PubMed Journals Articles About "Comprehensive Clinical Genetic Characterization Hyperprogression Based Volumetry Advanced" RSS

01:47 EDT 19th July 2019 | BioPortfolio

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Showing "Comprehensive Clinical Genetic Characterization Hyperprogression Based Volumetry Advanced" PubMed Articles 1–25 of 67,000+

Comorbidities and Survival in Patients with Lipodystrophy: An International Chart Review Study.

Limited natural history data are available in patients with non-HIV-related lipodystrophy syndromes who never received disease-specific therapies, making interpretation of benefits of novel therapies in lipodystrophy syndromes challenging.

Metatranscriptomics reveals mycoviral populations in the ovine rumen.

The rumen is known to contain DNA based viruses, although it is not known whether RNA based viruses that infect fungi (mycoviruses) are also present. Analysis of publicly available rumen metatranscriptome sequence data from sheep rumen samples (n = 20) was used to assess whether RNA based viruses exist within the ovine rumen. A total of 2,466 unique RNA viral contigs were identified that had homology to 9 viral families. The Partitiviridae was the most consistently observed mycoviral family. High variatio...

A prophage and two ICESa2603-family integrative and conjugative elements (ICEs) carrying optrA in Streptococcus suis.

To investigate the presence and transfer of the oxazolidinone/phenicol resistance gene optrA and identify the genetic elements involved in the horizontal transfer of the optrA gene in Streptococcus suis.

An RNA-based quantitative and compositional study of ammonium-oxidizing bacteria and archaea in Lake Taihu, a eutrophic freshwater lake.

Ammonium-oxidizing archaea (AOA) and bacteria (AOB) play crucial roles in ammonium oxidation in freshwater lake sediment. However, previous reports on the predominance of AOA and AOB in the surface sediment of Lake Taihu have been based on DNA levels, detecting the total abundance of microbiota (including inactive cells), and have resulted in numerous contradictory conclusions. Existing RNA-level studies detecting active transcription are very limited. The current study using RNA-based real-time quantificat...

Comparative Effectiveness of New Approaches to Improve Mortality Risk Models From Medicare Claims Data.

Risk adjustment models using claims-based data are central in evaluating health care performance. Although US Centers for Medicare & Medicaid Services (CMS) models apply well-vetted statistical approaches, recent changes in the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) coding system and advances in computational capabilities may provide an opportunity for enhancement.

Solar Lentigines are Associated with Better Outcome in Cutaneous Melanoma.

The rising incidence of cutaneous melanoma and its stable high mortality rates despite innovative cancer care, require better prediction of the clinical outcome. In a large cutaneous melanoma population we explored whether the known clinical risk factors for melanoma susceptibility (nevus phenotype, phototype, family and personal history of melanoma and sun damage) affect melanoma outcomes. A total of 1,530 melanoma patients were included. Multivariable analysis adjusted for age, gender, melanoma stage, loc...

Risk of bleeding and thrombosis in inherited qualitative fibrinogen disorders.

Inherited dysfibrinogenemia is a rare disorder, for which clinical studies related to the risk of bleeding or thrombosis and the type of causative mutation are scanty.

Enzyme Mimic Basing on Self-assembled Chitosan/DNA Hybrid Exhibits Superior Activity and Tolerance.

Nature has evolved exquisite active sites with which enzymes catalyze biotransformations with high efficiency. However, the exploitation of natural enzymes is often hampered by poor stability and natural enzyme production and purification are costly. Supramolecular self-assembly allows one to construct biomimetic active sites, although it is challenging to produce such artificial enzymes with catalytic activity and stability that rivals those of natural enzymes. In this work, we report a modular strategy to...

Diagnosis and Treatment of Alcohol-Related Liver Diseases: 2019 Practice Guidance from the American Association for the Study of Liver Diseases.

