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PubMed Journals Articles About "Drug Development Technology" RSS

00:35 EDT 22nd October 2017 | BioPortfolio

Drug Development Technology PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Drug Development Technology articles that have been published worldwide.

More Information about "Drug Development Technology" on BioPortfolio

We have published hundreds of Drug Development Technology news stories on BioPortfolio along with dozens of Drug Development Technology Clinical Trials and PubMed Articles about Drug Development Technology for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Drug Development Technology Companies in our database. You can also find out about relevant Drug Development Technology Drugs and Medications on this site too.

Showing "Drug Development Technology" PubMed Articles 1–25 of 28,000+

Drug development for breast, colorectal, and non-small cell lung cancers from 1979 to 2014.

Understanding the drug development pathway is critical for streamlining the development of effective cancer treatments. The objective of the current study was to delineate the drug development timeline and attrition rate of different drug classes for common cancer disease sites.


Microfluidics technology for drug delivery: A review.

Microfluidics is undoubtedly an influential technology that is currently revolutionizing the chemical and biological studies by replicating laboratory bench-top technology on a miniature chip-scale device. In the area of drug delivery science, microfluidics offers advantages, such as precise dosage, ideal delivery, target-precise delivery, sustainable and controlled release, multiple dosing, and slight side effects. These advantages bring significant assets to the drug delivery systems. Microfluidic technol...

The potential of multi-compound nanoparticles to bypass drug resistance in cancer.

The therapeutic efficacy of conventional chemotherapy against several solid tumors is generally limited and this is often due to the development of resistance or poor delivery of the drugs to the tumor. Mechanisms of resistance may vary between cancer types. However, with current development of genetic analyses, imaging, and novel delivery systems, we may be able to characterize and bypass resistance, e.g., by inhibition of the right target at the tumor site. Therefore, combined drug treatments, where one d...


The ProTide Prodrug Technology: From the Concept to the Clinic.

The ProTide technology is a prodrug approach developed for the efficient intracellular delivery of nucleoside analogue monophosphates and monophosphonates. In this approach, the hydroxyls of the monophosphate or monophosphonate groups are masked by an aromatic group and an amino acid ester moiety, which are enzymatically cleaved-off inside cells to release the free nucleoside monophosphate and monophosphonate species. Structurally, this represents the current end-point of an extensive medicinal chemistry en...

Life Under the Microscope: Quantifying Live Cell Interactions to Improve Nanoscale Drug Delivery.

The behavior of cells and how they react to stimuli is critically important for drug development, drug delivery, and understanding the molecular basis of many diseases. However, we still lack a comprehensive understanding of these interactions, particularly in relation to drug delivery from nanoparticles. This Sensors Issues article discusses the importance of quantifying these interactions and highlights some key areas where advances in sensor technology have the potential to transform our understanding of...

Applications of CRISPR Genome Editing Technology in Drug Target Identification and Validation.

Structured Abstract Introduction: The analysis of pharmaceutical industry data indicates that the major reason for drug candidates failing in late stage clinical development is lack of efficacy, with a high proportion of these due to erroneous hypotheses about target to disease linkage. More than ever, there is a requirement to better understand potential new drug targets and their role in disease biology in order to reduce attrition in drug development. Genome editing technology enables precise modificatio...

World Market Development and Consumer Acceptance of Irradiation Technology.

Food irradiation is an efficient technology that can be used to ensure food safety by eliminating insects and pathogens to prolong the shelf life. The process could be applied to fresh or frozen products without affecting the nutritional value. Presently more than 60 countries have adopted the technology. However, the technology adaptation differs from one country to another and, in some cases, consumers' misunderstanding and lack of acceptance may hinder the technology adaptation process. This review summa...

PubChem BioAssay.

High-throughput screening (HTS) is now routinely conducted for drug discovery by both pharmaceutical companies and screening centers at academic institutions and universities. Rapid advance in assay development, robot automation, and computer technology has led to the generation of terabytes of data in screening laboratories. Despite the technology development toward HTS productivity, fewer efforts were devoted to HTS data integration and sharing. As a result, the huge amount of HTS data was rarely made ava...

Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference.

The need for novel approaches to cardiovascular drug development served as the impetus to convene an open meeting of experts from the pharmaceutical industry and academia to assess the challenges and develop solutions for drug discovery in cardiovascular disease.

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.

The potential impact of using human genetic data linked to longitudinal electronic medical records on drug development is extraordinary; however, the practical application of these data necessitates some organizational innovations. Vanderbilt has created resources such as an easily queried database of >2.6 million de-identified electronic health records linked to BioVU, which is a DNA biobank with more than 230,000 unique samples. To ensure these data are used to maximally benefit and accelerate both de nov...

Significant Solubility of Carbon dioxide in Soluplus® Facilitates Impregnation of Ibuprofen Using Supercritical Fluid Technology.

Treatment of Soluplus® with supercritical carbon dioxide allows promising applications in preparing dispersions of amorphous solids. Several characterization techniques ware employed to reveal this effect, including CO2 gas sorption under high pressure and physicochemical characterizations techniques. A gravimetric method was used to determine the solubility of carbon dioxide in the polymer at elevated pressure. The following physicochemical characterizations were used: thermal analysis, X-ray diffraction,...

Endovascular Drug Delivery and Drug Elution Systems: First Principles.

Endovascular drug delivery continues to revolutionize the treatment of atherosclerosis in coronary and peripheral vasculature. The key has been to identify biologic agents that can counter the hyperplastic tissue responses to device expansion/implantation and to develop effective local delivery strategies that can maintain efficacious drug levels across the artery wall over the course of device effects. This article reviews the evolution of endovascular drug delivery technology, explains the mechanisms they...

