 18th July 2019 | BioPortfolio

Arete Pharmacy Network PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Arete Pharmacy Network articles that have been published worldwide.

More Information about "Arete Pharmacy Network" on BioPortfolio

We have published hundreds of Arete Pharmacy Network news stories on BioPortfolio along with dozens of Arete Pharmacy Network Clinical Trials and PubMed Articles about Arete Pharmacy Network for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Arete Pharmacy Network Companies in our database. You can also find out about relevant Arete Pharmacy Network Drugs and Medications on this site too.

Showing "Arete Pharmacy Network" PubMed Articles 1–25 of 5,800+

Estimating The Annual Abortion Rate in Kerman, Iran: Comparison of Direct, Network Scale-Up, and Single Sample Count Methods.

Abortion is a sensitive issue surrounded by social, cultural and religious stigmata. Therefore, estimation of its prevalence involves methodological challenges. The aim of this manuscript is to estimate the abortion prevalence, stratified by type, using a direct and two indirect methods.


Sphingolipidomics investigation of the temporal dynamics after ischemic brain injury.

Sphingolipids (SPL) have been proposed as a potential therapeutic target for strokes, but no reports have ever profiled the changes of the entire range of SPLs after stroke. This study applied sphingolipidomic methods to investigate the temporal and individual changes in the sphingolipidome including the effect of atorvastatin after ischemic brain injury. We conducted sphingolipidomic profiling of mouse brain tissue by liquid chromatography-electrospray ionization tandem mass spectrometry at 3 hour (hr) and...

The transcription factor Hey and nuclear lamins specify and maintain cell identity.

The inability of differentiated cells to maintain their identity is a hallmark of age-related diseases. We found that the transcription factor Hey supervises the identity of differentiated enterocytes (ECs) in the adult midgut. Lineage tracing established that Hey-deficient ECs are unable to maintain their unique nuclear organization and identity. To supervise cell identity, Hey determines the expression of nuclear lamins, switching from a stem-cell lamin configuration to a differentiated lamin configurati...


Collaborative Network to Take Responsibility for oral AntiCancer Therapy (CONTACT): Study-protocol investigating the impact of a care pathway.

To evaluate the effectiveness, feasibility, meaningfulness and appropriateness of the development and implementation of a transmural care pathway in four hospitals in Flanders to improve self-management support in healthcare professionals and self-management in patients treated with oral anticancer drugs.

Key modules and hub genes identified by coexpression network analysis for revealing novel biomarkers for larynx squamous cell carcinoma.

Larynx squamous cell carcinoma (LSCC) is the second most aggressive head and neck squamous cell carcinoma. Numerous genes have been identified to be aberrantly expressed during the development of LSCC. However, currently, researchers focus more on the individual molecule and downstream genes, leaving the coexpression among genes and key upstream disease driver genes unexploited. In this study, we applied weighted gene coexpression analysis (WGCNA) to decipher potential hub genes driving the development of L...

Integrated mRNA-Seq and miRNA-Seq analysis of PLCγ2-overexpressing hepatocarcinoma cells and identification of the associated miRNA-mRNA network.

Our previous study has discovered the positive effect of phospholipase Cγ 2 (PLCγ2) on the growth of hepatocarcinoma cells; however, the underlying mechanism is far from being understood. For this reason, this study attempts to identify the differently expressed microRNAs (miRNAs) and messenger RNAs (mRNAs) in PLCγ2-overexpressing hepatocarcinoma cells. The results showed that totally 596 differently-expressed genes (DEGs) were identified in PLCγ2-expressed cells, including 314 upregulated and 282 downr...

Projecting the future size of the Lebanese pharmacy workforce: forecasts until the year 2050.

Despite the rigorous regulations governing the pharmacy profession in Lebanon, the increasing numbers of pharmacy graduates seem to be the greatest threat of demise. No forecast is available to assess the long-term projections of pharmacists supply.

A unifying review of polymer networks: from rubbers and gels to porous frameworks.

Polymer networks, which are materials comprised of many smaller components -referred to as "junctions" and "strands"- that are connected together via covalent or non-covalent/supramolecular interactions, are arguably the most versatile, widely studied, broadly used, and important materials known. From the very first commercial polymers through the plastics revolution of the 20th century to today, there are almost no aspects of modern life that are not impacted by polymer networks. Nevertheless, there are st...

