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PubMed Journals Articles About "BERNARD KRIEF SEARCH" RSS

14:26 EST 21st February 2018 | BioPortfolio

BERNARD KRIEF SEARCH PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest BERNARD KRIEF SEARCH articles that have been published worldwide.

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Showing "BERNARD KRIEF SEARCH" PubMed Articles 1–25 of 1,800+

Louis Pasteur and Claude Bernard: about a posthumous controversy.

Claude Bernard and Louis Pasteur will meet on various occasions, scientific prizes were awarded by Claude Bernard to Louis Pasteur, Claude Bernard's lessons were followed by Louis Pasteur at the Faculty of Science or at the College de France, and friendly relationship were established. But the essential lies in a posthumous controversy where Claude Bernard, denying the role of microbes in the fermentation, seems to criticize Pasteur's assertions and, later, his method and vision. We shall report here the ex...


Claude Bernard - then and now.

The early life of Claude Bernard - dreamer and frustrated playwright - reveals no indication of his future scientific aptitude. Cartesian doubt, a principle that he would adhere to lifelong, clouded a failed pharmacy apprenticeship that led to medical studies in Paris - but without great success. Research was his only aim, it was made possible only by a lucrative but unsuccessful arranged marriage. His passion for work and over-riding principles of truth and proof would ultimately allow him to stand...

Supporting inter-topic entity search for biomedical Linked Data based on heterogeneous relationships.

The keyword-based entity search restricts search space based on the preference of search. When given keywords and preferences are not related to the same biomedical topic, existing biomedical Linked Data search engines fail to deliver satisfactory results. This research aims to tackle this issue by supporting an inter-topic search-improving search with inputs, keywords and preferences, under different topics.


More than a memory: Confirmatory visual search is not caused by remembering a visual feature.

Previous research has demonstrated a preference for positive over negative information in visual search; asking whether a target object is green biases search towards green objects, even when this entails more perceptual processing than searching non-green objects. The present study investigated whether this confirmatory search bias is due to the presence of one particular (e.g., green) color in memory during search. Across two experiments, we show that this is not the critical factor in generating a confir...

Remembering a pioneer of environmental health science: Colleagues honor Bernard "Bernie" Weiss (1925-2018)-a remarkable scientist, thinker, visionary and writer.

Claude Bernard and nicotinic receptors: from the neuromuscular junction to tobacco weaning.

Claude Bernard (1813-1878) was fascinated by the pharmacological mechanisms of poisons. In particular, using a huge amount of ingenious and robust experiments, he demonstrated the peripheral toxic action of the natural compound curare. His work generated controversies in a period where scientific methodology and technical development followed the progression of concepts and ideas. From his intense debates with Albert Vulpian emerged the location of curare's toxicity at the neuromuscular junction. These two ...

Review of Peter L. Rosenbaum, Gabriel M. Ronen, Bernard Dan, Jennifer Johannensen, and Eric Racine, eds., Ethics in Child Health: Principles and Cases in Neurodisability.

One visual search, many memory searches: An eye-tracking investigation of hybrid search.

Suppose you go to the supermarket with a shopping list of 10 items held in memory. Your shopping expedition can be seen as a combination of visual search and memory search. This is known as "hybrid search." There is a growing interest in understanding how hybrid search tasks are accomplished. We used eye tracking to examine how manipulating the number of possible targets (the memory set size [MSS]) changes how observers (Os) search. We found that dwell time on each distractor increased with MSS, suggesting ...

Surface-Assisted Dynamic Search Processes.

Many chemical and biological systems exhibit intermittent search phenomena when participating particles alternate between dynamic regimes with different dimensionality. Here we investigate theoretically a dynamic search process of finding a small target at two dimensional surface starting from the bulk solution, which is an example of such intermittent search process. Both continuum and discrete-state stochastic descriptions are developed. It is found that depending on the scanning length $\lambda$, which d...

Anatomy and evolution of database search engines-a central component of mass spectrometry based proteomic workflows.

Sequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database. Two decades of development, notably driven by advances in mass spectrometry, have provided scientists with more than 30 published search engines, each with its own properties. In this review, we present the common paradigm behind the different implementations, and its limitations for modern mass spectrometry datasets. We also detail how the search engine...

Involuntary top-down control by search-irrelevant features: Visual working memory biases attention in an object-based manner.

Many everyday tasks involve successive visual-search episodes with changing targets. Converging evidence suggests that these targets are retained in visual working memory (VWM) and bias attention from there. It is unknown whether all or only search-relevant features of a VWM template bias attention during search. Bias signals might be configured exclusively to task-relevant features so that only search-relevant features bias attention. Alternatively, VWM might maintain objects in the form of bound features....

Sweet Emotion: The Role of Odor-induced Context in the Search Advantage for Happy Facial Expressions.

The current study investigated the extent to which the concurrent presentation of pleasant and unpleasant odors could modulate the perceptual saliency of happy facial expressions in an emotional visual search task. Whilst a search advantage for happy faces was found in the no odor and unpleasant odor conditions, it was abolished under the pleasant odor condition. Furthermore, phasic properties of visual search performance revealed the malleable nature of this happiness advantage. Specifically, attention tow...

Low validity of Google Trends for behavioral forecasting of national suicide rates.

