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PubMed Journals Articles About "Effects Uterine Preservation Long Term Subjective Outcomes Sacrospinous" RSS

00:31 EDT 22nd August 2019 | BioPortfolio

Effects Uterine Preservation Long Term Subjective Outcomes Sacrospinous PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Effects Uterine Preservation Long Term Subjective Outcomes Sacrospinous articles that have been published worldwide.

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Showing "Effects uterine preservation long term subjective outcomes sacrospinous" PubMed Articles 1–25 of 37,000+

PROVISIONAL Genome-wide analysis of the transcriptional response to drought stress in root and leaf of common bean.

Genes related to the response to drought stress in leaf and root tissue of drought-susceptible (DS) and tolerant (DT) genotypes were characterized by RNA-Seq. In total, 54,750 transcripts, representative of 28,590 genes, were identified; of these, 1,648 were of high-fidelity (merge of 12 libraries) and described for the first time in the Andean germplasm. From the 1,239 differentially expressed genes (DEGs), 458 were identified in DT, with a predominance of genes in categories of oxidative stress, response ...


Augmenting Renal Lymphatic Density Prevents Angiotensin II-Induced Hypertension in Male and Female Mice.

Renal inflammation and immune cell infiltration are characteristic of several forms of hypertension. Our lab has previously demonstrated that renal inflammation-associated lymphangiogenesis occurs in salt-sensitive and nitric oxide inhibition-induced hypertension. Moreover, enhancing renal lymphatic density prevented the development of these two forms of hypertension. Here, we investigated the effects of angiotensin II-induced hypertension on renal lymphatic vessel density in male and female mice.

Case-Only Analysis of Gene-Environment Interactions Using Polygenic Risk Scores.

Investigations of gene (G)-environment (E) interactions have led to limited findings to date, possibly due to weak effects of individual genetic variants. Polygenic risk scores (PRS), which capture the genetic susceptibility associated with a set of variants, can be a powerful tool for detecting global patterns of interaction. Motivated by the case-only method for evaluating interactions with a single variant, we propose a case-only method for the analysis of interactions with a PRS in case-control studies....


Targeted DNA transposition in vitro using a dCas9-transposase fusion protein.

Homology-directed genome engineering is limited by transgene size. Although DNA transposons are more efficient with large transgenes, random integrations are potentially mutagenic. Here we present an in vitro mechanistic study that demonstrates efficient Cas9 targeting of the mariner transposon Hsmar1. Integrations were unidirectional and tightly constrained to one side of the sgRNA binding site. Further analysis of the nucleoprotein intermediates demonstrated that the transposase and Cas9 moieties can bind...

Insights to Nitric oxide-Melatonin Crosstalk and N-nitrosomelatonin Functioning in Plants: Where do We Stand?

The present review summarizes the current understanding of Nitric oxide-melatonin crosstalk in plants manifested by redox homoeostasis, regulation of gene expression and developmental changes. It further addresses the question of the possible role of NO-melatonin crosstalk to be operative through N-nitrosomelatonin formation (NOmela) in plants. Although NOmela appears to be a nascent molecule in plant systems, investigations on nitric oxide-melatonin cross talk in relation to abiotic stress tolerance, fruit...

Diagnostic challenge in a man with intractable hiccups and vomiting: a case of neuromyelitis optica spectrum disorder (NMOSD).

Neuromyelitis optica is an inflammatory CNS syndrome that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). According to the new diagnostic criteria the term NMO is replaced by the term NMOSD and for the first time criteria allow diagnosis in patients who have not experienced clinical involvement of either optic nerves or spinal cord. Area postrema, the emetic reflex center, may be a selective target of the disease. We report a case of a 74-year-old man who presented with intracta...

Zero-Balance Ultrafiltration of the Priming Blood Modifies the Priming Components and Improves the Clinical Outcome in Infants Undergoing Cardiopulmonary Bypass: A Randomized Controlled Trial.

Cardiopulmonary bypass (CPB) requirement in infants presents a unique challenge because of the large prime volume-to-blood volume ratio. Packed red blood cells (PRBCs) tend to deteriorate with long-term storage owing to their unphysiological composition and osmolality. Given that blood priming is inevitable in neonates, it is suggested that the metabolic load and osmolality be diminished before CPB initiation. We conducted the present study to test the hypothesis that the zero-balance ultrafiltration (Z-BUF...

The Tyranny of Hope.

