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PubMed Journals Articles About "Ageing" RSS

19:42 EST 9th December 2018 | BioPortfolio

Ageing PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Ageing articles that have been published worldwide.

More Information about "Ageing" on BioPortfolio

We have published hundreds of Ageing news stories on BioPortfolio along with dozens of Ageing Clinical Trials and PubMed Articles about Ageing for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Ageing Companies in our database. You can also find out about relevant Ageing Drugs and Medications on this site too.

Showing "Ageing" PubMed Articles 1–25 of 447

Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression.

The paramount role of senescent cells in ageing has prompted suggestions that re-expression of telomerase may prevent ageing; a proposition that is predicated on the assumption that senescent cells are the sole cause of ageing. Recently, several DNA methylation-based age estimators (epigenetic clocks) have been developed and they revealed that increased epigenetic age is associated with a host of age-related conditions, and is predictive of lifespan. Employing these clocks to measure epigenetic age , we int...


Measuring What Matters: Achieving Consensus on a Positive Ageing Indicator Set For Ireland.

The objective of this study was to measure consensus among expert stakeholders on a set of positive ageing outcome indicators in Ireland. Stakeholders from academic, public, and voluntary sectors and older people participated in a 3-round, online, Delphi study to evaluate indicators for participation, security, healthy ageing, attitudes to ageing, and information access. Evaluation criteria included: acceptability, utility, accessibility, ranking, and balance and coherence. Consensus was achieved on 56 key ...

Characteristics of healthy vascular ageing in pooled population-based cohort studies: the global Metabolic syndrome and Artery REsearch Consortium.

Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV). This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts.


Cancer-free aging: insights from Spalax ehrenbergi superspecies.

Cancer and ageing can be regarded as two different manifestations of the same underlying process-accumulation of cellular damage-and therefore both are closely linked. Nowadays, the ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities, and therefore the understanding of links between cancer and ageing is more important than ever. Spalax is considered an excellent model for ageing and, additionally, for cancer research, due to not show clear age-related pheno...

Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β) murine hearts.

Ageing and age-related bioenergetic conditions including obesity, diabetes mellitus and heart failure constitute clinical ventricular arrhythmic risk factors.

Prevalence and related factors of Active and Healthy Ageing in Europe according to two models: Results from the Survey of Health, Ageing and Retirement in Europe (SHARE).

Active and Healthy Ageing (AHA) is the process of optimizing opportunities related to health, participation, and safety in order to improve quality of life. The approach most often used to measure AHA is Rowe and Kahn's Satisfactory Ageing model. Nonetheless, this model has limitations. One of the strategic objectives of the WHO Global Strategy and Action Plan (2016) is to improve Healthy Ageing measurement. Our objectives were to compare two models of assessing AHA and further compare the results by countr...

Gene Expression-Based Drug Repurposing to Target Ageing.

Ageing is the largest risk factor for a variety of non-communicable diseases. Model organism studies have shown that genetic and chemical perturbations can extend both life- and health-span. Ageing is a complex process, with parallel and interacting mechanisms contributing to its aetiology, posing a challenge for the discovery of new pharmacological candidates to ameliorate its effects. In this study, instead of a target-centric approach, we adopt a systems level drug repurposing methodology to discover dru...

Major trauma and acceleration of the ageing process.

It is well established that numerous factors can affect the rate at which we age biologically. Diet, physical activity, lifestyle and our genes all play a major role in influencing the ageing trajectory and longevity. Major trauma affects millions globally, is the major cause of death in young adults and could influence ageing processes but has largely been ignored by biogenterologists. The long-term health consequences of physical trauma are well known in the medical community, how trauma effects the agein...

Attitudes to ageing and their relationship with quality of life in older adults in Turkey.

With the increase in life expectancy, it has become necessary to expand our knowledge of how older individuals perceive their own ageing and how ageing affects their quality of life. The aim of the study was to determine older adults' attitudes towards ageing and the relationship between attitudes and quality of life among community-dwelling older adults in Turkey.

MRI-based Evaluation of Structural Degeneration in the Ageing Brain: Pathophysiology and Assessment.

Advances in MRI technology have significantly contributed to our ability to understand the process of brain ageing, allowing us to track and assess changes that occur during normal ageing and neurological conditions. This paper focuses on reviewing structural changes of the ageing brain that are commonly seen using MRI, summarizing the pathophysiology, prevalence, and neuroanatomical distribution of changes including atrophy, lacunes, white matter lesions, and dilated perivascular spaces. We also review the...

Epigenetic and redox biomarkers: Novel insights from the MARK-AGE Study.

Ageing is a multifactorial process that affects most, if not all, of the body's tissues and organs and can be defined as the accumulation of physical and psychological changes in a human being over time. The rate of ageing differs between individuals of the same chronological age, meaning that 'biological age' of a person may be different from 'chronological age'. Furthermore, ageing represents a very potent risk factor for diseases and disability in humans. Therefore, establishment of markers of biological...

The role of melatonin, a multitasking molecule, in retarding the processes of ageing.

