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PubMed Journals Articles About "Receptor Binding Affinities Bisphenol Next Generation Analogs Human" RSS

01:46 EDT 19th July 2019 | BioPortfolio

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Showing "Receptor binding affinities bisphenol next generation analogs human" PubMed Articles 1–25 of 31,000+

Shift in the paradigm towards next-generation microbiology.

In this work, the position of contemporary microbiology is considered from the perspective of scientific success, and a list of historical points and lessons learned from the fields of medical microbiology, microbial ecology and systems biology are presented. In addition, patterns in the development of top-down research topics that emerged over time as well as overlapping ideas and personnel, which are the first signs of trans-domain research activities in the fields of metagenomics, metaproteomics, metatra...


Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia associated hypertension.

Homocysteine [HSCH2CH2CH(NH2)COOH] (Hcy), is a sulfur-containing amino acid of 135.18 Da of molecular weight, generated during conversion of methionine to cysteine. If there is a higher accumulation of Hcy in the blood, i.e. usually above 15 µmol/L, it leads to a condition referred to as hyperhomocysteinemia. A meta-analysis of observational study suggested an elevated concentration of Hcy in blood, which is termed as the risk factors leading to ischemic heart disease (IHD) and stroke. Further experimenta...

PAR2 does not contribute to renal inflammation or fibrosis in the obstructed kidney.

Protease-activated receptor 2 (PAR2) has been implicated in the development of renal inflammation and fibrosis. In particular, activation of PAR2 in cultured tubular epithelial cells induces ERK signalling and secretion of fibronectin, CCL2 and TGF-β1, suggesting a role in tubulointerstitial inflammation and fibrosis. We tested this hypothesis in unilateral ureteric obstruction (UUO) in which ongoing tubular epithelial cell damage drives tubulointerstitial inflammation and fibrosis.


End-diastolic force pre-activates cardiomyocytes and determines contractile force; role of titin and calcium.

Titin functions as a molecular spring and cardiomyocytes are able, through splicing, to control the length of titin. We hypothesized that together with diastolic [Ca ] titin-based stretch pre-activates cardiomyocytes during diastole and is a major determinant of force production in the subsequent contraction. Through this mechanism titin would play an important role in active force development and length-dependent activation. Mutations in the splicing factor RNA binding motif protein 20 (RBM20) result in ex...

Antibodies against the DNABII protein integration host factor (IHF) inhibit sinus implant biofilms.

Chronic rhinosinusitis is a common, costly condition often treated with endoscopic sinus surgery and intraoperative placement of intranasal sinus implant materials. Whereas these materials aid in postoperative healing, they also support bacterial biofilm formation and thus contribute to negative outcomes. This study examined pretreatment of sinus implant materials with antibody against an essential bacterial biofilm structural component, the DNABII family of DNA-binding proteins, as a strategy to prevent bi...

Developmental horizons in the pre-natal development of the Greater cane rat (Thryonomys swinderianus).

The Greater cane rat (GCR, Thyronomys swinderianus) is a precocial rodent predominantly found within Africa. Economic and scientific interests have led to several research efforts towards the domestication and better understanding of the biology and development of this rodent. Despite these efforts, information on the pre-natal development of this rodent is currently lacking. This study characterises distinct developmental milestones including skin pigmentation, emergence and distributions of hairs, calvari...

C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly.

Ragulator is a pentamer composed of p18, MP1, p14, C7orf59 and HBXIP (LAMTOR 1 - 5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 signaling. Here we present the crystal structure of human HBXIP-C7orf59 dimer (LAMTOR 4/5) at 2.9Å and identify a phosphorylation site on C7orf59 which modulates its interaction with p18. Additionally, we demonstrate the requirement of HBXIP-C7orf59 to stabilize p18 and allow further binding of MP1-p14. The structure of the dim...

Direct visualization of single nuclear pore complex proteins using genetically-encoded probes for DNA-PAINT.

The Nuclear Pore Complex (NPC) is one of the largest and most complex protein assemblies in the cell and - among other functions - serves as the gatekeeper of nucleocytoplasmic transport. Unraveling its molecular architecture and functioning has been an active research topic for decades with recent cryogenic electron microscopy and super-resolution studies advancing our understanding of the NPC's complex architecture. However, the specific and direct visualization of single copies of NPC proteins is thus fa...

Characterization of epidermal growth factor receptor (EGFR) P848L, an unusual EGFR variant present in lung cancer patients, in a murine Ba/F3 model.

