PubMed Journals Articles About "Connor House" RSS

15:32 EDT 19th October 2018 | BioPortfolio

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Showing "Connor House" PubMed Articles 1–25 of 396

Teaching medicine with the help of "Dr. House".

TV series such as "House MD", "Grey´s Anatomy" or "Emergency Room" are well perceived by medical students. Seminars featuring medical TV series such as "House MD" might serve as door-opener to attract medical students to learn more about rare diseases. The TV series "House MD" is troublesome for the main character Dr. House is an excellent diagnostician but at the same time a rather misanthropic person. Therefore, lecturing medicine with the help of "House MD" requires constant evaluation. From 2008 to 201...

Reconciling information and reliability in scaling local measurement precision: A comment on O'Connor (2017).

O'Connor (2017) illustrates the importance of accurately characterizing how measurement precision impacts effect size inference. As he demonstrates, attenuation of correlations can be much greater than traditional predictions based on classical test theory, due to fluctuating measurement error and other considerations. In his paper, however, O'Connor attempts to rescale information in terms of a local or conditional reliability. Although this is intuitively appealing and useful in certain respects, it can a...

Affordable house designs to improve health in rural Africa: a field study from northeastern Tanzania.

The population of sub-Saharan Africa is currently estimated to be 1245 million and is expected to quadruple by the end of the century, necessitating the building of millions of homes. Malaria remains a substantial problem in this region and efforts to minimise transmission should be considered in future house planning. We studied how building elements, which have been successfully employed in southeast Asia to prevent mosquitos from entering and cooling the house, could be integrated in a more sustainable h...

Case Study: Developing an In-House Magnetic Resonance Imaging Maintenance Program.

In 2015, the Children's Hospital of Eastern Ontario (CHEO) developed an in-house magnetic resonance imaging service team. Within two years, the team achieved substantial savings in operational costs, generated new revenue, improved uptime and response time, and improved customer satisfaction within the hospital. Through careful planning and collaboration, the Clinical Engineering Department at CHEO was able to bring imaging services in house successfully, demonstrating improvements over historical original ...

Host subspecific viral strains in European house mice: Murine cytomegalovirus in the Eastern (Mus musculus musculus) and Western house mouse (Mus musculus domesticus).

Murine cytomegalovirus (MCMV) has been reported from house mice (Mus musculus) worldwide, but only recently from Eastern house mice (M. m. musculus), of particular interest because they form a semi-permeable species barrier in Europe with Western house mice, M. m. domesticus. Here we report genome sequences of EastMCMV (from Eastern mice), and set these in the context of MCMV genomes from genus Mus hosts. We show EastMCMV and WestMCMV are genetically distinct. Phylogeny splitting analyses show a genome wide...

The Insecticide Resistance Allele kdr-his has a Fitness Cost in the Absence of Insecticide Exposure.

House flies, Musca domestica L. (Diptera: Muscidae), are major pests at animal production facilities. Insecticides, particularly pyrethroids, have been used for control of house fly populations for more than 30 yr, but the evolution of resistance will likely jeopardize fly control efforts. A major mechanism of pyrethroid resistance in the house fly is target site insensitivity (due to mutations in the Voltage-sensitive sodium channel [Vssc]). Based on a survey of house fly populations in 2007 and 2008, the ...

An improved in-house lysis-filtration protocol for bacterial identification from positive blood culture bottles with high identification rates by MALDI-TOF MS.

Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is now a well-established method for identification of microorganisms from positive blood cultures. Pretreatments to effectively remove non-bacterial proteins are a prerequisite for successful identification, and a variety of protocols have been reported. Although commercially available kits, mainly the Sepsityper Kit, are increasingly used, the identification rates reported often are not satisfactory, particularly f...

White House Report on Drug Prices Is a Detailed Road Map: Price-Lowering Ideas Generated, Some Already in Motion.

White House report on drug prices is a detailed road map.

Intradermal immunotherapy with low-dose house dust mite allergens in patients with allergic rhinitis: A proof-of-concept study.

High-dose aqueous subcutaneous immunotherapy is a validated and effective administration route for house dust mite and pollen allergens.

Identifying and Treating Opioid Side Effects: The Development of Methylnaltrexone.

Methylnaltrexone Reverses Chronic Opioid-induced Constipation: A Randomized, Controlled Trial. By Yuan CS, Foss JF, O'Connor M, Osinski J, Karrison T, Moss J, Roizen MF. JAMA 2000; 283:367-72. Reprinted with permission.

Chemical mixtures isolated from house dust disrupt thyroid receptor β (TRβ) signaling.

House dust is a source of exposure to chemicals that can impact hormone regulation. This study was designed to evaluate the potential of house dust mixtures (n=137) to disrupt thyroid hormone nuclear receptor signaling in a cell-based reporter assay and examine associations with thyroid hormones (TH) measured in residents of the homes. Approximately 41% of the extracts (ranging from 10.5 -4.097 g of dust/mL) significantly antagonized TRβ signaling by 20-67% relative to the hormone control. The concentra...

Malaria vector abundance is associated with house structures in Baringo County, Kenya.

Malaria, a major cause of morbidity and mortality, is the most prevalent vector borne disease in Baringo County; a region which has varied house designs in arid and semi-arid areas. This study investigated the association between house structures and indoor-malaria vector abundance in Baringo County. The density of malaria vectors in houses with open eaves was higher than that for houses with closed eaves. Grass thatched roof houses had higher density of malaria vectors than corrugated iron sheet roofs. Sim...

Inhalation of House Dust and Ozone Alters Systemic Levels of Endothelial Progenitor Cells, Oxidative Stress, and Inflammation in Elderly Subjects.

