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PubMed Journals Articles About "Omalizumab Healthy" RSS

18:12 EDT 18th July 2019 | BioPortfolio

Omalizumab Healthy PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Omalizumab Healthy articles that have been published worldwide.

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Showing "omalizumab Healthy" PubMed Articles 1–25 of 5,300+

Changes in beverage consumption in Canada.

Beverage consumption, especially water, is critical to a healthy diet. The 2007 Canada's Food Guide (CFG) makes specific recommendations regarding the intake of water, fruit juice, milk and energy-dense beverages. Earlier comparisons of 2004 and 2015 dietary data show that changing patterns in beverage intake can explain some of the changes in energy and sugar intake observed in the Canadian population. The objective of this study is to describe any changes in beverage consumption between 2004 and 2015, and...


The Vitamin D-Folate Hypothesis in Human Vascular Health.

The vitamin D-folate hypothesis has been proposed as an explanation for the evolution of human skin pigmentation. According to this hypothesis, a darkened skin pigment was adapted by early human populations living in equatorial Africa to protect against photodegradation of bioavailable folate by ultraviolet radiation (UVR). As humans moved away from the equator to more northern latitudes and occupied regions of lower UVR exposure and greater seasonal variation, however, depigmentation occurred to allow for ...

Fresh and Savory: Integrating Teaching Kitchens with Shared Medical Appointments.

In the fall of 2017, Fresh and Savory, a Culinary and Lifestyle Medicine Teaching Kitchen (TK) program proved systematically feasible as a Shared Medical Appointment (SMA). A portable TK complemented physician consultations, interactive didactic presentations, nutritious cooking, and mind-body exercises. A series of SMAs were launched to develop a system for physicians to address patients' nutritional and lifestyle needs. MedStar Health implemented three TK SMA programs to improve patients culinary and lif...


Group-Based Naturopathic Education for Primary Prevention of Noncommunicable Disease in Families and Children: A Feasibility Study.

Naturopathic medicine has demonstrated efficacy at reducing risk factors for chronic disease. Targeting health behaviors of parents and caregivers in a group-based setting may improve the behaviors of children in their care. This study sought to assess the feasibility of such a program. Participants of a six-session health education series were invited to respond to surveys and participate in a focus group about their health behaviors and their experience in the program. Caregivers of children aged 0-6 at...

Which Hand Position in Breastfeeding Is Better for Milk Intake: Palmar Grasp or Scissor Grasp? A Pilot Study.

During breastfeeding, there are two natural hand positions used most often by the mother to introduce her breast to the baby (palmar grasp [c-hold position] and scissor grasp). In this study, we aimed to investigate whether the milk intake is affected by the hand position. Both healthy term breastfed infants and their mothers were included in the study. Each mother-baby dyad was monitored during two feeding periods (100 mother-baby dyads, 200 breastfeeding sessions). Mothers were asked to grasp their breas...

Mitochondrial Respiration and HO Emission in Saponin-permeabilized Murine Diaphragm Fibers: Optimization of Fiber Separation and Comparison to Limb Muscle.

Diaphragm abnormalities in aging or chronic diseases include impaired mitochondrial respiration and HO emission, which can be measured using saponin-permeabilized muscle fibers. Mouse diaphragm presents a challenge for isolation of fibers due to relatively high abundance of connective tissue in healthy muscle that is exacerbated in disease states. We tested a new approach to process mouse diaphragm for assessment of intact mitochondria respiration and ROS emission in saponin-permeabilized fibers. We used th...

Muscle stiffness in rheumatoid arthritis is not altered or associated with muscle weakness: a shear wave elastography study.

To investigate muscle stiffness and strength in rheumatoid arthritis patients compared to healthy controls. A sample of 80 RA patients from three discrete groups: 1-newly diagnosed treatment-naïve RA (n = 29), 2-active RA for at least 1 year (n = 18) and 3-in remission RA for at least 1 year (n = 33), was compared to 40 healthy controls. Shear wave velocity (SWV) was measured using shear wave elastography as a surrogate for tissue stiffness in multiple muscles. All participants performed isome...

Serum Cortistatin Levels in Patients with Ocular Active and Ocular Inactive Behçet Disease.

