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PubMed Journals Articles About "Redistribution Intracellular Extracellular Free Adsorbed Antibiotic Resistance Genes" RSS

02:42 EDT 24th August 2019 | BioPortfolio

Redistribution Intracellular Extracellular Free Adsorbed Antibiotic Resistance Genes PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Redistribution Intracellular Extracellular Free Adsorbed Antibiotic Resistance Genes articles that have been published worldwide.

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Showing "Redistribution intracellular extracellular free adsorbed antibiotic resistance genes" PubMed Articles 1–25 of 25,000+

The RING finger E3 ligases PIR1 and PIR2 mediate PP2CA degradation to enhance abscisic acid response in Arabidopsis.

Recent work has established a core ABA signaling pathway in which A-type PP2C protein phosphatases act as central negative modulators. Although ABA signaling inhibits PP2C activity through ABA-receptor complex, it remains unknown if other mechanisms exist to modulate the level of PP2Cs. Here, we identified a RING domain ubiquitin E3 ligase, PIR1 (PP2CA interacting RING finger protein 1), that interacted with PP2CA. Of the two splicing isoforms, PIR1.2 was isolated from leaf tissue. The PIR1.2 exhibited E3 l...


Cluster miRNAs and cancer: Diagnostic, prognostic and therapeutic opportunities.

MiRNAs are class of noncoding RNA important for gene expression regulation in many plants, animals and viruses. MiRNA clusters contain a set of two or more miRNA encoding genes, transcribed together as polycistronic miRNAs. Currently, there are approximately 159 miRNA clusters reported in the human genome consisting of miRNAs ranging from two or more miRNA genes. A large proportion of clustered miRNAs resides in and around the fragile sites or cancer associated genomic hotspots and plays an important role i...

Cannabinoid receptor modulation changes the accumbal neuronal responses to morphine in the reinstatement of morphine-induced conditioned place preference.

The nucleus accumbens (NAc) is a central component of the brain reward system. It has been known that most of the drugs of abuse such as opioids and cannabinoids affect the NAc. Although cannabinoids can modulate different stages of morphine encounter such as the reinstatement of morphine-induced conditioned place preference (CPP), there is no evidence for the NAc neurons' response to prove it. That is why the present study was designed. The procedure was as follows: The rats were entered to CPP by sc 5 mg/...


Identification and functional expression of two subtypes of glycerol-3-phosphate acyltransferase differently regulating triacylglyceride synthesis during ovary development in Chinese mitten crab, Eriocheir sinensis.

Triacylglycerides (TAG) are a pivotal nutrient for crustacean reproduction, rapidly accumulating in gonads and hepatopancreas during the ovary development. Glycerol-3-phosphate acyltransferase (GPAT) is the enzyme catalyzing the first step in TAG synthesis. In the present study, two EsGPATs subtypes (EsGPAT1 and EsGPAT2) were identified and characterized. The transcript of EsGPAT1 was highly expressed in thoracic ganglia, hepatopancreas and ovary, while EsGPAT2 was mainly detected in nervous tissues and int...

Discovery of potential Toxoplasma gondii CDPK1 inhibitors with new scaffolds based on the combination of QSAR and scaffold-hopping method with in-vitro validation.

To discover drugs for toxoplasmosis with less side effects and less probability to get drug resistance is eagerly appealed for pregnant women, infant or immunocompromised patients. In this work, using TgCDPK1 as drug target, we design a method to discover new inhibitors for CDPK1 as potential drug lead for toxoplasmosis with novel scaffolds based on the combination of 2D/3D-QSAR and scaffold-hopping methods. All the binding sites of the potential inhibitors were checked by docking method and only the ones t...

Identification and molecular characterization of the tubulin-podophyllotoxin-type lignans binding site on Giardia lamblia.

There are several drugs for the treatment of giardiasis; however, there is a tendency for patients to abandon treatment because of drug-related adverse effects, resulting in relapses, acquired resistance and higher rates of treatment failure. Recently, we reported some podophyllotoxin-type lignans from Bursera fagaroides var. fagaroides showing antigiardial activity. In the present work, we demonstrated that 5'-desmethoxy-peltatin-A-methylether (5-DES), acetylpodophyllotoxin (APOD) and podophyllotoxin (POD)...

Comparison of Physical Activity by Lifestyle Between Two Rural Pediatric Population Groups.

Obesity prevalence is higher among rural populations than urban, including youth. Reduced physical activity levels are associated with childhood obesity. It could be assumed that the obesity disparity between rural and urban children is attributable, in part, to differences in physical activity levels; however, previous research quantifying and comparing physical activity levels between rural and urban youth are mixed. Lifestyle may be more important than geographic location in determining physical activity...

Rapid On-Demand Extracellular Vesicle Augmentation with Versatile Oligonucleotide Tethers.

