PubMed Journals Articles About "Cerebral Spinal Fluid Dynamics Effect Hypoxia Implications High" RSS

04:39 EDT 22nd May 2019 | BioPortfolio

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Showing "Cerebral spinal fluid dynamics Effect hypoxia implications high" PubMed Articles 1–25 of 58,000+

Dysphagia in cerebral hypoxia.

Dysphagia is a frequent problem in various neurological disorders. However, knowledge on swallowing function in patients with cerebral hypoxia is sparse. The objective of this study is to report the development of swallowing function in a series of adolescent and young-adult patients with cerebral hypoxia.

Proteomic analysis and ATP assay reveal a positive effect of artificial cerebral spinal fluid perfusion following microdialysis sampling on repair of probe-induced brain damage.

Microdialysis (MD) is conventionally used to measure the in vivo levels of various substances and metabolites in extracellular and cerebrospinal fluid of brain. However, insertion of the MD probe and subsequent perfusion to obtain samples cause damage in the vicinity of the insertion site, raising questions regarding the validity of the measurements.

Spinal cord perfusion MR imaging implicates both ischemia and hypoxia in the pathogenesis of cervical spondylosis.

Although a number of studies have implicated ischemia and hypoxia in the pathogenesis of cervical spondylosis (CS), quantification remains difficult and the role of ischemia and hypoxia on disease progression and disease severity in human CS remains largely unknown. Therefore, the objective of this study was to assess spinal cord perfusion and oxygenation in human CS and examine the relationship between perfusion, degree of spinal cord compression, and neurological status.

High-glucose-induced Mitochondrial Dynamics Disorder of Spinal Cord Neurons in Diabetic Rats and Its Effect on Mitochondrial Spatial Distribution.

A randomized, double-blind, controlled trial.

Prophylactic effect and mechanism of p-coumaric acid against hypoxic cerebral edema in mice.

Our previous study found that the anti-hypoxia effect of Tibetan turnip (Brassica rapa ssp. rapa) is directly related to its p-Coumaric acid (CA) and glucoside (p-Coumaric acid-beta-D-glucopyranoside, CAG) contents. The present study aimed to investigate the role and mechanism of CA against hypoxic cerebral edema. Male mice were randomly divided into one normoxia group and three hypoxia groups, which were gavaged with sterilized water, CA, or dexamethasone, respectively, once daily for 4 days. The mice were...

Fluid dynamics in a full-scale flat sheet MBR, an experimental and numerical study.

Fluid dynamics is used for fouling mitigation in membrane bioreactors (MBRs), whereby a proper understanding of the fluid dynamics is of great interest. The influence of fluid dynamics has led to the use of computational fluid dynamics for optimizing MBR systems. In this work, a model has been validated for flat sheet membranes, with use of the Eulerian multiphase method. The model is validated against a comparable setup where the liquid velocities are measured with a laser Doppler anemometer (LDA). Further...

Detraining effect on overweight/obese women after high-intensity interval training in hypoxia.

Promising benefits on fat mass and biochemical components may be reported after applying programs of cyclic hypoxia and HIIT.

Development of High-Performance Soft Robotic Fish by Numerical Coupling Analysis.

To design a soft robotic fish with high performance by a biomimetic method, we are developing a soft robotic fish using piezoelectric fiber composite (PFC) as a flexible actuator. Compared with the conventional rigid robotic fish, the design and control of a soft robotic fish are difficult due to large deformation of flexible structure and complicated coupling dynamics with fluid. That is why the design and control method of soft robotic fish have not been established and they motivate us to make a further ...

The effect of aggregation and adsorption behavior on the flow resistance of surfactant fluid on smooth and rough surface: A many-body dissipative particle dynamics study.

In order to study the effect of surfactant on the resistance of wall-bound flow, the adsorption and aggregation behaviors of surfactant fluid on both smooth and groove-patterned rough surface are investigated through many-body dissipative particle dynamics (MDPD) simulation. The MDPD models of surfactants were carefully parameterized and have been validated to be able to simulate the aggregation and adsorption behavior of surfactants. The simulation results show that the surfactant in laminar flow can only ...