Lung cancer patients with mutations in epidermal growth factor receptor (EGFR) benefit from treatments targeting tyrosine kinase inhibitors (TKIs). However, both intrinsic and acquired resistance of tumors to TKIs are common, and EGFR variants have been identified that are resistant to multiple TKIs. In the present study, we characterized selected EGFR variants previously observed in lung cancer patients and expressed in a murine bone marrow pro-B Ba/F3 cell model. Among these EGFR variants, we report that ...

Powering the Hydrogen Economy from Waste Heat: A Review of Heat to Hydrogen Concepts.

Ever increasing energy demand and environmental concerns requires new and clean energy supplies, many of which are intermittent and non-correlating with demand. In order to balance supply with demand a universal energy vector can be employed such that intermittent renewable energy can be stored and transported and then used when needed. Hydrogen is the perfect universal energy vector and one of the possible solutions that ensures environmental cleanness and maximum utilisation of renewable energy sources an...

A Practical Management Approach to Gastroparesis.

Gastroparesis is a syndrome characterised by delayed gastric emptying in the absence of mechanical obstruction. Symptoms can include early satiety, abdominal pain, bloating, vomiting, and regurgitation which cause significant morbidity in addition to nutritional deficits. There is a higher prevalence in diabetics and females, but the incidence in the Australian population has not been well studied. Management of gastroparesis involves investigating and correcting nutritional deficits, optimising glycaemic c...

Why nurses should be Marxists.

The argument that nurses should be Marxists is made by looking at the primary areas of nursing activity in turn, giving an example of how capitalist economic relations negatively impact upon that activity, and providing a Marxist explanation of the reasons why it has that impact. In relation to the nursing activity of health promotion, it is argued that capitalism's generation of social inequality undermines the health of the population. In relation to curative activities, the focus is on how capitalism's r...

Research paradigms and the politics of nursing knowledge: A reflective discussion.

A standard view would suggest that research is a neutral apolitical activity. It neutralizes external pressures by its fidelity to robust scientific methods. However, politics is an inevitable part of human knowledge. Our knowledge of the world is always mediated by human priorities. What matters is therefore a contested and political debate rather a neutral accumulation of factual data. How researchers manage this varies. Research paradigms are one way in which research engages with knowledge. They frame k...

Relationship between nucleotide-binding oligomerization domain-containing protein 2 variants and severity of acute pancreatitis.

Intestinal barrier dysfunction has been implicated in the development of infectious complications of acute pancreatitis. Nucleotide-Binding Oligomerization DomainContaining Protein 2 (NOD2) plays an important role in the proper functioning of intestinal defense mechanisms. Here, we investigated the frequency of NOD2 variants in patients with mild and severe acute pancreatitis.

Olmesartan-induced enteropathy treated with budesonide.

Olmesartan, an angiotensin receptor blocker, is a widely spread antihypertensive drug. Seronegative villous atrophy of the small intestine due to olmesartan use was first described in 2012. We present a new case of olmesartan-induced enteropathy and compare it to recent literature. This case might suggest a use of budesonide for treatment.

Stabilizing Polyether Electrolyte with 4 V Metal Oxide Cathode by Nanoscale Interfacial Coating.

Safety is critical to developing next-generation batteries with high energy density. Polyether-based electrolytes, such as polyethylene oxide (PEO) and polyethylene glycol (PEG), are attractive alternatives to current flammable liquid organic electrolyte, since they are much more thermally stable, and compatible with high-capacity lithium anode. Unfortunately, they are not stable with 4 V Li(NixMnyCo1-x-y)O2 (NMC) cathodes, hindering them from application in batteries with high energy density. Here we repor...

Tumor suppressor p53-mediated structural reorganization of the transcriptional coactivator p300.

Transcriptional coactivator p300, a critical player in eukaryotic gene regulation, primarily functions as a histone acetyltransferase (HAT). It is also an important player in acetylation of a number of non-histone proteins, p53 being the most prominent one. Recruitment of p300 to p53 is pivotal in the regulation of p53-dependent genes. Emerging evidence suggest that p300 adopts an active conformation upon binding to the tetrameric p53, resulting in its enhanced acetylation activity. As a modular protein, p3...

Effect of Iodination on the Photophysics of the Laser Borane -BH: Generation of Efficient Photosensitizers of Oxygen.

