PubMed Journals Articles About "Choline Chloride Vitamin" RSS

04:48 EDT 19th October 2018 | BioPortfolio

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Showing "Choline Chloride Vitamin" PubMed Articles 1–25 of 1,900+

Janus-faced role of water in defining nanostructure of choline chloride/glycerol deep eutectic solvent.

Deep eutectic solvents (DESs) have emerged as a set of intrinsically "designer solvents" for many bio-applications such as DNA nanotechnology and biocatalysis. However, the high viscosity of DESs tends to prevent bioactive components from being incorporated into the solvent. Although dilution with water may effectively reduce the viscosity of DES, the effect of water on its cooperative hydrogen-bonding network has not been evaluated systematically. This study conducted a series of molecular dynamics simulat...

Characterization of bio-based plastic made from a mixture of Momordica charantia bioactive polysaccharide and choline chloride/glycerol based deep eutectic solvent.

Momordica charantia bioactive polysaccharide was used as an alternative source for the production of bio-based plastics (BPs) and choline chloride/glycerol based deep eutectic solvent (DES) was added as a plasticizer. In this study, seven BPs were prepared: MCBP without plasticizer (as a control), with glycerol (as a reference), and with DES in different choline chloride/glycerol molar ratio (i.e. C-G 1.5:1; 1:1, 1:1.5, 1:2, 1:3). Characterization based on the physical properties and bioactivities was then ...

Concentrations of Water-Soluble Forms of Choline in Human Milk from Lactating Women in Canada and Cambodia.

Choline has critical roles during periods of rapid growth and development, such as infancy. In human milk, choline is mostly present in water-soluble forms (free choline, phosphocholine, and glycerophosphocholine). It is thought that milk choline concentration is influenced by maternal choline intake, and the richest food sources for choline are of animal origin. Scarce information exists on milk choline from countries differing in animal-source food availability. In this secondary analysis of samples from ...

Oral vitamin Bversus intramuscular vitamin Bfor vitamin Bdeficiency.

Vitamin Bdeficiency is common, and the incidence increases with age. Most people with vitamin Bdeficiency are treated in primary care with intramuscular (IM) vitamin B. Doctors may not be prescribing oral vitamin Bformulations because they may be unaware of this option or have concerns regarding its effectiveness.

Variations in plasma choline and metabolite concentrations in healthy adults.

Plasma concentrations of choline and its metabolites might serve as biomarkers for the health outcomes of several pathological states such as cardiovascular disease and cancer. However, information about the reliability of biomarkers of choline status is limited. We investigated biological variations in repeated measures of choline and metabolites in healthy adults to assess them as biomarkers.

OPLS Force Field for Choline Chloride-Based Deep Eutectic Solvents.

Deep eutectic solvents (DES) are a class of solvents frequently composed of choline chloride and a neutral hydrogen bond donor (HBD) at ratios of 1:1, 1:2, or 1:3, respectively. As cost-effective and eco-friendly solvents, DESs have gained considerable popularity in multiple fields, including materials, separations, and nanotechnology. In the present work, a comprehensive set of transferable parameters have been fine-tuned to accurately reproduce bulk-phase physical properties and local intermolecular inter...

Label-free colorimetric sensor for sensitive detection of choline based on DNAzyme-choline oxidase coupling.

Changes in choline levels can be associated with diseases such as Alzheimer, Parkinson, Huntington, fatty liver, interstitial lung abnormalities, autism and so on. Therefore, quantitative determination of choline is important in biological and clinical analysis. So far, several methods have been investigated for measuring choline in the body fluids, each of which has disadvantages such as the need for specialist ability, complexity, and high cost. For this purpose, a facile and sensitive colorimetric biosen...

Dissolution and regeneration of wool keratin in the deep eutectic solvent of choline chloride-urea.

Wool keratin is a kind of renewable protein which has great potential in environment-friendly materials. In this paper, the dissolution of wool fiber and the regeneration of wool keratin in the deep eutectic solvent (DES) of choline chloride-urea was detailed studied. The results showed that 35.1 mg wool completely dissolved in 1 g DES at 130 °C in 5 h. The polarizing microscope, scanning electron microscope (SEM) images along with the amino acid analysis suggested that the DES mainly dissolved the...

Plasma Betaine Is Positively Associated with Developmental Outcomes in Healthy Toddlers at Age 2 Years Who Are Not Meeting the Recommended Adequate Intake for Dietary Choline.

