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PubMed Journals Articles About "Comparative Toxicity Nanoparticulate Ionic Copper Following Dietary Exposure" RSS

01:50 EST 20th January 2020 | BioPortfolio

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Showing "Comparative toxicity nanoparticulate ionic copper following dietary exposure" PubMed Articles 1–25 of 14,000+

Comparative toxicity of nanoparticulate and ionic copper following dietary exposure to common carp (Cyprinus carpio).

Copper is an essential element for the normal growth and survival of all organisms including fish. However, its excessive presence in the environment can cause bioaccumulation and aquatic toxicology. The aim of the present study was to compare the dietary toxicity effects of two different Cu compounds, copper oxide nanoparticles (CuO-NPs) and ionic copper (CuSO) in juvenile common carp, Cyprinus carpio. To prepare experimental diets, two nominal concentrations of 100 and 1000 mg Cu kg diet were added to a...


The potential exposure and hazards of copper nanoparticles: A review.

Copper is an essential element for metabolism in plants and animals. In its nanoform, copper has found various applications, thus increasing potential environmental exposure. Released nanoparticles in the environment undergo various transformation processes while bioaccumulation and toxicity of copper nanoparticles have been demonstrated in plants and animals. This toxicity is thought to be a combined effect of intracellular particles and the release of dissolved copper ions. Oxidative stress responses have...

Combined effects of waterborne copper exposure and salinity on enzymes related to osmoregulation and ammonia excretion by blue crab Callinectes sapidus.

Copper is essential, but can be toxic to aquatic organisms when present in high concentrations. In freshwater crustaceans, copper inhibits enzymes related to ionic and osmoregulation and to the ammonia efflux, that leads to Na imbalance and inhibition of ammonia excretion. In the animals inhabiting estuarine or seawater, mechanisms of copper toxicity is not clear, but had been described as disruption of ionregulation and metabolism. To clarify the mechanism of copper toxicity in crustaceans inhabiting varia...


Influence of dissolved organic carbon on the acute toxicity of copper and zinc to white sturgeon (Acipenser transmontanus) and a cladoceran (Ceriodaphnia dubia).

We conducted acute lethality tests with White Sturgeon (Acipenser transmontanus) and Ceriodaphnia dubia exposed to copper and zinc at DOC concentrations ranging from 0.5 to 5.5 mg/L. DOC had minimal effects on zinc toxicity, but DOC did have a protective effect on acute copper toxicity which was equal to that predicted by the copper BLM. BLM adjusted copper EC50s for A. transmontanus ranged from 2.4-8.2 mg/L. This article is protected by copyright. All rights reserved.

Dietary exposure to elements from the German pilot total diet study (TDS).

Dietary exposure of the German adult population to the elements aluminium, copper, mercury (and as methylmercury), manganese and lead were assessed using data from the first total diet study (TDS) in Germany. In this pilot TDS, performed 2014-2015, 246 food samples were purchased in the Berlin area, prepared 'as consumed', and subsequently analysed. Dietary exposure for the German adult population between 14 and 80 years of age was estimated by combining TDS data with individual consumption data from the Ge...

Toxicities of copper oxide nanomaterial and copper sulphate in early life stage zebrafish: Effects of pH and intermittent pulse exposure.

Effort has been made to standardise regulatory ecotoxicity tests for engineered nanomaterials (ENMs), but the environmental realism of altered water quality and/or pulse exposure to these pollutants should be considered. This study aimed to investigate the relative toxicity to early life-stage zebrafish of CuO ENMs at acid pH and then under pulse exposure conditions, all compared to CuSO. At all pH values, CuSO was more toxic to zebrafish than CuO ENMs. Additions of H were protective of CuSO toxicity, with ...

Waterborne and dietary accumulation of well-dispersible hematite nanoparticles by zebrafish at different life stages.

The widespread use of nanoparticles (NPs) has drawn considerable attention because of their potential toxicity and the environmental consequences thereof. However, the effects of the exposure route and life stage of an organism on the bioaccumulation and toxicity of NPs are largely unknown. In the present study, we investigated the accumulation kinetics (uptake, assimilation, and efflux) and tissue distribution of waterborne and dietary hematite NPs (HemNPs) during three life stages (embryo, larva, and adul...

Importance of Surface Coating on Accumulation Dynamics and Acute Toxicity of Copper Nanomaterials and Dissolved Copper to Daphnia magna.

In this study the effect of copper oxide nanomaterials (CuO NMs), uncoated and with three different surface coatings (i.e. carboxylated, pegylated and ammonia groups), was evaluated on acute toxicity and accumulation dynamics in Daphnia magna. Biosorption and elimination rate constants were determined for D. magna following waterborne exposure to dissolved copper and copper oxide NMs using biodynamic modeling. The relationship between modeled parameters and acute toxicity endpoints was evaluated to investig...

