Topics

PubMed Journals Articles About "Characterization Microbiota Bile Acid Metabolism Cytokines Intrahepatic Cholangiocarcinoma" RSS

00:32 EDT 22nd August 2019 | BioPortfolio

Characterization Microbiota Bile Acid Metabolism Cytokines Intrahepatic Cholangiocarcinoma PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Characterization Microbiota Bile Acid Metabolism Cytokines Intrahepatic Cholangiocarcinoma articles that have been published worldwide.

More Information about "Characterization Microbiota Bile Acid Metabolism Cytokines Intrahepatic Cholangiocarcinoma" on BioPortfolio

We have published hundreds of Characterization Microbiota Bile Acid Metabolism Cytokines Intrahepatic Cholangiocarcinoma news stories on BioPortfolio along with dozens of Characterization Microbiota Bile Acid Metabolism Cytokines Intrahepatic Cholangiocarcinoma Clinical Trials and PubMed Articles about Characterization Microbiota Bile Acid Metabolism Cytokines Intrahepatic Cholangiocarcinoma for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Characterization Microbiota Bile Acid Metabolism Cytokines Intrahepatic Cholangiocarcinoma Companies in our database. You can also find out about relevant Characterization Microbiota Bile Acid Metabolism Cytokines Intrahepatic Cholangiocarcinoma Drugs and Medications on this site too.

Showing "Characterization microbiota bile acid metabolism cytokines intrahepatic cholangiocarcinoma" PubMed Articles 1–25 of 20,000+

PROVISIONAL Molecular characterization and transcription analysis of DNA methyltransferase genes in tomato (Solanum lycopersicum).

DNA methylation plays an important role in plant growth and development, gene expression regulation and maintenance of genome stability. However, only little information regarding development- or stress-related DNA methyltransferases (MTases) genes is available in tomato. Here, we report the analysis of nine tomato MTases which were categorized into four known subfamilies. Structural analysis suggested their DNA methylase domains are highly conserved, whereas the N-terminals are divergent. Tissue-specific a...


Screening of oleaginous algal strains from Chlamydomonas reinhardtii mutant libraries via density gradient centrifugation.

Microalgae have a high potential to be utilized as feedstock for biofuels because they have high growth rates and do not compromise food production. Commercialized algae-based biofuel production relies on the development of strains with high lipid content. Based on the relatively low density of lipids compared to other cellular components, density gradient centrifugation was used to isolate high lipid content algal strains from Chlamydomonas reinhardtii mutant libraries. The correlation between cell density...

Construction of pancreas-muscle-liver microphysiological system (MPS) for reproducing glucose metabolism.

Although in vitro models are widely accepted experimental platforms, their physiological relevance is often severely limited. The limitation of current in vitro models is strongly manifested in case of diseases where multiple organs are involved, such as diabetes and metabolic syndrome. Microphysiological systems (MPS), also known as organ-on-a-chip technology, enable a closer approximation of the human organs and tissues, by recreating the tissue microenvironment. Multi-organ MPS, also known as multi-organ...


Influence of salt and acetonitrile on the capillary zone electrophoresis analysis of imatinib in plasma samples.

A simple, sensitive, specific and cost-effective analytical methodology was developed for the analysis of human plasma samples spiked with imatinib by capillary zone electrophoresis (CZE) with on-line UV detection in the context of Therapeutic Drug Monitoring (TDM). Several analytical conditions such as the ionic strength (I) and the pH of the background electrolyte (BGE) composed of citric acid and ε-amino caproic acid were studied in regards of the presence of sodium chloride (NaCl) in plasma samples (1....

Nodular Regenerative Hyperplasia Associated With Primary Liver Malignancies.

Nodular Regenerative Hyperplasia (NRH) is histopathologic condition that may lead to the development of non-cirrhotic portal hypertension. This condition is characterized by regeneration of hepatocyte nodules in the absence of advanced liver fibrosis. NRH has been traditionally considered a benign process, with only two cases previously reported of NRH predating the development of hepatocellular carcinoma. In this study, we report 4 additional cases of primary liver malignancies identified in a large cohort...

