Topics

PubMed Journals Articles About "Childhood Drug Drug Poisoning Nigeria Economic Appraisal" RSS

01:11 EDT 22nd August 2019 | BioPortfolio

Childhood Drug Drug Poisoning Nigeria Economic Appraisal PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Childhood Drug Drug Poisoning Nigeria Economic Appraisal articles that have been published worldwide.

More Information about "Childhood Drug Drug Poisoning Nigeria Economic Appraisal" on BioPortfolio

We have published hundreds of Childhood Drug Drug Poisoning Nigeria Economic Appraisal news stories on BioPortfolio along with dozens of Childhood Drug Drug Poisoning Nigeria Economic Appraisal Clinical Trials and PubMed Articles about Childhood Drug Drug Poisoning Nigeria Economic Appraisal for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Childhood Drug Drug Poisoning Nigeria Economic Appraisal Companies in our database. You can also find out about relevant Childhood Drug Drug Poisoning Nigeria Economic Appraisal Drugs and Medications on this site too.

Showing "Childhood Drug Drug Poisoning Nigeria Economic Appraisal" PubMed Articles 1–25 of 14,000+

Averting Alert Fatigue to Prevent Adverse Drug Reactions.


Vitamin D Deficiency in Middle Childhood Is Related to Behavior Problems in Adolescence.

Vitamin D deficiency (VDD) is associated with depression and schizophrenia in adults. The effect of VDD in childhood on behavioral development is unknown.

Evaluation of patient-reported outcome measures of functional recovery following caesarean section: a systematic review using the consensus-based standards for the selection of health measurement instruments (COSMIN) checklist.

We performed a systematic review using 'consensus-based standards for the selection of health measurement instruments' (COSMIN) criteria to identify and evaluate the quality of patient-reported outcome measures (PROM) instruments that have been utilised to assess functional recovery following caesarean section, and determine the optimal instrument for use in this setting. A literature search was performed using five databases. Studies were included if a psychometrically validated instrument was used to asse...


Achieving a high-density oleaginous yeast culture: comparison of four processing strategies using Metschnikowia pulcherrima.

Microbial lipids have the potential to displace terrestrial oils for fuel, value chemical and food production, curbing the growth in tropical oil plantations and helping to reduce deforestation. However, commercialisation remains elusive partly due to the lack of suitably robust organisms and their low lipid productivity. Extremely high cell densities in oleaginous cultures are needed to increase reaction rates, reduce reactor volume and facilitate downstream processing. In this investigation the oleaginous...

Influence of salt and acetonitrile on the capillary zone electrophoresis analysis of imatinib in plasma samples.

A simple, sensitive, specific and cost-effective analytical methodology was developed for the analysis of human plasma samples spiked with imatinib by capillary zone electrophoresis (CZE) with on-line UV detection in the context of Therapeutic Drug Monitoring (TDM). Several analytical conditions such as the ionic strength (I) and the pH of the background electrolyte (BGE) composed of citric acid and ε-amino caproic acid were studied in regards of the presence of sodium chloride (NaCl) in plasma samples (1....

Clinical Trial Portfolios: A Critical Oversight in Human Research Ethics, Drug Regulation, and Policy.

Regulators rely on clinical trials for drug approval and labeling decisions. Health systems and clinicians rely on the evidence from trials to determine treatment, and patients rely on it to decide which courses of care to undertake. Many of these stakeholders presume that the careful review of individual studies is enough to address the ethical and scientific questions that arise in clinical trials. In what follows, however, we demonstrate that explicit consideration of trial portfolios-series of trials th...

Microscopic investigations and pharmacognostic techniques used for the standardization of leaf of Rhus succedanea var. Himalaica J. D. Hook.

Rhus succedanea is generally traded, distributed, and sold in the markets in its crude and raw form. This may have been mixed with adulterants, mismanaged by malpractices, and substituted with other closely related drugs having different effect. This study is therefore carried out to authenticate the plant through pharmacognostic evaluations including morphological microscopic and physio-chemical features. Morphologically, the Rhus is a perennial small sized deciduous tree, locally, called as Rakhkal in Pas...

Technical success and long-term outcomes after anomalous right coronary artery stenting with cardiac computed tomography angiography correlation.

