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PubMed Journals Articles About "Correction Biosynthesis Production Quercitols Their Application Production Pharmaceuticals" RSS

15:54 EDT 25th March 2019 | BioPortfolio

Correction Biosynthesis Production Quercitols Their Application Production Pharmaceuticals PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Correction Biosynthesis Production Quercitols Their Application Production Pharmaceuticals articles that have been published worldwide.

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Showing "Correction Biosynthesis production quercitols their application production pharmaceuticals" PubMed Articles 1–25 of 17,000+

Correction to: Biosynthesis and production of quercitols and their application in the production of pharmaceuticals: current status and prospects.

The published online version contains mistake in the chemical structure of scyllo-inosose in Fig. 5 and Fig. 7. The correct configuration of 1-hydroxyl group in scyllo-inosose should have been the same to myo-inositol.


The raise of Brettanomyces yeast species for beer production.

The adequate application of Brettanomyces species could raise a potential opportunity for the beer industry, generating new products and optimizing production processes. Several valuable properties like high ethanol yield, tolerance to low pH and production of unique flavors have brought this yeast species into the spotlight. Aroma and flavor production of Brettanomyces in beer is currently under discussion, and it can be adjusted if the mechanism insights are understood. This review summarizes the recent f...

Efficient biosynthesis of 3, 4-dihydroxyphenylacetic acid in Escherichia coli.

3, 4-Dihydroxyphenylacetic acid (3, 4-DHPA) is a phenolic acid with strong anti-oxidative activity, showing potential applications in food and pharmaceutical industries. In this study, a 3, 4-DHPA biosynthetic pathway was designed by connecting 4-hydroxyphenylacetic acid (4-HPA) biosynthesis with its hydroxylation. The starting strain produced only 46 mg/L of 4-HPA in 48 h. Enhancing the shikimate pathway increased the titer by 19-fold to 923 ± 57 mg/L. Furthermore, pykA and pykF were disrupted t...


Biosynthesis of resveratrol and piceatannol in engineered microbial strains: achievements and perspectives.

Resveratrol (3,5,4'-trihydroxystilbene) and piceatannol (3,5,3',4'-tetrahydroxystilbene) are well-known natural products that are produced by plants. They are important ingredients in pharmaceutical industries and nutritional supplements. They display a wide spectrum of biological activity. Thus, the needs for these compounds are increasing. The natural products have been found in diverse plants, mostly such as grapes, passion fruit, white tea, berries, and many more. The extraction of these products from p...

A linear pathway for mevalonate production supports growth of Thermococcus kodakarensis.

The sole unifying feature of Archaea is the use of isoprenoid-based glycerol lipid ethers to compose cellular membranes. The branched hydrocarbon tails of archaeal lipids are synthesized via the polymerization of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), but many questions still surround the pathway(s) that result in production of IPP and DMAPP in archaeal species. Isotopic-labeling strategies argue for multiple biological routes for production of mevalonate, but biochemical and b...

Landomycin biosynthesis and its regulation in Streptomyces.

This mini-review is centered on genetic aspects of biosynthesis of landomycins (La), a family of angucycline polyketides. From the very discovery in the 1990s, La were noted for unusual structure and potent anticancer properties. La are produced by a few actinobacteria that belong to genus Streptomyces. Biochemical logic behind the production of La aglycon and glycoside halves and effects of La on mammalian cells have been thoroughly reviewed in 2009-2012. Yet, the genetic diversity of La biosynthetic gene ...

Enhanced exopolysaccharide production by Cordyceps militaris using repeated batch cultivation.

Cordyceps militaris exo-polysaccharides (EPS) have been reported to possess many benefits, such as anti-tumor, anti-inflammatory and antioxidant activities. In this study, the production of EPS via cultivation in a bioreactor was investigated. Glucose and yeast extract were determined to be the most suitable carbon and nitrogen sources for EPS production. The appropriate levels of glucose and yeast extract were 40 g/L and 10 g/L, respectively, resulting in EPS production of 1.686 g/L in a submerged cultu...

Analysis of the L-malate biosynthesis pathway involved in poly(β-L-malic acid) production in Aureobasidium melanogenum GXZ-6 by addition of metabolic intermediates and inhibitors.

Poly(β-L-malic acid) (PMA) is a promising polyester formed from L-malate in microbial cells. Malate biosynthesis is crucial for PMA production. Previous studies have shown that the non-oxidative pathway or oxidative pathway (TCA cycle) is the main biosynthetic pathway of malate in most of PMAproducing strains, while the glyoxylate cycle is only a supplementary pathway. In this study, we investigated the effect of exogenous metabolic intermediates and inhibitors of the malate biosynthetic pathway on PMA pro...

Synergistic Roles of Biphasic Ethylene and Hydrogen Peroxide in Wound-Induced Vessel Occlusions and Essential Oil Accumulation in .

