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PubMed Journals Articles About "Terminal Aquaporin Regulates Lens Junction Channel Function" RSS

01:45 EDT 19th July 2019 | BioPortfolio

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Showing "Terminal Aquaporin Regulates Lens Junction Channel Function" PubMed Articles 1–25 of 19,000+

Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice.

Autophagy is a catabolic process that involves the degradation of cellular components through the lysosomal machinery, re-locating nutrients from unnecessary processes to more pivotal processes required for survival. It has been reported that systemic disruption of Atg5 or 7 gene, a component of autophagy, is lethal, and that its tissue-specific disruption causes tissue degeneration in several organs. However, the functional significance of autophagy in the thyroid glands remained unknown. Our preliminary d...


End-diastolic force pre-activates cardiomyocytes and determines contractile force; role of titin and calcium.

Titin functions as a molecular spring and cardiomyocytes are able, through splicing, to control the length of titin. We hypothesized that together with diastolic [Ca ] titin-based stretch pre-activates cardiomyocytes during diastole and is a major determinant of force production in the subsequent contraction. Through this mechanism titin would play an important role in active force development and length-dependent activation. Mutations in the splicing factor RNA binding motif protein 20 (RBM20) result in ex...

Motor function and the probability of prodromal Parkinson's disease in older adults.

Identification and characterization of Parkinson's disease (PD) in its prodromal stage is crucial.


Biological and evolutionary concepts for nanoscale engineering: Viruses as natural nanoparticles have great potential for a wide range of nanoscale products.

Biological materials are a rich resource for nanoscale engineering. Their structure is easily accessible via their DNA and they were optimised through evolution to fulfill their function.

The peu-miR160a-PeARF17.1/PeARF17.2 module participates in the adventitious root development of poplar.

Deep roots give rise to flourishing leaves, and the two complement each other. However, the genetic mechanisms underlying adventitious rooting for forest trees have remained elusive. In this study, we verified that peu-miR160a targets six poplar genes AUXIN RESPONSE FACTORS (ARFs), PeARF10.1, PeARF16.1, PeARF16.2, PeARF16.3, PeARF17.1 and PeARF17.2, using 5'RLM-RACE. Interaction experiments with peu-miR160a and PeARFs in poplar protoplasts further confirmed that peu-miR160a targets and negatively regulates ...

Elevated Insulin and Insulin Resistance are Associated with Altered Myelin in Cognitively Unimpaired Middle-Aged Adults.

Insulin regulates metabolism and influences neural health. Insulin resistance (IR) and type II diabetes have been identified as risk factors for Alzheimer disease (AD). Evidence has also suggested that myelinated white matter alterations may be involved in the pathophysiology of AD; however, it is unknown whether insulin or IR affect the underlying myelin microstructure. The relationships between insulin, IR, and myelin were examined, with the hypothesis that IR would be associated with reduced myelin.

BORC regulates late endosomal/lysosomal size through PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate.

Mechanisms that control lysosomal function are essential for cellular homeostasis. Lysosomes adapt in size and number to cellular needs but little is known about the underlying molecular mechanism. We demonstrate that the late endosomal/lysosomal multimeric BLOC-1 related complex (BORC) regulates size of these organelles via PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate [PI(3,5)P ] production. Deletion of the core BORC component Diaskedin led to increased levels of PI(3,5)P , suggesting activation...

The potential of glycomics as prognostic biomarkers in liver disease and liver transplantation.

The study of glycomics is a novel and fascinating approach for the development of biomarkers. It has become clear that in the field of liver disease specific glycomic patters are present in specific disease states, which has led to the development of diagnostic biomarkers. In this manuscript, we will describe two new applications of this technology for the development of prognostic biomarkers. The first biomarker is associated with the risk of hepatocellular carcinoma development in patients with compensate...

Synergetic effect of facet junction and specific facet activation of ZnFe2O4 nanoparticles on photocatalytic activity improvement.

Crystal facet engineering has been proved as a versatile approach in modulating the photocatalytic activity of semiconductors. However, the facet-dependent properties and underlying mechanisms of spinel ZnFe2O4 in photocatalysis still have rarely been explored. Herein, ZnFe2O4 nanoparticles with different {001} and {111} facets exposed were successfully synthesized via a facile hydrothermal method. Facet-dependent photocatalytic degradation performance towards gaseous toluene under visible light irradiation...

