PubMed Journals Articles About "Diseasemodifying Drugs" RSS

19:35 EST 13th December 2018 | BioPortfolio

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Showing "Diseasemodifying drugs" PubMed Articles 1–25 of 5,200+

Anti-retroviral drugs: current state and development in the next decade.

The pace of discovery of new antiretroviral (ARV) drugs has slowed, although the efficacy and safety of once-daily fixed dose combinations have been extensively investigated. Several traditional ARV drugs remain in phase III clinical trials. This review summarizes current information on ARV drugs in phase III clinical trials and focuses on the development of ARV drugs in the next decade.

Repurposing old drugs in oncology: Opportunities with clinical and regulatory challenges ahead.

In order to expedite the availability of drugs to treat cancers in a cost-effective manner, repurposing of old drugs for oncological indications is gathering momentum. Revolutionary advances in pharmacology and genomics have demonstrated many old drugs to have activity at novel antioncogenic pharmacological targets. We decided to investigate whether prospective studies support the promises of nonclinical and retrospective clinical studies on repurposing three old drugs, namely metformin, valproate and astem...

Overdosing of benzodiazepines/Z-drugs and falls in older adults: Costs for the health system.

Benzodiazepines and Z drugs (BZD/Z drugs) are commonly used for the treatment of insomnia and anxiety in older adults for long periods of time. Given the physiological and metabolic characteristics of this group of patients, they are more prone to the adverse effects of these drugs which include falls. The recommendations for use of BZD/Z drugs include the need to adjust the dose and select those with a short half-life, to avoid adverse events, which as well as potentially affecting patient outcome, increas...

Mental and Physical Health Correlates of Discrimination Against People Who Inject Drugs: A Systematic Review.

The perception that people who use illicit drugs are deviant has contributed to the stigmatization of this population. The primary aim of this review is to examine the links among injection-related discrimination, mental health, physical health, and quality of life in people who inject drugs. We also identify settings, perpetrators of discrimination, and coping strategies developed by people who inject drugs to deal with the issue.

Molecular dynamics simulation as a tool for assessment of drug binding property of human serum albumin.

Human serum albumin (HSA) is a major plasma protein and binding of drugs with this plasma protein has a great importance. It possess esterase activity which can cleave the drugs containing ester bond and thus, can regulate the effect of drugs. Till date no systematic study has been done to analyse binding of such drugs and to compare the results with the drugs which do not have ester bond. Therefore, in the present study two different categories-ester and non-ester drugs have been considered to analyse thei...

Weighing of evidence by health technology assessment bodies: retrospective study of reimbursement recommendations for conditionally approved drugs.

This study assessed whether five health technology assessment (HTA) bodies in Europe were more negative about drugs with a conditional marketing authorisation (CMA) that are approved without controlled studies compared to CMA drugs that are approved based on controlled studies. HTA recommendations were categorized into positive, restricted and negative. A total of 92 HTA recommendations were available for 27 drugs. 30/62 (48%) and 17/30 (57%) of recommendations were negative for drugs with and without contr...

Exploring what shapes injection and non-injection among a sample of marginalized people who use drugs.

Few studies have specifically explored what influences people who use drugs to consume them in certain ways (i.e., smoking, injecting). While a great deal of research has examined the transition from non-injection to injection routes of drug administration, less is known about people who use drugs (PWUD) but have never injected or have stopped injecting. This paper draws on actor-network theory to explore what moves people to inject or not, among both people who currently smoke/sniff drugs (PWSD) and people...

Patent term restoration for top-selling drugs in the USA.

Patents temporarily protect brand-name drugs from generic competition, but some of the 20-year patent term is used up before marketing approval. To compensate for patent life lost to clinical testing and regulatory review, current law provides patent term restoration (PTR) of up to 5 years. Examining 170 top-selling drugs approved between 2000 and 2012, we found that 49% (83 drugs) received a PTR extension (median extension: 2.75 years) yielding a median total exclusivity period of 13.75 years, compared wit...

Table: safety of drugs for IBD in pregnancy.

Table: drugs for Crohn's disease.

Table: drugs for ulcerative colitis.

Drugs for inflammatory bowel disease.

Comparison table: some FDA-approved drugs for weight management.

