PubMed Journals Articles About "Eslicarbazepine Acetate 1600 Eslicarbazepine Acetate 1200 Epilepsy" RSS

13:48 EST 15th December 2018 | BioPortfolio

Eslicarbazepine Acetate 1600 Eslicarbazepine Acetate 1200 Epilepsy PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Eslicarbazepine Acetate 1600 Eslicarbazepine Acetate 1200 Epilepsy articles that have been published worldwide.

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Showing "Eslicarbazepine acetate 1600 Eslicarbazepine acetate 1200 Epilepsy" PubMed Articles 1–25 of 1,800+

Eslicarbazepine acetate as monotherapy in clinical practice: outcomes from Euro-Esli.

To assess the effectiveness and safety/tolerability of eslicarbazepine acetate (ESL) monotherapy in clinical practice in Europe.

Tolerability of adjunctive eslicarbazepine acetate according to concomitant lamotrigine or carbamazepine use: A subgroup analysis of three phase III trials in adults with focal (partial-onset) seizures.

To evaluate and compare the effects of concomitant lamotrigine (LTG) or carbamazepine (CBZ) on the incidence of treatment-emergent adverse events (TEAEs) in patients taking adjunctive eslicarbazepine acetate (ESL) for focal (partial-onset) seizures (FS).

Formulation and Stability Study of Eslicarbazepine Acetate Oral Suspensions for Extemporaneous Compounding.

Eslicarbazepine acetate is an anticonvulsant drug with a recent U.S. Food and Drug Administration approval for expanded use in children and adolescents. Currently, eslicarbazepine acetate is only available in the U.S. as 200-mg to 800-mg strength tablets (Aptiom), which are not easy to administer for pediatric patients. This study was initiated to develop an oral suspension formulation for extemporaneous compounding by pharmacists and to generate stability data for storage recommendations. Nine suspension f...

Sudden unexpected death in epilepsy in a patient with a cardiac pacemaker.

Epilepsy is a common neurologic disorder requiring continued treatment during pregnancy. Treatment with antiepileptic drugs (AEDs) is needed for seizure control, but the risk of adverse events has to be minimized for both mother and foetus. Available data on pregnancy and foetal/postnatal outcomes following eslicarbazepine acetate (ESL) exposure via parent is herein presented for the first time.

Modeling and simulations to support dose selection for eslicarbazepine acetate therapy in pediatric patients with partial-onset seizures.

Modeling and simulations were used to support body weight-based dose selection for eslicarbazepine acetate (ESL) in pediatric subjects aged 4-17 years with partial-onset seizures. A one-compartment pediatric population pharmacokinetic model with formulation-specific first-order absorption, first-order elimination, and weight-based allometric scaling of clearance and distribution volume was developed with PK data from subjects 2-18 years of age treated with ESL 5-30 mg/kg/day. Covariate analysis was perfo...

Antiepileptic Mono-therapy in Newly Diagnosed Focal Epilepsy. A network meta-analysis.

Second and third generation AEDs have been directly compared to controlled-release carbamazepine (CBZ-CR) as initial monotherapy for new-onset focal epilepsy. Conversely, no head-to-head trials have been performed. The aim of this study was to estimate the comparative efficacy and tolerability of the antiepileptic monotherapies in adults with newly diagnosed focal epilepsy through a network meta-analysis (NMA). Randomized, double blinded, parallel group, mono-therapy studies comparing any AED to CBZ-CR in a...

Growth of Dehalococcoides mccartyi species in an autotrophic consortium producing limited acetate.

The dechlorinating Dehalococcoides mccartyi species requires acetate as carbon source, but little is known on its growth under acetate limiting conditions. In this study, we observed growth and dechlorination of a D. mccartyi-containing mixed consortium in a fixed-carbon-free medium with trichloroethene in the aqueous phase and H/CO in the headspace. Around 4 mM formate was produced by day 40, while acetate was constantly below 0.05 mM. Microbial community analysis of the consortium revealed dominance by ...

Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells.

