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PubMed Journals Articles About "Phenotypic Genotypic Characterization ESBLs AmpC Carbapenemase Producing Klebsiella" RSS

18:19 EDT 20th July 2019 | BioPortfolio

Phenotypic Genotypic Characterization ESBLs AmpC Carbapenemase Producing Klebsiella PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Phenotypic Genotypic Characterization ESBLs AmpC Carbapenemase Producing Klebsiella articles that have been published worldwide.

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Showing "Phenotypic Genotypic characterization ESBLs AmpC Carbapenemase Producing Klebsiella" PubMed Articles 1–25 of 7,700+

Strategies to Counteract Botulinum Neurotoxin A: Nature's Deadliest Biomolecule.

Botulinum neurotoxin serotype A (BoNT/A), marketed commercially as Botox, is the most toxic substance known to man with an estimated intravenous lethal dose (LD) of 1-2 ng/kg in humans. Despite its widespread use in cosmetic and medicinal applications, no postexposure therapeutics are available for the reversal of intoxication in the event of medical malpractice or bioterrorism. Accordingly, the Centers for Disease Control and Prevention categorizes BoNT/A as a Category A pathogen, posing the highest risk t...


Differential Isotope Labeling by Permethylation and Reversed-Phase Liquid Chromatography-Mass Spectrometry for Relative Quantification of Intact Neutral Glycolipids in Mammalian Cells.

Probing the role of glycolipids in health and disease warrants development of practical strategies to determine these molecules at the intact structural level, namely to simultaneously characterize and quantify the glycan and lipid moieties without breaking the linkage between them. Herein we present such an approach utilizing differential isotope labeling and reversed phase liquid chromatography-tandem mass spectrometry (RPLC-MS/MS) for structural characterization and relative quantification of intact neut...

Gα and the Phospholipase Cβ3 X-Y Linker Regulate Adsorption and Activity on Compressed Lipid Monolayers.

Phospholipase Cβ (PLCβ) enzymes are peripheral membrane proteins required for normal cardiovascular function. PLCβ hydrolyzes phosphatidylinositiol-4,5-bisphosphate (PIP), producing second messengers that increase intracellular Ca and activate protein kinase C (PKC). Under basal conditions, PLCβ is autoinhibited by its C-terminal domains and by the X-Y linker, which contains a stretch of conserved acidic residues required for interfacial activation. Following stimulation of G protein coupled receptors, ...


Clustering of Giant Unilamellar Vesicles (GUVs) Promoted by Covalent and Non-Covalent Bonding of Functional Groups at Membrane-Embedded Peptides.

Access to clusters of cell-sized globular objects such as giant unilamellar vesicles (GUVs) is of increasing interest due to their potential applications in prototissue and cell-cell adhesion studies. Aggregations of GUVs by four different approaches were observed via covalent as well as non-covalent bond participa-tions of functional groups at membrane embedded cholesterylpeptides using optical microscopy. Passive air oxidation of GUV-surface thiols into trans-GUV disulfide bonds promoted multi-vesicle agg...

Structural and Functional Characterization of YdjI, an Aldolase of Unknown Specificity in Escherichia coli K12.

The ydj gene cluster is found in 80% of sequenced Escherichia coli genomes and other closely related species found in the human microbiome. Based on the annotations of the enzymes located in this cluster, it is expected that together they catalyze the catabolism of an unknown carbohydrate. The focus of this investigation is on YdjI, which is found in the ydj gene cluster of E. coli K-12. It is predicted to be a class II aldolase of unknown function. Here we describe a structural and functional characterizat...

Synthesis and structural characterization of a ubiquitous transformation product of fungicide prochloraz (BTS 40348).

Prochloraz is a widely used imidazole fungicide that has to be analyzed together with its metabolites or transformation products for food safety monitoring purposes in the European Union. Although the focus in food of plant origin has been set on metabolites BTS 44595 and BTS 44596, we consider relevant the study of BTS 40348 metabolite too, since it has been detected in both raw and processed foods based on citrus fruits in the EU. Metabolite BTS 40348 should be monitored in surface water due to its ecotox...

Photodissociation of S (XΣ, aΔ and bΣ) in the 320-205 nm Region.

Photodissociation of vibrationally and electronically excited sulfur dimer molecules (S2) has been studied in a combined experimental and computational quantum chemistry study in order to characterize bound-continuum transitions. Ab initio quantum chemistry calculations are carried out to predict the potential energy curves, spin-orbit coupling, transition moments, and bound-continuum spectra of S2 for comparison with the experimental data. The experiment uses velocity map imaging to measure S-atom producti...

In situ Electrochemical Mapping of Lithium-Sulfur Battery Interfaces using AFM-SECM.