Treatment of the laser borane -BH (compound ) with iodine in ethanol gives the monoiodinated derivative 7-I--BH (compound ) in 67% yield, or, by reaction with iodine or ICl in the presence of AlCl in dichloromethane, the diiodinated derivative 4,4'-I--BH (compound ) in 85% yield. On excitation with 360 nm light, both compounds and give strong green phosphorescent emissions (λ = 525 nm, Φ = 0.41 and λ = 545 nm, Φ = 0.71 respectively) that are quenched by dioxygen to produce O(Δ) singlet oxygen with qu...

Unraveling the rapid assembly process of stiff cellulosic fibers from mistletoe berries.

The mucilaginous viscin tissue within mistletoe berries possesses an extraordinary ability to be rapidly processed under ambient conditions into stiff cellulosic fibers (>14 GPa) through simple mechanical drawing. This rapid and extreme transformation process is hydration-dependent and involves an astonishing >200-fold increase in length, providing a relevant role model for efforts to produce advanced composites from cellulose-based structures such as cellulose nanocrystals (CNCs) or cellulose nanofibrils (...

Generation of Microsecond Charge-Separated Excited States in Rhenium(I) Diimine Complexes: Driving Force Is the Dominant Factor in Controlling Lifetime.

A transition-metal-based donor-(linker)-acceptor system can produce long-lived charge transfer excited states using visible excitation wavelengths. The ground- and excited-state photophysical properties of a series of [ReCl(CO)(dppz-(linker)-TPA)] complexes, with varying donor and acceptor energies, have been systematically studied using spectroscopic techniques (both vibrational and electronic) supported by computational chemistry. The long-lived excited state is ILCT in nature for all complexes studied, c...

Functional Characterization of YdjH, a Sugar Kinase of Unknown Specificity in K12.

The ydj gene cluster is annotated to catalyze the catabolism of an unknown carbohydrate. Previously, YdjI, a class II aldolase, was shown to catalyze the retro-aldol cleavage of L-glycero-L-galacto-octuluronate-1-phosphate into DHAP and L-arabinuronate. In this report, the functional characterization of YdjH is presented. YdjH catalyzes the phosphorylation of 2-keto-monosaccharides at the C1 hydroxyl group with a significantly more stringent substrate profile relative to YdjI. Similar to YdjI, YdjH shows a ...

Chemoselective Peptide Cyclization and Bicyclization Directly on Unprotected Peptides.

Cyclic peptides are drawing wide attentions as potential medium-sized modulators of biomolecular interactions with large binding surfaces. Simple but effective peptide cyclization methods are needed to construct cyclic peptide libraries by both peptide and non-peptide chemists. Herein, we report a highly chemoselective and operation-simple method directly cyclizing unprotected peptides, in which ortho-phthalaldehyde (OPA) is found to react with the lysine/N-terminus and cysteine within one unprotected pepti...

Dinitrogen Fixation and Reduction by Ta3N3H0,1- Cluster Anions at Room Temperature: Hydrogen-Assisted Enhancement of Reactivity.

Dinitrogen activation and reduction is one of the most challenging and important subjects in chemistry. Herein, we report the N2 binding and reduction at the well-defined Ta3N3H- and Ta3N3- gas-phase clusters by using mass spec-trometry (MS), anion photoelectron spectroscopy (PES), and quantum-chemical calculations. The PES and calculation results show clear evidence that N2 can be adsorbed and completely activated by Ta3N3H- and Ta3N3- clusters, yielding to the products Ta3N5H- and Ta3N5-, but the reactivi...

A Fast Implementation of the Nudged Elastic Band Method in AMBER.

We present a fast implementation of the nudged elastic band (NEB) method into the particle mesh Ewald molecular dynamics (pmemd) module of the Amber software package both for central processing units (CPU) and graphics processing units (GPU). The accuracy of the new implementation has been validated for three cases: a conformational change of alanine dipeptide, the -helix to sheet transition in polyalanine, and a large conformational transition in human 8-oxoguanine-DNA glycosylase with DNA complex (OGG1-DN...

Resonant Two-Photon Photoelectron Imaging and Intersystem Crossing from Excited Dipole-Bound States of Cold Anions.

We report the observation of a dipole-bound state (DBS) 659 cm-1 below the electron detachment threshold of cryogenically-cooled deprotonated 4,4'-biphenol anion (bPh-) and nineteen of its lowest vibrational levels. Resonant two-photon photoelectron imaging (R2P-PEI) via the vibrational levels of the DBS display a sharp peak with a constant binding energy. This observation indicates vertical detachment from the vibrational levels of the DBS to the corresponding neutral levels with the conservation of the vi...


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