The heartwood of (), named "Jiang Xiang" in traditional Chinese medicine, is highly valuable. Mechanical wounding induced the production of "Jiang Xiang" in Ethylene and hydrogen peroxide (HO) are proposed to play vital roles in wound signaling. However, little is known about the role of ethylene or HO in the wound-induced formation of vessel occlusions and biosynthesis of "Jiang Xiang" in . In this study, the pruning of saplings resulted in the synergistic biosynthesis of biphasic ethylene and HO, which...

Production of pyruvic acid from glycerol by Yarrowia lipolytica.

The aim of the study was to screen Yarrowia lipolytica strains for keto acid production and determine optimal conditions for pyruvic acid biosynthesis from glycerol by the best producer. The analyzed parameters were thiamine concentration, medium pH, stirring speed, and substrate concentration. The screening was performed in flask cultures, whereas pyruvic acid production was carried out in 5-L stirred-tank reactor with 2 L of working volume. In total, 24 Y. lipolytica strains were compared for their abili...

E2β Stimulates Ovine Uterine Artery Endothelial Cell H2S Production in vitro by ER-dependent Upregulation of CBS and CTH Expression.

Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger synthesized from L-cysteine by cystathionine β-synthase (CBS) and cystathionine γ-lyase (CTH). Estrogens are potent vasodilators that stimulate H2S biosynthesis in uterine arteries (UA) in vivo; however, the underlying mechanisms are unknown. We hypothesized that estrogens stimulate H2S biosynthesis in UA endothelial cells (UAEC) via specific estrogen receptor (ER)-dependent mechanisms. In cultured primary UAEC, t...

Enhancement of acid re-assimilation and biosolvent production in Clostridium saccharoperbutylacetonicum through metabolic engineering for efficient biofuel production from lignocellulosic biomass.

In the clostridial acetone-butanol-ethanol (ABE) fermentation, the intermediate acetate and butyrate are re-assimilated for solvent production. Here, key genes in ABE pathways in Clostridium saccharoperbutylacetonicum N1-4 were overexpressed to enhance acid re-assimilation and solvent production. With the overexpression of sol operon, acid re-assimilation was enhanced, and ABE production was increased by 20%, with ethanol production increased by six times but almost no increase in butanol production. To fur...

Development of Aurantiochytrium limacinum SR21 cultivation using salt-rich waste feedstock for docosahexaenoic acid production and application of natural colourant in food product.

Microalgae biorefinery is presently receiving a lot of attention as driven by its production of high value-added products. In this study, an oleaginous microalga Aurantiochytrium limacinum SR21 was cultured for docosahexaenoic acid (DHA) production using 20% (w/v) of KHPO-waste feedstock to replace 0.005% (w/v) of KHPO in the flask culture. DHA is an essential nutrient for human's brain functionalities. Collectively, the KHPO-waste feedstock with working concentration of 0.005% (w/v) in the cultivation prom...

A bZIP transcription factor, CaLMF, mediated light-regulated camptothecin biosynthesis in Camptotheca acuminata.

Camptothecin (CPT) has powerful biological activities and its analogs, irinothecan and topothecan, are effective anti-cancer drugs for clinical therapy. Camptothecin was first isolated from Camptotheca acuminata and its low accumulation in planta limits drug supply in the market. Previous works have confirmed that many environmental factors and plant hormones/elicitors could regulate CPT biosynthesis, but only light irradiance has a negative effect on CPT production in C. acuminata. Although light irradianc...

Increased Glucosinolate Production in Brassica oleracea var. italica Cell Cultures Due to Coronatine Activated Genes Involved in Glucosinolate Biosynthesis.

In this work, the effect of different elicitors and culture conditions on the production of glucosinolates in broccoli cell cultures was studied. The results showed that 0.5 μM coronatine was the best elicitor for increasing glucosinolate production (205-fold increase over untreated cells after 72 h of treatment). Furthermore, the expression levels of some genes related to the biosynthetic pathway of glucosinolates as well as three Myb transcription factors also have been studied. The highest glucosinolate...

Automated radiosynthesis of 5-Cl-glutamine, an important tracer for glutamine utilization.

The natural amino acid l-Glutamine (Gln) is essential for both cell growth and proliferation. In addition to glucose, cancer cells utilize Gln as a carbon source for ATP production, biosynthesis, and as a defense against reactive oxygen species. The utilization of [C]Gln has been previously reported as a biomarker for tissues with an elevated demand for Gln, however, the previous reports for the preparation of [C]Gln were found to be lacking several crucial aspects necessary for transition to human producti...

Xylose as preferred substrate for sarcosine production by recombinant Corynebacterium glutamicum.

The aim of this work was to study the fermentative production of the N-methylated amino acid sarcosine by C. glutamicum. Characterization of the imine reductase DpkA from Pseudomonas putida revealed that it catalyses N-methylamination of glyoxylate to sarcosine. Heterologous expression of dpkA in a C. glutamicum strain engineered for glyoxylate overproduction enabled fermentative production of sarcosine from sugars and monomethylamine. Glucose-based fermentation reached sarcosine production titers of 2.4 ...