Copper-Hydride-Catalyzed Enantioselective Processes with Allenyl Boronates. Mechanistic Nuances, Scope, and Utility in Target-Oriented Synthesis.

Synthesis of complex bioactive molecules is substantially facilitated by transformations that efficiently and stereoselectively generate polyfunctional compounds. Designing such processes is hardly straightforward, however, especially when the desired route runs counter to the inherently favored reactivity profiles. Furthermore, in addition to being efficient and stereoselective, it is crucial that the products generated can be easily and stereodivergently modified. Here, we introduce a catalytic process th...

First-principles nonequilibrium Green's function approach to ultrafast charge migration in glycine.

We investigate the photo-induced ultrafast charge migration phenomenon in the glycine molecule using a recently proposed nonequilibrium Green's functions (NEGF) approach. We first consider the dynamics resulting from the sudden removal of an electron in the valence shells, finding a satisfactory agreement with available data. Then we explicitly simulate the laser-induced photo-ionization process and study the evolution of the system after the pulse. We disentangle polarization and correlation effects in the...

Contact Engineering High Performance -Type MoTe Transistors.

Semiconducting MoTe is one of the few two-dimensional (2D) materials with a moderate band gap, similar to silicon. However, this material remains underexplored for 2D electronics due to ambient instability and predominantly -type Fermi level pinning at contacts. Here, we demonstrate unipolar -type MoTe transistors with the highest performance to date, including high saturation current (>400 µA/µm at 80 K and >200 µA/µm at 300 K) and relatively low contact resistance (1.2 to 2 kΩ∙µm from 80 to 300 K)...

Inter-individual differences in the ischemic stimulus and other technical considerations when assessing reactive hyperemia.

Reactive hyperemia is an established, non-invasive technique to assess microvascular function, and is a powerful predictor of all-cause and cardiovascular morbidity and mortality. Emerging evidence from our lab suggests that reactive hyperemia is closely linked to the metabolic rate of the ischemic limb, and that large inter-individual differences exist, contributing to markedly different stimuli to vasodilate. Here we relate forearm tissue desaturation (i.e. the ischemic stimulus to vasodilate, measured by...

Heart failure developed after myocardial infarction does not affect gut microbiota composition in the rat.

There is a body of evidence that supports that gut dysbiosis plays a role in the pathogenesis of cardiovascular diseases. Decreased cardiac function can reduce intestinal perfusion, resulting in morphological alterations witch may contribute to changes in the gut microbiota composition in heart failure (HF) patients. In this regard, a germane question is whether changes in gut microbiota composition are a cause or consequence of the cardiovascular disturbance. We tested the hypothesis that the development o...

High-Content Screening Identifies New Inhibitors of Connexin 43 Gap Junctions.

Gap junctions (GJs) are dynamic structures composed of hexamers of connexins (Cxs), a class of transmembrane proteins enabling channel-mediated direct intercellular communication through cell-cell diffusion of ions and small metabolites. In defined conditions, Cxs also work as hemichannels allowing exchanges between the cytoplasm and the extracellular medium. The most common GJ channel is formed by connexin 43 (Cx43) and plays an important role in physiological and pathological processes in excitable tissue...

The developmentally regulated fetal enterocyte gene, ZP4, mediates anti-inflammation by the symbiotic bacterial surface factor polysaccharide A on B. fragilis.

Initial colonizing bacteria play a critical role in completing the development of the immune system in the gastrointestinal tract of infants. Yet, the interaction of colonizing bacterial organisms with the developing human intestine favors inflammation over immune homeostasis. This characteristic of bacterial-intestinal interaction contributes to the pathogenesis of necrotizing enterocolitis (NEC), a devastating premature infant intestinal inflammatory disease. However, paradoxically unique pioneer bacteria...

Mitochondrial Respiration and HO Emission in Saponin-permeabilized Murine Diaphragm Fibers: Optimization of Fiber Separation and Comparison to Limb Muscle.

Diaphragm abnormalities in aging or chronic diseases include impaired mitochondrial respiration and HO emission, which can be measured using saponin-permeabilized muscle fibers. Mouse diaphragm presents a challenge for isolation of fibers due to relatively high abundance of connective tissue in healthy muscle that is exacerbated in disease states. We tested a new approach to process mouse diaphragm for assessment of intact mitochondria respiration and ROS emission in saponin-permeabilized fibers. We used th...