Ambient air pollution including ozone and especially particulate matter represents important causes of cardiovascular disease. However, there is limited knowledge on indoor air dust with respect to this risk and the potential interactions between dust and ozone. Here, we exposed 23 healthy elderly subjects for 5.5 h, to either clean air, house dust at 275 µg/m3 (diameter < 2.5 µm), ozone at 100 ppb or combined house dust and ozone in a double-blinded randomized cross-over study. The combined house dust an...

Mixed bacterial responses to dust exposure in an A549 eukaryotic co-culture.

Recent studies evaluated the impact of dust exposure on pure and mixed cultures of Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, and Pseudomonas aeruginosa, revealing increased biofilm formation and altered sensitivities to HO. In this study, we examined the impact of lead (Pb), house, road, and combined dust on K. pneumoniae and P. aeruginosa in pure, mixed, or eukaryotic co-culture with human alveolar basal epithelial (A549) cells. Although no impact on pure or mixed culture growth was o...

Exploratory behavior is linked to stress physiology and social network centrality in free-living house finches (Haemorhous mexicanus).

Animal personality has been linked to individual variation in both stress physiology and social behaviors, but few studies have simultaneously examined covariation between personality traits, stress hormone levels, and behaviors in free-living animals. We investigated relationships between exploratory behavior (one aspect of animal personality), stress physiology, and social and foraging behaviors in wild house finches (Haemorhous mexicanus). We conducted novel environment assays after collecting samples of...

Exposures Related to House Dust Microbiota in a U.S. Farming Population.

Environmental factors can influence the house dust microbiota, which may impact health outcomes. Little is known about how farming exposures impact the indoor microbiota.

The Allergen Der p3 from House Dust Mite Stimulates Store-Operated Ca Channels and Mast Cell Migration through PAR4 Receptors.

The house dust mite is the principal source of perennial aeroallergens in man. How these allergens activate innate and adaptive immunity is unclear, and therefore, there are no therapies targeting mite allergens. Here, we show that house dust mite extract activates store-operated Ca channels, a common signaling module in numerous cell types in the lung. Activation of channel pore-forming Orai1 subunits by mite extract requires gating by STIM1 proteins. Although mite extract stimulates both protease-activate...

SQ house dust mite sublingual immunotherapy tablet subgroup efficacy and local application site reaction duration.

Allergic rhinitis with or without conjunctivitis (AR/C) is common, necessitating evaluation of SQ house dust mite (HDM) sublingual immunotherapy (SLIT)-tablet efficacy in various subgroups.

Underestimation of house dust mite-specific IgE with extract-based ImmunoCAPs compared to molecular ImmunoCAPs.

We identified 6 house dust mite (HDM) allergen molecules to comprising the majority of HDM IgE-binding components and show that molecular ImmunoCAPs based on these six allergens are superior to allergen extract-based ImmunoCAPs for quantifying HDM-specific IgE.

Efficacy of house dust mite sublingual tablet in the treatment of allergic rhinoconjunctivitis: A randomized trial in a pediatric population.

The efficacy and safety of 300 index of reactivity (IR) tablets of house dust mite (HDM) allergen extracts in Japanese pediatric (5-16 years old) patients with allergic rhinitis (AR) were assessed in a double-blind, randomized, placebo-controlled study (JAPIC CTI-152981).

How clean is your house? A study of house dust mites, allergens and other contents of dust samples collected from households.

Household dust contains an array of constituents, including house dust mites (HDM) and the HDM allergen, Der p 1, which can cause sensitivities such as asthma and eczema. Vacuuming can help alleviate symptoms, yet little is understood about cleaning behaviour in different households. This pilot study investigated the contents of dust from four household types (students; over 65 s; and families with and without pets). This was then related to cleaning behaviours and perceptions of cleanliness. Our investiga...

Cerium dioxide nanoparticles exacerbate house dust mite induced type II airway inflammation.

Nanomaterial inhalation represents a potential hazard for respiratory conditions such as asthma. Cerium dioxide nanoparticles (CeONPs) have the ability to modify disease outcome but have not been investigated for their effect on models of asthma and inflammatory lung disease. The aim of this study was to examine the impact of CeONPs in a house dust mite (HDM) induced murine model of asthma.

Preliminary comparison of an in-house real-time PCR with the automated BD Max Enteric Parasite Panel for the detection of Giardia intestinalis.

Giardia intestinalis is a parasite that commonly causes diarrheal disease throughout the world. An accurate and rapid diagnosis is essential to reduce the infection. Classically, diagnosis of giardiasis is performed by microscopic examination of stool samples, but in the recent years many DNA-based methods have been developed. In this preliminary observational study we compared the results of the commercial BD Max Enteric Parasite Panel (EPP) with an in-house real-time PCR for Giardia intestinalis. The stud...

Occurrence of polybrominated diphenyl ethers in floor and elevated surface house dust from Shanghai, China.

House dust is the main source of human exposure to flame retardants by ingestion. This study investigated the occurrence of polybrominated diphenyl ethers (PBDEs) in indoor dust from 22 houses in Shanghai, China. House dust was separately collected from the floor and elevated furnishings surface (mostly between 0.5 and 2 m height) for comparison. The concentrations of ∑ PBDEs ranged from 19.4 to 3280 ng/g (with a geometric mean of 203 ng/g) and from 55.1 to 792 ng/g (with a geometric mean of 166 ng/g...

Role of House Dust Mite-Derived Extracellular Vesicles in a Murine Model of Airway Inflammation.

House dust mite (HDM) is the major source of indoor allergens that cause airway disease. Recent evidence suggests that Gram-negative/positive bacteria produce nano-sized extracellular vesicles (EVs) containing diverse components, including various immunostimulatory molecules. However, the association between bacteria-derived EVs and development of airway disease is unclear.

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