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PubMed Journals Articles About "Development Engineering Artificial RNAs" RSS

13:12 EDT 18th July 2019 | BioPortfolio

Development Engineering Artificial RNAs PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Development Engineering Artificial RNAs articles that have been published worldwide.

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Showing "Development engineering artificial RNAs" PubMed Articles 1–25 of 23,000+

Leukocyte cell-derived chemotaxin 2 inhibits development of atherosclerosis in mice.

Leukocyte cell-derived chemotaxin 2 (LECT2), a multifunctional hepatokine, is involved in many pathological conditions. However, its role in atherosclerosis remains undefined. In this study, we administered vehicle or LECT2 to male mice fed a Western diet for 15 weeks. Atherosclerotic lesions were visualized and quantified with Oil-red O and hematoxylin staining. The mRNA expression levels of MCP-1, MMP-1, IL-8, IL-1β, and TNF-α were analyzed by quantitative real-time polymerase chain reaction. Serum TNF...


Development and Validation of A Decision-Making Donor Conception Questionnaire in Iranian Infertile Couples.

Despite the fact that many infertile couples have to decide about whether or not to choose donor conception, there is no predictive scale for evaluating the process of decision-making on donor conception and its determinants in such couples. The present study was conducted to develop a decision-making questionnaire for selecting donor conception and assess its psychometric properties in Iranian infertile couples.

Endowing Lithium Metal Surface with Self-healing Property via In-situ Gas-solid Reaction for High-performance Lithium Metal Batteries.

The property of solid electrolyte interphase (SEI) layer is of prime importance for the performance of lithium metal anodes. Replacing the spontaneously formed inhomogeneous and unstable SEI layer with a high-performance artificial SEI is an effective strategy. Herein, a self-healing SEI layer with high lithium ion conductivity and stable framework to address the issues of poor performance of lithium metal anode is achieved. C, Li2S and LiI are uniformly distributed on lithium surface via a "sauna" reaction...


Organic and Organometallic Chemistry at the Single-Molecule, -Particle, and -Molecular-Catalyst-Turnover Level by Fluorescence Microscopy.

Mechanistic studies have historically played a key role in the discovery and optimization of reactions in organic and organometallic chemistry. However, even apparently simple organic and organometallic transformations may have surprisingly complicated multistep mechanisms, increasing the difficulty of extracting this mechanistic information. The resulting reaction intermediates often constitute a small fraction of the total reaction mixture, for example, creating a long-term analytical challenge of detecti...

Pistachio and cashew nut allergy in childhood: Predictive factors towards development of a decision tree.

Pistachio and cashew nut, which belong to the same botanical family, are tree nuts that induce serious allergic reactions.

miR-4513 promotes gastric cancer cell proliferation and epithelial-mesenchymal transition through targeting KAT6B.

The purpose of this study was to investigate the expression level of microRNA-4513 (miR-4513) in gastric cancer, and the underlying mechanisms of miR-4513 in regulating gastric cancer (GC) progression. Quantitative real time-polymerase chain reaction (qRT-PCR) was performed to measure the expression level of miR-4513 in GC cells. Transfection efficacy of synthetic miRNAs was examined by qRT-PCR. After synthetic miRNAs transfection, cell counting kit-8 assay and transwell invasion assay was conducted to meas...

An Investigation Into the Factor Structure of the Attitudes to Suicide Prevention Scale.

The aim of this study was to investigate the factor structure of the Attitudes to Suicide Prevention Scale (ASPS). The ASPS was distributed to all staff in a UK National Health Service Trust ( = 957). We conducted an exploratory factor analysis followed by a confirmatory factor analysis by splitting the data 60/40 into training and testing subsets. A multiple regression analysis was carried out to investigate whether the overall scale score varied as a function of professional role, age, and gender and whe...

Preliminary Assessment of Visible, Near-Infrared, and Short-Wavelength-Infrared Spectroscopy with a Portable Instrument for the Detection of Biofilms on Surfaces.

Bacterial biofilms constitute a major source of sanitary problems and economic losses in the food industry. Indeed, biofilm removal may require intense mechanical cleaning procedures or very high concentrations of disinfectants or both, which can be damaging to the environment and human health. This study assessed the efficacy of a technique based on spectroscopy in the visible, near-infrared, and short-wavelength infrared range for the quick detection of biofilms formed on polystyrene by the pathogenic bac...

Efficiency of human olfactory ensheathing cell transplantation into spinal cysts to improve mobility of the hind limbs.