Alcoholic liver disease (ALD) represents a spectrum of liver injury resulting from alcohol use, ranging from hepatic steatosis to more advanced forms including alcoholic hepatitis (AH), alcoholic cirrhosis (AC), and acute alcoholic hepatitis presenting as acute on chronic liver failure (ACLF). ALD is a major cause of liver disease worldwide, both on its own and as a co-factor in the progression of chronic viral hepatitis, nonalcoholic fatty liver disease (NAFLD), iron overload and other liver diseases. ALD ...

Long noncoding RNA single-nucleotide polymorphisms: a new cause of genetic susceptibility to autoimmune blistering disease.

End-diastolic force pre-activates cardiomyocytes and determines contractile force; role of titin and calcium.

Titin functions as a molecular spring and cardiomyocytes are able, through splicing, to control the length of titin. We hypothesized that together with diastolic [Ca ] titin-based stretch pre-activates cardiomyocytes during diastole and is a major determinant of force production in the subsequent contraction. Through this mechanism titin would play an important role in active force development and length-dependent activation. Mutations in the splicing factor RNA binding motif protein 20 (RBM20) result in ex...

Does older adults' use of social care influence their healthcare utilisation? A systematic review of international evidence.

Improving our understanding of the complex relationship between health and social care utilisation is vital as populations age. This systematic review aimed to synthesise evidence on the relationship between older adults' use of social care and their healthcare utilisation. Ten databases were searched for international literature on social care (exposure), healthcare use (outcome) and older adults (population). Searches were carried out in October 2016, and updated May 2018. Studies were eligible if they we...

Genetic testing for prevention of severe drug-induced skin rash.

Drug-induced skin reactions present with a range of clinical symptoms, from mild maculopapular skin rashes to potentially fatal blistering skin rashes - such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) - which may result in death. Milder reactions may be troublesome and lead to low drug compliance. The pathogenesis of these drug reactions is not yet fully understood; however, there is evidence that pretreatment genetic testing may help to predict and prevent these reactions in some...

Motor function and the probability of prodromal Parkinson's disease in older adults.

Identification and characterization of Parkinson's disease (PD) in its prodromal stage is crucial.

Fatty Acid Profile of Pacific Oyster, Crassostrea gigas, Fed Different Ratios of Dietary Seaweed and Microalgae during Broodstock Conditioning.

The fatty acid (FA) profile of oysters generally reflects the dietary FA composition. Moreover, incorporation of FA into tissues is modulated by various metabolic factors, and final composition will depend upon the dietary sources, cumulative intake, and oysters' development stage. Thus, the aim of this study was to assess the impact of dietary incorporation of seaweed (SW) Ulva rigida, in replacement of traditional microalgae diet, on the FA composition of Pacific oysters Crassostrea gigas, during broodsto...

BFGF blockade enhances lung cancer cell invasion by activating the AKT/MMP-2/VEGF pathway.

Basic fibroblast growth factor (bFGF) can stimulate cancer cell growth and invasion; however, the influence of bFGF blockade remains unclear. Therefore, we aimed to explore the effects of bFGF blockade on the growth and invasion in A549 (high bFGF expression) and H2122 (low bFGF expression) lung cancer cells. We found that the blocking of bFGF by a neutralizing monoclonal antibody suppressed the growth of A549 cells but not of H2122 cells, as well as strongly induced the invasiveness of A549 cancer cells. F...

The draft genome of a wild barley genotype reveals its enrichment in genes related to biotic and abiotic stresses compared to cultivated barley.

Wild barley (Hordeum spontaneum) is the progenitor of cultivated barley (H. vulgare) and provides a rich source of genetic variations for barley improvement. Currently, the genome sequences of wild barley and its differences with cultivated barley remain unclear. In this study, we report a high-quality draft assembly of wild barley accession (AWCS276; henceforth named as WB1), which consists of 4.28 Gb genome and 36,395 high-confidence protein coding genes. BUSCO analysis revealed that the assembly included...

