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PubMed Journals Articles About "Patch Based Adaptive Weighting With Segmentation Scale PAWSS" RSS

06:03 EDT 24th August 2019 | BioPortfolio

Patch Based Adaptive Weighting With Segmentation Scale PAWSS PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Patch Based Adaptive Weighting With Segmentation Scale PAWSS articles that have been published worldwide.

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Showing "Patch based adaptive weighting with segmentation scale PAWSS" PubMed Articles 1–25 of 38,000+

Role of dose dependent Lactobacillus farciminis exhibits ruminal micorflora biogases and fermentation activities of three silage-based rations.

The influence of Lactobacillus farciminis (LB) on ruminal fermentation characteristic was elucidated in this study.


A synthetic glycerol assimilation pathway demonstrates biochemical constraints of cellular metabolism.

The engineering of synthetic metabolic routes can provide valuable lessons on the roles of different biochemical constraints in shaping pathway activity. In this study, we designed and engineered a novel glycerol assimilation pathway in E. coli. While the synthetic pathway was based only on well-characterized endogenous reactions, we were not able to establish robust growth using standard concentrations of glycerol. Long-term evolution failed to improve growth via the pathway, indicating that this limitatio...

Phenomenology as a political position within maternity care.

In this article, the authors use the context of childbirth to consider the power that is endemic in certain forms of evidence within maternity care research. First, there is consideration of how the current evidence hierarchy and experimental-based studies are the gold standard to determine and direct women's maternity experiences, although this can be at the detriment of care and irrespective of women's needs. This is followed by a critique of how the predominant means to assess women's experiences via sat...


Pharmacists practising in family medicine groups: What are their activities and needs?

Pharmacists' responsibilities and practices have expanded over the years to be more clinical. Working in other settings and collaborating with other healthcare professionals can lead to new needs that are unmet by actual training. This study was performed to describe the characteristics and practices of pharmacists working in family medicine groups (FMGs) and to assess their needs to develop a practice-based network fostering best practices.

Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors.

Middle-East Respiratory Syndrome-Coronavirus (MERS-CoV) is a zoonotic virus transmitted between animals and human beings. It causes MERS with high mortality rate. However, no vaccine or specific treatment is currently available. Since antiviral activity of some flavonoids are known, we applied a flavonoid library to probe inhibitory compounds against MERS-CoV 3C-like protease (3CLpro). Herbacetin, isobavachalcone, quercetin 3-β-d-glucoside and helichrysetin were found to block the enzymatic activity of MER...

Tetrasubstituted cyclopentenone-based fluorescent chemosensors for the selective detection of Fe and Cu ions.

Fluorescent chemosensors based on 4-hydroxy cyclopentenones were synthesized by the base catalyzed reaction of 1,5-diphenyl-pentane-1,3,5-trione with benzil and thenil. The molecule obtained by the benzil reaction was found to be useful for the selective detection of Fe by fluorescence turn-off, while the molecule synthesized by the thenil reaction was useful for selective detection of Cu by fluorescent turn-on. Details of the synthesis, complexation mode, nature of binding, reversibility, and pH studies of...

Increased incidence of autoimmune hepatitis is associated with wider use of biological drugs.

Population based studies on the epidemiology of autoimmune hepatitis (AIH) are scarce. Drug-induced AIH (DIAIH) is increasingly recognized in association with immunomodulatory therapy. We aimed to determine the incidence, prevalence and natural history of AIH in a population-based setting.

Discovery of potential Toxoplasma gondii CDPK1 inhibitors with new scaffolds based on the combination of QSAR and scaffold-hopping method with in-vitro validation.

To discover drugs for toxoplasmosis with less side effects and less probability to get drug resistance is eagerly appealed for pregnant women, infant or immunocompromised patients. In this work, using TgCDPK1 as drug target, we design a method to discover new inhibitors for CDPK1 as potential drug lead for toxoplasmosis with novel scaffolds based on the combination of 2D/3D-QSAR and scaffold-hopping methods. All the binding sites of the potential inhibitors were checked by docking method and only the ones t...

Effect of thermal and acid challenges on the surface properties of pink restorative materials.

To compare the effect of thermal cycling and erosive challenge on color change, surface roughness, surface loss and biofilm deposition of three resin-based composites.