Development and evaluation of human T-cell leukemia virus-1 and -2 multiplex quantitative PCR.

Diagnosis of human T -cell leukemia virus type 1 (HTLV-1) infection in Japan is usually performed by serological testing, but the high rate of indeterminate results from western blotting makes it difficult to assess the infection accurately. Nucleic acid tests for HTLV-1 and/or HTLV-2 are used to confirm infection with HTLV-1 and/or HTLV-2 and are also used for the follow-up of HTLV-1 related diseases. To prepare a highly sensitive method that can discern infection with HTLV-1 and HTLV-2, we developed a mul...

Liver kinase B1 fine-tunes lineage commitment of human fetal synovium-derived stem cells.

Liver kinase B1 (LKB1), a serine/threonine protein, is a key regulator in stem cell function and energy metabolism. Herein, we describe the role of LKB1 in modulating the differentiation of synovium-derived stem cells (SDSCs) toward chondrogenic, adipogenic, and osteogenic lineages. Human fetal SDSCs were transduced with CRISPR associated protein 9 (Cas9)-single guide RNA (sgRNA) vectors to knock out or lentiviral vectors to overexpress the LKB1 gene. Analyses including ICE (Inference of CRISPR Edits) data ...

A dual-readout nanosensor based on biomass-based C-dots and chitosan@AuNPs with hyaluronic acid for determination of hyaluronidase.

A dual-signal strategy is proposed based on fluorescent biomass-based carbon dots (BC-dots) and chitosan stabilized AuNPs (CS@AuNPs) to determine hyaluronidase (HAase). BC-dots can induce aggregation of CS@AuNPs nanoparticles with a colour change from red to blue. Positively charged CS@AuNPs interacted with the negatively charged hyaluronic acid (HA) through electrostatic adsorption, and CS@AuNPs maintained stability due to the semirigid coil conformation of HA. However, in the presence of HAase, due to enz...

Further characterization of a novel EP2 and EP3 receptor dual agonist, ONO-8055, on lower urinary tract function in normal and lumbar canal stenosis rats.

To further explore the effects of a novel EP2 and EP3 dual agonist, ONO-8055, on detrusor contractility, we investigated the responses of bladder strips from sham and lumbar canal stenosis (LCS) rats to this agonist, its effects on lower urinary tract function in normal rats, and mRNA expression of EP2 and EP3 receptors in the sham and LCS rats.

A new approach to the production of a biovital skin graft based on human acellular dermal matrix produced in-house, in vitro revitalized internally by human fibroblasts and keratinocytes on the surface.

Patients with extensive and deep burns who do not have enough donor sites for autologous skin grafts require alternative treatment methods. Tissue engineering is a useful tool to solve this problem. The aim of this study was to find the optimal method for the production of a biovital skin substitute based on acellular dermal matrix (ADM) and in vitro cultured fibroblasts and keratinocytes. In this work, nine methods of ADM production were assessed. The proposed methods are based on the use of the following ...

Impact of chronic wounds of various etiology on systemic profiles of key inflammatory cytokines, chemokines, and growth factors and their interplay.

Non-healing wounds are becoming a growing concern for public health as a result of their increasing prevalence in progressively aging societies.

The influence of statin monotherapy and statin-ezetimibe combined therapy on FoxP3 and IL 10 mRNA expression in patients with coronary artery disease.

FoxP3 is a marker of human T regulatory cells (Tregs), which are supposed to play an important role in the pathophysiology of atherosclerosis. Interleukin 10 (IL-10) is a cytokine with pleiotropic, immunoregulatory properties, produced mostly by Tregs and B regulatory cells. Due to their anti-inflammatory action, both Tregs and IL-10 are believed to inhibit plaque development and decrease atherosclerosis progression. The effect of hypolipidemic drugs - statins or ezetimibe - on FoxP3-positive Tregs and anti...