Comparing clinical characteristics of pediatric patients with pancreatic diabetes to patients with type 1 diabetes - a matched case-control study.

Only few studies have been conducted on pancreatic diabetes and data from large epidemiological studies are missing. Our main objective was to study the most important differences and similarities between pediatric individuals with pancreatic diabetes and type 1 diabetes.

Characterization of epidermal growth factor receptor (EGFR) P848L, an unusual EGFR variant present in lung cancer patients, in a murine Ba/F3 model.

Lung cancer patients with mutations in epidermal growth factor receptor (EGFR) benefit from treatments targeting tyrosine kinase inhibitors (TKIs). However, both intrinsic and acquired resistance of tumors to TKIs are common, and EGFR variants have been identified that are resistant to multiple TKIs. In the present study, we characterized selected EGFR variants previously observed in lung cancer patients and expressed in a murine bone marrow pro-B Ba/F3 cell model. Among these EGFR variants, we report that ...

A double armed, hydrophilic, transition metal complex as paramagnetic NMR probe.

Synthetic metal complexes find use as paramagnetic probes for the study of proteins and protein complexes. Here, two transition metal NMR probes (TraNPs) are reported. TraNPs are attached via two arms to a protein to generate pseudocontact shift (PCS) using cobalt (II), or paramagnetic relaxation enhancement (PRE) with manganese (II). The PCS analysis of TraNPs attached to three different proteins shows that the size of the anisotropic component of the magnetic susceptibility depends on the probe surroundin...

All that fails to abduct may not be an abducens palsy.

The authors enjoyed the case report by Singh et al. of a low flow carotid cavernous fistula producing defective abduction in one eye..

Detecting and quantifying stress granules in tissues of multicellular organisms with the Obj.MPP analysis tool.

Stress Granules (SGs) are macromolecular assemblies induced by stress and composed of proteins and mRNAs stalled in translation initiation. SGs play an important role in the response to stress and in the modulation of signaling pathways. Furthermore, these structures are related to the pathological ribonucleoprotein (RNP) aggregates found in neurodegenerative disease contexts, highlighting the need to understand how they are formed and recycled in normal and pathological contexts. Although genetically tract...

The peu-miR160a-PeARF17.1/PeARF17.2 module participates in the adventitious root development of poplar.

Deep roots give rise to flourishing leaves, and the two complement each other. However, the genetic mechanisms underlying adventitious rooting for forest trees have remained elusive. In this study, we verified that peu-miR160a targets six poplar genes AUXIN RESPONSE FACTORS (ARFs), PeARF10.1, PeARF16.1, PeARF16.2, PeARF16.3, PeARF17.1 and PeARF17.2, using 5'RLM-RACE. Interaction experiments with peu-miR160a and PeARFs in poplar protoplasts further confirmed that peu-miR160a targets and negatively regulates ...

Big data in nephrology: are we ready for the change?

Chronic kidney disease (CKD) is a major public health issue worldwide. However, the status of kidney health care needs to be strengthened globally and research evidence in nephrology is relatively limited. The unmet needs in nephrology leave ample space for imagination regarding leveraging big data and artificial intelligence (AI). Big data has potential to drive medical innovation, reduce medical costs and improve health care quality. Compared with other specialties such as cardiology, the scopes of utiliz...

Tissue and cell-type specific expression of a splice variant in the II-III cytoplasmic loop of Cacna1b.

Presynaptic Ca 2.2 (N-type) channels are fundamental for transmitter release across the nervous system. The gene encoding Ca 2.2 channels, Cacna1b, contains alternatively spliced exons that result in functionally distinct splice variants (e18a, e24a, e31a and 37a/37b). Alternative splicing of the cassette exon 18a generates two mRNA transcripts (+e18a-Cacna1b and Δe18a-Cacna1b). In this study, using novel mouse genetic models and in situ hybridization (BaseScope ), we confirmed that +e18a-Cacna1b splice va...

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