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PubMed Journals Articles About "Configuration Polyhedra Truncated Tetrahedron Cuboctahedron Truncated Octahedron" RSS

04:47 EDT 19th May 2019 | BioPortfolio

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Showing "Configuration polyhedra Truncated Tetrahedron Cuboctahedron Truncated Octahedron" PubMed Articles 1–25 of 1,000+

Configuration of DNA polyhedra of Truncated Tetrahedron, Cuboctahedron, Truncated Octahedron.

The synthesis of DNA polyhedra has attracted more interest because of their wide application prospect, but their formation mechanism from mathematical viewpoint remains poorly understood. This paper presents the assembly process and mechanism of DNA truncated tetrahedron, cuboctahedron and truncated octahedron by the means of mathematics and computer program. Firstly, based on the assumption that the total number of all the crossings within each face of a DNA polyhedron must be an even number, potential typ...


Investigation of shutter scan acquisition parameters in a prototype chest digital tomosynthesis system.

A shutter scan acquisition (SSA) method is proposed to reduce patient exposure dose in a chest digital tomosynthesis system. Projections obtained using the SSA constitute a combination of truncated and non-truncated projections. The truncated projections are images in which the lung field is set within a region-of-interest (ROI), and the non-truncated projections are full images in which the ROI is not set at all. We proposed a shutter weighting factor (SWF) as an acquisition parameter for SSA. We call the ...

Restoration of F508-del Function by Transcomplementation: The Partners Meet in the Endoplasmic Reticulum.

Because of the small size of adeno-associated virus, AAV, the cystic fibrosis conductance regulator, CFTR, cDNA is too large to fit within AAV and must be truncated. We report here on two truncated versions of CFTR, which, when inserted into AAV1 and used to infect airway cells, rescue F508-del CFTR via transcomplementation. The purpose of this study is to shed light on where in the cell transcomplementation occurs and how it results in close association between the endogenous F508-del and truncated CFTR.


TMEM173 Alternative Spliced Isoforms Modulate Viral Replication through the STING Pathway.

The innate immune system provides a primary line of defense against pathogens. Stimulator of IFN genes (STING), encoded by the TMEM173 gene, is a critical protein involved in IFN-β induction in response to infection by different pathogens. In this study, we describe the expression of three different alternative-spliced human (h) TMEM173 mRNAs producing STING truncated isoforms 1, 2, and 3 in addition to the full-length wild-type (wt) hSTING. All of the truncated isoforms lack exon 7 and share the N-termina...

Fluorometric determination of lipopolysaccharides via changes of the graphene oxide-enhanced fluorescence polarization caused by truncated aptamers.

A broad-spectrum ssDNA aptamer containing 80 nucleotides (LA80) and capable of binding to four different sources of lipopolysaccharides (LPSs) was truncated. Two strategies are used to produce truncated aptamers of different length. The results show that LA27, a 27-nt aptamer, retained broad-spectrum capability and has a higher affinity (K = 46.2 ± 9.5 nM). A graphene oxide based fluorescence polarization assay (excitation/emission wavelengths: 485/520 nm) was worked out using FAM-labeled LA27. I...

Author Correction: Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis.

This Article contains an error in the last sentence of the 'Variant analysis suggests they are pathogenic' section of the Results, which incorrectly reads 'No truncated PIEZO1 protein products were identified in western blot analysis in GLD1:II.3 and GLD2:II.2 (Fig. 2, Supplementary Fig. 6), suggesting that the truncated protein is not stable and therefore degraded.' This should read 'No full-size PIEZO1 protein products were identified in western blot analysis in GLD1:II.3 and GLD2:II.2 (Fig. 2, Supplement...

Bimetallic Pt-Pd nano-catalyst: size, shape and composition matter.

The goal of this work is to understand how the phase diagram of the platinum-palladium (Pt-Pd) alloy changes with size and shape and how it correlates with catalytic properties. By using nano-thermodynamics, the size and shape effects on the phase diagram of Pt-Pd nanoparticles were determined theoretically. The phase diagram of some nanoparticles (sphere, tetrahedron, octahedron, decahedron, cube, cuboctahedron and rhombic dodecahedron) exhibits a congruent melting point that becomes more and more pronounc...

Trimetallic PtPdNi-Truncated Octahedral Nanocages with a Well-Defined Mesoporous Surface for Enhanced Oxygen Reduction Electrocatalysis.

Engineering the architectures and compositions of noble metal-based nanocrystals is an effective strategy to optimize their catalytic performance. Herein, we report the synthesis of unique trimetallic PtPdNi mesoporous-truncated octahedral nanocages (PtPdNi MTONs), which is simply performed by first constructing Pd@PtPdNi core-shell mesoporous truncated octahedra (Pd@PtPdNi MTOs) and further selective etching of the Pd cores using concentrated nitric acid. The rational combinations of polyhedral shape, meso...