Biological ageing is generally accompanied by a gradual loss of cellular functions and physiological integrity of organ systems, the consequential enhancement of vulnerability, senescence and finally death. Mechanisms which underlie ageing are primarily attributed to an array of diverse but related factors including free radical-induced damage, dysfunction of mitochondria, disruption of circadian rhythms, inflammaging, genomic instability, telomere attrition, loss of proteostasis, deregulated sensing of nut...

Aging-related anorexia and its association with disability and frailty.

Anorexia of ageing may be a precursor to various geriatric syndromes. We elucidated whether anorexia of ageing had a significant impact on incident disability and investigated whether anorexia of ageing had a direct association with future disability or an indirect association with disability via frailty.

Biogerontology: research status, challenges and opportunities.

Biogerontology is the study of the biological basis of ageing and age-related diseases. The phenomenon and the process of ageing are well understood in evolutionary and biological terms; and a conceptual framework has been established within which general principles of ageing and longevity can be formulated. The phenotype of ageing in terms of progressive loss of physical function and fitness is best seen during the period of survival after the evolution-determined essential lifespan (ELS) of a species. How...

Ageing patients in forensic psychiatric settings: A review of the literature.

The prevalence of ageing patients in forensic psychiatric settings is increasing. However, limited research has reported around this population. The aim of this scoping review is to synthesise the current evidence around ageing forensic psychiatric patients.

Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence.

Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular level, ageing entails decreased replicative capacity and dysregulation of cellular processes in myocardial and nonmyocyte cells. Various extrinsic parameters, such as lifestyle and environment, integrate important signalling pathways, such as those involving inflammation and oxidative stress, with intrinsic molecular mechanisms underlying resistance versus progression to cellular senescence. Mitigation of cardiac fun...

Ageing, the autonomic nervous system and arrhythmia: From brain to heart.

An ageing myocardium possesses significant electrophysiological alterations that predisposes the elderly patient to arrhythmic risk. Whilst these alterations are intrinsic to the cardiac myocytes, they are modulated by the cardiac autonomic nervous system (ANS) and consequently, ageing of the cardiac ANS is fundamental to the development of arrhythmias. A systems-based approach that incorporates the influence of the cardiac ANS could lead to better mechanistic understanding of how arrhythmogenic triggers an...

The Contribution of Peripheral Airway Function to Changes in FEV/FVC and RV/TLC with Ageing.

Multiple breath nitrogen washout (MBNW) indices provide insight into ventilation heterogeneity globally (LCI) and within acinar (S) and conducting (Scond) airways. Normal ageing leads to an accelerated deterioration of S in older adults, but little is known about the contribution of peripheral airway function to changes in pulmonary function indices reflecting expiratory airflow (FEV/FVC) and gas trapping (RV/TLC) with ageing.

To Adapt or not to Adapt: Consequences of Declining Adaptive Homeostasis and Proteostasis with Age.

Many consequences of ageing can be broadly attributed to the inability to maintain homeostasis. Multiple markers of ageing have been identified, including loss of protein homeostasis, increased inflammation, and declining metabolism. Although much effort has been focused on characterization of the ageing phenotype, much less is understood about the underlying causes of ageing. To address this gap, we outline the age-associated consequences of dysregulation of 'Adaptive Homeostasis' and its proposed contribu...

Cellular and epigenetic drivers of stem cell ageing.

Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post-reproductive lifespan is caused, at least in part, by a decline in stem cell function and is associated with an increased incidence of diseases. Hallmarks of ageing include the accumulation of molecular damage, failure of quality control systems, metabolic changes and alterations in epigenome stability. In this Review, we discuss recent...

The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae.

The concept of ageing is one that has intrigued mankind since the beginning of time and is now more important than ever as the incidence of age-related disorders is increasing in our ageing population. Over the past decades, extensive research has been performed using various model organisms. As such, it has become apparent that many fundamental aspects of biological ageing are highly conserved across large evolutionary distances. In this review, we illustrate that the unicellular eukaryotic organism Saccha...

Tracking changes in frailty throughout later life: results from a 17-year longitudinal study in the Netherlands.

to better understand the development of frailty with ageing requires longitudinal studies over an extended time period.

Analysis of gut microbiota in long-lived older adults and their relatives: a gradual change with ageing.

Promoting the health span and lifespan of humans is the ultimate proposition of medical science. Several lifespan-reducing chronic diseases are associated with alterations in the gut microbiota (GM) composition. We aimed to identify the particular age-related GM trajectory in older Chinese adults and investigated the characteristic gut bacterial taxa of long-lived Chinese individuals. Faecal samples from 375 older adults (centenarians or adults nearly 100 years old and their younger immediate relatives) fro...

Lifestyle determinants of healthy ageing in a Mediterranean population: The multinational MEDIS study.

To evaluate modifiable, lifestyle risk factors of cardiovascular disease (CVD) among older adults, across ageing, in the Mediterranean area.

Leucocyte telomere length is no molecular marker of physical frailty in late-life depression.

Although average life-expectancy is still increasing worldwide, ageing processes markedly differ between individuals, which has stimulated the search for biomarkers of biological ageing.


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