Pharmacoresistance is a problem affecting ∼30% of chronic epilepsy patients. An understanding of the mechanisms of pharmacoresistance requires a precise understanding of how antiepileptic drugs interact with their targets in control and epileptic tissue. Although the effects of (S)-licarbazepine (S-Lic) on sodium channel fast inactivation are well understood and have revealed maintained activity in epileptic tissue, it is not known how slow inactivation processes are affected by S-Lic in epilepsy.

The injectable contraceptive medroxyprogesterone acetate attenuates Mycobacterium tuberculosis-specific host immunity through the glucocorticoid receptor.

The effects of the widely used progestin-only injectable contraceptives, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A), on host susceptibility to Mycobacterium tuberculosis (M.tb) are unknown.

The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures.

Immunological mechanisms can be triggered as a response to central nervous system insults and can lead to seizures. In this study an investigation was made to determine if glatiramer acetate (GA), an immunomodulator currently used in the treatment of multiple sclerosis, could protect rats from pilocarpine-induced seizures and chronic epilepsy.

Histologic Validation of Carbon-Acetate Positron Emission Tomography/Computer Tomography in Detecting Lymph Node Metastases in Prostate Cancer.

Conventional imaging cannot definitively detect nodal metastases from prostate cancer (PCa). We histologically validated 11-carbon-Acetate (C-Acetate) PET/CT for identifying nodal metastases, examining PCa factors that influence detection rates.

Palladium Acetate Revisited: Unusual Ring-Current Effects, One-Electron Reduction, and Metal-Metal Bonding.

Palladium(II) acetate (1) and two new complexes of the ligand α,α,α',α'-tetramethyl-1,3-benzenedipropionate (esp), C -Pd(esp) ( C-2) and C-Pd(esp) ( C-2), are studied in the solid state and in solution. Variable-temperature NMR and DFT studies of C -2 reveal an unusual shielding region above the Pd atoms. The compounds show a surprising quasi-reversible reduction between -880 and -1200 mV versus Fc/Fc, and the Pd(esp) complexes may be cleanly reduced electrochemically. EPR spectra of reduced samples sho...

Subchronic (90-day) repeated dose oral toxicity study of 2-hydroxybenzylamine acetate in rabbit.

2-hydroxybenzylamine (2-HOBA), a naturally occurring compound found in buckwheat, has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress. In a series of rodent toxicity studies, 2-HOBA acetate was well-tolerated and did not produce any toxic effects over 28 or 90 days of repeated oral administration. However, it remained necessary to test the potential toxicity of 2-HOBA acetate in a non-rodent species. In this investigation, 2-HOBA ace...

A phase 2 trial of abiraterone acetate without glucocorticoids for men with metastatic castration-resistant prostate cancer.

Abiraterone acetate suppresses adrenal androgens and glucocorticoids through the inhibition of CYP17; however, given the risk of mineralocorticoid excess, it is administered with glucocorticoids. Herein, the authors performed a phase 2, single-arm study that was designed to assess the safety of abiraterone acetate without steroids in patients with castration-resistant prostate cancer.

Inhibitory effect of α-terpinyl acetate on cytochrome P450 2B6 enzymatic activity.

Human cytochrome P450 2B6 is an important hepatic enzyme for the metabolism of xenobiotics and clinical drugs. Recently, more attention has been paid to P450 2B6 because of the increasing number of drugs it metabolizes. It has been known to interact with terpenes, the major constituents of the essential oils used for various medicinal purposes. In this study, the effect of monoterpenes on P450 2B6 catalytic activity was investigated. Recombinant P450 2B6 was expressed in Escherichia coli and purified using ...

Tracking acetate through a journey of living world: Evolution as alternative cellular fuel with potential for application in cancer therapeutics.

Acetate is a short chain fatty acid, comprising carbon, hydrogen and oxygen (CHO) has emerged as a key alternative fuel for cellular metabolism. Beginning this voyage from the abiotic atmosphere, acetate has contributed to the physiology of both prokaryotes and eukaryotes. The main role of acetate includes its contribution to the global carbon cycle, bioenergetic and biosynthetic metabolic processes. Based on the ability to produce and consume organisms are categorized as acetogenic, acetate consumers or bo...

