Advertisement

Topics

PubMed Journals Articles About "Basics Market" RSS

18:14 EDT 15th July 2019 | BioPortfolio

Basics Market PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Basics Market articles that have been published worldwide.

More Information about "Basics Market" on BioPortfolio

We have published hundreds of Basics Market news stories on BioPortfolio along with dozens of Basics Market Clinical Trials and PubMed Articles about Basics Market for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Basics Market Companies in our database. You can also find out about relevant Basics Market Drugs and Medications on this site too.

Showing "Basics Market" PubMed Articles 1–25 of 711

Quality-by-Design Approach for Biological API Encapsulation into Polymersomes Using "Off-the-Shelf" Materials: a Study on L-Asparaginase.

Polymersomes are versatile nanostructures for protein delivery with hydrophilic core suitable for large biomolecule encapsulation and protective stable corona. Nonetheless, pharmaceutical products based on polymersomes are not available in the market, yet. Here, using commercially available copolymers, we investigated the encapsulation of the active pharmaceutical ingredient (API) L-asparaginase, an enzyme used to treat acute lymphoblastic leukemia, in polymersomes through a quality-by-design (QbD) approach...


Protein-protein interaction modulators: advances, successes and remaining challenges.

Modulating disease-relevant protein-protein interactions (PPIs) using small-molecule inhibitors is a quite indispensable diagnostic and therapeutic strategy in averting pathophysiological cues and disease progression. Over the years, targeting intracellular PPIs as drug design targets has been a challenging task owing to their highly dynamic and expansive interfacial areas (flat, featureless and relatively large). However, advances in PPI-focused drug discovery technology have been reported and a few drugs ...

Is prodrug design an approach to increase water solubility?

Water solubility has been identified as a critical parameter and the main responsible by affecting poor performance of oral drug delivery. Poorly soluble drugs can originate unsatisfactory ADME properties leading to low oral bioavailability, insufficient chemical stability, low half-life, fast pre-systemic metabolism and difficulties in formulation. In this context, the prodrug design is an alternative in order to improve physicochemical, biopharmaceutical and pharmacokinetic properties such as permeability...


Phenomenology 2.0.

An estimated 10,000 mental health apps are now available for download to your mobile device. The appetite for digital and mobile technology related to health is undeniable. While a broad array of selection options in the marketplace is generally positive for consumers, many challenges exist in determining which of these apps are helpful. Most reach the market with limited information on utility and the majority have no research supporting the suggested uses or claims. The MONARCA group from Denmark, whose s...

In vitro biosafety of pro-ecological chitosan based hydrogels modified with natural substances.

Hydrogels belong to the group of materials with growing interest on the market of polymers. In presented paper hydrogels based on Beetosan were obtained using UV radiation. Main component of hydrogel matrix - Beetosan - is chitosan obtained from naturally died honeybees. Such hydrogels were modified with active substances, i.e. caffeine, bee pollen, Salvia officinalis (sage) and Aloe vera juice. Next, analysis of cytotoxicity of hydrogels in relation to murine fibroblasts by MTT and neutral red uptake assay...

Quantitative Kinetic Models from Intravital Microcopy: A Case Study Using Hepatic Transport.

The liver performs critical physiological functions, including metabolizing and removing substances, such as toxins and drugs, from the bloodstream. Hepatotoxicity itself is intimately linked to abnormal hepatic transport and hepatotoxicity remains the primary reason drugs in development fail and approved drugs are withdrawn from the market. For this reason, we propose to analyze, across liver compartments, the transport kinetics of fluorescein--a fluorescent marker used as a proxy for drug molecules--using...

Work identity development in young adults with mental health problems.

How we identify ourselves is strongly related to employment. Young adults are a vulnerable group with regard to entering the Labor market. If they also have mental health problems, entering becomes more difficult and increases risk of early marginalization. Nevertheless, working can be essential for personal recovery process. To explore experiences of young adults with mental health problems who are starting to work, with a focus on the process of developing work identity. Grounded theory design was used....

Lactobacilli-containing vaginal probiotics to cure or prevent bacterial or fungal vaginal dysbiosis: a systematic review and recommendations for future trial designs.

Vaginal probiotics claiming to cure and/or prevent bacterial and/or fungal vaginal dysbiosis are available on the market but did, until recently, not have to be approved as drugs for human use.