Anomalous origin of coronary arteries has been observed in about 0.35-2.10% of the population. Patients with anomalous right coronary artery (ARCA) may present with significant symptoms, arrhythmias or ACS, and at times sudden death. Traditionally, surgical correction has been the recommended treatment. However, these may be technically challenging, and bypass grafting for such anomalies has the potential for graft failure because of competitive flow. We sought to determine the intermediate and long-term ou...

Reframing the Individual Stress Response: Balancing our Knowledge of Stress to Improve Responsivity to Stressors.

While responses to stressors have both adverse and positive consequences on health, many believe that stress is entirely negative. Research revealed that negative beliefs about stress can hinder well-being and result in the avoidance of stressors. Stress-optimizing interventions that target various stress appraisal processes may be a useful tool to reframe how individuals understand and respond to stressors. The current study extends previous findings on stress reframing, and sought to examine the extent to...

Catalyst-Free and Solvent-Free Facile Hydroboration of Imines.

A facile process for the catalyst-free and solvent-free hydroboration of aromatic as well as heteroaromatic imines is reported. This atom-economic methodology is scalable, compatible with sterically and electronically diverse imines displaying excellent tolerance towards various functional groups, and works efficiently at ambient temperature for majority cases affording secondary amines in good to excellent yield after hydrolysis.

Engineering Steps for Mobile Point-of-Care Diagnostic Devices.

Mobile phone technology is a perfect companion for point-of-care diagnostics as they come equipped with advanced processors, high resolution cameras, and network connectivity. Despite several academic pursuits, only a few mobile phone diagnostics have been tested in the field, commercialized or achieved regulatory approval. This review will address the challenges associated with developing mobile diagnostics and suggest strategies to overcome them. We aim to provide a resource for researchers to accelerate ...

Redox Sensitive Self-Assembling Dipeptide for Sustained Intracellular Drug Delivery.

The rational design and synthesis of molecules with functional supramolecular assemblies continues to be a challenging endeavor. Self-assembled nano- and micro-structures from natural building blocks are considered more appropriate for medical applications due to their biocompatible nature. We report for the first time, a simple redox-responsive dipeptide that self-assembles to form vesicles in aqueous medium. The experimental results based on the control compound and all-atom molecular dynamics (MD) simula...

Phosphorylated zein as biodegradable and aqueous nano-carriers for pesticides with sustained-release and anti-UV properties.

Zein's prevalent hydrophobic character is one of major challenges associated with ineffective utilization as aqueous nano-carrier for pesticides. Herein, we reported an effective approach to hydrophilic modification of zein by phosphorylation using nontoxic sodium tripolyphosphate (STP), thereby improving the water-solubility, foliage wettability and adhesion ability of zein as nano-carrier for sustained release of pesticides. The procedure relied on zein grafted with STP via N- and O- phosphate bonds and e...

Torsional Energy Barriers of Biaryls could be Predicted by Electron-richness/deficiency of Aromatic Rings; Advancement of Molecular Mechanics towards Atom-Type Independence.

Biaryl molecules are one of the most ubiquitous pharmacophores found in natural products and pharmaceuticals. In spite of this, existing molecular mechanics force fields are unable to accurately reproduce their torsional energy profiles, except in a few well-parametrized cases. This effectively limits the ability of structure-based drug design methods to correctly identify hits involving biaryls with confidence (eg. during virtual screening, employing docking and/or molecular dynamics simulations). Continui...

Structural Analysis and Identification of Colloidal Aggregators in Drug Discovery.

Aggregation has been posing a great challenge in drug discovery. Current computational approaches aiming to filter out aggregated molecules based on their similarity to known aggregators, such as Aggregators Advisor, have low prediction accuracy, and therefore development of reliable in silico models to detect aggregators is highly desirable. In this study, we built a dataset consisting of 12,119 aggregators and 24,172 drugs or drug candidates and then developed a group of classification models based on the...

Intravitreal Pharmacokinetics in Mice: SPECT/CT Imaging and Scaling to Rabbits and Humans.

Preclinical in vivo tests of retinal drug responses are carried out in mice and rats, often after intravitreal injections. However, quantitative pharmacokinetics in the mouse eye is poorly understood. Ocular pharmacokinetics studies are usually done in the rabbits. We investigated elimination of three compounds ([99mTc]Tc-pentetate, [111In]In-pentetreotide, [99mTc]Tc-human serum albumin with molecular weights of 510.2 Da, 1506.4 Da, and 66.5 kDa, respectively) from mouse vitreous using imaging with single p...

