PubMed Journals Articles About "That Wheezes Night Asthma" RSS

16:21 EDT 16th July 2019 | BioPortfolio

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Showing "that wheezes night asthma" PubMed Articles 1–25 of 1,300+

The first year of treatment predicts the prognosis of asthma over 25 years - A prospective study.

An investigator-driven, real-life follow-up study of adult-onset steroid-naïve, newly diagnosed asthma (162 patients) to investigate the treatment results over the 25-year course of the disease and whether the first treatment year's forced expiratory volume in one second (FEV ) predicts the long-term prognosis.

Experiences of Speaking With Noninvasive Positive Pressure Ventilation: A Qualitative Investigation.

Purpose The aim of this study was to describe experiences of speaking with 2 forms of noninvasive positive pressure ventilation (NPPV)-mouthpiece NPPV (M-NPPV) and nasal bilevel positive airway pressure (BPAP)-in people with neuromuscular disorders who depend on NPPV for survival. Method Twelve participants (ages 22-68 years; 10 men, 2 women) with neuromuscular disorders (9 Duchenne muscular dystrophy, 1 Becker muscular dystrophy, 1 postpolio syndrome, and 1 spinal cord injury) took part in semistructured i...

Plant extract-based diets differently modulate immune responses and resistance to bacterial infection in striped catfish (Pangasianodon hypophthalmus).

A feeding trial was performed to compare the effects of five ethanol herbal extracts (bhumi amla, Phyllanthus amarus Schum and Thonn [Pa]; guava, Psidium guajava L. [Pg]; sensitive plant, Mimosa pudica L. [Mp]; neem, Azadirachta indica A. Juss [Ai] and asthma plant, Euphorbia hirta L. [Eh]) on the immune response and disease resistance against Edwardsiella ictaluri infection of striped catfish (Pangasianodon hypophthalmus). Fish were fed diets supplemented with two doses of each plant extract (0% [basal die...

Anti-inflammatory activity of SintMed65, an N-acylhydrazone derivative, in a mouse model of allergic airway inflammation.

Asthma is a chronic, complex and heterogeneous inflammatory illness, characterized by obstruction of the lower airways. About 334 million people worldwide suffer from asthma, and these estimates, as well as the severity of the disease, have increased in the last decades. Glucocorticoids are currently the most widely used drugs in the treatment and control of asthma symptoms, but their prolonged use can cause serious adverse effects. N-acylhydrazone derivatives have been tested in pre-clinical studies in mod...

Immunologic Adverse Effects of Biologics for the Treatment of Atopy.

The use of biologic agents as therapies for atopic diseases such as asthma and atopic dermatitis has increased greatly in recent years. The biological agents used to treat atopic diseases are for the most part monoclonal antibodies that suppress the immune response and reduce inflammation by targeting particular cytokines or other molecules involved in Th1, Th2, or Th17 immune reactions. Various side effects and rare complications have been reported from these agents. In this review, we discuss mechanisms o...

Prevalence of Sleep Apnea in Patients with Carotid Artery Stenosis.

Obstructive sleep apnea (OSA) is a common disease affecting about 13% of men and 6% of women, usually having severe cardiovascular sequalae. OSA is responsible for the systemic inflammatory response and oxidative stress and results in endothelial injury being a risk factor for atherosclerosis. The aim of this study was to estimate the prevalence of OSA among patients with severe carotid artery stenosis. Fifty-five patients (F/M-24/31, mean age 70 ± 7 years, body mass index 28.3 ± 6.3 kg/m) were enrolled i...

Rural to urban migration contributes to the high burden of asthma in the urban area.

It is unknown whether rural-urban migration contributes to worse the burden of asthma in the cities.

Nasal polyps 15-lipoxygenase 1 promotes CCL26/Eotaxin3 expression through ERK activation.

15-lipoxygenase 1 (15LO1) is expressed in airway epithelial cells in Type-2-High asthma, in association with eosinophilia. Chronic rhinosinusitis with nasal polyps (CRSwNP) is also associated with Type-2 inflammation and eosinophilia. CCL26/Eotaxin3 has been reported to be regulated by 15LO1 in lower airway epithelial cells. However, its relation to 15LO1 in CRSwNP or mechanisms for its activation are unclear.

Perceptions of asthma and exercise, and associations with weight status and asthma morbidity in urban children.

Given the high prevalence of asthma and obesity in minority children, there is a need to identify targets for intervention to decrease the impact of these conditions on children's functioning in this high-risk group.

Pharmacoeconomics of Bronchial Asthma.

Pharmacoeconomics (PE) treats the problems of pharmacotherapy policy, drug marketing and reimbursement and clinical trials. It guides policy makers for effective health resources utilization and determines the profitability of the new drugs on the basis of their price, efficacy and benefits for society. Types of health costs and pharmacoeconomic analyses: In the current review the main types of health costs are discussed. The main PE analyses with their advantages and disadvantages are presented. Pharmacoec...

Factors associated with well-controlled asthma - a cross-sectional study.