NiO/NiCo2O4 Truncated Nanocages with PdO Catalyst Functionalization as Sensing Layers for Acetone Detection.

Achieving a novel structural construction and adopting appropriate catalyst materials are key to overcoming inherent limitations of gas sensors in terms of designing sensing layers. This work introduces NiO/NiCo2O4 truncated nanocages functionalized with PdO nanoparticles, which were proved to possess the ability of the effective acetone detection. The device realized an enhanced acetone-sensing sensitivity, together with excellent selectivity and long-term stability. The sensing performance is far better t...

Using a proxy state to improve the accuracy of truncated hyperpolarizability calculations.

We present a simple algorithm for defining a single proxy state that accounts for state truncation in the sum-over-states calculations of the dispersion of the molecular hyperpolarizabilities. The transition strengths between the proxy state and the truncated set of states are determined using the Thomas-Reiche-Kuhn sum rules further constrained by the zero-frequency linear polarizability. This proxy state method can augment experimentally determined parameters or finite-state theories to allow for a more a...

Truncated titanium/semiconductor cones for wide-band solar absorbers.

A truncated Ti and Si cones metasurface has been proposed for wide-band solar absorber (WSA), which produced a high average absorption of 94.7% in the spectral region from 500 nm to 4000 nm. A maximal enhancement factor of 166.0% was achieved by the WSA in comparison with the absorption of Ti/Si cylinder resonators based absorber. Under the standard solar radiance, a high full-spectrum solar absorption efficiency of 96.1% was obtained for the WSA in the energy range from 0.28 eV to 4.0 eV. The spectral band...

Systematic truncating of aptamers to create high-performance graphene oxide (GO)-based aptasensors for the multiplex detection of mycotoxins.

Graphene oxide (GO)-based aptasensors are currently one of the most popular sensing platforms for the simple and rapid detection of various targets. Unfortunately, the GO-based aptasensors with long aptamer strands typically show unsatisfactory performance resulting from insignificant structural transformations upon target binding. We report herein the utilization of an aptamer-truncating strategy to combat such a challenge. Taking a pre-selected anti-aflatoxin B1 (AFB1) aptamer (P-AFB1-50) as a trial syste...

Accurate Vibrational Cofiguration Interaction Calculations on Diborane and Its Isotopologues.

The fundamental vibrational modes of BH, BD, BH, and BD have been obtained from vibrational configuration interaction calculations including up to 6-tuple excitations. An n-mode expansion of the underlying potential energy surface obtained from explicitly correlated coupled cluster theory was truncated after the 4-mode coupling terms, which were found to be very important for these particular systems. All molecules are strongly affected by Fermi resonances, which are discussed in detail. The final results a...

Experimental Insights into the Growth of Single Truncated Anatase Bipyramids.

Fluorine has been recognized to selectively stabilize anatase titanium dioxide (TiO₂) crystal facets, however, resolving its physical location at the nanometer scale remains empirically elusive. Here, we provide direct experimental evidence to reveal the spatial distribution of fluorine on single truncated anatase bipyramids (TABs) using nanoscale secondary ion mass spectrometry (NanoSIMS). Fluorine was found to preferentially adsorb on the (001) facet compared to the (101) facet of TABs. Moreover, NanoSI...

N-Terminal Truncated Aβ4 - 42 Is a Substrate for Neprilysin Degradation in vitro and in vivo.

In sporadic Alzheimer's disease (AD), an imbalance between production and clearance of amyloid-β (Aβ) peptides seems to account for enhanced Aβ accumulation. The metalloprotease neprilysin (NEP) is an important Aβ degrading enzyme as shown by a variety of in vitro and in vivo studies. While the degradation of full-length Aβ peptides such as Aβ1 - 40 and Aβ1 - 42 is well established, it is less clear whether NEP is also capable of degrading N-terminally truncated Aβ species such as the common va...

Validation of normalized truncated navicular height as a clinical assessment measure of static foot posture to determine flatfoot in children and adolescents: A cross sectional study.

Reliability of clinical measures of static foot posture has been widely debated. However, validity of these measures has not been fully established especially in a pediatric population. The purpose of the study was to investigate reliability and validity of normalized truncated navicular height (NTNH) in assessment of static foot posture to determine flatfoot in children and adolescents using radiographic measures as a criterion gold standard measure.

Correction of diffusion calculations when using two types of non-rectangular simulation boxes in molecular simulations.

