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PubMed Journals Articles About "Open Systems Technologies" RSS

12:27 EDT 22nd July 2019 | BioPortfolio

Open Systems Technologies PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Open Systems Technologies articles that have been published worldwide.

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We have published hundreds of Open Systems Technologies news stories on BioPortfolio along with dozens of Open Systems Technologies Clinical Trials and PubMed Articles about Open Systems Technologies for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Open Systems Technologies Companies in our database. You can also find out about relevant Open Systems Technologies Drugs and Medications on this site too.

Showing "Open Systems Technologies" PubMed Articles 1–25 of 14,000+

Anesthesiological management in endovascular stroke treatment.

Early recanalization of the closed cerebral arteries after acute ischemic stroke (AIS) is the only treatment to minimize long-term disability and to reduce the associated morbidity and mortality. For a long time the only proven causal treatment of AIS was intravenous thrombolysis; however, after the publication of a series of randomized prospective studies concerning endovascular mechanical thrombectomy using stent retriever systems after AIS, new guidelines were published. It was found that endovascular ...


Multiple administrations of fluconazole increase plasma exposure to ruxolitinib in healthy adult subjects.

Ruxolitinib is metabolized by cytochrome P450 (CYP)3A4 and CYP2C9. Dual inhibitors of these enzymes (like fluconazole) lead to increased ruxolitinib exposure relative to a single pathway inhibition of CYP3A4 or CYP2C9. The magnitude of this interaction, previously assessed via physiologically based pharmacokinetic (PBPK) models, was confirmed in an open-label, phase 1 study in healthy subjects.

Bone-Bound Bisphosphonates Inhibit Proliferation of Breast Cancer Cells.

Bisphosphonates are used in treating patients with breast cancer. In vitro studies have shown that bisphosphonates act directly on tumour cells, inhibiting cell proliferation and inducing apoptosis. In most such studies, drugs were added to culture media exposing cells to high bisphosphonate concentrations in solution. However, since bisphosphonates bind to bone hydroxyapatite with high affinity and remain bound for very long periods of time, these experimental systems are not an optimal model for the actio...


Can chemotaxis speed up or slow down the spatial spreading in parabolic-elliptic Keller-Segel systems with logistic source?

The current paper is concerned with the spatial spreading speed and minimal wave speed of the following Keller-Segel chemoattraction system, [Formula: see text]where [Formula: see text], a, b, [Formula: see text], and [Formula: see text] are positive constants. Assume [Formula: see text] . Then if in addition [Formula: see text] holds, it is proved that [Formula: see text] is the spreading speed of the solutions of (0.1) with nonnegative continuous initial function [Formula: see text] with nonempty compact ...

How Ponto-Caspian invaders affect local parasite communities of native fish.

Invasive species are a major threat to ecosystems worldwide. Their effects are versatile and mostly well studied. However, not much is known about the impact of invasion on native parasite communities, although parasites are usually important response variables for ecosystem health. To improve the knowledge on how native fish parasite communities and their dynamics are affected by invasive species and how these processes change local host-parasite interactions over time, we studied different host-parasite s...

A Second Course of Radiotherapy in Patients with Recurrent Malignant Gliomas: Clinical Data on Re-irradiation, Prognostic Factors, and Usefulness of Digital Biomarkers.

The treatment of malignant gliomas has undergone a significant intensification during the past decade, and the interdisciplinary treatment team has learned that all treatment opportunities, including surgery and radiotherapy (RT), also have a central role in recurrent gliomas. Throughout the decades, re-irradiation (re-RT) has achieved a prominent place in the treatment of recurrent gliomas. A solid body of evidence supports the safety and efficacy of re-RT, especially when modern techniques are used, and j...

NICE and Fair? Health Technology Assessment Policy Under the UK's National Institute for Health and Care Excellence, 1999-2018.

The UK's National Institute for Health and Care Excellence (NICE) is responsible for conducting health technology assessment (HTA) on behalf of the National Health Service (NHS). In seeking to justify its recommendations to the NHS about which technologies to fund, NICE claims to adopt two complementary ethical frameworks, one procedural-accountability for reasonableness (AfR)-and one substantive-an 'ethics of opportunity costs' (EOC) that rests primarily on the notion of allocative efficiency. This study i...