While lithium-sulfur (Li-S) batteries are explored extensively, many aspects of the lithium polysulfide (LiPS) redox mechanism at the electrode/electrolyte interface still remains unclear. Though various in situ and ex situ characterization techniques have been deployed in recent years, many spatial aspects related to local electrochemical phenomena of the electrode are not elucidated. Herein, we introduce the atomic force microscopy-based scanning electrochemical microscopy (AFM-SECM) technique to study th...

Acetylcholine-producing T-cells augment innate immune driven colitis but are redundant in T-cell driven colitis.

Clinical trials suggest that vagus nerve stimulation presents an alternative approach to classical immune suppression in Crohn's disease. T-cells capable of producing acetylcholine (ChATT-cells) in the spleen are essential mediators of the anti-inflammatory effect of vagus nerve stimulation. Besides the spleen, ChATT-cells are found abundantly in Peyer's patches of the small intestine. However, the role of ChATT-cells in colitis pathogenesis is unknown. Here, we made use of CD4ChATmice (CD4ChATmice), lackin...

Cotton cellulose nanofiber/chitosan nanocomposite: characterization and evaluation of cytocompatibility.

Cellulose is a renewable polymer quite abundant on the Earth and very attractive for applications in the construction of eco-friendly biomedical products. The aim of this study was to investigate the chemical-physical characteristics of cotton cellulose nanofiber (CCN)/chitosan nanocomposite and its cytocompatibility with human embryonic kidney cells. First, the chemical composition, swelling ratio and surface topography of the nanocomposite were evaluated. Cytocompatibility was then assessed through spread...

Phenotypic factors associated with amisulpride-induced weight gain in first-episode psychosis patients (from the OPTIMISE cohort).

Antipsychotic-induced weight gain (AiWG) is a debilitating adverse effect of most antipsychotics. First-episode psychosis patients are particularly vulnerable to the detrimental consequences of AiWG. Amisulpride has good efficacy and tolerability. We here aimed to identify the phenotypic factors associated with amisulpride-induced weight gain in first-episode psychosis patients.

Molecular identification and diapause-related functional characterization of a novel dual-specificity kinase gene, MPKL, in Locusta migratoria.

Diapause is an important overwintering strategy of Locusta migratoria to survive under stressed conditions. We identified a novel dual-specificity kinase gene that is differentially expressed between long and short day-treated L. migratoria. To determine its function on photoperiodic diapause induction, we cloned the specific gene. Interestingly, phylogenetic analysis shows that this dual-specificity kinase is a Mycetozoa Protein Kinase-Like (MPKL) that may have been transferred horizontally from Mycetozoa ...

Predicting lncRNA-disease associations using network topological similarity based on deep mining heterogeneous networks.

A kind of noncoding RNA with length more than 200 nucleotides named long noncoding RNA (lncRNA) has gained considerable attention in recent decades. Many studies have confirmed that human genome contains many thousands of lncRNAs. LncRNAs play significant roles in many important biological processes, including complex disease diagnosis, prognosis, prevention and treatment. For some important diseases such as cancer, lncRNAs have been novel candidate biomarkers. However, the role of lncRNAs in human diseases...

Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans.

In order to develop a better understanding of the role environmental toxicants may play in the onset and progression of neurodegenerative diseases, it has become increasingly important to optimize sensitive methods for quickly screening toxicants to determine their ability to disrupt neuronal function. The nematode C. elegans can help with this effort. They have an integrated nervous system producing behavioral function, they provide easy access for molecular studies, they have rapid lifespans, and they are...

Noninvasive characterization of In Situ forming implant diffusivity using diffusion-weighted MRI.

In situ forming implants (ISFIs) form a solid drug-eluting depot, releasing drug for an extended period of time after a minimally-invasive injection. Clinical use of ISFIs has been limited because many factors affect drug release kinetics. The aim of this study was to use diffusion-weighted MRI (DWI) to noninvasively quantify spatial-temporal changes in implant diffusivity in situ. ISFIs were formed using poly(lactic-co-glycolic) acid, with a molecular weight of either 15 kDa or 52 kDa, and fluorescein ...

Artificial humification of lignin architecture: Top-down and bottom-up approaches.

Humic substances readily identifiable in the environment are involved in several biotic and abiotic reactions affecting carbon turnover, soil fertility, plant nutrition and stimulation, xenobiotic transformation and microbial respiration. Inspired by natural roles of humic substances, several applications of these substances, including organic fertilizers, redox mediators, anti-oxidants, human medicines, environmental remediation and fish feeding, have been developed. The annual market for humic substances ...

Heterologous expression and characterization of a novel subtilisin-like protease from a thermophilic Thermus thermophilus HB8.