Biomedical science is usually framed for the public in terms of its "promise." When a breakthrough results from scientific inquiry, that promise is translated into a hope for a cure. The "promise" of such advances in biomedical research can have a paradoxical effect. In the case of pediatric neuromuscular disease, rather than reducing suffering, the expectation of cure can be a burden-both physically and emotionally-for affected children and their families. If a family expects a cure, it is likely to do eve...

Efficacy and safety of 3-year denosumab therapy for osteoporosis in patients with autoimmune liver diseases.

Osteoporosis is a major complication in patients with primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH). Denosumab, a fully human monoclonal antibody against the receptor activator of nuclear factor-κB ligand (RANKL), increases bone mineral density (BMD) by inhibiting development and activity of osteoclasts and decreasing bone resorption. We have already reported the efficacy and safety of short-term (1-year) denosumab therapy for osteoporosis in patients with PBC or AIH (1), but the effect ...

Propofol inhibits biological functions of leukemia stem and differentiated cells through suppressing Wnt/β-catenin and Akt/mTOR.

The biological roles of intravenous anesthetic propofol in cancer have been shown by various studies using cancer cell lines that represent differentiated cancer cells. However, the activities of propofol in cancer stem cells have not been elucidated. In this work, we examined the effects and mechanisms of propofol on acute myeloid leukemia (AML) differentiated and CD34 CD38 stem cells. We found that propofol inhibited growth, differentiation and self-renewal capabilities of AML stem cells regardless of cel...

Liver kinase B1 fine-tunes lineage commitment of human fetal synovium-derived stem cells.

Liver kinase B1 (LKB1), a serine/threonine protein, is a key regulator in stem cell function and energy metabolism. Herein, we describe the role of LKB1 in modulating the differentiation of synovium-derived stem cells (SDSCs) toward chondrogenic, adipogenic, and osteogenic lineages. Human fetal SDSCs were transduced with CRISPR associated protein 9 (Cas9)-single guide RNA (sgRNA) vectors to knock out or lentiviral vectors to overexpress the LKB1 gene. Analyses including ICE (Inference of CRISPR Edits) data ...

Chondroblastomas presenting in adulthood: a study of 39 patients with emphasis on histologic features and skeletal distribution.

Chondroblastomas (CB) are rare bone tumors that typically arise in the epiphysis/apophysis of long bones in skeletally immature patients. We explore the clinicopathologic features of CB presenting in adults.

The effect of volunteers' care and support on the health outcomes of older adults in acute care: A systematic scoping review.

To examine the available evidence on the effects of care and support provided by volunteers on the health outcomes of older adults in acute care services.

From one species to another: A review on the interaction of chemistry and microbiology in relation to cleaning in the built environment.

Since the advent of soap, personal hygiene practices have revolved around removal, sterilization, and disinfection - both of visible soil and microscopic organisms - for a myriad of cultural, aesthetic, or health-related reasons. Cleaning methods and products vary widely in their recommended use, effectiveness, risk to users or building occupants, environmental sustainability, and ecological impact. Advancements in science and technology have facilitated in-depth analyses of the indoor microbiome and studie...

Curcuminoid-Based Difluoroboron Dyes as High-Performance Photosensitizers in Long-Wavelength (Yellow and Red) Cationic Photopolymerization.

Difluoroboron β-diketonate dyes are reported to exhibit excellent photophysical properties (e.g., broad absorption and large extinction coefficients) and have the potential to act as high-performance photosensitizers in cationic photopolymerization (CP). In this study, four curcuminoid-based difluoroboron dyes (BF Curs) are prepared. Their ability to initiate the CP of epoxides or vinyl ethers in combination with an iodonium salt under yellow and red LEDs is investigated. Some of the BF Curs-based photoini...

Incentivizing organ donation through a nonmonetary posthumous award.

Since 2013, The Order of St John Award for Organ Donation has been offered to the families of deceased solid organ donors in the United Kingdom to honor the donors and inspire others to donate. We evaluate the effects of this award using a difference-in-differences approach that builds on the fact that solid organ donors are eligible for the award, whereas cornea-only donors are not. We find that the introduction of the award led to an increase in the number of deceased solid organ donors.

Diagnostic performance of multiparametric MRI in the evaluation of treatment response in glioma patients at 3T.

MRI is one of the most important techniques to assess the treatment response of gliomas. However, differentiating tumor recurrence (TuR) from treatment effects (TrE) remains challenging.