Distribution of contaminants in the environment and wildlife habitat use: a case study with lead and waterfowl on the Upper Texas Coast.

The magnitude and distribution of lead contamination remain unknown in wetland systems. Anthropogenic deposition of lead may be contributing to negative population-level effects in waterfowl and other organisms that depend on dynamic wetland habitats, particularly if they are unable to detect and differentiate levels of environmental contamination by lead. Detection of lead and behavioral response to elevated lead levels by waterfowl is poorly understood, but necessary to characterize the risk of lead-conta...

Changes in cerebral and renal oxygenation during laparoscopic pyloromyotomy.

Although a laparoscopic approach may be preferred over open procedures for abdominal surgery, there are limited data on the effect of laparoscopic procedures on cerebral and renal oxygenation in neonates and young infants. Here, we evaluated the effect in neonates and infants. In this two-center prospective observational study, we evaluated changes in cerebral and renal regional oxygen saturation (rSO) in infants during laparoscopic pyloromyotomy. Intraoperative hemodynamic and respiratory parameters and rS...

Human immune globulin 10% with recombinant human hyaluronidase in multifocal motor neuropathy.

The primary aim was to determine the safety of treatment with human immune globulin 10% with recombinant human hyaluronidase (fSCIg) compared to intravenous immunoglobulin (IVIg) in a prospective open-label study in patients with multifocal motor neuropathy (MMN).

Herd management and welfare assessment of dairy goat farms in Northern Cyprus by using breeding, health, reproduction, and biosecurity indicators.

This study describes the results of a farm-based welfare assessment, herd management, and some yield indicators in Northern Cyprus dairy goat farms. Out of 324 intensive milk goat farms which produce goats, only the 42 goat farms which had 7950 heads were chosen by random sampling in Northern Cyprus (2016), and face-to-face questionnaires and observations were conducted to collect data. Regarding the breeding techniques in these farms, of all the goats in these farms, 45.2% were cross-breed, 38.1% were Dama...

Validation and educational impact study of the NANEP high-fidelity simulation model for open preperitoneal mesh repair of umbilical hernia.

The aim of the study was to develop, validate and analyze the educational impact of a high-fidelity simulation model for open preperitoneal mesh repair of an umbilical hernia. The number of surgical simulators available for training residents is limited. Primary for ethical reasons and secondary for the emerging pay-per-quality policies, practicing-on simulators rather than patients is considered gold standard. Validated full-procedural surgical models will become more and more important in training residen...

Predicting Outpatient Appointment Demand Using Machine Learning and Traditional Methods.

Traditional methods have long been used for clinical demand forecasting. Machine learning methods represent the next evolution in forecasting, but model choice and optimization remain challenging for achieving optimal results. To determine the best method to predict demand for outpatient appointments comparing machine learning and traditional methods, this retrospective study analyzed "appointment requests" at a major outpatient department in a destination medical center. Two separate locations (A and B) we...

Environmental impact and economic sustainability analysis of a novel anaerobic digestion waste-to-energy pilot plant in Pakistan.

A novel medium-large industrial-scale, anaerobic digestion (AD) waste-to-energy pilot plant has been investigated in terms of cost-benefit, environmental impact, and economic sustainability. This pilot plant exclusively features a multi-digester AD system induced by motorized stirring, methane purification, compression, storage and digestate-fertilizer processing systems, and subsequent electricity generation. The operational productivity and success of the pilot plant has been proven on a variety of waste ...

Impact of Surgeon Volume on Outcomes and Expenditure Among Medicare Beneficiaries Undergoing Liver Resection: the Effect of Minimally Invasive Surgery.

Although the role of annual surgeon volume on perioperative outcomes after liver resection (LR) has been investigated, there is a paucity of data regarding the impact of surgeon volume on outcomes of minimally invasive LR (MILR) versus open LR (OLR).

Phase II trial of an AKT inhibitor (perifosine) for recurrent glioblastoma.

