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PubMed Journals Articles About "Transient Receptor Potential Vanilloid Involved Upregulation Connexin Expression" RSS

17:58 EDT 24th August 2019 | BioPortfolio

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Showing "Transient receptor potential vanilloid involved upregulation connexin expression" PubMed Articles 1–25 of 45,000+

Low Doses of Ionizing Radiation Enhance the Angiogenic Potential of Adipocyte Conditioned Medium.

At low doses, ionizing radiation activates endothelial cells and promotes angiogenesis. However, it is still unknown if other cells may contribute to this process. In this study, the effect of low-dose ionizing radiation (LDIR) in modulating the pro-angiogenic potential of adipocytes was investigated. Adipocytes are known to secrete multiple angiogenic factors and adipokines that induce angiogenesis. In this work, a confluent monolayer of 3T3-L1 pre-adipocytes was exposed to low doses (0.1 and 0.3 Gy) and t...


Semi-Field Evaluation of Modified 00ZZZero Traps with Sticky Paper to Increase the Collection Efficacy of Gravid .

The 00ZZZero trap (0Z) is a small black plastic container with permethrin and pyriproxyfen, designed and marketed to both attract and kill gravid mosquitoes (unmodified trap ([UMT] or modified trap [MT]). The 0Z trap without the insecticide was modified with addition of a sticky paper, coated with an adhesive glue (MT) and evaluated for collection efficacy of released gravid mosquito, (L.) in outdoor screened enclosures in St. Augustine, in northeastern Florida. The mean numbers (±SE) of mosquitoes caugh...

Evaluation and Comparison of Spray Equipment for Indoor Residual Spraying.

The World Health Organization (WHO) has recently recommended indoor residual spraying (IRS) as part of a vector control strategy to combat -borne diseases, including dengue, chikungunya, and Zika viruses. Hand compression sprayers have been used in malaria prevention and control programs worldwide since the 1950s and are a standard for IRS application. However, there are technological advances that should be considered to improve IRS application (e.g., flow-control valves, rechargeable-battery equipment, re...


A Survey for in Delaware and the Virus-Positive Pool Rates of and for West Nile and Zika Viruses.

The introduction of Zika virus to the USA in 2015 engendered heightened interest in its known vectors. is the primary vector, with considered a potential secondary vector, together with several other possible marginal vectors. In Delaware, has been collected rarely, but no breeding populations were detected during past intensive statewide surveillance efforts. However, there is an abundance of statewide. Both species are container breeders and are peri-domestic-increasing the risk for virus transmission...

Adenosine Triphosphate-Binding Cassette Transporters Are Not Involved In the Detoxification of Extracts In Larvae.

Detoxifying pathways of mosquitoes against the neem () extracts are still unclear. The aim of the present study was to investigate the role of adenosine triphosphate-binding cassette (ABC) transporters in this process in , one of the main malaria vectors in southern Asia. Third-stage larvae of were fed with fish food alone or in combination with neem extract at 0.5%, 1%, 5%, and 10%. Six ABC-transporter genes from 3 different subfamilies (B, C, and G) were analyzed to assess their relative expression compa...

Evaluation of Partially Submerged Sticky Traps On Lake Spillways For Adult Black Fly (Diptera: Simuliidae) Surveillance and Arbovirus Detection.

Sentinel surveillance systems demonstrate an improved ability to supplement monitoring data and anticipate arbovirus outbreaks (i.e., sentinel avian species). Management complications can arise during unpredictable or unseasonal disease detections, especially in rural areas where resident distribution is patchy. Using spillways near residential lake communities as static surveillance locations, we tested a novel partially submerged sticky trapping technique and screened wild populations of adult female blac...

Repellent Activity of Carrot Seed Essential Oil and Its Pure Compound, Carotol, Against Mosquitoes.

In our natural products screening program for mosquitoes, carrot seed essential oil showed high repellency. The gas chromatography (GC)/flame ionization detector and GC/mass spectrometry analysis of the essential oil revealed the presence of 47 compounds. Carotol was more than 75% w/w, followed by muurolene (4.86%), ()-β-farnesene (2.9%), and diepicedrene (1.1%). Systematic bioassay-guided fractionation of the essential oil was performed to identify active repellent compounds. In both Klun and Debboun (K&D...

Portable Battery Power and Small-Reservoir Modifications For Pesticide Misting Systems.