"Combined Pulsed Dye Laser and QS Nd:YAG laser in traumatic facial tattoo removal: a case series".

Traumatic tattoos can be treated with several methods, including mechanical and chemical devices. However, they are rarely used due to the high risk of permanent side effects such as scarring and depigmentation. Recently, laser devices, especially the Q-Switched (QS) laser and the Pulsed Dye Laser (PDL), applied in combination, have achieved complete clearance of the lesions without any risk of side effects. Herein, we reported three cases of traumatic facial tattoos successfully treated with combined PDL a...

Technical success and long-term outcomes after anomalous right coronary artery stenting with cardiac computed tomography angiography correlation.

Anomalous origin of coronary arteries has been observed in about 0.35-2.10% of the population. Patients with anomalous right coronary artery (ARCA) may present with significant symptoms, arrhythmias or ACS, and at times sudden death. Traditionally, surgical correction has been the recommended treatment. However, these may be technically challenging, and bypass grafting for such anomalies has the potential for graft failure because of competitive flow. We sought to determine the intermediate and long-term ou...

Posttraumatic Growth during Cognitive Behavioral Therapy for Posttraumatic Stress Disorder: Relationship to Symptom Change and Introduction of Significant Other Assessment.

Posttraumatic growth (PTG) may play a role in the treatment of posttraumatic stress disorder as it is supposed to have either beneficial or dysfunctional effects on treatment-related PTS symptom (PTSS) changes. This study examined whether cognitive behavioral therapy (CBT) for PTSD patients can foster PTG assessed by self-reports and reports from significant others. Forty-eight PTSD patients participating in trauma-focused CBT were assessed twice: at the beginning of therapy (T1) and after three months of t...

Reframing the Individual Stress Response: Balancing our Knowledge of Stress to Improve Responsivity to Stressors.

While responses to stressors have both adverse and positive consequences on health, many believe that stress is entirely negative. Research revealed that negative beliefs about stress can hinder well-being and result in the avoidance of stressors. Stress-optimizing interventions that target various stress appraisal processes may be a useful tool to reframe how individuals understand and respond to stressors. The current study extends previous findings on stress reframing, and sought to examine the extent to...

What if I had not fallen from grace? Psychological distress and the gap between factual and counterfactual subjective social status.

The aim of this work was to test the hypothesis that the discrepancy between factual and counterfactual subjective social status (DCS) relates to psychological distress beyond the effect of current (i.e., factual) subjective and objective social status. Participants were 124 single mothers (Study 1) and 310 persons who have become unemployed (Study 2). In both samples, higher DCS was related to more severe symptoms of stress and depression beyond the effect of current subjective and objective social status....

Short-term hypoxia promotes vascularization in co-culture system consisting of primary human osteoblasts and outgrowth endothelial cells.

Prevascularization of tissue constructs before implantation has been developed as a novel and promising concept for successful implantation. Since hypoxia might induce angiogenesis, we have investigated the effects of hypoxic treatment on vascularization by using co-cultures of primary human osteoblasts (POBs) and outgrowth endothelial cells (OECs). Our results show that: (a) repeated short-term hypoxia (2% O for 8 h), not long-term hypoxia (2% O for 24 h), over 1 or 2 weeks, significantly enhances microv...

Nitrous oxide emissions associated with ammonia-oxidizing bacteria abundance in fields of switchgrass with and without intercropped alfalfa.

The nitrogen (N) fertilizer required to supply a bioenergy industry with sufficient feedstocks is associated with adverse environmental impacts, including loss of oxidized reactive nitrogen through leaching and the production of the greenhouse gas nitrous oxide (N O). We examined effects on crop yield, N fate, and the response of ammonia-oxidizing bacteria (AOB) and ammonia-oxidizing archaea (AOA) to conventional fertilizer application or intercropping with N-fixing alfalfa, for N delivery to switchgrass (P...

Further characterization of a novel EP2 and EP3 receptor dual agonist, ONO-8055, on lower urinary tract function in normal and lumbar canal stenosis rats.

To further explore the effects of a novel EP2 and EP3 dual agonist, ONO-8055, on detrusor contractility, we investigated the responses of bladder strips from sham and lumbar canal stenosis (LCS) rats to this agonist, its effects on lower urinary tract function in normal rats, and mRNA expression of EP2 and EP3 receptors in the sham and LCS rats.


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