Development of sugarcane resource for efficient fermentation of exopolysaccharide by using a novel strain of Kosakonia cowanii LT-1.

This work focuses on the development of non-food fermentation for the cost-effective biosynthesis of exopolysaccharide (EPS) by using a new strain of Kosakonia cowanii LT-1. This novel strain more efficiently utilizes sucrose for EPS production than other glycosyl donors. Comparative transcriptomic analysis is used to understand EPS synthesis promotion and the effects of sucrose on EPS biosynthesis. We speculate that ATP-binding cassette transporter, phosphotransferase, and two-component systems may be the ...

Identification of a novel cytochrome P450 enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories.

C-2α hydroxylated triterpenoids are a large class of plant secondary metabolites. These compounds, such as maslinic, corosolic and alphitolic acid, have important biological activities against HIV, cancer and diabetes. However, the biosynthesis pathways of these compounds have not been completely elucidated. Specifically, the cytochrome P450 (CYP) enzyme responsible for C-2α hydroxylation was unknown. In this study, a novel CYP enzyme that catalyzes C-2α hydroxylation was identified in Crataegus pinnatif...

Aging deficits in naturalistic speech production and monitoring revealed through reading aloud.

The current study investigated how aging affects production and self-correction of errors in connected speech elicited via a read aloud task. Thirty-five cognitively healthy older and 56 younger participants read aloud 6 paragraphs in each of three conditions increasing in difficulty: (a) normal, (b) nouns-swapped (in which nouns were shuffled across pairs of sentences in each paragraph), and (c) exchange (in which adjacent words in every two sentences were reversed in order). Reading times and errors incre...

Simultaneously enhanced biopolymers production and sludge dewaterability of waste activated sludge by synergetic integration process of short-time aerobic digestion with cocoamidopropyl betaine and calcium oxide.

Waste activated sludge (WAS) has seriously threatened the environment safety and the public health due to its rapid growth and complex components. Simultaneously enhanced the biopolymers production and the sludge dewaterability of WAS were investigated by synergetic integration process of the short-time aerobic digestion (STAD) with cocoamidopropyl betaine (CAPB) and calcium oxide (CaO). STAD could improve the biopolymers production by biosynthesis. CAPB could further significantly enhance the biopolymers p...

Co-production of 1,2,4-butantriol and ethanol from lignocellulose hydrolysates.

The aim of this work was to realize 1,2,4-butantriol (BT) production from sugarcane bagasse hydrolysates by microbial fermentation, and obtain co-production of BT and ethanol. Candida glycerinogenes UG21 was utilized to reduce the effect of osmolality resulting from high glucose concentration and furfural in hydrolysates on cell growth of BT-producing strains, and produced 54.1 g/L ethanol from glucose. After ethanol recovering, xylose containing stillage was obtained and used for BT production. 1.3 g/L...

Hydrogen peroxide burst triggers accumulation of jasmonates and salicylic acid inducing sesquiterpene biosynthesis in wounded Aquilaria sinesis.

Agarwood, a non-timber fragrant wood, is produced in wounded Aquilaria trees and widely used in perfume, incense, and medicine. Sesquiterpene is one of its main active compounds. It has been demonstrated that hydrogen peroxide (HO) plays a role in promoting agarwood sesquiterpene biosynthesis, but little is known about its signaling pathway. In this study, the pruning of actively growing saplings of A. sinensis resulted in an HO burst and the accumulation of jasmonic acid (JA), salicylic acid (SA), and ethy...

Improvement of kojic acid production in Aspergillus oryzae AR-47 mutant strain by combined mutagenesis.

Kojic acid is a kind of secondary metabolites, whose biosynthesis pathway remains unclear to date. It is produced industrially by microbial fermentation, and thus, mutagenesis breeding still plays a vital role for obtaining strains with high kojic acid production. The starting strain KA-11 isolated from mildewed fruits was identified as Aspergillus oryzae and then subjected to a combined mutagenesis program including microwave mutagenesis, UV irradiation, heat-LiCl, atmospheric, and room temperature plasma ...

MilR2, a novel TetR family regulator involved in 5-oxomilbemycin A3/A4 biosynthesis in Streptomyces hygroscopicus.

Milbemycins produced by several Streptomyces species are a group of 16-membered macrolides with potent insecticidal and anthelminthic activity. Milbemycin A3/A4, the main components of the milbemycins biosynthetic pathway, and 5-oxomilbemycin A3/A4, the analogs of milbemycin A3/A4 without the reduction of the C-5 keto group, have been developed as acaricides, insecticides, and anthelmintics. However, so far, little is known about the regulation of milbemycins biosynthesis, which has greatly hampered the gen...


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