Treatment of allergic disease with nanoemulsion adjuvant vaccines.

The majority of allergic diseases, including asthma, atopic dermatitis and food allergy, are caused by allergen-specific IgE production and Th2-polarized immune responses. Allergic sensitization is caused by DC activation of naïve T cells to generate and expand Th2-biased cellular immune responses, resulting in the production of cytokines such as IL-4, IL-5 and IL-13. Th2 cytokines induce the generation and expansion of allergen-specific IgE by B cells as well as accumulation of mast cells in tissues (Figu...

Healthcare utilization in infants and toddlers with asthma-like symptoms.

Recurrent asthma-like symptoms are common in infants, but few population studies describe diagnostic and treatment practice.

SERPINA1 gene polymorphisms in a population-based ALSPAC cohort.

There is an association between persistent preschool wheezing phenotypes and school-age asthma. These wheezing/asthma phenotypes likely represent clinical entities having specific genetic risk factors. The SERPINA1 gene encodes α -antitrypsin (AAT), and mutations in the gene are important in the pathophysiology of pulmonary diseases. We hypothesized that there might be an association between SERPINA1 gene polymorphisms and the risk of developing wheezing/school age asthma.

Prognostic and predictive value of blood eosinophil count, fractional exhaled nitric oxide and their combination in severe asthma: a post-hoc analysis.

Give Me Some Room to Breathe! Can Targeting SPHK2 Reduce Airway Smooth Muscle Thickening in Asthma?

Effectiveness and Safety of Inhaled Corticosteroids in Older Individuals with COPD and/or Asthma: A Population Study.

Inhaled corticosteroids (ICS) are established medications for the management of both asthma and chronic obstructive pulmonary disease (COPD), two common chronic airway diseases. However, there is still uncertainty with respect to their use in some areas, specifically for asthma in older adults, for people with concurrent asthma and COPD and for some people with COPD given their association with pneumonia.

Comparison of Serum Eosinophil-Derived Neurotoxin Levels between Wheezing and Non-wheezing Groups in Children with Respiratory Tract Infection.

: Eosinophil-derived neurotoxin (EDN) is associated with recurrent wheezing episodes after bronchiolitis, childhood asthma, and allergic rhinitis. We investigated if there is a measurable difference between serum EDN levels in children with wheezing and non-wheezing respiratory infections. : 171 children who visited a university hospital with respiratory infections were enrolled in the study. Subjects were divided into two groups: wheezing (n = 46) and non-wheezing (n = 125). Serum EDN levels were c...

Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD.

Evidences have shown a strong link between particulate matter (PM) and increased risk in human mortality and morbidity, including asthma, chronic obstructive pulmonary disease (COPD), respiratory infection, and lung cancer. However, the underlying toxicologic mechanisms remain largely unknown. Utilizing PM-treated human pulmonary fibroblasts (HPF) models, we analyzed gene expression microarray data and Ingenuity Pathway Analysis (IPA) to identify that the transcription factor was the main downstream regula...

Single and Multiple Time-point Allergic Sensitization during Childhood and Risk of Asthma by Age 13.

The relationship between allergic sensitization during childhood and risk of developing asthma remains unclear.

Androgen Receptor-Mediated Regulation of Intracellular Calcium in Human Airway Smooth Muscle Cells.

With the prevalence of asthma being greater in women, detrimental effects of female sex steroids have been explored, but potential protective effects of androgens are not established. Airway smooth muscle (ASM) is a key cell type in contractility and remodelling of asthma. There are no data on expression and functionality of androgen receptor (AR) in human ASM cells.

Small Airway Dysfunction by Impulse Oscillometry in Symptomatic Patients with Preserved Pulmonary Function.

Asthma and chronic obstructive pulmonary disease (COPD) are characterized by persistent airway inflammation and airflow limitation. Early detection of these diseases in patients with respiratory symptoms and preserved pulmonary function (PPF) defined by spirometry is difficult. Impulse oscillometry (IOS) may have better sensitivity to detect small airway dysfunction (SAD) than effort-dependent forced expiratory flow between 25% and 75% (FEF).

How maternal BMI modifies the impact of personalised asthma management in pregnancy.

Maternal asthma is associated with perinatal complications and respiratory illness in offspring. Obesity increases asthma exacerbation risk in pregnancy and risk of wheeze in offspring.

Suicidality among patients with asthma: A systematic review and meta-analysis.

Asthma is associated with multiple psychiatric comorbidities. However, the relationship between asthma and suicidality has not be well established.

Scottish consensus statement on the role of FeNO in adult asthma.

Fractional exhaled nitric oxide (FeNO) is the only available point of care test to assess type-2 inflammation in asthma. In making a diagnosis of asthma, FeNO should be used together with blood eosinophils and spirometry, alongside a history. Raised FeNO in conjunction with blood eosinophilia are treatable traits of type 2 inflammation in asthma, which in turn may guide personalised management. A FeNO suppression test can be used to assess adherence and device use with ICS therapy. Furthermore FeNO may be u...

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