Acetate Mediates Alcohol Excitotoxicity in Dopaminergic-Like PC12 Cells.

Neuronal excitotoxicity is the major cause of alcohol-related brain damage, yet the underlying mechanism remains poorly understood. Using dopaminergic like PC12 cells, we evaluated the effect of N-methyl-D-aspartate receptors (NMDAR) on acetate induced changes in PC12 cells: cell death, cytosolic calcium and expression levels of the pro-inflammatory cytokine, tumor necrosis factor alpha (TNFα). Treatment of PC12 cells with increasing concentrations of acetate for 4 hrs caused a dose-dependent increase in p...

Comparison of Acetate-butyrate and Acetate-ethanol Metabolic Pathway in Biohydrogen Production.

Hydrogen gas is the cleanest energy carrier and could be produced by biological process. Dark fermentation is one of the biohydrogen production methods that carried out just on organic wastes conversion.

Combined oral contraceptive interference with the ability of ulipristal acetate to delay ovulation: A prospective cohort study.

To determine if a combined oral contraceptive (COC) initiated shortly after ulipristal acetate (UPA) administration interferes with its mechanism of action.

The Acetate Uptake Transporter family motif "NPAPLGL(M/S)" is essential for substrate uptake.

Organic acids are recognized as one of the most prevalent compounds in ecosystems, thus the transport and assimilation of these molecules represent an adaptive advantage for organisms. The AceTr family members are associated with the active transport of organic acids, namely acetate and succinate. The phylogenetic analysis shows this family is dispersed in the tree of life. However, in eukaryotes, it is almost limited to microbes, though reaching a prevalence close to 100% in fungi, with an essential role i...

Ulipristal Acetate for Unscheduled Bleeding in Etonogestrel Implant Users: A Randomized Controlled Trial.

To evaluate whether ulipristal acetate reduces the number of bleeding days in etonogestrel implant users in a 30-day period as compared with placebo.

DeastringentPeel Extracts of Persimmon ( Thunb. cv. Cheongdo-Bansi) Protect Neuronal PC-12 andSH-SY5Y Cells against Oxidative Stress.

Peel of astringent persimmon ( Thunb. cv. Cheongdo-Bansi) is a by-product of dried persimmon ().We investigated if deastringentpeel extracts of persimmon cv. Cheongdo-Bansi had antioxidative and neuroprotective properties.Two different extracts were prepared: thermallyand nonthermallytreated persimmon peel extracts (TPE and NTPE, respectively). Both TPE and NTPE were fractionated sequentially in -hexane, chloroform, ethyl acetate, -butanol, and water. TPE and NTPE ethyl acetate fractions had the highest tot...

Fluidized granular activated carbon electrode for efficient microbial electrosynthesis of acetate from carbon dioxide.

The electricity-driven bioreduction of carbon dioxide to multi-carbon organic compounds, particularly acetate, has been achieved in microbial electrosynthesis (MES). MES performance can be limited by the amount of cathode surface area available for biofilm formation and slow substrate mass transfer. Here, a fluidized three-dimensional electrode, containing granular activated carbon (GAC) particles, was constructed via MES. The volumetric acetate production rate increased by 2.8 times through MES with 16 g...

Administration of leuprolide acetate, a GnRH agonist, improves urodynamic parameters in ovariectomized rats.

To evaluate the effects of a treatment with leuprolide acetate (LA) on bladder overactivity as well as the expression of gonadotropin releasing hormone receptor (GnRH-R), and neurofilaments NF68 and NF200 in female rats with overactive bladder induced by castration.

Women's satisfaction, use, storage, and disposal of subcutaneous depot medroxyprogesterone acetate (DMPA-SC) during a randomized trial.

To describe women's experiences with subcutaneous depot medroxyprogesterone acetate (DMPA-SC) to inform scale-up of self-administered DMPA-SC.

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