Glycosaminoglycans in human cerebrospinal fluid determined by LC-MS/MS MRM.

Glycosaminoglycans (GAGs) were recovered from human cerebral spinal fluid (CSF) and after their conversion to disaccharides using polysaccharide lyases were analyzed by liquid chromatography tandem mass spectrometry using multiple reaction monitoring. CSF showed ng/mL levels of heparan sulfate, chondroitin sulfates and hyaluronan. The amounts and disaccharide composition of these GAGs differed from those found in human plasma. This approach may offer a new method for the discovery of biomarkers for diseases...

UBC-nepal expedition: Phenotypical evidence for evolutionary adaptation in the control of cerebral blood flow and oxygen delivery at high altitude.

Sherpa have lived in the Nepal Himalaya for 25-40 thousand years and display positive physiological adaptations to hypoxia Sherpa have previously been demonstrated to suffer less negative cerebral side effects of ascent to extreme altitude, yet little is known as to whether or not they display differential regulation of oxygen delivery to the brain compared to lowland natives We demonstrate that Sherpa have lower brain blood flow during ascent to and acclimatization at high-altitude compared to lowlanders a...

The protective effect of zeranol in cerebral ischemia reperfusion via p-CREB overexpression.

Cerebral ischemia reperfusion (I/R) is a neurovascular disease leading to cerebral damage. It was found that postmenopausal women are liable to more dangerous effects than men at same age in stroke. The objective of this study is to investigate the neuroprotective effect of zeranol against cerebral ischemia reperfusion in ovariectomized rats.

Cerebral ischemic stroke: cellular fate and therapeutic opportunities.

In cerebral tissues, due to continuous and high metabolic demand, energy is produced exclusively by mitochondrial oxidative phosphorylation (OXPHOS). Obstruction of blood flow leads to cerebral ischemia, hypoxia and decreased cellular ATP production. The reactive oxygen species (ROS) generated as by-product of OXPHOS alter many intracellular signaling pathways and result in damaged cellular components. Under such hypoxic conditions, a key factor known as hypoxia inducible factor 1 (HIF1) is stabilized and a...

Computational fluid dynamics analysis of a carotid-ophthalmic aneurysm with concomitant ophthalmic artery infundibulum in a patient-specific model.

Although previous studies have reported cases of coexistence of carotid-ophthalmic aneurysm (COA) and ophthalmic artery (OA) infundibulum, the hemodynamic characteristics of this complicated structure and its damaging effect on vision remain to be elucidated. The aim of this study was to analyze this specific artery structure using computational fluid dynamics (CFD) techniques.

Compact Conjugated Polymer Dots with Covalently Incorporated Metalloporphyrin for Hypoxia Bioimaging.

Hypoxia is closely related to multiple diseases especially in tumors, which increased aggressiveness and drugs resistance of cancer cells. Precise hypoxia imaging is of great significance for cancer diagnosis and evaluation of therapeutic effect. A kind of hydrophobic polymer (PFPtTFPP) as hypoxia imaging probe with fluorene as energy donor and oxygen-sensitive Pt(II) porphyrin as energy acceptor was developed. Compact polymer dots (Pdots) were prepared by nanoprecipitation with small size. The PFPtTFPP Pdo...

Effect of magnesium-degradation products and hypoxia on the angiogenesis of human umbilical vein endothelial cells.

Biodegradable magnesium (Mg) metals have been applied in orthopaedic and stent applications due to their biodegradability, bioabsorbability and adaptability to tissue regeneration. However, further investigations are still needed to understand how angiogenesis will respond to high concentrations of Mg and oxygen content differences, which are vital to vascular remodelling and bone fracture regeneration or tissue healing. Human primary endothelial cells were exposed to various concentrations (2 to 8 mM) of e...

Ginkgolides B alleviates hypoxia-induced PC-12 cell injury by up-regulation of PLK1.

Finding novel agent for cerebral ischemia therapy is urgently required. In our present study, we aimed to investigate the regulatory mechanism of Ginkgolides B (GB) in hypoxia-injured PC-12 cells.

Stability analysis for a thermodynamically consistent model of relativistic fluid dynamics.