Choline is an important nutrient during development. However, there are limited data on dietary choline intake and status in toddlers and the relation to neurodevelopmental outcomes.

Rickets/Osteomalacia. Treatment of vitamin D deficiency in adults.

Treatment of vitamin D deficiency in adults requires adequate diagnosis based on the rigorous definition of the disease. Recently, it has been reported that assessment criteria for vitamin D deficiency/insufficiency in Japan proposed by an expert panel. However, it is not yet certain whether supplementation of vitamin D as a nutrient to patients with diseases due to vitamin D deficiency per se is sufficient and appropriate if they are judged to be vitamin D deficient.

Rickets/Osteomalacia. Symptomatic vitamin D deficiency in children and its prevention and treatment.

Vitamin D deficiency rickets is characterized by mineralization impairment in bone and cartilage of children caused by vitamin D deficiency in the body due to limited sunlight exposure and vitamin D intake. Vitamin D supplementation is recommended in developed countries. Low calcium intake is a risk factor for vitamin D deficiency rickets. For treatment, native vitamin D is used in developed countries, while active vitamin D is used in Japan.

Atomistic Insights Into the Electrochemical Double Layer of Choline Chloride-Urea Deep Eutectic Solvent: A Clustered Interfacial Structuring.

Green, stable and wide electrochemical window deep eutectic solvents (DESs) are ideal candidates for electrochemical systems. However, despite several studies of their bulk properties, their structure and properties under electrified confinement are barely investigated, which hinders the widespread use of these solvents in electrochemical applications. In this letter, we explore the electrical double layer structure of 1:2 choline chloride-urea (Reline), with a particular focus on the electrosorption of the...

Effect of vitamin D supplementation on free and total vitamin D: a comparison of Asians vs Caucasians.

It is well established that UK Asians typically have lower vitamin D levels than Caucasians. It is also known that vitamin D binding protein (DBP) is lower in some races than Caucasians. To investigate how ethnicity, skin colour and genetic variation affect the response to vitamin D (150,000 IU) administered to young Asian and Caucasian men.

Nonscarring alopecia associated with vitamin D deficiency.

Vitamin D is well known for its role in bone health and immune regulation, playing a role in cell differentiation, proliferation, and apoptosis. Vitamin D deficiency also has been associated with various forms of nonscarring hair loss. We describe a notable case of nonscarring alopecia associated with only vitamin D deficiency in which vitamin D replacement therapy helped promote hair regrowth. We also discuss diagnosis, prevention, and treatment of vitamin D deficiency.

Choline Inhibits Ischemia-Reperfusion-Induced Cardiomyocyte Autophagy in Rat Myocardium by Activating Akt/mTOR Signaling.

Backgroud/Aims: Growing evidence suggests that both cardiomyocyte apoptosis and excessive autophagy exacerbates cardiac dysfunction during myocardial ischemia-reperfusion (IR). As a precursor of acetylcholine, choline has been found to protect the heart by repressing ischemic cardiomyocyte apoptosis. However, the relationship between choline and cardiomyocyte autophagy is unclear. The present study aimed to investigate whether autophagy was involved in the cardioprotection of choline during IR.

High-Dose Vitamin D: Without Benefit but Not Without Risk.

It is now 100 years since deficiency of vitamin D was identified as the cause of rickets and osteomalacia (see Figure). Since then, enormous amounts of work have been undertaken elucidating the synthesis and catabolism of vitamin D, the regulation of these processes, and the mechanisms of action of vitamin D metabolites on calcium and bone metabolism. The findings of the early studies, mainly in children, that vitamin D promotes the growth and mineralisation of the skeleton have been generalised to other co...

PEMT rs12325817 and PCYT1A rs7639752 polymorphisms are associated with betaine but not choline concentrations in pregnant women.

Maternal metabolism during gestation may depend on nutrient intake but also on polymorphism of genes encoding enzymes involved in metabolism of different nutrients. Data on choline or carnitine metabolism in pregnant women are scarce. We hypothesized that (1) choline intake in Polish pregnant women is inadequate and (2) choline and carnitine metabolism would differ by genotype and nutritional status of pregnant women. One hundred three healthy Polish women aged 18 to 44 years in the third trimester of pregn...

