PubMed Journals Articles About "3921 Dose 3921 High Dose Spinal Cord Injury" RSS

14:42 EST 19th January 2020 | BioPortfolio

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Showing "3921 dose 3921 High dose Spinal Cord Injury" PubMed Articles 1–25 of 41,000+

The effect of TLR4/MyD88 inhibition by salvianolic acid B on neuropathic pain following spinal cord injury in mice.

Spinal cord injury (SCI) is a common type of injury and about one half of the patients affected by SCI will suffer from neuropathic pain within a year after injury. However, the treatment effect of the neuropathic pain is far from satisfactory. Our study attempted to reveal whether SalB could relieve the neuropathic pain caused by SCI in mice by inhibiting the TLR4/MyD88 pathway. The mice were randomly divided into sham group, model group, high-dose treatment group and low-dose treatment group. The high- an...

Fecal transplant prevents gut dysbiosis and anxiety-like behaviour after spinal cord injury in rats.

Secondary manifestations of spinal cord injury beyond motor and sensory dysfunction can negatively affect a person's quality of life. Spinal cord injury is associated with an increased incidence of depression and anxiety; however, the mechanisms of this relationship are currently not well understood. Human and animal studies suggest that changes in the composition of the intestinal microbiota (dysbiosis) are associated with mood disorders. The objective of the current study is to establish a model of anxiet...

Proprioception: Bottom-up directive for motor recovery after spinal cord injury.

Proprioceptive feedback provides movement-matched sensory information essential for motor control and recovery after spinal cord injury. While it is understood that the fundamental contribution of proprioceptive feedback circuits in locomotor recovery is to activate the local spinal cord interneurons and motor neurons in a context-dependent manner, the precise mechanisms by which proprioception enables motor recovery after a spinal cord injury remain elusive. Furthermore, how proprioception contributes to m...

Trends in nonroutine physician visits and hospitalizations: findings among five cohorts from the Spinal Cord Injury Longitudinal Aging Study.

Longitudinal cohort study OBJECTIVE: To evaluate lifetime variation in healthcare utilization among individuals with a chronic spinal cord injury (SCI).

Susceptibility of Cervical Spinal Stenosis to Hypoxic Ischemic Cord Injury.

The adult spinal cord is typically resistant to hypoxic ischemic injury (HII) because of collateral blood supply; however, congenital or acquired stenosis may result in baseline maximal vasodilatation, such as superimposed hemodynamic stresses, that cannot be accommodated, leaving the spinal cord vulnerable to ischemic injury.

Employment and job benefits among those with spinal cord dysfunction: A comparison of people with spinal cord injury and multiple sclerosis.

(1) Identify the proportion of participants with spinal cord dysfunction (SCD) reporting each of 10 job benefits and compare the proportions between participants with spinal cord injury (SCI) and multiple sclerosis (MS), and (2) examine if diagnostic criteria, demographics, education level, and functional limitations are associated with the number of job benefits received.

Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats with Spinal Cord Injury.

Electromyographic studies have shown that external anal sphincter activity is modified in response to distension in animals with spinal cord injury. Gonadotropin-releasing hormone and its agonist leuprolide acetate have neurotrophic properties in animals with spinal cord injury.

Current Agents and Related Therapeutic Targets for Inflammation Following Acute Traumatic Spinal Cord Injury.

Infliction of a traumatic spinal cord injury propagates damage that is seen in two stages. The first phase of trauma occurs from the initial mechanical insult, while the second phase involves the degradation of nervous tissue but is likely not affected by the initial insult. Thus therapeutic targets with a high specificity for these secondary injury processes are of increasing interest. The pathophysiologic cascades of inflammation after spinal cord injuries and potential therapeutic targets are reviewed.

Acute Adverse Events After Spinal Cord Injury and Their Relationship to Long-term Neurologic and Functional Outcomes: Analysis From the North American Clinical Trials Network for Spinal Cord Injury.

There are few contemporary, prospective multicenter series on the spectrum of acute adverse events and their relationship to long-term outcomes after traumatic spinal cord injury. The goal of this study is to assess the prevalence of adverse events after traumatic spinal cord injury and to evaluate the effects on long-term clinical outcome.

Spinal cord stimulation prevents paclitaxel-induced mechanical and cold hypersensitivity and modulates spinal gene expression in rats.

Paclitaxel-induced peripheral neuropathy (PIPN) is a common dose-limiting side effect of this cancer treatment drug. Spinal cord stimulation (SCS) has demonstrated efficacy for attenuating some neuropathic pain conditions.

Acute ventilatory support during whole-body hybrid rowing in patients with high-level spinal cord injury: a randomized controlled cross-over trial.

High-level spinal cord injury (SCI) results in profound spinal and supraspinal deficits, leading to substantial ventilatory limitation during whole-body hybrid functional electrical stimulation (FES)-rowing, a form of exercise that markedly increases the active muscle mass via electrically-induced leg contractions. We tested the effect of non-invasive ventilation (NIV) on ventilatory and aerobic capacities during in SCI.