Potential-Driven Electron Transfer Lowers the Dissociation Energy of the C-F Bond and Facilitates Reductive Defluorination of Perfluorooctane Sulfonate (PFOS).

The wide-spread environmental occurrence of per- and polyfluoroalkyl substances (PFAS) has attracted significant regulatory, research, and media attention because of their toxicity, recalcitrance, and ability to bioaccumulate. Perfluorooctane sulfonate (PFOS) is a particularly troublesome member of the PFAS family due to its immunity to biological remediation and radical-based oxidation. In the present study, we present a heterogeneous reductive degradation process that couples direct electron transfer (ET)...

A d-band electron correlated thermoelectric thermistor established in meta-stable perovskite family of rare-earth nickelates.

The d-band electron correlations shed a light on bridging multiple functionalities within one material system, and this further extends the horizon in material designs and their emerging device applications. Herein, we demonstrate the combination of thermoelectric and thermistor functionalities within the perovskite family of correlated rare-earth nickelates (ReNiO3) having small rare-earth elements (i.e., YNiO3 and DyNiO3), in addition to their already known metal to insulator transitions. In contrast to c...

Solid and aqueous speciation of yttrium in passive remediation systems of acid mine drainage.

Yttrium belongs to the rare earth elements (REE) together with lanthanides and scandium. REE are commonly used in modern technologies, and their limited supply has made it necessary to look for new alternative resources. Acid mine drainage (AMD) is a potential resource since is moderately enriched in REE. In fact, in passive remediation systems, which are implemented to minimize the environmental impacts of AMD, REE are mainly retained in basaluminite, an aluminum hydroxysulfate precipitate. In this study, ...

Activating Graphyne Nanosheet via sp-Hybridized Boron Modulation for Electrochemical Nitrogen Fixation.

Exploring new metal-free catalysts with high activity for nitrogen reduction reaction (NRR) is highly desirable but remains a big challenge. Graphyne (GY) is a typical two-dimensional carbon material with many excellent properties. However, the NRR has rarely been envisaged on a GY-based metal-free catalyst up to now. Density functional theory calculations reveal that although pristine GY is inactive for N reduction, boron modulation can endow it with efficient activity toward NRR. Natural bond orbitals ana...

Reduced-Order Dispatch Model for Simulating Marginal Emissions Factors for the United States Power Sector.

This study develops a reduced-order power plant dispatch model and uses it to simulate marginal emissions factors (MEFs) for the 2014-2017 United States (U.S.) electric grid at the North American Electric Reliability Corporation (NERC) regional level. MEFs help quantify the health, environmental, and climate change impacts caused by changes in marginal net electricity consumption, which could result, for example, from new technologies or policies. This study develops the model, validates it against historic...

On the Calculation of IR Spectra with a Fully Polarizable QM/MM Approach Based on Fluctuating Charges and Fluctuating Dipoles.

The fully polarizable QM/MM approach based on Fluctuating charges and Fluctuating dipoles, named QM/FQFμ (J. Chem. Theory Comput. 2019, 15, 2233-2245), is extended to the evaluation of nuclear gradients and the calculation of IR spectra of molecular systems in condensed phase. To this end, analytical equations defining first and second energy derivatives with respect to nuclear coordinates are derived and discussed. The potentialities of the approach are shown by applying the model to the calculation of IR...

Chemical Synthesis of Atomically Tailored SUMO E2 Conjugating Enzymes for the Formation of Covalently Linked SUMO-E2-E3 Ligase Ternary Complexes.

E2 conjugating enzymes are the key catalytic actors in the transfer of ubiquitin, SUMO, and other ubiquitin-like modifiers to their substrate proteins. Their high rates of transfer and promiscuous binding complicate studies of their interactions and binding partners. In order to access specific, covalently-linked conjugates of the SUMO E2 conjugating enzyme Ubc9, we prepared synthetic variants bearing site-specific non-native modifications including: 1) replacement of Cys93 to 2,3-diaminopropionic acid to f...

Anti-prion Butenolides and Diphenylpropanones from the Australian Ascidian .

A library of 500 Australian marine invertebrate extracts was screened for anti-prion activity using a yeast-based assay, and this resulted in an extract from the ascidian showing potent activity. Purification of this extract led to the isolation of six new butenolide metabolites, the procerolides - and two related diphenylpropanones, the procerones and , as the bioactive components. The structures of - were elucidated from the analysis of 1D/2D NMR and MS data, and their absolute configurations determined...

