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PubMed Journals Articles About "Critical Illness" RSS

21:38 EST 19th January 2020 | BioPortfolio

Critical Illness PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Critical Illness articles that have been published worldwide.

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Showing "Critical Illness" PubMed Articles 1–25 of 8,900+

Exploration of muscle loss and metabolic state during prolonged critical illness: Implications for intervention?

Muscle wasting in the critically ill is up to 2% per day and delays patient recovery and rehabilitation. It is linked to inflammation, organ failure and severity of illness. The aims of this study were to understand the relationship between muscle depth loss, and nutritional and inflammatory markers during prolonged critical illness. Secondly, to identify when during critical illness catabolism might decrease, such that targeted nutritional strategies may logically be initiated.


Red blood cell distribution width provides additional prognostic value beyond severity scores in adult critical illness.

The prognostic value of red blood cell distribution width (RDW) in critical illness remains controversial. The aim of this study was to investigate the prognostic value of on-admission RDW for in-hospital and 4-year mortality in adults with critical illness.

Activation of pituitary axis according to underlying critical illness and its effect on outcome.

Critical illness is a life threatening condition inducing a severe acute physical stress. The aim of the study was to investigate the activation of pituitary axis early after ICU admission in patients with critical illnesses of different etiology and its association with outcome.


Association of Organ Dysfunction Scores and Functional Outcomes Following Pediatric Critical Illness.

Short-term and long-term morbidity and mortality are common following pediatric critical illness. Severe organ dysfunction is associated with significant in-hospital mortality in critically ill children; however, the performance of pediatric organ dysfunction scores as predictors of functional outcomes after critical illness has not been previously assessed.

Outcomes Six-Months After 100% or 70% of Enteral Calorie Requirements During Critical Illness (TARGET): A Randomized Controlled Trial.

The long-term effects of delivering approximately 100% of recommended calorie intake via the enteral route during critical illness compared to a lesser amount of calories are unknown.

Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness.

Although early survival from sepsis has improved with timely resuscitation and source control, survivors frequently experience persistent inflammation and develop chronic critical illness. We examined whether increased copy number of endogenous alarmins, mitochondrial DNA, and nuclear DNA are associated with the early "genomic storm" in blood leukocytes and the development of chronic critical illness in hospitalized patients with surgical sepsis.

A qualitative multicase study of the trajectories of prolonged critical illness: Patient, family, and healthcare professionals' experiences.

Contemporary intensive care enables many critically ill patients to survive their initial illness; however, a small group of patients require a protracted stay in the intensive care unit (ICU), experiencing many complications throughout their illness. It is only when we understand the total illness experience from patients' and families' perspectives, as well as the complexity of care for healthcare professionals, that we can fully engage in developing services and promoting evidence-based practice to impro...

Anterior pituitary function in critical illness.

Critical illness is hallmarked by major changes in all hypothalamic-pituitary-peripheral hormonal axes. Extensive animal and human studies have identified a biphasic pattern in circulating pituitary and peripheral hormone levels throughout critical illness. In the acute phase of critical illness, following a deleterious event, rapid neuroendocrine changes try to direct the human body towards a catabolic state to ensure provision of elementary energy sources, whereas costly anabolic processes are postponed. ...

Metabolic aspects of muscle wasting during critical illness.

Skeletal muscle wasting during critical illness is the result of disturbed metabolism. No proven effective interventions targeting skeletal muscle mass and function during critical illness currently exist. This review summarizes recent advances regarding the complexity of metabolic factors involved and the challenge of establishing the clinical effects of metabolic interventions targeting the muscle.

Investigating Swallowing and Tracheostomy Following Critical Illness: A Scoping Review.

Tracheostomy and dysphagia often coexist during critical illness; however, given the patient's medical complexity, understanding the evidence to optimize swallowing assessment and intervention is challenging. The objective of this scoping review is to describe and explore the literature surrounding swallowing and tracheostomy in the acute care setting.

Patient-Centered Outcomes in Critical Illness: Will My Patient Be Functionally and Cognitively Intact?

Survival in the intensive care unit (ICU) has steadily increased over the past several decades; millions of patients now survive a critical illness every year. ICU survivors are at a significantly increased risk of impairments in physical function, cognitive function, and mental health. These patient-centered outcomes are among the most meaningful to patients. Landmark studies concerning treatment preferences have demonstrated that patients value functional and cognitive outcomes over mortality. In this cha...

Healthcare trajectories before and after critical illness: population-based insight on diverse patients clusters.

