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PubMed Journals Articles About "Topical Ketoprofen Cream Topical Placebo Cream Sprain" RSS

07:58 EDT 20th July 2019 | BioPortfolio

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Showing "Topical Ketoprofen Cream Topical Placebo Cream Sprain" PubMed Articles 1–25 of 1,500+

International multidisciplinary expert panel consensus on breast reconstruction and radiotherapy.

Conflicting evidence challenges clinical decision-making when breast reconstruction is considered in the context of radiotherapy. Current literature was evaluated and key statements on topical issues were generated and discussed by an expert panel at the International Oncoplastic Breast Surgery Meeting in Milan 2017.


A systematic review of treatments for pityriasis lichenoides.

Pityriasis lichenoides (PL) represents a spectrum of inflammatory skin diseases comprising pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC). This study aimed to provide a summary of effective treatments for PL. A systematic review was performed according to PRISMA guidelines for studies investigating PL treatment including ≥3 subjects and published in English between January 1, 1970 and April 15, 2019. A total of 441 papers were screened and 37 original manus...

Dietary nitrate supplementation enhances cerebrovascular CO reactivity in a sex-specific manner.

Insufficient nitric oxide (NO) bioavailability plays an important role in endothelial dysfunction and increased NO has the potential to enhance cerebral blood flow (CBF). Dietary supplementation with sodium nitrate, a precursor of NO, could improve cerebrovascular function but this has not been investigated. In seventeen individuals, we examined the effects of a 7-day supplementation of dietary nitrate (0.1mmol/kg/day) on cerebrovascular function using a randomised, single-blinded placebo-controlled crossov...


Fractionated Irradiation in Photobiomodulation Therapy of Ankle Sprain.

The aim of this study was to test whether fractionated irradiation in photobiomodulation therapy enhances short-term recovery in patients with moderate severity ankle sprain.

Conditioned place avoidance using encapsulated calcium propionate as an appetite suppressant for broiler breeders.

Broiler breeders, the parent stock of meat chickens, are feed-restricted throughout the production cycle to avoid obesity-related problems in their health and reproductive performance. Broiler breeders often show signs of chronic hunger, lack of satiety and feeding frustration, and the development of alternative feeding strategies has investigated the inclusion of calcium propionate (CaP) as an appetite suppressant. The mechanisms involved in the reduction of voluntary feed intake are unknown, but are thoug...

Modulation of antimicrobial potency of human cathelicidin peptides against the ESKAPE pathogens and in vivo efficacy in a murine catheter-associated biofilm model.

Antimicrobial peptides are essential components of innate immune systems that protect hosts from infection. They are also useful candidates for developing a new generation of antibiotics to fight antibiotic-resistant pathogens. Human innate immune peptide LL-37 can inhibit biofilm formation, but suffers from high cost due to a long peptide length and rapid protease degradation. To improve the peptide, we previously identified the major active region and changed the peptide backbone structure. This study des...

In vivo quantitative molecular absorption of glycerol in human skin using coherent anti-Stokes Raman scattering (CARS) and two-photon auto-fluorescence.

The penetration of small molecules through the human skin is a major issue for both safety and efficacy issues in cosmetics and pharmaceutic domains. To date, the quantification of active molecular compounds in human skin following a topical application uses ex vivo skin samples mounted on Franz cell diffusion set-up together with appropriate analytical methods. Coherent anti-Stokes Raman scattering (CARS) has also been used to perform active molecule quantification on ex vivo skin samples, but no quantific...

Polyoxazolines based mixed micelles as PEG free formulations for an effective quercetin antioxidant topical delivery.

This study aims to prove the value of the polyoxazolines polymer family as surfactant in formulations for topical application and as an alternative to PEG overuse. The amphiphilic polyoxazolines (POx) were demonstrated to have less impact on cell viability of mice fibroblasts (NIH3T3) than their PEG counterparts. Mixed micelles, made of POx and phosphatidylcholine, were manufactured using thin film and high pressure homogenizer process. The mixed micelles were optimized to produce nanosized of vesicles abou...

Physiologically based ocular pharmacokinetic modeling using computational methods.