Although simulation boxes used in molecular dynamics are normally chosen to be cubic or rectangular, two other cell shapes that are very familiar to crystallographers-the truncated octahedron and the rhombic dodecahedron-could also be used because they are also space-filling cells. Due to their spherical nature, these boxes have been intentionally applied in simulations of biomolecular solutions and liquid structures. Indeed, due to the advantages of running many molecular dynamic codes in parallel, simulat...

C-terminal truncation exacerbates the aggregation and cytotoxicity of α-Synuclein: A vicious cycle in Parkinson's disease.

Parkinson's disease (PD) is a common neurodegenerative disease which usually associates with neuroinflammation. The main pathological characteristics of PD are dopaminergic neurons death and the presence of Lewy bodies which are composed of aggregated α-synuclein (α-Syn). Truncated forms of α-Syn are found in the brain of PD patients, and account for 10-30% of total synuclein in Lewy bodies. Caspase-1, which plays an important role in neuroinflammation, cleaves full-length α-Syn (α-Syn FL) to generate ...

Discovery of Potent, Selective and Short-Acting Peptidic V Receptor Agonists.

The vasopressin analogue desmopressin (dDAVP, 1) is a potent V receptor agonist approved in many countries for the treatment of diabetes insipidus, primary nocturnal enuresis, nocturia, and coagulation disorders. Since 1 is primarily excreted via the kidneys, an age-related decline in kidney function leads to slower elimination, prolonged antidiuresis and hyponatremia. In search of novel, potent, selective and short-acting peptidic VR agonists, we synthesized a series of C-terminally truncated analogues of ...

Role of truncated oxidized phospholipids in acute endothelial barrier dysfunction caused by particulate matter.

Particulate matter (PM) air pollution is a global environmental health problem contributing to more severe lung inflammation and injury. However, the molecular and cellular mechanisms of PM-induced exacerbation of lung barrier dysfunction and injury are not well understood. In the current study, we tested a hypothesis that PM exacerbates vascular barrier dysfunction via ROS-induced generation of truncated oxidized phospholipids (Tr-OxPLs). Treatment of human pulmonary endothelial cells with PM caused endoth...

Production and Characterization of Monoclonal and Polyclonal Antibodies Against Truncated Recombinant DKK-1 as a Candidate Biomarker.

Cooperation of helix insertion and lateral pressure to remodel membranes.

Nature has developed different protein mediated mechanisms to remodel cellular membranes. One of the proteins that is implicated in these processes is α-synuclein (αS). Here we investigate if besides αS's membrane bound amphipathic helix the disordered, solvent exposed tail of the protein contributes to membrane reshaping. We produced αS variants with elongated or truncated disordered solvent exposed domains. We observe a transformation of opaque multi lamellar vesicle solutions into non-scattering solu...

Down-selecting circumsporozoite protein-based malaria vaccine: a comparison of malaria sporozoite challenge model.

Plasmodium falciparum circumsporozoite protein (PfCSP) is the main target antigen in development of pre-erythrocytic malaria vaccines. To evaluate PfCSP vaccines in animal models, challenge by intravenous sporozoite injection is preferentially used. However, in clinical trials, vaccinated human volunteers are exposed to the bites of malaria-infected mosquitoes. In this study, we down-selected Escherichia coli-produced full-length PfCSP (PfCSP-F), and its three truncated PfCSPs based on their abilities to el...

Cytoplasmic R-peptide of murine leukemia virus envelope protein negatively regulates its interaction with the cell surface receptor.

Cytoplasmic tails of envelope (Env) glycoproteins of many retroviruses inhibit their membrane fusion activity. The cytoplasmic 16-amino acid peptide of ecotropic murine leukemia virus (E-MLV) Env protein, called the R-peptide, also inhibits the membrane fusion activity of the Env protein. However, the molecular mechanism of the inhibition has not been elucidated yet. In this study, we found that R-peptide-containing Env protein of E-MLV binds to the cell surface receptor cationic amino acid transporter-1 (C...

Fluorescent Recognition of 4-Amino-2,6-dinitrotoluene by a Cerium-Based Metal-Organic Tetrahedron.

A cerium-based metal-organic tetrahedron has been developed as a highly selective and sensitive fluorescence sensor for the recognition of 4-amino-2,6-dinitrotoluene (4-ADNT). The redox-active tetrahedron could encapsulate 4-ADNT through weak interaction and spatial stereoselectivity, resulting in an enhanced fluorescence. The tetrahedral sensor Ce-ZPS is capable of realizing fluorescent sensing in urine and in cells and thus has the potential to detect 4-ADNT in organisms.


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