Multicenter study of 37 pediatric patients with SCIWORA or other spinal cord injury without associated bone lesion.

Pure traumatic spinal cord injury (without associated bone lesion) are encountered in pediatric accidentology, the most typical being spinal cord injury without radiological abnormality (SCIWORA). The present study reports a multicenter series of under-18-year-olds admitted for traumatic medullary lesion. The objectives were: (1) to describe the causes of pure spinal cord injuries in children in France and their clinical presentation; (2) to identify any prognostic factors; and (3) to describe their medical...

Enhancement of Motor Function Recovery after Spinal Cord Injury in Mice by Delivery of Brain-Derived Neurotrophic Factor mRNA.

Spinal cord injury (SCI) is a debilitating condition that can cause impaired motor function or full paralysis. In the days to weeks following the initial mechanical injury to the spinal cord, inflammation and apoptosis can cause additional damage to the injured tissues. This secondary injury impairs recovery. Brain-derived neurotrophic factor is a secreted protein that has been shown to improve a variety of neurological conditions, including SCI, by promoting neuron survival and synaptic plasticity. This st...

Ziconotide for spinal cord injury related pain.

Central neuropathic pain related to spinal cord injury is notoriously difficult to treat. So far most pharmacological and surgical options have shown but poor results. Recently ziconotide has been approved for use both neuropathic and non-neuropathic pain. In this cohort study, we assessed responder rate and long term efficacy of intrathecal ziconotide in patients with pain related to spinal cord injury.

Discontinuation of chronic opiate therapy after successful spinal cord stimulation is highly dependent upon the Daily Opioid Dose.

The aim of this study was to determine if any of the factors recorded on a standard clinical history of a patient considered for spinal cord stimulation (SCS) would be associated with reduction or cessation of opioids following implantation.

Quantitative proteomics reveal the alterations in the spinal cord after myocardial ischemia‑reperfusion injury in rats.

There is now substantial evidence that myocardial ischemia‑reperfusion (IR) injury affects the spinal cord and brain, and that interactions may exist between these two systems. In the present study, the spinal cord proteomes were systematically analyzed after myocardial IR injury, in an attempt to identify the proteins involved in the processes. The myocardial IR injury rat model was first established by cross clamping the left anterior descending coronary artery for 30‑min ischemia, followed by reperfu...

Therapeutic target for external beam x-irradiation in experimental spinal cord injury.

X-irradiation has been shown to be beneficial to recovery from spinal cord injury (SCI); however, the optimal therapeutic target has not been defined. Experiments were designed to determine the optimal target volume within the injured spinal cord for improving functional recovery and sparing tissue with stereotactic x-irradiation.

Current barriers and ethical considerations for clinical implementation of epidural stimulation for functional improvement after spinal cord injury.

: To determine current barriers for clinical implementation of epidural stimulation for functional improvement after spinal cord injury and highlight applicable ethical constructs to approach future research. : Survey of spinal cord injury medicine physicians, January 2019. : Spinal cord injury model systems hospital sites across the United States. : Spinal cord injury medicine physicians. : NA. : Physician-identified current barriers to clinical implementation of epidural stimulation. : The response rate f...

International Standards for Neurological Classification of Spinal Cord Injury: factors influencing the frequency, completion and accuracy of documentation of neurology for patients with traumatic spinal cord injuries.

We aim to evaluate the effects of injury-related factors and clinician training grades on the frequency, completion and accuracy of International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) charts in a tertiary care neurosurgery unit.

Osteoporosis-related fractures after spinal cord injury: a retrospective study from Brazil.

Retrospective study OBJECTIVES: To describe the epidemiological and clinical profile in a retrospective chart review of individuals with spinal cord injury (SCI) and osteoporosis-related fractures.

Outcomes in the Treatment of Femur Fractures in Patients with Pre-Existing Spinal Cord Injury.

Spinal cord injured patients have an estimated 25% to 34% lifetime incidence of sustaining an extremity fracture. The objective of this study is to describe the outcomes of femur fractures treated in patients with pre-existing spinal cord injury (SCI) and lower extremity paraplegia.

MiR-100 suppresses inflammatory activation of microglia and neuronal apoptosis following spinal cord injury via TLR4/NF-κB pathway.

This study aims to ascertain the effect of miR-100 on inflammation, apoptosis and functional rehabilitation after spinal cord injury (SCI) and the potential mechanism.

CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells.

Chemokines play a key role in post-traumatic inflammation and secondary injury after spinal cord injury (SCI). CCL28, the chemokine CC-chemokine ligand 28, is involved in the epithelial and mucosal immunity. However, whether CCL28 participates in the physiopathologic processes after SCI remains unclear.

Osteoporosis in the lower extremities in chronic spinal cord injury.

Cross-sectional study.

Effects of hypertonia on contracture development in rat spinal cord injury.

Experimental animal study.

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