The post intensive care syndrome (PICS) gathers various disabilities, associated with a substantial healthcare use. However, patients' comorbidities and active medical conditions prior to intensive care unit (ICU) admission may partly drive healthcare use after ICU discharge. To better understand retative contribution of critical illness and PICS-compared to pre-existing comorbidities-as potential determinant of post-critical illness healthcare use, we conducted a population-based evaluation of patients' he...

Patient characteristics, ICU-specific supports, complications, and outcomes of persistent critical illness.

The primary objective was to identify the proportion of patients on mechanical ventilation (MV) beyond day 10, the recently defined time of onset of Persistent Critical Illness (PerCI). The secondary objective was to identify underlying diagnoses, intensive care unit (ICU) based therapies, relevant complications, and outcomes of patients with PerCI.

Liquid Biopsies and Critical Illness Insurance: Uncomfortable Bedfellows?

Liquid biopsies hold great promise for the diagnosis and treatment of cancer. Earlier recognition of recurrent and metastatic disease and better treatment choices based on liquid biopsies seem achievable in the near future. However, earlier cancer diagnosis, the most heralded application, will remain the most challenging. The impact of liquid biopsies on life insurance will be positive. The impact on critical illness insurance will be more nuanced. It will depend on 2 factors: the success of liquid biopsies...

Health Insurance and Disparities in Mortality among Older Survivors of Critical Illness: A Population Study.

The 1.5 million Medicare beneficiaries who survive intensive care each year have a high post-hospitalization mortality rate. We aimed to determine whether mortality after critical illness is higher for Medicare beneficiaries with Medicaid compared with those with commercial insurance.

Impact of paediatric critical illness and injury on families: An updated systematic review.

paediatric ICUs (PICU) that have adopted family-centered care models welcome families to the critically ill child's bedside to partner with clinicians in decision-making and the provision of care. The aim of this review was to synthesize the evidence on the impact of critical illness and injury on families of children admitted to the PICU to identify research needs in paediatric critical care.

If I die young: Reflections on the social determinants of critical illness.

Serial Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 and the Prognosis for Acute Kidney Injury over the Course of Critical Illness.

Over the course of critical illness, there is a risk of acute kidney injury (AKI), and when it occurs, it is associated with increased length of stay, morbidity, and mortality. The urinary cell-cycle arrest markers tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) have been utilized to predict the risk of AKI over the next 12 h from the time of sampling. The aim of this analysis was to evaluate the utility of [TIMP-2] × [IGFBP7] measured serially to ...

Is slower advancement of enteral feeding superior to aggressive full feeding regimens in the early phase of critical illness.

An excessive caloric intake during the acute phase of critical illness is associated with adverse effects, presumably related to overfeeding, inhibition of autophagy and refeeding syndrome. The purpose of this review is to summarize recently published clinical evidence in this area.

Sex Disparities and Functional Outcomes after Critical Illness.

Liver injury and failure in critical illness.

The frequency of acquired liver injury and failure in critical illness has been significantly increasing over the last decades. Currently, liver injury and failure are observed in up to twenty percent of patients at the intensive care unit and are associated with significantly increased morbidity and mortality. Secondary forms of liver injury in critical illness are mainly divided in cholestatic, hypoxic or mixed forms. Therefore, key for a better understanding of clinical manifestations, prognostic implica...

Traumatic Stress After Critical Illness, Could a Hippocratic Approach Limit the Reverberations of an ICU Stay?

Muscle wasting associated co-morbidities, rather than sarcopenia are risk factors for hospital mortality in critical illness.

Low skeletal muscle mass on intensive care unit admission is related to increased mortality. It is however unknown whether this association is influenced by co-morbidities that are associated with skeletal muscle loss. The aim of this study was to investigate whether sarcopenia is an independent risk factor for hospital mortality in critical illness in the presence of co-morbidities associated with muscle wasting.

Pro-resolving lipid mediators in sepsis and critical illness.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection that remains a huge clinical challenge. Recent evidence indicates that bioactive lipid mediators derived from polyunsaturated fatty acids termed specialized pro-resolving mediators (SPMs) are promising new candidates for treating critical illness.

Contemporary Review in Critical Care Medicine:Mitochondria and Critical Illness.

Classically, mitochondria have largely been thought to influence the development of illness by modulating cell metabolism and determining the rate of production of high energy phosphate compounds (e.g. ATP). It is now recognized that this is a simplistic view and that mitochondria play key roles in many other processes, including cell signaling, regulating gene expression, modulating cellular calcium levels and influencing the activation of cell death pathways (e.g. caspase activation). Moreover, these mult...


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