United States military personnel deployed in austere hot-arid, temperate, and tropical conditions in remote locations worldwide rely on the Department of Defense (DoD) Pest Management System measures such as application of pesticide residual and ultra-low-volume or thermal fog treatments for protection from routine exposure to nuisance and disease-vector insects. Timed pesticide misting systems originally developed for residential outdoor use show promise as potential enhancements to standard DoD Pest Manag...

Habitat Characteristics For Immature Stages of In Zanzibar City, Tanzania.

is the main vector for dengue, chikungunya, yellow fever, Zika, and other arboviruses of public health importance. The presence of has never been systematically assessed in Zanzibar, including its preferred larval habitats. In 2016 we conducted a cross-sectional entomological survey to describe the preferred larval habitats of in Zanzibar City, the main urban area of the Zanzibar archipelago. The surveys for container habitats were conducted for a 17-wk period beginning in January 2016. Immature stages (l...

Diversity Of Mosquito Species Ovipositing In Different Zones of Light Intensity Within Limestone Caves In Thailand.

Climate change and human activity affect the geographical and annual distribution and population abundance of mosquitoes. As natural habitats are reduced, it is hypothesized that mosquitoes may seek refuge in more stable environments such as cave habitats. Therefore, we explored the species diversity of mosquitoes exploiting cave habitats in Thailand. Ten species belonging to 4 genera were collected, of which none were considered to be true cave-dwelling species (Troglobiont). The known cavernicolous specie...

New National Record for from Kuwait.

Mosquitoes can transmit a wide variety of viral and parasitic pathogens. Several species have recently been reported in new locations throughout the Arabian Peninsula as a result of entomological surveillance by the US military. We report a new national record for from Kuwait based on morphologic and molecular identification of captured samples. This mosquito might pose a public health threat to local populations and to military personnel as a potential vector of both Sindbis and West Nile viruses.

2018 Highlights of Mosquito and Vector Biology and Control in Latin America.

The 28th Annual Latin American Symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 84th Annual Meeting of the AMCA held in Kansas City, MO, in February 2018. The Latin American Symposium promotes the participation of vector control specialists, public health workers, and academic members from Latin America and the sharing of scientific data between continents. Generally, presentations are in Spanish with simultaneous translation into English. The majority of prese...

First Record of in Hidalgo State, Mexico.

is one of the rare species endemic in Mexico. This species was originally described from specimens collected in the state of Morelos in 1970; however, very few occurrence records have been published since. During an ovitrap survey of mosquitoes in 2018, eggs of were collected for the 1st time in the state of Hidalgo, Mexico. appears to have become common and the species is frequently found in ovitraps, and often confused with other common species of , such as , , , and . Females of are highly anthropopha...

Rescuing Troves of Hidden Ecological Data to Tackle Emerging Mosquito-Borne Diseases.

Despite the major impact of mosquitoes on human health, knowledge gaps exist regarding their natural population dynamics. Even the most basic information-such as spatiotemporal abundance-is mostly unavailable. In the USA, municipalities have created agencies for mosquito control and monitoring, yet no national open-access repository for mosquito surveillance data exists. Vectors, and the pathogens they transmit, know no jurisdictions. We identify >1,000 mosquito control agencies and identify those which mak...

Mood disorders impaired quality of life but not the mortality or morbidity risk in stable coronary heart disease patients.

It was suggested that depression and anxiety might be associated with increased cardiovascular risk in both primary and secondary prevention. In stable coronary heart disease (CHD) patients, we aimed to assess prevalence of depression and anxiety, its relations to conventional risk profile and mortality or morbidity and to quality of life (QoL). We examined 969 patients, at least 6 months after myocardial infarction or coronary revascularisation. Depression or anxiety was assessed using a standard HADS (...

Urban-rural Differences in Drug Overdose Death Rates, by Sex, Age, and Type of Drugs Involved, 2017.

Drug overdose deaths remain a significant public health concern in the United States (1-3). This report uses the most recent data from the National Vital Statistics System (NVSS) to examine urban-rural differences in drug overdose death rates by sex, age group, and the type of drugs involved.

Copy number variations primed lncRNAs deregulation contribute to poor prognosis in colorectal cancer.

Copy number variations (CNVs) are crucial genetic change elements in malignancies, and lncRNAs deregulation induced by genomic and epigenomic aberrations plays key driving role in tumorigenesis, including colorectal cancer (CRC). However, effects of CNVs associated with lncRNAs in CRC is largely unknown. Here, we perform integrative analysis considering messenger RNA expression levels, DNA methylation and DNA copy numbers from 289 cases of CRC specimens. There are five prognostic subtypes of CRC determined ...