Tailoring the Chemical Modification of Chitosan Hydrogels to Fine Tune the Release of a Synergistic Combination of Chemotherapeutics.

Combination chemotherapy with defined ratio and sequence of drug release is a clinically established and effective route to treat advanced solid tumors. In this context, a growing body of literature demonstrates the potential of hydrogels constructed with chemically modified polysaccharides as depots for controlled release of chemotherapeutics. Identifying the appropriate modification in terms of physicochemical properties of the functional group and its degree of substitution (χ) to achieve the desired re...

Role of Water Hydrogen Bonding on Transport of Small Molecules Inside Hydrophobic Channels.

We conducted a systematic analysis of water networking inside smooth hyperboloid hydrophobic structures (cylindrical, barrel, and hourglass shapes) in order to elucidate the role of water hydrogen bonding on the transport of small hydrophobic molecules (ligands). Through a series of molecular dynamic simulations, we established that a hydrogen bonded network forming along the centerline resulted in a water exclusion zone adjacent to the walls. The size of the exclusion zone is a function of the geometry and...

Convolutional Neural Network of Atomic Surface structures to Predict Binding Energies For High-throughput Screening of Catalysts.

High-throughput screening of catalysts can be performed using density functional theory calculations to predict catalytic properties, often correlated with adsorbate binding energies. However, more complete investigations would require an order of 2 more calculations compared to the current approach, making the computational cost a bottleneck. Recently developed machine-learning methods have been demonstrated to predict these properties from hand-crafted features but have struggled to scale to large composi...

Analyzing pharmacological intervention points: A method to calculate external stimuli to switch between steady states in regulatory networks.

Once biological systems are modeled by regulatory networks, the next step is to include external stimuli, which model the experimental possibilities to affect the activity level of certain network's nodes, in a mathematical framework. Then, this framework can be interpreted as a mathematical optimal control framework such that optimization algorithms can be used to determine external stimuli which cause a desired switch from an initial state of the network to another final state. These external stimuli are ...

Comparative accuracy of needle sizes and designs for EUS tissue sampling of solid pancreatic masses: a network meta-analysis.

Variable diagnostic performance of sampling techniques during EUS-guided tissue acquisition of solid pancreatic masses based on needle type [fine-needle aspiration (FNA) versus fine-needle biopsy (FNB)] and gauge (19-gauge vs 22-gauge vs 25-gauge) has been reported. We performed a systematic review with network meta-analysis to compare the diagnostic accuracy of EUS-guided techniques for sampling solid pancreatic masses.

Estrogen receptor-mediated targeting of the extracellular matrix network in cancer.

The biological functions of estrogens are regulated by estrogen receptors (ERα and ERβ), which contribute in the progression of several hormone-responsive cancer types via estrogen signaling mechanisms. The coordinated actions of ERs and extracellular matrix (ECM) macromolecules are principal mediators of ECM remodeling in the tumor and the adjacent stroma. In breast cancer, ERs are critical biomarkers as their expression in breast tumor determines the disease-free survival, yet guiding treatment decision...

Spoken language proficiency predicts print-speech convergence in beginning readers.

Learning to read transforms the brain, building on children's existing capacities for language and visuospatial processing. In particular, the development of print-speech convergence, or the spatial overlap of neural regions necessary for both auditory and visual language processing, is critical for literacy acquisition. Print-speech convergence is a universal signature of proficient reading, yet the antecedents of this convergence remain unknown. Here we examine the relationship between spoken language pro...

Plasticity in auditory categorization is supported by differential engagement of the auditory-linguistic network.

To construct our perceptual world, the brain categorizes variable sensory cues into behaviorally-relevant groupings. Categorical representations are apparent within a distributed fronto-temporo-parietal brain network but how this neural circuitry is shaped by experience remains undefined. Here, we asked whether speech and music categories might be formed within different auditory-linguistic brain regions depending on listeners' auditory expertise. We recorded EEG in highly skilled (musicians) vs. less exper...

Keystone taxa regulate microbial assemblage patterns and functional traits of different microbial aggregates in simultaneous anammox and denitrification (SAD) systems.