Diet, drugs, devices, and surgery for weight management.

Comparison table: some drugs for inflammatory bowel disease.

In utero exposure to antiepileptic drugs is associated with learning disabilities among offspring.

In utero exposure to antiepileptic drugs has previously been associated with adverse outcome among offspring, but evidence on longer term milestone development remains limited. We investigated the association between in utero exposure to antiepileptic drugs and learning disabilities in the first year of compulsory education among offspring and assessed which antiepileptic drugs carried the highest risk.

The Texture of Psychoactive Illicit Drugs in Iran: Adulteration with Lead and other Active Pharmaceutical Ingredients.

Psychoactive illicit drugs are widely used all over the world. Due to the high demand for illicit drugs, adulteration of substances with poisonous and active pharmaceutical ingredients is a common phenomenon in some countries. Lead and other active pharmaceutical ingredients are among adulterants added to illicit drugs intentionally. In the present study, we analyzed four major abused street drugs in Iran's drug black market (opium, Iranian crack, ecstasy tablets, and crystal methamphetamine) to assess acti...

Drugs for rheumatoid arthritis.

Measurements and correlations in solution-state for charge transfer products caused from the 1:2 complexation of TCNE acceptor with several important drugs.

In our previous work, we highlighted the thermodynamic and spectroscopic characteristics of the 1:1 charge transfer (CT) complexation of TCNE acceptor with various medically important drugs. Continuing that work, we further examine drugs that react with the TCNE acceptor via a 1:2 interaction. The examined drugs are atenolol, quinidine, cimetidine, reserpine, and levofloxacin. We aimed through this study to: i) make the spectrophotometric and thermodynamic data of the examined drugs, both initially and when...

Optimization of cloned enzyme donor immunoassay cut-offs for drugs of abuse in whole blood of drivers involved in road accidents.

Immunoassay (IA) tests should be able to detect low concentrations of illegal drugs when used for the screening of drugs in drivers. False negatives should be avoided, and false positives should be reduced as far as possible. In this study, semi-quantitative results for blood samples containing illicit drugs (cannabinoids, cocaine, amphetamines/methamphetamines, opiates and methadone) obtained with cloned enzyme donor immunoassay (CEDIA), were compared with results of confirmatory analysis performed through...

Repurposing available drugs for neurodevelopmental disorders: The fragile X experience.

Many available drugs have been repurposed as treatments for neurodevelopmental disorders. In the specific case of fragile X syndrome, many clinical trials of available drugs have been conducted with the goal of disease modification. In some cases, detailed understanding of basic disease mechanisms has guided the choice of drugs for clinical trials, and several notable successes in fragile X clinical trials have led to common use of drugs such as minocycline in routine medical practice. Newer technologies li...

Two new drugs for glaucoma.

Subjectivity and autonomy: meanings and narratives with respect to discontinuing psychiatric drugs.

The objective of this work was to reconstruct the meanings and narratives surrounding the process of discontinuing psychiatric drugs, taking into account the strategies used to abandon these drugs and the processes of construction of identity. In 2015, in-depth semi-structured interviews were conducted individually with five people from Santiago, Chile who had experiences of psychiatric diagnosis, who received treatment with psychiatric drugs during eight o more years, and who discontinued the use of psychi...

A biological, fluorescence and computational examination of synthetic coumarin derivatives with antithrombotic potential.

Scientists still look for new drugs, which have anticoagulant properties. This is so important because existing anticoagulant drugs give many side effects, for example major bleeding. In this study we examined nine coumarin derivatives - candidates to be future antithrombotic drugs, which were synthetized and crystallized in our previous paper.

A multifactorial critical appraisal of substances found in drug facilitated sexual assault cases.

Drug-facilitated sexual assault (DFSA) is a sexual act in which the victim is unable to give or rescind consent due to intoxication with alcohol and/or drugs that have been self-administered (opportunistic DFSA) or covertly administered by the perpetrator (predatory DFSA). The drugs that are most commonly associated with DFSA are flunitrazepam and gamma-hydroxybutyric acid (GHB). They cause sedation and amnesia, are readily dissolved in beverages and are rapidly eliminated from the system. However, drugs su...

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