Quantitative analysis of the human ovarian carcinoma mitochondrial phosphoproteome.

To investigate the existence and their potential biological roles of mitochondrial phosphoproteins (mtPPs) in human ovarian carcinoma (OC), mitochondria purified from OC and control tissues were analyzed with TiO enrichment-based iTRAQ quantitative proteomics. Totally 67 mtPPs with 124 phosphorylation sites were identified, which of them included 48 differential mtPPs (mtDPPs). Eighteen mtPPs were reported previously in OCs, and they were consistent in this study compared to previous literature. GO analysis...

A disparate role of RP11-424C20.2/UHRF1 axis through control of tumor immune escape in liver hepatocellular carcinoma and thymoma.

The immune system is critical in modulating cancer progression. Pseudogenes are a special type of long non-coding RNAs that regulate different tumorigenic processes. However, the potential roles of pseudogenes in tumor-immune interaction remain largely unclear. Here, we reported that pseudogene RP11-424C20.2 and its parental gene UHRF1 were frequently up-regulated and positively correlated in liver hepatocellular carcinoma (LIHC) and thymoma (THYM), but associated with distinct clinical outcomes. We further...

Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.

Antibodies developed for research and clinical applications may exhibit suboptimal stability, expressibility, or affinity. Existing optimization strategies focus on surface mutations, whereas natural affinity maturation also introduces mutations in the antibody core, simultaneously improving stability and affinity. To systematically map the mutational tolerance of an antibody variable fragment (Fv), we performed yeast display and applied deep mutational scanning to an anti-lysozyme antibody and found that m...

Evolution of intron splicing towards optimized gene expression is based on various Cis- and Trans-molecular mechanisms.

Splicing expands, reshapes, and regulates the transcriptome of eukaryotic organisms. Despite its importance, key questions remain unanswered, including the following: Can splicing evolve when organisms adapt to new challenges? How does evolution optimize inefficiency of introns' splicing and of the splicing machinery? To explore these questions, we evolved yeast cells that were engineered to contain an inefficiently spliced intron inside a gene whose protein product was under selection for an increased expr...

Aging- and obesity-related peri-muscular adipose tissue accelerates muscle atrophy.

Sarcopenia due to loss of skeletal muscle mass and strength leads to physical inactivity and decreased quality of life. The number of individuals with sarcopenia is rapidly increasing as the number of older people increases worldwide, making this condition a medical and social problem. Some patients with sarcopenia exhibit accumulation of peri-muscular adipose tissue (PMAT) as ectopic fat deposition surrounding atrophied muscle. However, an association of PMAT with muscle atrophy has not been demonstrated. ...

A genetic sum score of risk alleles associated with body mass index interacts with socioeconomic position in the Heinz Nixdorf Recall Study.

Body mass index (BMI) is influenced by genetic, behavioral and environmental factors, while interactions between genetic and socioeconomic factors have been suggested. Aim of the study was to investigate whether socioeconomic position (SEP) interacts with a BMI-related genetic sum score (GRSBMI) to affect BMI in a population-based cohort. SEP-related health behaviors and a GRS associated with educational attainment (GRSEdu) were included in the analysis to explore potential interactions underlying the GRSBM...

MicroRNA profiling identifies a novel compound with antidepressant properties.

Patients with traumatic brain injury (TBI) are frequently diagnosed with depression. Together, these two leading causes of death and disability significantly contribute to the global burden of healthcare costs. However, there are no drug treatments for TBI and antidepressants are considered off-label for depression in patients with TBI. In molecular profiling studies of rat hippocampus after experimental TBI, we found that TBI altered the expression of a subset of small, non-coding, microRNAs (miRNAs). One ...

Silencing Nogo-B receptor inhibits penile corpus cavernosum vascular smooth muscle cell apoptosis of rats with diabetic erectile dysfunction by down-regulating ICAM-1.

Erectile dysfunction (ED) is a major sexual problem for men. Nogo-B receptor (NgBR) has been found to be involved in the regulation of vascular remodeling and angiogenesis. The present study explores the effects of NgBR in penile corpus cavernosum in rats with diabetic ED. Firstly, the ED model of Sprague Dawley rats was established. Hematoxylin-eosin staining and Masson staining were conducted to observe pathological morphology. Immunochemical assay was adopted to detect α-smooth muscle actin (α-SMA), Ng...


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