Here, we apply physiologically based models to simulate ocular drug administration. A non-anatomical model is used that applies a simple theorem for calculating ocular bioavailability from a topical dose. A computational fluid dynamic model is also described that incorporates ocular physiology in anatomical models for rabbit, monkey and man. This second method applies material properties and boundary conditions for various tissues enabling simulation of fluid flows, pressures, temperatures, convection, and ...

Dexmedetomidine to facilitate non-invasive ventilation after blunt chest trauma: a randomised, double-blind, crossover, placebo-controlled pilot study.

Although non-invasive ventilation (NIV) is recommended in patients with chest trauma, this procedure may expose to discomfort and even failure due to agitation or excessive pain. We tested the impact of dexmedetomidine on the duration of the first session of NIV.

Choice of topical prodrug in daylight photodynamic therapy for actinic keratoses.

Allergic contact dermatitis to amorolfine in a nail lacquer.

Topical drugs containing amorolfine are frequently used for the treatment of mycosis. Many use amorolfine as empiric treatment of suspected fungal nail infection with once or twice weekly application. It is usually well tolerated; only minor localised adverse events have been reported. This article is protected by copyright. All rights reserved.

Effectiveness and safety of betrixaban extended prophylaxis for venous thromboembolism compared with standard-duration prophylaxis intervention in acute medically ill patients: a systematic literature review and network meta-analysis.

To determine the clinical effectiveness and safety of venous thromboembolism (VTE) prophylaxis using United States- (US) and Europe-approved anticoagulants relative to extended-duration VTE prophylaxis with betrixaban. Low molecular weight heparins (LMWHs), unfractionated heparin (UFH), fondaparinux sodium and placebo were each compared to betrixaban, as standard-duration VTE prophylaxis for hospitalized, nonsurgical patients with acute medical illness at risk of VTE. A systematic literature review was con...

Retinal Vasculitis Associated with Ipilimumab.

: To describe a case of retinal vasculitis associated with ipilimumab. : Case report. : A 49-year-old Caucasian man presented with anterior uveitis of the left eye. He had a history of chronic myeloid leukemia undergoing ipilimumab therapy. He was treated with topical corticosteroids and achieved inactive inflammation. Ipilimumab was stopped by his oncologist since he manifested other immune-related adverse events (irAEs). Five months later, his visual acuity decreased in his left eye and optical coherence ...

Pharmacokinetic and pharmacodynamic effects of a γ-secretase modulator, PF-06648671, on CSF amyloid-β peptides in randomized Phase 1 studies.

γ-Secretase modulators (GSMs) represent a promising therapy for Alzheimer's disease by reducing pathogenic amyloid-β (Aβ) peptide production. Three Phase 1 studies (NCT02316756, NCT02407353, NCT02440100) investigated the safety/tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of the oral GSM, PF-06648671. A PKPD indirect-response model was developed (using biomarker data) to simultaneously characterize differential effects of PF-6648671 on multiple Aβ species in cerebrospinal fluid (CSF). ...

Topical Treatment of Cutaneous Leishmaniasis in Israel, Part 2.

Cutaneous leishmaniasis is the most common form of leishmaniasis with global incidence of about 1.5 million cases annually. The disease is endemic in Israel and caused by two types, leishmania major and leishmania tropica. The two types of cutaneous leishmaniasis in Israel are not life threatening, but the multiple skin lesions developed from the contaminated sand fly bites cause significant damage to the quality of life for a few months in patients with leishmania major and sometimes for more than a year i...

Extemporaneous Indomethacin Oral Suspension Prepared from Injectable Ampules for Therapy in Premature Infants and Pediatric Patients.

Indomethacin is used for off-label prescription for the treatment of patent ductus arteriosus in premature infants. In Argentina, indomethacin is only available as a suppository, dermic cream, injectable ampules, and delayed-release capsules. Aiming to improve pediatric treatment and minimize the risk associated with improper dosage, this work focused on the development of an extemporaneous 0.2% indomethacin oral suspension, starting from the commercially injectable formulation. Two 150-mL batches of suspen...

Erratum: Zur E. Topical Treatment of Primary Focal Hyperhidrosis, Part 2. IJPC 2019; 23(2):94-104.