: To evaluate serum cortistatin (CST) levels in patients with ocular active and ocular inactive Behçet disease (BD) and its relationship with disease activity. : 24 BD patients with ocular active, 24 BD patients with ocular inactive patients and 24 healthy control subjects were included in the study. : In ocular active and ocular inactive BD patients and healthy control subjects, the mean serum CST levels were 4.38 ± 1.63ng/ml, 5.46 ± 1.81ng/ml and 7.56 ± 1.73ng/ml, respectively. ESR, serum CRP, CST lev...

Help Your Patients Stay Healthy on Their Cruise Vacation: Suggestions for Primary Care Physicians from a Cruise Ship Physician.

Propofol Sedation Alters Perceptual and Cognitive Functions in Healthy Volunteers as Revealed by Functional Magnetic Resonance Imaging.

Loss of consciousness during anesthesia is associated with a loss of anterior-posterior connectivityHowever, during anesthesia local sensory cortex function may be preserved WHAT THIS ARTICLE TELLS US THAT IS NEW: During propofol sedation, activation on functional magnetic resonance imaging in higher cognitive areas, such as semantic and phonologic processing, is abolished with deep sedation and only partially suppressed with light sedationActivation related to lower sensory processing continues with deep a...

Growth patterns, metabolic indicators and osteoarticular status in the Lusitano horse: A longitudinal study.

Development of a healthy musculoskeletal system is of high concern for horse breeders and users. A longitudinal field study was performed in order to: (i) evaluate growth patterns and long-term changes on bone quality, bone metabolism, growth factors and metabolic variables in the Lusitano horse; and (ii) retrospectively assess whether these changes were related with radiographic findings regarding osteochondrosis-like lesions (OC) at the onset of training. Thirty-four Lusitano foals born and raised at four...

Altered temporal dynamics of brain activity in patients with generalized tonic-clonic seizures.

Generalized seizures engage bilateral networks from their onset at a low temporal scale. Previous studies findings have demonstrated focal/local brain activity abnormalities in the patients with generalized tonic-clonic seizures (GTCS). Resting state functional magnetic resonance imaging (fMRI) allows the detection of aberrant spontaneous brain activity in GTCS. Little is known, however, about alterations of dynamics (temporal variability) of spontaneous brain activity. It also remains unclear whether tempo...

Sexual communal motivation in couples coping with low sexual interest/arousal: Associations with sexual well-being and sexual goals.

Women coping with female sexual interest/arousal disorder (FSIAD) report lower sexual and relationship satisfaction compared to healthy controls. In community samples, high sexual communal strength (i.e., the motivation to meet a partner's sexual needs) is associated with higher sexual desire and satisfaction, but high unmitigated sexual communion (i.e., the prioritization of a partner's needs to the exclusion of one's own needs) is associated with lower sexual satisfaction. People higher in sexual communal...

The role of oxidant stress and gender in the erythrocyte arginine metabolism and ammonia management in patients with type 2 diabetes.

To study the differences in the levels of nitrogen metabolites, such as ammonia and nitric oxide and the correlations existing among them in both red blood cells (RBCs) and serum, as well as the possible differences by gender in healthy subjects and patients with type 2 Diabetes Mellitus (DM).

Functional correlates of cognitive dysfunction in clinically isolated syndromes.

Cognitive dysfunction can be identified in patients with clinically isolated syndromes suggestive of multiple sclerosis using ocular motor testing. This study aimed to identify the functional neural correlates of cognitive dysfunction in patients with clinically isolated syndrome using MRI. Eighteen patients with clinically isolated syndrome and 17 healthy controls were recruited. Subjects underwent standard neurological and neuropsychological testing. Subjects also underwent functional MRI (fMRI) during a ...

Physical Activity and Healthy Eating Patterns in Public Schools in Brazil: A Strategy to Avert Risk Factors in Adulthood.

Biomechanical in vitro test of a novel dynamic spinal stabilisation system incorporating polycarbonate urethane material under physiological conditions.

Posterior dynamic stabilisation systems were developed to provide stabilisation to pathologic or hypermobile spinal segments while maintaining the healthy biomechanics of the spine. Numerous novel dynamic devices incorporate the temperature and moisture dependent material polycarbonate urethane due to its mechanical properties and biocompatibility. In this study, standardised pure moment in vitro tests were carried out on human lumbar spines to evaluate the performance of a device containing polycarbonate u...