Exosomes show potential as ideal vehicles for drug delivery because of their natural role in transferring biological cargo between cells. However, current methods to engineer exosomes without negatively impacting their function remain challenging. Manipulating exosome-secreting cells is complex and time-consuming, while direct functionalization of exosome surface proteins suffers from low specificity and low efficiency. We demonstrate a rapid, versatile and scalable method with oligonucleotide tethers to en...

CDs@ZIF-8 modified thin film polyamide nanocomposite membrane for simultaneous enhancement of chlorine-resistance and disinfection byproducts removal in drinking water.

Reverse osmosis (RO) is an emerging membrane technology for disinfection byproducts (DBPs) removal. However, the chlorine-resistance and DBPs removal performance of thin film composite (TFC) polyamide membranes should be simultaneously improved when used in chlorinated drinking water. This study was dedicated to synthesize a novel nanoparticle of ZIF-8 with carbon dots (CDs@ZIF-8) and then modify thin film nanocomposite (TFN) membranes to enhance their performance in removing four trihalomethanes (THMs), fo...

Vapor-Phase Incommensurate Heteroepitaxy of Oriented Single-Crystal CsPbBr on GaN: Towards Integrated Optoelectronic Applications.

Integrating metallic halide perovskites with established modern semiconductor technology is significant for promoting the development of application-level optoelectronic devices. To realize such devices, exploring the growth dynamics and interfacial carrier dynamics of perovskites deposited on the core materials of semiconductor technology is essential. Herein, we report the incommensurate heteroepitaxy of highly oriented single-crystal cesium lead bromide (CsPbBr) on -wurtzite GaN/sapphire substrates with ...

A d-band electron correlated thermoelectric thermistor established in meta-stable perovskite family of rare-earth nickelates.

The d-band electron correlations shed a light on bridging multiple functionalities within one material system, and this further extends the horizon in material designs and their emerging device applications. Herein, we demonstrate the combination of thermoelectric and thermistor functionalities within the perovskite family of correlated rare-earth nickelates (ReNiO3) having small rare-earth elements (i.e., YNiO3 and DyNiO3), in addition to their already known metal to insulator transitions. In contrast to c...

Activating Graphyne Nanosheet via sp-Hybridized Boron Modulation for Electrochemical Nitrogen Fixation.

Exploring new metal-free catalysts with high activity for nitrogen reduction reaction (NRR) is highly desirable but remains a big challenge. Graphyne (GY) is a typical two-dimensional carbon material with many excellent properties. However, the NRR has rarely been envisaged on a GY-based metal-free catalyst up to now. Density functional theory calculations reveal that although pristine GY is inactive for N reduction, boron modulation can endow it with efficient activity toward NRR. Natural bond orbitals ana...

AIE-Active Functionalized Acrylonitriles: Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission and Two-Photon Bioimaging.

Acrylonitriles with aggregation-induced emission (AIE) characteristics have found to show promising applications in two-photon biomedical imaging. Generally, elaborate synthetic efforts are required to achieve different acrylonitriles with dis-tinct functionalities. In this work, we first reported the synthesis of two different group-functionalized AIE-active acrylo-nitriles (TPAT-AN-XF and 2TPAT-AN) obtained simply by mixing the same reactants at different temperature using a facile and transition metal-fr...

Ligand-Induced G-Quadruplex Polymorphism: A DNA Nanodevice for Label-Free Aptasensor Platforms.

G-Quadruplexes (GQs) serve as popular recognition elements for DNA aptasensors and are incorporated into a DNA nanodevice capable of controlled conformational changes to activate a sensing mechanism. Herein we highlight the utili-ty of a GQ-GQ nanodevice fueled by GQ-specific ligands as a label-free aptasensor detection strategy. The concept was first illustrated utilizing the prototypical polymorphic human telomeric repeat sequence (H-Telo22, d[AG3(T2AG3)3]) that can undergo ligand-induced topology changes...

Chemo-Selective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage Under Catalyst-free Condition.

Conversion of a wide range of N-Boc amides into aryl ketones was achieved with Grignard reagents via chemoselective C(O)-N bond cleavage. The reactions proceeded under catalyst-free condition with different aryl, alkyl and alkynyl Grignard reagents. α-Ketoamide was successfully converted into aryl diketones while α,β-unsaturated amide undergoes 1,4-addition followed by C(O)-N bond cleavage to provide diaryl propiophenones. N-Boc amides displayed higher reactivity than Weinreb amides with Grignard reagent...

An Integrated Markov State Model and Path Metadynamics Approach to Characterize Drug Binding Processes.

Unveiling the mechanistic features of drug-target binding is of central interest in biophysics and drug discovery. Herein, we address this challenge by combining two major computational approaches, namely Molecular Dynamics (MD) simulations and Markov State Models (MSM), with a Path Collective Variables (PCVs) description coupled with metadynamics. We apply our methodology to reconstruct the binding process of the antagonist alprenolol to the β2-adrenergic receptor, a well-established pharmaceutical target...