Understanding the impacts of the ecological patterns and niche-based selection on microbial community assembly and nitrogen-cycling network is crucial for achieving energy-neutral wastewater treatment. However, little is known about the niche differentiation and microbial nitrogen-cycling traits of keystone taxa in flocs and granules in anammox-based systems. Herein, the aspects of community assemblage patterns, metabolic functions and nitrogen transformation pathways were explored. The findings discovered ...

Correlation of Inhaled Long-acting Bronchodilators with Adverse Cardiovascular Outcomes in Patients with Stable COPD: A Bayesian Network Meta-Analysis of Randomized Controlled Trials.

A majority of existing studies have focused on the efficacy of inhaled long-acting bronchodilators (ILABs), such as long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs), and LABAs combined with LAMAs in treating chronic obstructive pulmonary disease (COPD). The current meta-analysis aimed to investigate the correlation of ILABs with specific cardiovascular adverse events (CAEs). Five electronic databases, including PubMed, Embase, Cochrane Library, Scopus and Web of Science, were ...

A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression.

Major depression is a common and severe psychiatric disorder with a highly polygenic genetic architecture. Genome-wide association studies have successfully identified multiple independent genetic loci that harbour variants associated with major depression, but the exact causal genes and biological mechanisms are largely unknown. Tissue-specific network approaches may identify molecular mechanisms underlying major depression and provide a biological substrate for integrative analyses. We provide a framework...

High-resolution contact networks of free-ranging domestic dogs Canis familiaris and implications for transmission of infection.

Contact patterns strongly influence the dynamics of disease transmission in both human and non-human animal populations. Domestic dogs Canis familiaris are a social species and are a reservoir for several zoonotic infections, yet few studies have empirically determined contact patterns within dog populations. Using high-resolution proximity logging technology, we characterised the contact networks of free-ranging domestic dogs from two settlements (n = 108 dogs, covering >80% of the population in each settl...

A Performance Comparison of CNN-based Image Denoising Methods: The Effect of Loss Functions on Low-dose CT Images.

Convolutional neural network (CNN)-based image denoising techniques have shown promising results in low-dose CT denoising. However, CNN often introduces blurring in denoised images when trained with a widely used pixel-level loss function. Feature-level loss and adversarial loss have been proposed recently to further improve the image denoising performance. In this paper, we investigate the effect of different loss functions on image denoising performance using task-based image quality assessment methods fo...

Reply to Letter: Nonselective beta blockers versus variceal band ligation, beyond bleeding prophylaxis.

We thank Gin-Ho Lo for taking interest in our study and for the comments.(1) Dr. Lo raises important points comparing the different adverse effect profiles of nonselective beta-blockers (NSBB) and variceal band ligation (VBL). Current guidelines still recommend the use of either NSBB or VBLfor the primary prevention of esophageal variceal bleeding and the debate is likely to continue.(2) In our systematic review and network meta-analysis, when compared toVBL, NSBB were associated with higher rate of overall...

Structures of single-layer β-sheet proteins evolved from β-hairpin repeats.

Free-standing single β-sheets are extremely rare in naturally occurring proteins, even though β-sheet motifs are ubiquitous. Here we report on crystal structures of three homologous, single-layer, anti-parallel β-sheet proteins, comprised of three or four twisted β-hairpin repeats. The structures reveal that, in addition to the hydrogen bond network characteristic of β-sheets, additional hydrophobic interactions mediated by small clusters of residues adjacent to the turns likely play a significant role...

Identification of pathogenic genes and transcription factors in vitiligo.

Our study aimed to identify the key genes and upstream regulators in vitiligo. To screen the pathogenic genes of vitiligo, an integrated analysis was performed by using the microarray datasets in vitiligo derived from the Gene Expression Omnibus (GEO) database. The functional annotation and potential pathways of differentially expressed genes (DEGs) were further explored by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. We constructed a vitiligo-specific transcrip...

Motor-Induced Suppression of the N100 Event-Related Potential During Motor Imagery Control of a Speech Synthesizer Brain-Computer Interface.

Purpose Speech motor control relies on neural processes for generating sensory expectations using an efference copy mechanism to maintain accurate productions. The N100 auditory event-related potential (ERP) has been identified as a possible neural marker of the efference copy with a reduced amplitude during active listening while speaking when compared to passive listening. This study investigates N100 suppression while controlling a motor imagery speech synthesizer brain-computer interface (BCI) with inst...


Quick Search