Perifosine (PRF) is an oral alkylphospholipid with antineoplastic effects and reasonable tolerability. It inhibits signaling through the PI3/AKT axis and other cascades of biologic importance in glioblastoma, and has promising pre-clinical activity in vitro and in vivo. Therefore, we conducted a phase II open-label single-arm clinical trial of perifosine for patients with recurrent glioblastoma (GBM).

Out-of-Pocket Cancer Care Costs and Value Frameworks: A Case Study in a Community Oncology Practice with a Financial Navigator Program.

Medical Costs of Patients with Type 2 Diabetes in a Single Payer System: A Classification and Regression Tree Analysis.

Many studies and systematic reviews have estimated the healthcare costs of diabetes using a cost-of-illness approach. However, in the studies based on this approach patients' heterogeneity is rarely taken into account. The aim of this study was to stratify patients with type 2 diabetes into homogeneous cost groups based on demographic and clinical characteristics.

Pharmacokinetics and tissue residues of enrofloxacin in the largemouth bass (Micropterus salmoides) after oral administration.

The study was carried out to evaluate the pharmacokinetic disposition of enrofloxacin (ENF) with a single dose of 20 mg/kg after oral administration in largemouth bass (Micropterus salmoides) at 28°C. The concentrations of ENF and of its metabolite ciprofloxacin (CIP) in plasma, liver, and muscle plus skin in natural proportions were determined using HPLC. The concentration-time data for ENF in plasma were best described by a two-compartment open model. After oral administration, the maximum ENF concentra...

Exploring the use of mobile information and communication technologies by people with mood disorders.

Information and communication technologies (ICTs) have become increasingly integrated into how care is delivered and received. However, no research has yet explored how people with mood disorders use mobile information and communication technologies (mICTs) in their everyday lives and, more specifically, how they might use mICTs to look after themselves. An exploratory qualitative study, within secondary and specialist mental health Services, was undertaken. Data generation involved in-depth, semi-structure...

Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model.

Treatment modalities for kidney disease caused by long-term exposure to heavy metals, such as cadmium (Cd), are limited. Often, chronic, long-term environmental exposure to heavy metal is not recognized in the early stages; therefore, chelation therapy is not an effective option. Extracellular vesicles (EVs) derived from stem cells have been demonstrated to reduce disease pathology in both acute and chronic kidney disease models. To test the ability of EVs derived from human bone marrow mesenchymal stem cel...

Gender Inequity in Cardiovascular Care - Global Perspective.

In the last decades, promotion of women's health has become a growing field for health professionals. Although global society has recognized the importance of providing women with appropriate health services to maintain healthy families and communities, women are still underserved in every segment of health systems worldwide. The inequity in health services for women results from a lack of knowledge, stigma, and social norms for women. This gender inequity exists in every segment of the health system worldw...

A Smart and Multifaceted Mobile Health System for Delivering Evidence-Based Secondary Prevention of Stroke in Rural China: Design, Development, and Feasibility Study.

Mobile health (mHealth) technologies hold great promise in improving the delivery of high-quality health care services. Yet, there has been little research so far applying mHealth technologies in the context of delivering stroke care in resource-limited rural regions.

Imaging the kidney: from light to super-resolution microscopy.

The important achievements in kidney physiological and pathophysiological mechanisms can largely be ascribed to progress in the technology of microscopy. Much of what we know about the architecture of the kidney is based on the fundamental descriptions of anatomic microscopists using light microscopy and later by ultrastructural analysis provided by electron microscopy. These two techniques were used for the first classification systems of kidney diseases and for their constant updates. More recently, a ser...

An integrated approach to study the molecular aspects of regulatory peptides biological mechanism.

An integrated methodological approach to study the molecular aspects of short regulatory neuropeptides biological mechanism is proposed. The complex research is based on radioligand-receptor method of analysis and covers such points of peptides molecular activity as: specific binding of peptides to brain cells plasmatic membranes, formation of tissue specific synacton, influence of peptides (as allosteric modulators) on functionality of different neuroreceptors as well as delayed in time effects of peptides...


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