The pathological processes developing after spinal cord injuries often lead to the formation of cysts. Existing surgical and medical methods are insufficient for the treatment of posttraumatic spinal cord cysts. One of the emerging tools is cell therapy. The olfactory ensheathing cells are perspective cells for the cell therapy. Here, we demonstrated that the human olfactory ensheathing cell transplantation is effective in experimental spinal cysts. For our experiments, we selected animals only at the inter...

Rift Valley fever: biology and epidemiology.

Rift Valley fever (RVF) is a mosquito-borne viral zoonosis that was first discovered in Kenya in 1930 and is now endemic throughout multiple African countries and the Arabian Peninsula. RVF virus primarily infects domestic livestock (sheep, goats, cattle) causing high rates of neonatal mortality and abortion, with human infection resulting in a wide variety of clinical outcomes, ranging from self-limiting febrile illness to life-threatening haemorrhagic diatheses, and miscarriage in pregnant women. Since it...

Vocal and locomotor coordination develops in association with arousal state.

In adult animals, movement and vocalizations are coordinated, sometimes facilitating, and at other times inhibiting, each other. What is missing is how these different domains of motor control become coordinated over the course of development. We investigated how postural-locomotor behaviors may influence vocal development, and the role played by physiological arousal during their interactions. Using infant marmoset monkeys, we densely sampled vocal, postural and locomotor behaviors and estimated arousal fl...

CCAT1 promotes triple-negative breast cancer progression by suppressing miR-218/ZFX signaling.

Long non-coding RNAs (lncRNAs) regulate cancer development and progression. Here, we investigated the role of the lncRNA CCAT1 in triple-negative breast cancer (TNBC). CCAT1 expression was higher in TNBC cells than normal breast epithelial cells. Additionally, CCAT1 expression was higher in TNBC patient tumor tissue than adjacent normal breast tissue. Silencing CCAT1 inhibited TNBC cell proliferation, migration, and invasion , and tumor growth and progression . Bioinformatics analysis revealed that microRNA...

Distribution of Pheromone Biosynthesis-Activating Neuropeptide in the Central Nervous System of Plutella xylostella (Lepidoptera: Plutellidae).

Insect neuropeptides in the pyrokinin/pheromone biosynthesis-activating neuropeptide (PBAN) family are actively involved in many essential endocrinal functions and serve as potential targets in the search for novel insect control agents. Here, we dissect the nervous system of larval, pupal, and adult Plutella xylostella (L.) (Lepidoptera: Plutellidae) and describe the ganglion morphology and localization of PBAN during different insect developmental stages. Our results show that the central nervous system (...

A perspective on risk factors for esophageal adenocarcinoma: emphasis on Helicobacter pylori infection.

Gastroesophageal reflux disease (GERD) and the increasing rate of its associated complications, including esophageal adenocarcinoma (EAC), has stimulated a plethora of studies attempting to evaluate provocative and protective factors. Helicobacter pylori (Hp) infection (Hp-I) was initially considered as a beneficial condition in GERD management based on rather limited data. Large-scale regional studies revealed an alternative approach, by suggesting a positive relationship between Hp-I and EAC development. ...

Biological and clinical relevance of metastasis-associated long noncoding RNAs in esophageal squamous cell carcinoma: A systematic review.

Esophageal squamous cell carcinoma (ESCC) is a foremost cancer-related death worldwide owing to rapid metastasis and poor prognosis. Metastasis, as the most important reason for death, is biologically a multifaceted process involving a range of cell signaling pathways. Long noncoding RNAs (lncRNAs), as transcriptional regulators, can regulate numerous genomic processes and cellular processes such as cell proliferation, migration, and invasion. LncRNAs have also been shown to involve in/regulate the cancer m...

Application of multiple-population viability analysis to evaluate species recovery alternatives.

Population viability analysis (PVA) is a powerful conservation tool, but one that remains unapproachable for many species. This is particularly true for species with multiple, broadly-distributed populations for which collecting suitable data can be challenging. A recently-developed method of multiple population viability analysis (MPVA), however, addresses many limitations of traditional PVA. We build on previous development of MPVA for Lahontan cutthroat trout (LCT), a species listed under the US Endanger...

Pamidronate Administration during Pregnancy and Lactation Induces Temporal Preservation of Maternal Bone Mass in a Mouse Model of Osteogenesis Imperfecta.