The Oral Curcumin via Hydrophobic Porous Silicon Carrier: Preparation, Characterization and Toxicological Evaluation in Vivo.

Curcumin has antioxidant, anti-inflammatory, antimicrobial and anticarcinogenic activities. However, the clinical application of curcumin has been restricted by the poor water solubility and low bioavailability of this molecule. In the work, hydrophobic porous silicon (pSi) particles were prepared by electrochemical etching method and grafted with the different hydrophobic groups on their surfaces. The loading efficiency of curcumin in pSi has been investigated. The properties of pSi particles have been cha...

Evaluation of Chemically-Cleavable Linkers for Quantitative Mapping of Small Molecule-Cysteinome Reactivity.

Numerous reagents have been developed to enable chemical proteomic analysis of small molecule-protein interactomes. However, the performance of these reagents has not been systematically evaluated and compared. Herein, we report our efforts to conduct a parallel assessment of two widely-used chemically-cleavable linkers equipped with dialkoxydiphenylsilane (DADPS linker) and azobenzene (AZO linker) moieties. Profiling a cellular cysteinome using iodoacetamide alkyne probe demonstrated a significant discrepa...

Highly Luminescent and Water Resistant CsPbBr3-CsPb2Br5 Perovskite Nanocrystals Coordinated with Partially Hydrolyzed Poly(methyl methacrylate) and Polyethylenimine.

All inorganic lead halide perovskite nanocrystals (PNCs) typically suffer from poor stability against moisture and UV radiation, as well as degradation during thermal treatment. The stability of PNCs can be significantly enhanced through polymer encapsulation, often accompanied by a decrease of photoluminescence quantum yield (PLQY) due to the loss of highly dynamic oleylamine/oleic acid (OLA/OA) ligands. Herein, we propose a solution for this problem by utilizing partially hydrolyzed poly(methyl methacryla...

Three Silver Coordination Polymers with Diverse Architectures Constructed from Pyridine Carboxylic Hydrazide Ligands.

A series of silver coordination polymers (CPs) have been synthesized through self-assembly of three pyridinecarboxylic acid hydrazide (-, -, -position) ligands with silver clusters (named Ag1-iah, Ag2-iah, and Ag3-iah). These silver CPs show different one- and two-dimensional topologies including cross-helical chains, planar network, and parallel helical chains for Ag1-iah, Ag2-iah, and Ag3-iah, respectively. The combination of experimental and computational results reveals the critical role in the space di...

Detection of biomarkers in blood using liquid crystals assisted with aptamer-target recognition triggered in situ rolling circle amplification on magnetic beads.

Detection of biomarkers in body fluids is critical to both diagnosing the life-threatening diseases and optimizing therapeutic interventions. We herein report use of liquid crystals (LCs) to detect biomarkers in blood with high sensitivity and specificity by employing in situ rolling circle amplification (RCA) on magnetic beads (MBs). Specific recognition of cancer biomarkers, such as platelet derived growth factor BB (PDGF-BB) and adenosine, by aptamers leads to formation of a nucleic acid circle on MBs pr...

Exploring Soft Donor Character of the -2-Pyrazinylmethyl Group by Coordinating Trivalent Actinides and Lanthanides Using Aminopolycarboxylates.

The trivalent f-element coordination chemistry of a novel aminopolycarboxylate complexant was investigated. The novel reagent is an octadentate complexant that resembles diethylenetriamine-,,',″,″-pentaacetic acid (DTPA), but a single -acetate pendant arm was substituted with a -2-pyrazinylmethyl functional group. Thermodynamic studies of ligand protonation and trivalent lanthanide, americium and curium, complexation by -2-pyrazinylmethyldiethylenetriamine-,',″,″-tetraacetic acid (DTTA-PzM) emphasiz...