Comparative Transcriptomic Analysis Reveals Regulatory Mechanisms of Theanine Synthesis in Tea (Camellia sinensis) and Oil Tea (Camellia. oleifera) Plants.

Tea provides a rich taste and has healthy properties due to its variety of bioactive compounds, such as theanine, catechins and caffeine. Theanine is the most abundant free amino acid (40%70%) in tea leaves. Key genes related to theanine biosynthesis have been studied, but relatively little is known about the regulatory mechanisms of theanine accumulation in tea leaves. Herein, we analyzed theanine content in tea (Camellia sinensis) and oil tea (C. oleifera), and found it to be higher in roots than other...

QresFEP: an automated protocol for the free energy calculation of protein mutations in Q.

Predicting the effect of single-point mutations on protein stability or protein-ligand binding is a major challenge in computational biology. Free energy calculations constitute the most rigorous approach to this problem, though the estimation of converged values for amino acid mutations is still challenging. To overcome this limitation, we developed tailored protocols to calculate free energy shifts associated to single point mutations. We herein describe QresFEP, which includes an extension of our early p...

From a Liquid to a Crystal without Going through a First Order Phase Transition: Determining the Free Energy of Melting with Glassy Intermediates.

The excess free energy of a liquid relative to an Einstein crystal reference state is calculated without going through a first-order phase transition. This is accomplished by going through an arrested glassy state to avoid a direct liquid to gas or liquid to crystal transition. The method is demonstrated by calculating the free energy difference between liquid water and ice Ih using the TIP4P and WAIL water models. TIP4P ice Ih melts at 232±1 K in close agreement with other estimates in the literature. WAI...

Antimicrobial and anti-inflammatory activities of three halophyte plants from Algeria and detection of some biomolecules by HPLC-DAD.

Antimicrobial activity of hydroalcoholic extracts (30/70) from leaves and stems of three halophytes ( and ) was investigated. toxicological study and anti-inflammatory activity of leaf extract of were tested on carrageenan-induced inflammatory paw edema. possessed significant anti-inflammatory activity at 150 and 300 mg/kg confirmed by histological study of inflamed tissues. Six phenolic acids and 10 flavonoids where identified by HPLC-DAD. Gallic acid, Rutin and Kaempferol-3--glucoside were the major ...

"We know this will be hard at the beginning, but better in the long term": understanding PrEP uptake in the general population in Eswatini.

Information regarding HIV pre-exposure prophylaxis (PrEP) for the general population is largely lacking, because the majority of PrEP demonstration projects have focused on key populations. This qualitative study examines barriers and facilitators to PrEP uptake and adherence among the general population in Eswatini, where PrEP is offered through public-sector primary-care clinics. We analysed 106 semi-structured in-depth interviews with healthcare workers ( = 26), stakeholders ( = 30), and clients ...

Obesity and cardio-metabolic health.

Obesity is a major and growing global health problem. It is associated with increased mortality as a result of an increasing number of complications, including type 2 diabetes, dyslipidaemia, hypertension, non-alcoholic hepatic steatosis, cardiovascular disease, sleep apnoea, gallbladder disease, obesity-related renal disease, increased risk of falls and injuries, and mental health problems as well as increased risk of certain malignancies. This article discusses the metabolic derangements associated with o...

Association of Promoter Region Polymorphisms of IL-6 and IL-18 Genes with Risk of Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis.

The present meta-analysis was performed to investigate the association of promoter region polymorphisms at IL-6 and IL-18 genes with recurrent pregnancy loss (RPL) risk. An electronic search of the PubMed, Embase, ISI Web of Knowledge and CNKI databases was performed to identify eligible studies up to May 30, 2019. A total of 31 case-control studies were finally selected. Significant associations with the risk of RPL were detected for the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C ...

Recombinant protein CCN5/WISP2 promotes islet cell proliferation and survival .

Pancreatic ß cell proliferation, survival and function are key elements that need to be considered in developing novel antidiabetic therapies. We recently identified CCN5/WISP2 to have potential growth promoting properties when overexpressed in ß cells; however, further investigations are needed to validate those properties. In this study, we demonstrated that exogenous treatment of insulinoma cells and primary islets with recombinant CCN5 (rh-CCN5) protein enhanced the proliferative capacity which was co...

Incorporating molecular biomarkers into clinical practice for gastric cancer.

: Gastric cancer is one of the most common causes of cancer-related mortality worldwide. To improve clinical outcomes, it is critical to develop appropriate approaches to diagnosis and treatment. Biomarkers have numerous potential clinical applications, including screening, assessing risk, determining prognosis, monitoring recurrence, and predicting response to treatment. Furthermore, biomarkers may contribute to the development of effective therapies. : Here we review recent progress in exploiting GC-speci...


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