Recent research suggests that search volumes of the most popular search engine worldwide, Google, provided via Google Trends, could be associated with national suicide rates in the USA, UK, and some Asian countries. However, search volumes have mostly been studied in an ad hoc fashion, without controls for spurious associations. This study evaluated the validity and utility of Google Trends search volumes for behavioral forecasting of suicide rates in the USA, Germany, Austria, and Switzerland. Suicide-rela...

Search strategies in practice: Influence of information and task constraints.

The practice of a motor task has been conceptualized as a process of search through a perceptual-motor workspace. The present study investigated the influence of information and task constraints on the search strategy as reflected in the sequential relations of the outcome in a discrete movement virtual projectile task. The results showed that the relation between the changes of trial-to-trial movement outcome to performance level was dependent on the landscape of the task dynamics and the influence of inhe...

The topography of the environment alters the optimal search strategy for active particles.

In environments with scarce resources, adopting the right search strategy can make the difference between succeeding and failing, even between life and death. At different scales, this applies to molecular encounters in the cell cytoplasm, to animals looking for food or mates in natural landscapes, to rescuers during search and rescue operations in disaster zones, and to genetic computer algorithms exploring parameter spaces. When looking for sparse targets in a homogeneous environment, a combination of bal...

"Practice-related changes in eye movement strategy in healthy adults with simulated hemianopia".

The impact of visual field deficits such as hemianopia can be mitigated by eye movements that position the visual image within the intact visual field. Effective eye movement strategies are not observed in all patients, however, and it is not known whether persistent deficits are due to injury or to pre-existing individual differences. Here we examined whether repeated exposure to a search task with rewards for good performance would lead to better eye movement strategies in healthy individuals. Participant...

Formula: see text: Oblivious similarity based searching for encrypted data outsourced to an untrusted domain.

Public cloud storage services are becoming prevalent and myriad data sharing, archiving and collaborative services have emerged which harness the pay-as-you-go business model of public cloud. To ensure privacy and confidentiality often encrypted data is outsourced to such services, which further complicates the process of accessing relevant data by using search queries. Search over encrypted data schemes solve this problem by exploiting cryptographic primitives and secure indexing to identify outsourced dat...

The HMMER Web Server for Protein Sequence Similarity Search.

Protein sequence similarity search is one of the most commonly used bioinformatics methods for identifying evolutionarily related proteins. In general, sequences that are evolutionarily related share some degree of similarity, and sequence-search algorithms use this principle to identify homologs. The requirement for a fast and sensitive sequence search method led to the development of the HMMER software, which in the latest version (v3.1) uses a combination of sophisticated acceleration heuristics and math...

Optimal Length of Conformational Transition Region in Protein Search for Targets on DNA.

The starting point of many fundamental biological processes is associated with protein molecules finding and recognizing specific sites on DNA. However, despite a large number of experimental and theoretical studies on protein search for targets on DNA, many molecular aspects of underlying mechanisms are still not well understood. Experiments show that proteins bound to DNA can switch between slow recognition and fast search conformations. However, from a theoretical point of view, such conformational trans...

Understanding the Role of DNA Topology in Target Search Dynamics of Proteins.

A wide range of cellular processes initiates upon recognising and binding of proteins to specific DNA sites. Typically, the recognition process is incredibly fast owing to a complex mechanism that combines different 3D and 1D modes of translocation of the protein. While few studies performed on selected DNA topologies suggested that the DNA topology might alter the balance between these two modes and therefore the target search kinetics, its detail role in target search mechanism remains unclear. Here, we p...

Pre-stimulus pupil dilation and the preparatory control of attention.

Task preparation involves multiple component processes, including a general evaluative process that signals the need for adjustments in control, and the engagement of task-specific control settings. Here we examined the dynamics of these different mechanisms in preparing the attentional control system for visual search. We explored preparatory activity using pupil dilation, a well-established measure of task demands and effortful processing. In an initial exploratory experiment, participants were cued at th...

Bringing European physiologists together.

The modern science of physiology began in Europe. Deciding on exactly who the first physiologist was is not easy but excellent candidates include Claude Bernard and Carl Ludwig. The Nobel Prize in Physiology or Medicine was inaugurated in 1901 with the first award mentioning the word "physiology" being made to Ivan Pavlov (Russia) in 1904. This article is protected by copyright. All rights reserved.

Measuring Clinical Supervision; how beneficial is yours and how do you know?

The origins of latter day Clinical Supervision [CS] can be traced back to the pioneering charity work of European and North American social reformers of the eighteenth century [White & Winstanley 2014], since when the historical development has been variously interpreted in the contemporary international literature [Yegdich & Cushing 1998; Bernard 2006] This article is protected by copyright. All rights reserved.

Training Techniques for Visual Search in Complex Task Environments.

The goal for this study was to evaluate several visual search training techniques in an unmanned aerial vehicle (UAV) simulated task environment.

Intrinsic position uncertainty impairs overt search performance.

Uncertainty regarding the position of the search target is a fundamental component of visual search. However, due to perceptual limitations of the human visual system, this uncertainty can arise from intrinsic, as well as extrinsic, sources. The current study sought to characterize the role of intrinsic position uncertainty (IPU) in overt visual search and to determine whether it significantly limits human search performance. After completing a preliminary detection experiment to characterize sensitivity as...


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