Subtilisins are a family of serine proteases used widely throughout the detergent, leather and food industries, with the identification and development of new enzymes holding much potential value. Thermus thermophilus HB8 was examined for serine proteases and found TTHA0724 gene. Sequence analysis of this putative serine protease placed it within the subtilisin family. To obtain active T. thermophilus HB8 subtilisins, three genes encoding prepro-subtilisin, pro-subtilisin and mature-subtilisin were cloned a...

Expanding the repertoire of conservative site-specific recombination in Clostridioides difficile.

Recent genomic analysis of an epidemic ribotype 027 (RT027) Clostridioides difficile strain revealed the presence of several chromosomal site-specific invertible sites hypothesized to control the expression of adjacent genes in a bimodal on-off mode. This process, named phase variation, is thought to enhance phenotypic variability under homogeneous conditions ultimately increasing population fitness in unpredictable environmental fluctuations. The full extent of phase variation mediated by DNA-inversions in...

Mutations in the KEAP1-NFE2L2 pathway define a molecular subset of rapidly progressing lung adenocarcinoma.

Molecular characterization studies revealed recurrent KEAP1/NFE2L2 alterations in non-small cell lung cancer (NSCLC). These genes encode two interacting proteins (stress response pathway, SRP) that mediate a cytoprotective response to oxidative stress and xenobiotics. Nevertheless, whether KEAP1/NFE2L2 mutations impact on clinical outcomes is unclear.

The regulation properties of RNA secondary structure in alternative splicing.

The RNA secondary structure is important for many functional processes in the cell. The secondary and tertiary structures of cellular RNAs are essential for the activity of these molecules in processes such as transcription, splicing, translation, and localization. New high-throughput analytical methods, including next generation sequencing, have allowed for the in-depth characterization of the 'RNA structurome': a new term describing how the RNA structure controls the activity of RNA by itself and how it r...

Antimicrobial PHAs coatings for solid and porous tantalum implants.

Biomaterial-associated infections (BAI) are the major cause of failure of indwelling medical devices. The risk of BAI can end dramatically in the surgical removal of the affected device. Therefore, a major effort must be undertaken to guarantee the permanence of the implant. In this regard, we have developed antimicrobial coatings for tantalum (Ta) implants, using polyhydroxyalkanoates (PHAs) as matrices for carrying an active principle. The dip-coating technique was successfully used for covering solid Ta ...

Inactivation of Shiga toxin-producing Escherichia coli in fresh beef by electrolytically-generated hypochlorous acid, peroxyacetic acid, lactic acid and caprylic acid.

Several studies have been conducted to verify the decontamination potential of electrolytically-generated hypochlorous acid, peroxyacetic acid, lactic acid and caprylic acid against Shiga toxin-producing Escherichia coli (STEC) in beef products. However, there is no consensus regarding their effectiveness. The aim of this study was to compare these four treatments under the same conditions and establish a ranking according to their effectiveness to inactivate STEC in fresh beef. Samples were inoculated with...

Normal ultrasound anatomy and common anatomical variants of the thyroid gland plus adjacent structures - A pictorial review.

High-resolution ultrasound is considered the best imaging technique for evaluating the thyroid gland, as it is accessible, non-invasive, and highly sensitive concerning the detection and characterization of thyroid nodules. However, a background knowledge of the normal ultrasound anatomy of the thyroid gland, adjacent structures, and its anatomical variants is crucial to avoid misdiagnosis in daily practice. Through this pictorial review, we intend to.

Can contaminated waters or wastewater be alternative sources for technology-critical elements? The case of removal and recovery of lanthanides.

Technology critical elements (TCE) are considered the vitamins of nowadays technology. Factors such as high demand, limited sources and geopolitical pressures, mining exploitation and its negative impact, point these elements as new emerging contaminants and highlight the importance for removal and recycling TCE from contaminated waters. This paper reports the synthesis, characterization and application of hybrid nanostructures to remove and recover lanthanides from water, promoting the recycling of these h...

Synthesis, vibrational spectroscopy and X-ray structural characterization of novel NIR emitter squaramides.

Two new 2-naphthyl squaramides, 3-methoxy -4-(2-naphtalenylamino)-3-cyclobutene-1,2-dione (SQ-NPh1) and bis-3,4-(2-naphtalenylamino)-3-cyclobutene-1,2-dione (SQ-NPh2) were synthesized via condensation reaction between the dimethylsquarate and 2-naphthylamine. The spectrometric characterization by C NMR confirmed the obtaining of the squaramide derivative and nor the squaraine analog. This hypothesis was corroborated by Raman and Infrared spectroscopy since the characteristic vibrational bands related to the...


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