During pregnancy and lactation, the maternal skeleton undergoes significant bone loss through increased resorption to provide the necessary calcium supply to the developing fetus and suckling neonate. This period of skeletal vulnerability has not been clearly associated with increased maternal fracture risk, but these physiological conditions can exacerbate an underlying metabolic bone condition like osteogenesis imperfecta. While bisphosphonates are commonly used in post-menopausal women, there are cases w...

Collaborative Network to Take Responsibility for oral AntiCancer Therapy (CONTACT): Study-protocol investigating the impact of a care pathway.

To evaluate the effectiveness, feasibility, meaningfulness and appropriateness of the development and implementation of a transmural care pathway in four hospitals in Flanders to improve self-management support in healthcare professionals and self-management in patients treated with oral anticancer drugs.

An evaluation of different Cripto-1 antibodies and their variable results.

Cripto-1 is a protein expressed during embryonal development and has been linked to several malignant processes in cancer. Since the discovery of cripto-1 in the late 1980s, it has become a subject of biomarker investigation in several types of cancer which in many cases relies on immunolocalization of cripto-1 using antibodies. Investigating cripto-1 expression and localization in primary glioblastoma cells, we discovered nonspecific binding of cripto-1 antibody to the extracellular matrix Geltrex. A panel...

A multistate model for early decision-making in oncology.

The development of oncology drugs progresses through multiple phases, where after each phase, a decision is made about whether to move a molecule forward. Early phase efficacy decisions are often made on the basis of single-arm studies based on a set of rules to define whether the tumor improves ("responds"), remains stable, or progresses (response evaluation criteria in solid tumors [RECIST]). These decision rules are implicitly assuming some form of surrogacy between tumor response and long-term endpoints...

Key modules and hub genes identified by coexpression network analysis for revealing novel biomarkers for larynx squamous cell carcinoma.

Larynx squamous cell carcinoma (LSCC) is the second most aggressive head and neck squamous cell carcinoma. Numerous genes have been identified to be aberrantly expressed during the development of LSCC. However, currently, researchers focus more on the individual molecule and downstream genes, leaving the coexpression among genes and key upstream disease driver genes unexploited. In this study, we applied weighted gene coexpression analysis (WGCNA) to decipher potential hub genes driving the development of L...

Integrated mRNA-Seq and miRNA-Seq analysis of PLCγ2-overexpressing hepatocarcinoma cells and identification of the associated miRNA-mRNA network.

Our previous study has discovered the positive effect of phospholipase Cγ 2 (PLCγ2) on the growth of hepatocarcinoma cells; however, the underlying mechanism is far from being understood. For this reason, this study attempts to identify the differently expressed microRNAs (miRNAs) and messenger RNAs (mRNAs) in PLCγ2-overexpressing hepatocarcinoma cells. The results showed that totally 596 differently-expressed genes (DEGs) were identified in PLCγ2-expressed cells, including 314 upregulated and 282 downr...

ZnO Quantum Dots Coupled with Graphene toward Electrocatalytic N2 Reduction: Experimental and DFT Investigations.

Electrochemical reduction of N2 to NH3 offers a promising way for artificial N2 production, but requires the efficient and robust electrocatalysts to boost the N2 reduction reaction (NRR). Herein, a combination of experimental measurements and theoretical calculations revealed that the ZnO quantum dots (QDs) supported on reduced graphene oxide (ZnO/RGO) hybrid could be a highly active and stable catalyst for NRR at ambient conditions. Experimentally, the ZnO/RGO was confirmed to favor the N2 adsorption due ...

A recurrent missense mutation in the EDAR gene causes severe autosomal recessive hypohidrotic ectodermal dysplasia in two consanguineous Kashmiri families.

Hypohidrotic ectodermal dysplasia (HED) is a rare congenital disorder arising from the abnormal development of ectoderm derived structures including skin, hair, nails, teeth and glands. These patients have sparse hair on the whole body including scalp and hypoplastic teeth. They have no resistance to heat due to abnormal sweat glands. A total number of four genes namely ectodysplasin A (EDA), ectodysplasin A receptor (EDAR), EDAR-associated death domain protein (EDARADD) and Wnt family member 10A (WNT10A) a...

Physiological polyspermy: Selection of a sperm nucleus for the development of diploid genomes in amphibians.

The union between a sperm and an egg nucleus in egg fertilization is necessary to mix genetic materials to create a new diploid genome for the next generation. In most animals, only one sperm is incorporated into the egg (monospermy), but several animals exhibit physiological polyspermy in which several sperms enter the egg during normal fertilization. However, only one sperm nucleus forms the zygote nucleus with the egg nucleus, even in a polyspermic egg. The cellular and molecular mechanisms involved in t...


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