Chemical and Morphological Origins of Improved Ion Conductivity in Perfluoro Ionene Chain Extended Ionomers.

The performance of ion-conducting polymer membranes is complicated by an intricate interplay between chemistry and morphology that is challenging to understand. Here, we report on perfuoro ionene chain extended (PFICE) ionomers that contain either one or two bis(sulfonyl)imide groups on the side-chain in addition to a terminal sulfonic acid group. PFICE ionomers exhibit greater water uptake and conductivity compared to prototypical perfluorinated sulfonic acid ionomers. Advanced synchrotron characterizati...

Synthesis and Investigation of Linker-Free BODIPY-Gly Conjugates Substituted at the Boron Atom.

An efficient synthesis of boron-functionalized cyclic BODIPY-Gly conjugates, using commercially available -protected glycine amino acids and a BF-BODIPY moiety as starting materials, is reported. The existence of two conformers (up and down) is revealed through comprehensive DFT calculations and H and B NMR analyses. The experimental and computational results indicate that all BODIPYs are stable in aqueous solutions at neutral pH and that Fmoc-BODIPY () is more stable than Ac-BODIPY () in the presence of tr...

Induction of Antioxidant Metabolites in Callus by Abiotic Stresses.

has recently been subjected to numerous scientific studies pursuing its biological properties. However, biotechnological approaches promoting the synthesis of pharmacological compounds in this species are still scarce, despite the fact that moringa metabolites have shown significant nutraceutical effects. For this reason, in vitro cultures of moringa callus, obtained from leaf explantation, were subjected to various abiotic stresses such as temperature, salicylic acid, and NaCl, to identify the best growth ...

Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells.

A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors was found among resin acid derivatives. Several novel ureas and thioureas derived from dehydroabietylamine were synthesized and tested for TDP1 inhibition. The synthesized compounds showed IC values in the range of 0.1 to 3.7 μM and demonstrated low cytotoxicity against the human tumor cell lines U-937, U-87MG, MDA-MB, SK-Mel8, A-549, MCF7, T98G, and SNB19. Several compounds showed enhancement of the cytotoxic activity of the alkylating agent...

Infrared Signatures of the HHe and DHe , n = 3-6, Complexes.

Combination of a cryogenic ion-trap machine, operated at 4.7~K, with the free-electron-laser FELIX allows the first experimental characterization of the unusually bright antisymmetric stretch ($\nu_3$) and $\pi$-bending ($\nu_2$) fundamentals of the \mbox{He--X$^+$--He} (X\,=\,H, D) chromophore of the \emph{in situ} prepared \HHe{n} and \DHe{n}, $n=3-6$, complexes. The band origins obtained are fully supported by first-principles quantum-chemical computations, mostly performed at the gold-standard CCSD(T) a...

Hypoxia exacerbates non-alcoholic fatty liver disease HIF-2α/PPARα pathway.

This study aimed to investigate whether hypoxia can affect non-alcoholic fatty liver disease (NAFLD) progression and the associated mechanisms, specifically regarding the HIF-2α / PPARα pathway . Recent studies have reported that, compared with HIF-1α, HIF-2α has different effects on lipid metabolism. We propose hypoxia may exacerbate NAFLD by the HIF-2α upregulation-induced suppression of PPARα in the liver. To verify this hypothesis, a steatotic human hepatocyte (L02) cell line treated with free fat...

Low 24-hour core body temperature as a thrifty metabolic trait driving catch-up fat during weight regain after caloric restriction.

The recovery of body weight after substantial weight loss or growth retardation is often characterized by a disproportionately higher rate of fat mass vs lean mass recovery, with this phenomenon of 'preferential catch-up fat' being contributed by energy conservation (thrifty) metabolism. To test the hypothesis that a low core body temperature (Tc) constitutes a thrifty metabolic trait underlying the high metabolic efficiency driving catch-up fat, the Anipill® system - with the telemetry capsules implanted ...


Quick Search