Online course on basics of management of behavioral addictions involving use of internet: Observations from the first batch of participants.

Problematic internet use has been reported to be high among school students. An online course was developed with an aim to strengthen the capacity of school teachers and counsellors on early identification, detection and intervention for behavioral addictions involving use of internet. The current report presents the observation from the first batch of participants of this course. Of the 28 teachers and counselors who expressed interest by enrollment in the course, a total of 15 participants provided both t...

Drug Policy and the Public Good: A Summary of the Second Edition.

The second edition of Drug Policy and the Public Good presents up-to-date evidence relating to the development of drug policy at local, national, and international levels. The book explores both illicit drug use and nonmedical use of prescription medications from a public health perspective. The core of the book is a critical review of the scientific evidence in five areas of drug policy: 1) primary prevention programs in schools and other settings; 2) treatment interventions and harm reduction approaches; ...

A free-energy landscape for the glucagon-like peptide 1 receptor GLP1R.

G-protein-coupled receptors (GPCRs) are among the most important receptors in human physiology and pathology. They serve as master regulators of numerous key processes and are involved in as well as cause debilitating diseases. Consequently, GPCRs are among the most attractive targets for drug design and pharmaceutical interventions (>30% of drugs on the market). The glucagon-like peptide 1 (GLP-1) hormone receptor GLP1R is closely involved in insulin secretion by pancreatic β-cells and constitutes a major...

Sexually Transmitted Disease, Human Immunodeficiency Virus, and Pregnancy Testing Behaviors Among Internet and Mobile Dating Application Users and Nonusers, 2016.

We examined 2016 United States market research to understand the demographics and sexual health testing behaviors of dating app users. Internet/app users were more likely to be young adults, male, nonwhite, of Hispanic ethnicity, and unmarried. Users also reported greater testing for sexually transmitted disease, human immunodeficiency virus, and pregnancy.

Warming increases Bacterial Panicle Blight (Burkholderia glumae) occurrences and impacts on USA rice production.

Bacterial Panicle Blight (BPB), caused by Burkholderia glumae, is a bacterial disease in rice (Oryza sativa) that reduces rice yield and quality for producers and consequently creates higher market prices for consumers. BPB is caused by the simultaneous occurrence of high daily minimum temperatures (~22°C) and relative humidity (~77%), which may increase under the current scenario of global warming. This study hypothesized that the economic damage from warming may cause an increase in economic losses, thou...

An integrative view on breast cancer signature panels.

Breast cancer is heterogeneous with distinct clinical outcomes. Diverse types of markers are available on the market for breast cancer prognosis, diagnosis, and therapeutics, with distinct assay approaches. These, though they enlarge our selection pool for characterizing breast cancer patients and help improve the precision on the therapeutics, they can complicate our understanding and choice of marker panels. Areas covered: This review aims at classifying the commonly used marker panels according to their ...

Complementary use of H NMR and multi-element IRMS in association with chemometrics enables effective origin analysis of cocoa beans (Theobroma cacao L.).

Within the cocoa market (Theobroma cacao L.), quality and prices are often determined by geographical origin, making traceability indispensable. Therefore, to investigate possibilities of tracing by analytical methods, 48 carefully selected cocoa samples from 20 countries have been profiled using a combination of stable isotope-ratio mass spectrometry (IRMS) and proton nuclear magnetic resonance (H NMR). Chemometric analysis of combined data sets from both, stable isotope data (δC, δN, δO, δH, %C, %N, %...

Exploring the analytical power of the QTOF MS platform to assess monoclonal antibodies quality attributes.

The biopharmaceutical industry is growing at a fast pace, making nowadays 20% of the pharma market. Within this market, therapeutic monoclonal antibodies (mAbs) are the dominant product class. With the patent expirations, biosimilars and, perhaps more relevant, biobetters, are in fast development. Thus, a comprehensive characterization at the molecular level of antibodies heterogeneity such as glycoforms, post-translational modifications (PTMs) and sequence variations is of utmost importance. Mass spectrome...

Stepwise approach of development of dermo-cosmetic products in healthy and atopic dermatitis (AD) paediatric population: safety evaluation, clinical development and post-market surveillance.