Mouse ES-Cell Derived Cardiomyocytes Cease to Beat following Exposure to Monochromatic Light: Associated with Increased ROS and Loss of Calcium Transients.

We earlier established mouse embryonic stem (ES)-cell 'GS-2' line expressing EGFP and have been routinely using it to understand the molecular regulation of differentiation into cardiomyocytes. During such studies, we made a serendipitous discovery that functional cardiomyocytes derived from ES-cells stopped beating when exposed to blue light. We observed a gradual cessation of contractility within a few minutes, regardless of wavelength (nm) ranges tested: blue, green and red with green light manifesting t...

Downregulated Long Noncoding RNA GAS5 Fails to Function as Decoy of CEBPB, Resulting in Increased GDF15 Expression and Rapid Ovarian Cancer Cell Proliferation.

Growth differentiation factor 15 (GDF15), a newly identified member of transforming growth factor (GDF) superfamily, is upregulated in ovarian (OV) cancer. Upregulated GDF15 positively correlates with poor prognosis of OV cancer. Thus, elucidation of the mechanism underlying GDF15 overexpression is important. PROMO and JASPAR prediction software were used to find transcription factors for GDF15 expression. Data from TCGA database were analyzed to find long noncoding RNAs (lncRNAs) that were also abnormally...

modulates X-box-binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response.

During endoplasmic reticulum (ER) stress conditions, an adaptive signaling network termed the unfolded protein response (UPR) is activated. The UPR's function is to increase ER protein-folding capacity in order to attenuate ER stress, restore ER homeostasis, and, most importantly, promote cell survival. X-box-binding protein 1 (XBP1) is one component of the UPR and is a proadaptive transcription factor that is subject to transcriptional, post-transcriptional, and post-translational control. In the present s...

Maternal fructose-induced oxidative stress occurs and epigenetic regulation in offspring hippocampi.

Fructose consumption is rising globally, but maternal high fructose intake might adversely affect offspring. Our previous report demonstrated that excess maternal fructose intake impairs hippocampal function in offspring, indicating that the hippocampi of offspring are highly sensitive to maternal fructose. Here, we examined the effect of maternal high fructose on mitochondrial physiology and uncoupling protein (UCP) expression. Rat dams received a 20% fructose solution during gestation and lactation. Immed...

A novel mutation in gene causes a severe neurodevelopmental delay due to mitochondrial dysfunction with complex I impairments and altered pyruvate metabolism.

Loss-of-function mutations in the gene cause Troyer syndrome, a recessive form of spastic paraplegia resulting in muscle weakness, short stature, and cognitive defects. encodes for Spartin, a protein linked to endosomal trafficking and mitochondrial membrane potential maintenance. Here, we identified with whole exome sequencing (WES) a novel frameshift mutation in the gene in 2 brothers presenting an uncharacterized developmental delay and short stature. Functional characterization in an SH-SY5Y cell mod...

Visual performance and high order aberrations with different contact lens prototypes with potential for myopia control.

: Contact lenses used for myopia control incorporate variable power distribution across the optic zone potentially creating degradation of the high order aberrations. The present study aims to evaluate the retinal image quality and visual performance in three prototypes of contact lenses intended to control axial elongation of the eye before they are considered for clinical trials. : This is a non-dispensing cross-over, double blind study where 30 right eyes of myopic subjects worn 3 multifocal test lenses ...

An Objective Evaluation of the Upper Eyelid Position after Phacoemulsification Cataract Surgery.

: To objectively measure the upper eyelid position following phacoemulsification cataract surgery and to identify the determinants of postoperative transient ptosis. : This is a single arm prospective study of patients who underwent cataract surgery from January to May 2017 at a tertiary Eye Hospital in Spain. Data comprised of: the type of anesthesia, the duration that the speculum remained in place and the total surgical time (duration of the procedure). The total surgical time was defined as, the time fr...

Missing Pieces of the Piezo1/Piezo2 Baroreceptor Hypothesis: An Autonomic Perspective.

Baroreceptors play a pivotal role in the regulation of blood pressure through moment to moment sensing of arterial blood pressure and providing information to the central nervous system to make autonomic adjustments to maintain appropriate tissue perfusion. A recent publication by Zeng and colleagues (Science 2018) suggests the mechanosensitive ion channels Piezo1 and Piezo2 represent the cellular mechanism by which baroreceptor nerve endings sense changes in arterial blood pressure. However, before Piezo1 ...


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