Toxicity of copper oxide nanoparticles: a review study.

Copper oxide nanoparticles (CuO NPs) use has exponentially increased in various applications (such as industrial catalyst, gas sensors, electronic materials, biomedicines, environmental remediation) due to their flexible properties, i.e. large surface area to volume ratio. These broad applications, however, have increased human exposure and thus the potential risk related to their short- and long-term toxicity. Their release in environment has drawn considerable attention which has become an eminent area of...

Preliminary study of cellular metal accumulation in two Antarctic marine microalgae - implications for mixture interactivity and dietary risk.

Localised sites in Antarctica are contaminated with mixtures of metals, yet the risk this contamination poses to the marine ecosystem is not well characterised. Recent research showed that two Antarctic marine microalgae have antagonistic responses to a mixture of five common metals (Koppel et al., 2018a). However, the metal accumulating potential and risk to secondary consumers through dietary exposure are still unknown. This study investigates cellular accumulation following exposure to a mixture of cadm...

Selenium-Rich Yeast Mitigates Aluminum-Mediated Testicular Toxicity by Blocking Oxidative Stress, Inhibiting NO Production, and Disturbing Ionic Homeostasis.

Aluminum (Al) poisoning has been linked to the development of several reproductive system dysfunctions. Dietary supplementation with selenium-rich yeast (SeY) has been shown to prevent a variety of pathologic conditions. In the present study, the potential protect role of SeY on Al-induced testicular toxicity was evaluated, and the possible underlying mechanisms were discussed. Mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 4 weeks. Histopathologic changes were observed in...

MXR response in sea anemones: Effect of temperature, salinity and copper.

Multixenobiotic resistance (MXR) phenotype is a cellular defense which can eliminate toxic substances from cells. Several studies describe the MXR activity after pollutant exposure, but little is known about the interference of abiotic factors in this mechanism. The present study aimed to evaluate MXR activity in sea anemones Bunodosoma cangicum after in vivo and in vitro exposures to different temperatures (15, 20 and 25 °C) and salinities (15, 30 and 45‰) associated or not with copper (0, 7.8 and 15....

Organoarsenicals in seafood: Occurrence, Dietary exposure, Toxicity and Risk Assessment Considerations - A Review.

Diet, especially seafood, is the main source of arsenic exposure for humans. Total arsenic content of a diet offers inadequate information for assessment of the toxicological consequences of arsenic intake, which has impeded progress in the establishment of regulatory limits for arsenic in food. Toxicity assessments are mainly based on inorganic arsenic, a well-characterized carcinogen, and arsenobetaine, the main organoarsenical in seafood. Scarcity of toxicity data for organoarsenicals, and the predominan...

Arsenic trioxide or/and copper sulfate co-exposure induce glandular stomach of chicken injury via destruction of the mitochondrial dynamics and activation of apoptosis as well as autophagy.

Arsenic and copper are naturally occurring element. Contamination from natural processes and anthropogenic activities can be discovered all over the world and their unique interactions with the environment lead to widespread toxicity. When the content was excessive, the organism would be hurt seriously. The glandular stomach is an important organ of the poultry gastrointestinal tract. This study was aimed to investigate the toxicity of arsenic trioxide or/and copper sulfate (As or/and Cu) on chicken glandul...

Comparative study on the effects of salinomycin, monensin and meso-2,3-dimercaptosuccinic acid on the concentrations of lead, calcium, copper, iron and zinc in lungs and heart in lead-exposed mice.

Environmental lead (Pb) exposure damages the lungs and is a risk factor for death from cardiovascular disease. Pb induces toxicity by a mechanism, which involves alteration of the essential elements homeostasis. In this study we compare the effects of salinomycin (Sal), monensin (Mon) and meso-2,3-dimercaptosuccinic acid (DMSA) on the concentrations of lead (Pb), calcium (Ca), copper (Cu), iron (Fe) and zinc (Zn) in the lungs and heart of lead-exposed mice.

The Activation of Heat-Shock Protein After Copper(II) and/or Arsenic(III)-Induced Imbalance of Homeostasis, Inflammatory Response in Chicken Rectum.

Arsenic and copper, two toxic pollutants, are powerful inducers of oxidative stress. Exposure to copper and arsenic can cause intestinal injury in cockerel. This study was carried out to investigate the effects of these two pollutants on the gastrointestinal tract of cockerels. Experimental results showed that the activity of antioxidant enzymes (catalase and glutathione peroxidase) was inhibited and the ionic balance was destroyed after exposure to copper sulfate (300 mg/kg) and/or arsenic trioxide (30 m...

Biomass of the Cyanobacterium Lyngbya wollei Alters Copper Algaecide Exposure and Risks to a Non-target Organism.