Paediatric skin, considered sensitive, and infant skin, more susceptible to percutaneous toxicity, require specially formulated cosmetic products. As recently shown, early use of emollients in infants "at risk" of developing atopic dermatitis can reduce the incidence of this condition, establishing the importance of preventative use of dermo-cosmetics in this population. Development of dermo-cosmetic products for this specific population should especially ensure tolerance and safety. In absence of good clin...

A New Tymovirus Isolated From : Characterization and Prevalence in Two Solanaceous Crops in Ecuador.

Naranjilla ( Lam.) and tamarillo ( Cav.) are two important perennial solanaceous crops grown in Ecuador for the fresh market and juice production. Viruses infecting tamarillo and naranjilla are currently poorly studied, and no clean stock program exists in Ecuador. Here, we report a new virus, provisionally named as naranjilla mild mosaic virus (NarMMV) (genus , family ), isolated from naranjilla grown in an orchard in Pichincha Province, Ecuador. The complete genome of the virus consists of 6,348 nucleotid...

Factors impacting producer marketing through community supported agriculture.

Nowadays, consumers have become increasingly aware of their local food system as a result of concerning about health and nutrition, food safety and sustainability, and local economic development. This transitional shift from global to direct-to-consumer farm operations has increased the demand for locally produced foods. As an alternative, community supported agriculture (CSA), a direct and sustainable food channel, has gained tremendous popularity in the US. Despite the interest garnered by local agricultu...

Effect of health status upon arrival at a single milk-fed veal facility on breakeven purchase price of calves.

Male calves are purchased from the dairy industry in North America to produce red meat. The price paid for male calves varies widely, and it is unclear which variables influence the price paid for each calf. The objective of this study was to assess how the health traits of calves at the time of arrival and demographic variables affect the breakeven purchase price of a male calf entering the veal industry. A financial model was constructed using the prevalence of health abnormalities, weight at arrival, sou...

Haemagglutinin stability was not the primary cause of the reduced effectiveness of live attenuated influenza vaccine against A/H1N1pdm09 viruses in the 2013-2014 and 2015-2016 seasons.

During the 2013-2014 influenza season, the quadrivalent live attenuated influenza vaccine (QLAIV), had lower than expected vaccine effectiveness (VE) against circulating A/H1N1pdm09 viruses in the USA. The underlying reason proposed for this was that the A/H1N1pdm09 vaccine strain, A/California/07/2009 (A/CA09), had a thermally unstable haemagglutinin (HA) protein. Consequently, a new A/H1N1pdm09 candidate strain, A/Bolivia/559/2013 (A/BOL13), was developed for inclusion in the 2015-2016 QLAIV. A key parame...

A LC-MS/MS method for the determination of common synthetic cathinones in meconium.

New psychoactive substances have been introduced into the market in the last years due to their unregulated status. Synthetic cathinones are one of their main representatives, and they have shown to produce neonatal complications. It is important to have objective tools to identify in utero exposure to drugs that have shown to produce neonatal complications. An analytical method was developed and fully validated for the determination of common synthetic cathinones, including methylone, methedrone, mephedron...

An automated computer vision based preliminary study for the identification of a heavy metal (Hg) exposed fish-channa punctatus.

Fishes available in the market may be cultured either in fresh or contaminated water bodies. Heavy metals are one of those contaminants which may cause menace to fish health and thereby affect the health of living beings consuming them. The identification of heavy metal residues in fish samples is a challenging task and may require expensive and sophisticated instruments and testing. This paper investigates visual changes which may be used as benchmark for differentiating between fresh water and heavy metal...

Do report cards predict future quality? The case of skilled nursing facilities.

Report cards on provider performance are intended to improve consumer decision-making and address information gaps in the market for quality. However, inadequate risk adjustment of report-card measures often biases comparisons across providers. We test whether going to a skilled nursing facility (SNF) with a higher star rating leads to better quality outcomes for a patient. We exploit variation over time in the distance from a patient's residential ZIP code to SNFs with different ratings to estimate the cau...

Environmental sustainability assessment of ready-made baby foods: Meals, menus and diets.

Although there is a growing body of literature on the environmental impacts of food, virtually none of the studies has addressed baby foods. Therefore, this work explored the life cycle environmental impacts of different ready-made baby foods, both at the level of individual meals and their combinations within a weekly menu. Twelve different meals were considered, based on baby food products available on the UK market, spanning breakfast, lunch and dessert. Menus following four different diets - omnivorous,...


Advertisement
Quick Search
Advertisement
Advertisement