The METHOD OF PREPARATION in the formulation titled Compounded Oxybutynin Chloride 10% Topical Gel on page 102 in the article titled Topical Treatment of Primary Focal Hyperhidrosis, Part 2. IJPC. 2019; 23(2): 94-104 was published incorrectly. Please replace that information with the data provided herein.

Effect of Rivastigmine (Acetyl Cholinesterase Inhibitor) versus Placebo on Manic Episodes in Patients with Bipolar Disorders: Results from a Double Blind, Randomized, Placebo-Controlled Clinical Trial.

To treat patients with bipolar disorders (BPD) during the acute phase, the standard procedure is to administer lithium or sodium valproate. To further optimize treatment, acetylcholinesterase inhibitors such as donepezil and galantamine have gained increased interest, though with conflicting results. In the present randomized, double-blind, placebo-controlled clinical trial, we investigated whether, and to what extent, adjuvant rivastigmine might improve symptoms of mania in patients with BPD during the acu...

Beneficial Effects of Oral Lactobacillus on Pain Severity in Women Suffering from Endometriosis: A Pilot Placebo-Controlled Randomized Clinical Trial.

This study assessed the effects of a lactobacillus-based medication on pain intensity scores in women with endometriosis.

Clinical characteristics and treatment outcomes of 36 pyoderma gangrenosum patients - a retrospective, single institution observation.

Pyoderma gangrenosum (PG) is a rare, non-infectious neutrophilic dermatosis of unclear aetiology. PG is associated with inflammatory bowel disease, the metabolic syndrome, rheumatic or hematologic disorders or malignancies in up to 70% of cases . Due to its low incidence (3-10/1 000 000) randomised data on the efficacy of different treatment modalities are sparse. Topical and systemic corticosteroids, topical tacrolimus and systemic cyclosporine are among the most commonly utilized pharmacologic agents for ...

Intravenous administration of ghrelin increases serum cortisol and aldosterone concentrations in heavy-drinking alcohol-dependent individuals: Results from a double-blind, placebo-controlled human laboratory study.

Increasing evidence supports the role of appetite-regulating hormones, including ghrelin, in alcohol use disorder (AUD). Effects of ghrelin administration on cortisol and aldosterone, two hormones known to influence the development and maintenance of AUD, have been observed in ghrelin-exposed tissues or cells, as well as rodents and healthy volunteers, however whether these effects replicate in individuals with AUD is unknown. Here, we tested the hypothesis that intravenous administration of ghrelin leads t...

Hydrocortisone loaded poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles for topical ophthalmic administration: preparation, characterization and evaluation of ophthalmic toxicity.

Poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles (PHBV-NPs) to encapsulate hydrocortisone (HC) for topical ophthalmic administration were prepared and characterized. The technique used to prepare the nanoparticles (NPs) was emulsification/solvent evaporation. The obtained size was 237.3 ± 2.7 nm, suitable for topical ocular administration. The obtained results for the entrapment efficiency were between 1-2.5% and for the drug loading were around 0.5%. The release behaviour of HC from the PHBV-NP...

Correlation of Inhaled Long-acting Bronchodilators with Adverse Cardiovascular Outcomes in Patients with Stable COPD: A Bayesian Network Meta-Analysis of Randomized Controlled Trials.

A majority of existing studies have focused on the efficacy of inhaled long-acting bronchodilators (ILABs), such as long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs), and LABAs combined with LAMAs in treating chronic obstructive pulmonary disease (COPD). The current meta-analysis aimed to investigate the correlation of ILABs with specific cardiovascular adverse events (CAEs). Five electronic databases, including PubMed, Embase, Cochrane Library, Scopus and Web of Science, were ...

The pharmacodynamic effects of a dopamine-somatostatin chimera agonist on the cardiovascular system.

The quantification of the effect of pharmacological treatment on the cardiovascular system is complicated due to the high level of inter-individual and circadian variability. Recently, a dopamine-somatostatin chimera, BIM23B065, was under investigation to concurrently target the somatostatin and dopamine D2 receptors for the treatment of neuroendocrine tumors. However, both dopamine and somatostatin interact with different components of the cardiovascular system. This study established the response of the h...


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