Nuisance algal infestations are increasing globally in distribution and frequency. Copper-based algaecides are routinely applied to control these infestations, though there is an ever-present concern of risks to non-target species. This research evaluated risks associated with a commonly applied chelated copper algaecide (Captain® XTR; SePRO Corporation) to a sentinel non-target species (Daphnia magna) and further assessed alteration of the exposure and toxicity when a nuisance mat-forming cyanobacterium, ...

Detoxification and reproductive system-related gene expression following exposure to Cu(OH) nanopesticide in water flea (Daphnia magna Straus 1820).

The extensive use of copper-based nanopesticides in agriculture has led to their release into the aquatic environment and causes a potential risk to aquatic biota. However, there is a lack of knowledge regarding the possible toxic effect of these nanopesticides on non-target aquatic organisms including invertebrates. Therefore, in this study, effects of commonly used copper-based nanopesticide "Kocide 3000" on gene expression related to detoxification (cyp360a8, gst, P-gp, and hr96) and reproductive system ...

The Effects of Natural Suspended Solids on Copper Toxicity to the Cardinal Tetra in Amazonian River Waters.

The aim of the present study was to characterize the effects of particles on metal aquatic toxicity in a tropical system. To this end, we investigated the effects of natural suspended solids on copper geochemistry and acute toxicity to the cardinal tetra (Paracheirodon axelrodi), in two Amazonian rivers with different total suspended solids (TSS) levels: the Rio Negro (low TSS ~ 8 mg L ) and the Rio Solimões (high TSS ~ 70 mg L ). The effect of particles on Cu aqueous geochemistry was assessed by measuring...

Amelioration of Cd-induced bioaccumulation, oxidative stress and intestinal microbiota by Bacillus cereus in Carassius auratus gibelio.

The heavy metal cadmium (Cd) is a hazardous pollutant known to exert various toxic effects and other sublethal to lethal effects on aquatic organisms, and can be commonly found in environment. The genus Bacillus was one of dominant probiotics, which was commonly used in aquaculture. The aim of this study was to evaluate the effects of dietary administration of Bacillus cereus (B. cereus) on bioaccumulation, oxidative stress and intestinal microbiota of Carassius auratus gibelio (C. gibelio) after Cd expos...

Dietary exposure to furan of the Austrian population.

In the period from 2007 to 2017 furan levels of foods were analysed by the Austrian Agency for Health and Food Safety. Based on these analytical data and the Austrian consumption data the dietary exposure of children and adults to furan was estimated by using a deterministic approach. For the adult population the mean and 95 percentile dietary exposures to furan were estimated at 0.31 µg/kg bodyweight per day and at 0.72 µg/kg bodyweight per day, respectively. The mean dietary exposure of children was e...

Dietary determinants of inorganic arsenic exposure in the Strong Heart Family Study.

Chronic exposure to inorganic arsenic (iAs) in the US occurs mainly through drinking water and diet. Although American Indian (AI) populations have elevated urinary arsenic concentrations compared to the general US population, dietary sources of arsenic exposure in AI populations are not well characterized.

Influence of 96h sub-lethal copper exposure on aerobic scope and recovery from exhaustive exercise in killifish (Fundulus heteroclitus).

Production of industrial effluents have led to increased copper (Cu) pollution of aquatic ecosystems, impacting the physiology of aquatic vertebrates. Past work has shown that Cu exerts its toxicity by disruption ion regulation and/ or increasing oxidative stress. However, it remains unclear how Cu may influence aerobic metabolism and hypoxia tolerance, two possible targets of its toxicity. To address this issue, we exposed freshwater acclimated killifish (F. heteroclitus) to a 96 h Cu exposure at a targe...

Ionic liquid-based water treatment technologies for organic pollutants: Current status and future prospects of ionic liquid mediated technologies.

Water scarcity motivated the scientific researcher to develop efficient technologies for the wastewater treatment for its reuse. Ionic liquids have been applied to many industrial and analytical separation processes, but their applications in the wastewater treatment, especially in the removal of organic pollutants, are still not well explored. Potential applications of ionic liquids include solvent extraction, solvent membrane technologies and ionic liquid-modified materials that are mainly used as adsorbe...

Intraocular Deposition of Copper and ERG Findings in a Patient With Progressive Vision Loss From Hypercupremia.

A 46-year-old woman who presented for progressive glare was found to have dense deposition of copper within Descemet's membrane and lens capsule in both eyes (OU). Systemic workup revealed elevated serum copper secondary to multiple myeloma. Following bilateral Descemet stripping automated endothelial keratoplasty and cataract extraction, a green discoloration of the vitreous was noted. The patient was followed for 3 years with serial exams and electroretinograms. Electroretinograms showed declining photopi...


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