Hypoxic Pulmonary Vasoconstriction Is Lacking In Rats With Type 1 Diabetes.

Hypoxic pulmonary vasoconstriction (HPV) is the most important feature of intact lung circulation that matches local blood perfusion to ventilation. The main goal of this work was to study the effects of diabetes on the HPV development in rats. The experimental design comprised diabetes mellitus induction by streptozotocin, video-morphometric measurements of the lumen area of intrapulmonary arteries (iPAs) using perfused lung tissue slices and patch-clamp techniques. It was shown that iPA lumen size was sig...

Pharmacokinetic and pharmacodynamic effects of a γ-secretase modulator, PF-06648671, on CSF amyloid-β peptides in randomized Phase 1 studies.

γ-Secretase modulators (GSMs) represent a promising therapy for Alzheimer's disease by reducing pathogenic amyloid-β (Aβ) peptide production. Three Phase 1 studies (NCT02316756, NCT02407353, NCT02440100) investigated the safety/tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of the oral GSM, PF-06648671. A PKPD indirect-response model was developed (using biomarker data) to simultaneously characterize differential effects of PF-6648671 on multiple Aβ species in cerebrospinal fluid (CSF). ...

Nerve growth factor-induced muscle hyperalgesia facilitates ischemic contraction-evoked pain.

Intramuscular injection of Nerve Growth Factor (NGF) may influence the responsiveness of active chemo-sensitive channels affecting muscle pain sensitivity. This double-blinded crossover study in healthy humans assessed contraction-evoked pain responses and pain sensitivity during acute ischemia in the tibialis anterior (TA) muscle before and 24h after five distributed NGF injections (1μg, 4 cm interval) compared with control injections (isotonic-saline).

The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet-C exposed skin in healthy volunteers.

Three TRPV1 (Transient Receptor Potential Vanilloid Receptor 1) antagonists were developed for testing in situ in human skin (Sjögren et al., 2016; Sjögren et al., 2018; Sjogren et al., 2018). The first human study using these compounds and capsaicin, was done to determine the required local antagonist concentrations needed for target engagement (Proof of Mechanism, PoM) (Sjogren et al., 2018). For this paper, the aim was to address a TRPV1 antagonist's ability to inhibit a more complex pain signal, a...

The positive impacts of early-life education on cognition, leisure activity, and brain structure in healthy aging.

Education in people's early lives are positively related to their cognitive function, but its modulating effects on detailed cognition domains, its interaction with leisure activities and the associated brain changes have yet to be investigated. This report used data from 659 cognitively normal community dwelling elderly who completed neuropsychological tests, leisure activities measurement, and 78 of them underwent structural and diffusion MRI scans. We found that: (i) the highly educated elderly had a bet...

Striatal volume and functional connectivity correlate with weight gain in early-phase psychosis.

Second-generation antipsychotic drugs (SGAs) are essential in the treatment of psychotic disorders, but are well-known for inducing substantial weight gain and obesity. Critically, weight gain may reduce life expectancy for up to 20-30 years in patients with psychotic disorders, and prognostic biomarkers are generally lacking. Even though other receptors are also implicated, the dorsal striatum, rich in dopamine D2 receptors, which are antagonized by antipsychotic medications, plays a key role in the human ...

The Safety of Maternal and Fetal MRI at 3T.

The purpose of this study was to evaluate the effects of clinical 3-T MRI during pregnancy on fetal growth and neonatal hearing in neonates at low risk of congenital hearing impairment or of brain or chromosomal abnormalities. This single-center retrospective case-control study included consecutively born healthy neonates exposed in utero to 3-T MR during MRI for maternal or fetal indications and born between January 2008 and March 2015. Each exposed neonate was randomly matched 1:2 by birth date to health...

Intact Mycobacterium leprae Isolated from Placenta of a Pregnant Woman, China.

Whether Mycobacterium leprae transmits from placenta to fetus remains unknown. We describe the case of a pregnant woman with untreated histoid leproma. Although her newborn was healthy, laboratory examination revealed intact M. leprae present in the placenta, suggesting that the placental barrier might prevent vertical dissemination of M. leprae.


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