In relativistic fluid mechanics, positive entropy production is known to be insufficient for guaranteeing stability. Much stronger criteria for thermodynamic admissibility have become available in nonequilibrium thermodynamics. We here perform a linear stability analysis for a model of relativistic hydrodynamics that is based on the general equation for the nonequilibrium reversible-irreversible coupling (GENERIC) framework of nonequilibrium thermodynamics. Assuming a quadratic entropy function near equilib...

Effects of periodic carbohydrate ingestion on endurance and cognitive performances during a 40-km cycling time-trial under normobaric hypoxia in well-trained triathletes.

The purpose of this study was to examine CHO ingestion on a cognitive task using a field-simulated time-trial (TT) under hypoxia in well-trained triathletes. Ten male triathletes (age: 22.1 ± 1.1 years; VOmax: 59.4 ± 1.4 ml/kg/min) participated in this double-blind/crossover/counter-balanced design study. Participants completed 3 TT trials: 1) normoxic placebo (NPLA; FiO = 20.9%), 2) hypoxic placebo (HPLA; FiO = 16.3%), and 3) hypoxic CHO (HCHO; 6% CHO provided as 2 ml/kg/15 min; FiO = 16.3%). During the ...

Sustaining cerebral perfusion in intracranial atherosclerotic stenosis: The roles of antegrade residual flow and leptomeningeal collateral flow.

We aimed to investigate the roles of antegrade residual flow and leptomeningeal collateral flow in sustaining cerebral perfusion distal to an intracranial atherosclerotic stenosis (ICAS). Patients with apparently normal cerebral perfusion distal to a symptomatic middle cerebral artery (MCA)-M1 stenosis were enrolled. Computational fluid dynamics models were built based on CT angiography to obtain a translesional pressure ratio (PR) to gauge the residual antegrade flow. Leptomeningeal collaterals (LMCs) were...

Clinical relevance of preservation fluid contamination in solid organ transplantation: a call for mounting the evidence.

Literature concerning preservation fluid contamination in solid organ transplantation is limited. Incidence of contamination is probably high, however its clinical implications are not well established and rates of true infection are probably low. Preemptive therapy of positive preservation fluid cultures is controversial. In this issue of CMI, a large retrospective study by Yu et al. valuated 1002 preservation fluid samples from 517 renal donors for contamination. Incidence of contamination was 77.8% (402/...

Alert Timing and Corresponding Intervention with Intraoperative Spinal Cord Monitoring for High Risk Spinal Surgery.

Prospective multicenter study OBJECTIVE.: To analyze the incidence of intraoperative spinal neuromonitoring (IONM) alerts and neurological complications, as well as to determine which interventions are most effective at preventing postoperative neurological complications following IONM alerts in high risk spinal surgeries.

The Clinical Implications of Peripancreatic Fluid Collection After Distal Pancreatectomy.

Pancreatic fistula after distal pancreatectomy (DP) remains an unsolved problem, and postoperative CT imaging often demonstrates fluid collection (FC) around the pancreatic remnant. This study sought to clarify the clinical implications of FC.

Infectious causes and outcomes in patients presenting with cerebral spinal fluid pleocytosis.

To evaluate the infectious etiologies, clinical features, and outcomes of patients with CNS infections at a tertiary care center. Patients that present with a pleocytosis in the cerebral spinal fluid (CSF), defined as a CSF WBC count > 5 cells/mm, from July 2015 to June 2016 at a tertiary care hospital were analyzed for this report. Data from patients with confirmed (n = 43) and presumed (n = 51) CNS infections were analyzed. CNS infection was the leading known cause of CSF pleocytosis (n = 4...

Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain.

The aging brain is associated with atrophy along with functional and metabolic changes. In this study, we examined age-related changes in resting brain functions and the vulnerability of brain physiology to hypoxic exposure in humans in vivo. Brain functions were examined in 81 healthy humans (aged 18-62 years) by acquisitions of gray and white matter volumes, cerebral blood flow, cerebral oxygen consumption, and concentrations of lactate, N-acetylaspartate, and glutamate+glutamine using magnetic resonance ...

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