Gum Arabic mediated synthesis of glyco-pea protein hydrolysate via Maillard reaction improves solubility, flavor profile, and functionality of plant protein.

Pea protein hydrolysate (PPH) is successfully conjugated with gum arabic (GA) through Maillard-driven chemistry. The effect of cross-linking conjugation on the structure, solubility, volatile substances, emulsification, and antioxidative activity of glyco-PPH is investigated, and found to improve all properties. The formation of glyco-PPH is confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), Fourier-transform infrared (FTIR), and scanning electron microscopy (SEM). Size exclu...

QresFEP: an automated protocol for the free energy calculation of protein mutations in Q.

Predicting the effect of single-point mutations on protein stability or protein-ligand binding is a major challenge in computational biology. Free energy calculations constitute the most rigorous approach to this problem, though the estimation of converged values for amino acid mutations is still challenging. To overcome this limitation, we developed tailored protocols to calculate free energy shifts associated to single point mutations. We herein describe QresFEP, which includes an extension of our early p...

Asymmetric Synthesis of Spirocyclic Oxindole δ-Lactams via NHC-Catalyzed Formal 2+4 Annulation of Aliphatic Aldehydes with Oxindole-derived α,β-Unsaturated Ketimines.

An N-heterocyclic carbene (NHC) catalyzed formal [2+4] annulation reaction of aliphatic aldehydes with oxindole-derived α,β-unsaturated ketimines under oxidative condition is reported, affording spirocyclic oxindole δ-lactams with good yields, moderate diastereoselectivies, and good to excellent enantioselectivies. This reaction can be readily carried out on gram scale, and the products could be further transformed to other synthetically useful compounds.

From Target to Drug: Generative Modeling for Multimodal Structure-Based Ligand Design.

Chemical space is impractically large and conventional structure-based virtual screening techniques cannot be used to simply search through the entire space to discover effective bioactive molecules. To address this shortcoming we propose a generative adversarial network to generate, rather than search, diverse three-dimensional ligand shapes complementary to the pocket. Furthermore, we show that the generated molecule shapes can be decoded using a shape-captioning network into a sequence of SMILES enabling...

The Emotional and Behavioral Impact of Delivering Bad News to Virtual versus Real Standardized Patients: A Pilot Study.

Virtual standardized patients (SPs) are becoming increasingly common in medical education, though one limitation of SPs is the artificiality of computer-based simulators. Past research on the use of SPs has not clearly established whether learners have different emotional responses to real SPs (SPs) compared with SPs; however, understanding learners' emotional responses to SPs is important in providing realistic learning experiences and establishing the validity of this teaching and assessment tool. This st...

Sleepiness, Exertion Fatigue, Arousal, and Vigilant Attention in Persons With Chronic Aphasia.

Purpose Individuals in the acute and chronic stages of stroke recovery often report more daytime sleepiness (Sterr, Herron, Dijk, & Ellis, 2008) and fatigue that qualitatively differs from "normal" feelings of fatigue they experienced prestroke (De Doncker, Dantzer, Ormstad, & Kuppuswamy, 2018). Speech-language pathologists frequently observe signs of fatigue in their clients with aphasia and perceive that client fatigue impedes therapeutic interventions (Riley, 2017). The current study aimed to quantify da...

Trends in Survival Based on Treatment Modality in Non-Small Cell Lung Cancer Patients: A Population-Based Study.

We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. We investigated the trends in survival based on treatment modality. Among 56,417 identified patients, the mean age at diagnosis was 70.1 years (SD = 10.7). Treatment modalities varied significantly over time (

Diagnosis of ulnar-sided wrist pain: a pragmatic approach for the non-specialist.

Ulnar-sided wrist pain is often unfairly labelled as the 'back pain' of the wrist. This reputation comes from the complexity of diagnosing problems related to this area of the wrist. This article summarizes the anatomy and biomechanics of the wrist and presents a logical approach to diagnosing the aetiology of the pain. The problems are categorised based on the anatomical structure from which the pain arises: either bony, soft tissue-related or arising from nerves or vascular structures. The article also ou...


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