Liposomal Formulations in Clinical Use: An Updated Review.

Liposomes are the first nano drug delivery systems that have been successfully translated into real-time clinical applications. These closed bilayer phospholipid vesicles have witnessed many technical advances in recent years since their first development in 1965. Delivery of therapeutics by liposomes alters their biodistribution profile, which further enhances the therapeutic index of various drugs. Extensive research is being carried out using these nano drug delivery systems in diverse areas including th...

3D Culture as a Clinically Relevant Model for Personalized Medicine.

Advances in understanding many of the fundamental mechanisms of cancer progression have led to the development of molecular targeted therapies. While molecular targeted therapeutics continue to improve the outcome for cancer patients, tumor heterogeneity among patients, as well as intratumoral heterogeneity, limits the efficacy of these drugs to specific patient subtypes, as well as contributes to relapse. Thus, there is a need for a more personalized approach toward drug development and diagnosis that take...

Experiences with SCRAMx alcohol monitoring technology in 100 alcohol treatment outpatients.

Transdermal alcohol monitoring technology allows for new research on alcohol use disorders. This study assessed feasibility, acceptability, and adherence with this technology in the context of two clinical research trials.

High-throughput flow cytometry for drug discovery: principles, applications, and case studies.

Flow cytometry is a technology providing multiparametric analysis of single cells or other suspension particles. High-throughput (HT) flow cytometry has become an attractive screening platform for drug discovery. In this review, we highlight the recent HT flow cytometry applications, and then focus on HT flow cytometry deployment at AstraZeneca (AZ). Practical considerations for successful HT flow cytometry assay development and screening are provided based on experience from four project case studies at AZ...

Age and Sex in Drug Development and Testing for Adults.

Individualization of drug therapy requires that the right drug be administered at the correct dose to patients who are likely to achieve the highest benefit and lowest risk. Female sex and age comprise two important risk factors for altered drug exposure and response. This review summarizes the current state of science for considering age and sex-related factors along the drug development pipeline, from cell culture and animal research through to Phase 1, 2 and 3 clinical trials in humans. A set of recommen...

Research and Development Spending to Bring a Single Cancer Drug to Market and Revenues After Approval.

A common justification for high cancer drug prices is the sizable research and development (R&D) outlay necessary to bring a drug to the US market. A recent estimate of R&D spending is $2.7 billion (2017 US dollars). However, this analysis lacks transparency and independent replication.

Designing Optimal Formulations for Hot-Melt Coating.

Hot-melt coating (HMC) as a solvent-free technology grants faster and more economic coating processes with reduced risk of dissolving the drug during the process. Moreover, traditional coating equipment can be modified to enable the HMC process. Despite the indubitable advantages and feasibility of the process, HMC is not well-known to pharmaceutical industry and its employment is still limited. The main aspect hindering the widespread application of this technique is the need of materials alternative to th...

Biofloc technology application in aquaculture to support sustainable development goals.

Biofloc technology (BFT) application offers benefits in improving aquaculture production that could contribute to the achievement of sustainable development goals. This technology could result in higher productivity with less impact to the environment. Furthermore, biofloc systems may be developed and performed in integration with other food production, thus promoting productive integrated systems, aiming at producing more food and feed from the same area of land with fewer input. The biofloc technology is ...

Development of Electrosprayed Artesunate-Loaded Core-Shell Nanoparticles.

Artesunate (ART) is proven to have potential anti-proliferative activities, but its instability and poor aqueous solubility limit its application as an anti-cancer drug. The present study was undertaken to develop coaxial electrospraying as a novel technique for fabricating nanoscale drug delivery systems of ART as the core-shell nanostructures.

Discovery and Development of Novel Drugs.

Drug discovery and development process is nowadays conducted in relatively standardised sequence of phases, starting with Discovery and being followed by Preclinical, Clinical and Non-Clinical Development. Discovery phase is divided in Hit Finding, Lead generation, Lead Optimisation and Candidate Identification Phase. Main drivers of the whole process are regulatory requirements and the aim to eliminate the unnecessary spending by early elimination of unlikely drug candidates. Marine products, once purified...

Medical 3-D Printing.

Three-dimensional printing is used in the manufacturing industry, medical and pharmaceutical research, drug production, clinical medicine, and dentistry, with implications for precision and personalized medicine. This technology is advancing the development of patient-specific prosthetics, stents, splints, and fixation devices and is changing medical education, treatment decision making, and surgical planning. Diagnostic imaging modalities play a fundamental role in the creation of 3-D printed models. Altho...

Harnessing the Versatility of Optical Biosensors for Target-Based Small-Molecule Drug Discovery.

Optical biosensors entered target-based small-molecule drug discovery more than two decades ago and have since transformed into a value-adding component in the decision-making process. Here, we briefly highlight the major application areas of optical biosensors and focus on desirable profiles of such platforms in order to ensure their effective use in small molecule drug discovery. Furthermore, we will emphasize current technology-based constraints and discuss experimental strategies to address these limita...

The Use of Social Media in Orphan Drug Development.

Social media has transformed how people interact with one another through the Internet, and it has the potential to do the same for orphan drug development. Currently, social media influences the orphan drug development process in the following three ways: assisting the study of orphan diseases, increasing the awareness of orphan disease, and playing a vital role in clinical trials. However, there are some caveats to the utilization of social media, such as the need to protect patient privacy by adequately ...


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