Additional value of integrated F-choline PET/4D contrast-enhanced CT in the localization of hyperfunctioning parathyroid glands and correlation with molecular profile.

The localization of hyperfunctioning parathyroid gland(s) (HPTG) in patients with primary hyperparathyroidism (PHPT) with negative or inconclusive first-line imaging is a significant challenge. This study aimed to evaluate the role of integrated F-choline PET/4D contrast-enhanced computed tomography (4DCeCT) in these patients, compare its detection rate and sensitivity with those of F-choline PET/CT and (4DCeCT), and analyse the association between choline metabolism and morphological, biochemical and molec...

Dietary vitamin D, vitamin D receptor, and microbiome.

The current review is to summarize the recent progress of vitamin D/vitamin D receptor (VDR) and microbiome in intestinal homeostasis, airway function, and other organs.

Feasibility and acceptability of maternal choline supplementation in heavy drinking pregnant women: A randomized, double-blind, placebo-controlled clinical trial.

Choline, an essential nutrient, serves as a methyl-group donor for DNA methylation and is a constituent of the neurotransmitter acetylcholine and a precursor to major components of cell membranes. Findings from animal studies suggest that choline supplementation during pregnancy may mitigate adverse effects of prenatal alcohol exposure on growth and neurocognitive function. We conducted a randomized, double-blind exploratory trial to examine feasibility and acceptability of a choline supplementation interve...

Implications of vitamin D toxicity & deficiency.

Vitamin D deficiency is an increasing problem affecting all ages. Patients should be assessed for risk factors as part of preventive health maintenance. Vitamin D toxicity is a rare occurrence caused by oversupplementation and errors in food fortification. The connection between vitamin D deficiency and osteoporosis, is well established. However, a cause and effect relationship has yet to be established between vitamin D deficiency and many chronic illnesses. An evidence-based approach is treating patients ...

C. elegans MRP-5 Exports Vitamin B12 from Mother to Offspring to Support Embryonic Development.

Vitamin B12 functions as a cofactor for methionine synthase to produce the anabolic methyl donor S-adenosylmethionine (SAM) and for methylmalonyl-CoA mutase to catabolize the short-chain fatty acid propionate. In the nematode Caenorhabditis elegans, maternally supplied vitamin B12 is required for the development of offspring. However, the mechanism for exporting vitamin B12 from the mother to the offspring is not yet known. Here, we use RNAi of more than 200 transporters with a vitamin B12-sensor transgene ...

The use of synthetic and natural vitamin D sources in pig diets to improve meat quality and vitamin D content.

This study investigated the effects of synthetic and natural sources of vitamin D biofortification in pig diets on pork vitamin D activity and pork quality. One hundred and twenty pigs (60 male, 60 female) were assigned to one of four dietary treatments for a 55 d feeding period. The dietary treatments were (1)50 μg vitamin D₃/kg of feed; (2)50 μg of 25-hydroxvitamin D₃/kg of feed (25-OH-D₃); (3)50 μg vitamin D₂/kg of feed; (4)50 μg vitamin D₂-enriched mushrooms/kg of feed (Mushroom ...

No improvement in vitamin D status in German infants and adolescents between 2009 and 2014 despite public recommendations to increase vitamin D intake in 2012.

Vitamin D is a key component for the growth and development of children and adolescents, influencing a multitude of functions. Worldwide epidemiological studies have shown that minimum vitamin D blood levels of ≥ 20.0 ng/ml, often defined as vitamin D sufficiency by international and national nutrition and pediatric organizations, are often not met in practice. In 2012 the D-A-CH (Germany, Austria, Switzerland) nutrition societies increased their vitamin D intake recommendations fourfold from 200 IU (...

Vitamin D C3-epimer levels are proportionally higher with oral vitamin D supplementation compared to ultraviolet irradiation of skin in mice but not humans.

A proportion of circulating 25-hydroxy vitamin D (25(OH)D) undergoes epimerization to form C3-epi 25(OH)D and C3-epi 1,25(OH)D. These epimers have less calcaemic activity than non-epimerized metabolites and are not differentiated by many immunoassays when reporting total 25(OH)D levels. This study aimed to compare the effect of exposure to ultraviolet radiation (UVR) and oral vitamin D supplementation on vitamin D C3-epimer levels. C57Bl/6 female mice were fed either vitamin D-sufficient (vitamin D 2000 IU/...

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