Risk-benefit balance assessment of SSRI antidepressant use during pregnancy and lactation based on best available evidence - an update.

: Depression affects 300 million individuals worldwide. While selective serotonin reuptake inhibitors (SSRI) are one of the first-line pharmacological treatments of major depression in the general population, there is still uncertainty regarding their potential benefits and risks during pregnancy. : Outcomes requisite for a proper risk/benefit assessment of SSRI in pregnancy and lactation were considered: (a) potential risks associated with untreated depression, (b) effectiveness of different treatment opti...

Partnering with Panama: Exploring Anthropometrics, Dietary Patterns, and the Built Food Environment of School-aged Children.

Childhood obesity is a global public health concern in developed and developing countries. Approximately 3 in 10 Panamanian children suffer from obesity, and overweight/obesity is responsible for the highest number of premature or avoidable deaths in this country. A formative community assessment and exploration of the built food environment was conducted. Analysis suggests that almost one-third of the children measured were overweight or obese, and the availability of foods recommended for optimal health i...

Associations between affect and alcohol consumption in adults: an ecological momentary assessment study.

: Consuming alcohol for coping with negative affect (NA) or enhancing positive affect (PA) may lead to risky drinking patterns. Previous research has yielded mixed findings regarding these affective drinking associations. : To examine support for the self-medication and expectancy models of alcohol use in an adult community sample, by examining reciprocal associations between alcohol consumption and NA and PA within and between persons. : During seven consecutive days, 162 adults from the community (109 fem...

Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors.

: Acetyl-CoA Carboxylase (ACC) is an essential rate-limiting enzyme in fatty acid metabolism. For many years, ACC inhibitors have gained great attention for developing therapeutics for various human diseases including microbial infections, metabolic syndrome, obesity, diabetes, and cancer. : We present a comprehensive review and update of ACC inhibitors. We look at the current advance of ACC inhibitors in clinical studies and the implications in drug discovery. We searched ScienceDirect ( https://www.scienc...

Enhancing laccase production by white-rot fungus SSM-3 in co-culture with yeast SSM-8.

Due to wide application of laccase, many researchers have shown great interest in over production of white-rot fungi laccase by co-culture. In this study, a white-rot fungus SSM-3, and a yeast SSM-8 were isolated and identified from Mulberry fruit. The capacity of to enhance laccase production was remarkable in , yielding 31777 ± 742 U/L, about 9.9 times higher than the result from the monoculture. The stimulatory factor in the cells might be temperature-sensitive. The laccase production was enha...

Predictability of individual circadian phase during daily routine for medical applications of circadian clocks.

Circadian timing of treatments can largely improve tolerability and efficacy in patients. Thus, drug metabolism and cell cycle are controlled by molecular clocks in each cell, and coordinated by the core body temperature 24-hour rhythm, which is generated by the hypothalamic pacemaker. Individual circadian phase is currently estimated with questionnaire-based chronotype, center-of-rest time, dim light melatonin onset (DLMO), or timing of CBT maximum (acrophase) or minimum (bathyphase).

Comparison of self-controlled designs for evaluating outcomes of drug-drug interactions: simulation study.

Self-controlled designs, both case-crossover and self-controlled case series, are well suited for evaluating outcomes of drug-drug interactions in electronic healthcare data. Their comparative performance in this context, however, is unknown.

Air pollution as cause of mental disease: Appraisal of the evidence.

A causal association of air pollution with mental diseases is an intriguing possibility raised in a Short Report just published in PLOS Biology. Despite analyses involving large data sets, the available evidence has substantial shortcomings, and a long series of potential biases may invalidate the observed associations. Only bipolar disorder shows consistent results, with similar effects across United States and Denmark data sets, but the effect has modest magnitude, appropriate temporality is not fully sec...

Associations of fat mass and fat-free mass accretion in infancy with body composition and cardiometabolic risk markers at 5 years: The Ethiopian iABC birth cohort study.

Accelerated growth in early childhood is an established risk factor for later obesity and cardiometabolic disease, but the relative importance of fat mass (FM) and fat-free mass (FFM) accretion is not well understood. We aimed to study how FM and FFM at birth and their accretion during infancy were associated with body composition and cardiometabolic risk markers at 5 years.


Quick Search