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PubMed Journals Articles About "Functional Molecules Enable Selective Stimuli Responsive Nanoparticles Biomedical" RSS

01:37 EDT 21st September 2019 | BioPortfolio

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Showing "Functional Molecules Enable Selective Stimuli Responsive Nanoparticles Biomedical" PubMed Articles 1–25 of 26,000+

pH-Responsive Polymer Nanoparticles for Drug Delivery.

Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli-responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironm...


Functional DNA Molecules Enable Selective and Stimuli-Responsive Nanoparticles for Biomedical Applications.

Nanoparticles (NPs) have enormous potential to improve disease diagnosis and treatment due to their intrinsic electronic, optical, magnetic, mechanical, and physiological properties. To realize their full potential for nanomedicine, NPs must be biocompatible and targetable toward specific biomolecules to ensure selective sensing, imaging, and drug delivery in complex environments such as living cells, tissues, animals, and human bodies. In this Account, we summarize our efforts to impart specific biocompati...

Targeted, Stimuli-responsive and Theranostic F Magnetic Resonance Imaging Probes.

Unlike the conventional 1H magnetic resonance imaging (MRI), 19F MRI features unambiguous detection of fluorine spins due to negligible background signals. Therefore, it is considered a promising non-invasive and selective imaging method for the diagnosis of cancers and other diseases. For 19F MRI, fluorine-rich molecules such as perfluorocarbons (PFC) have been formulated into nanoemulsions and used as its tracer agent. Along with advancements in other types of nanoparticles as targeted theranostics and st...


A Comprehensive Outlook of Synthetic Strategies and Applications of Redox-Responsive Nanogels in Drug Delivery.

Increasing recognition of the role of oxidative stress in the pathogenesis of many clinical conditions and the existence of defined redox potential in healthy tissues has led to extensive research in the development of redox-responsive materials for biomedical applications. Especially, considerable growth has been seen in the fabrication of polymeric nanogel-based drug delivery carriers utilizing redox-responsive cross-linkers bearing a variety of functional groups via various synthetic strategies. Redox-re...

New Insights Towards Mesoporous Silica Nanoparticles as a Technological Platform for Chemotherapeutic Drugs Delivery.

Mesoporous silica nanoparticles (MSNs) displays interesting properties for biomedical applications such as high chemical stability, large surface area and tunable pores diameters and volumes, allowing the incorporation of large amounts of drugs, protecting them from deactivation and degradation processes acting as an excellent nanoplatform for drug delivery. However, the functional MSNs do not present the ability to transport the therapeutics without any leakage until reach the targeted cells causing side e...

Correction to "Enzymatic stimuli-responsive methotrexate-conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition".

Redox-responsive Pickering Emulsions Based on Silica Nanoparticles and Electrochemical Active Fluorescent Molecule.

In this paper, we report a novel redox responsive water-in-oil Pickering emulsion stabilized by negatively charged silica nanoparticles in combination with a trace amount of redox switchable fluorescent molecule ferrocene azine (FcA), in which ferrocene serves as a redox-sensitive group, and anthryl unit serves as a fluorescence emission center. By alternately adding oxidant and reducing agent at a moderate condition, the amphiphilicity of silica nanoparticles changes because of the adsorption of Fc+A and t...

4D Printing and Stimuli-responsive Materials in Biomedical Aspects.

Three-dimensional (3D) printing has revolutionized the world manufacturing production. In biomedical applications, however, 3D printed constructs fell short of expectations mainly due to their inability to adequately mimic the dynamic human tissues. To date, most of the 3D printed biomedical structures are largely static and inanimate as they lack the time-dependant dimension. To adequately address the dynamic healing and regeneration process of human tissues, 4D printing emerges as an important development...

Oppositely Charged, Stimuli-Responsive Anisotropic Nanoparticles for Colloidal Self-Assembly.

Anisotropic nanoparticles (ANPs) composed of distinct compartments are of interest as advanced materials because they offer unique physicochemical properties controlled by the polymer composition, distribution of functional groups, and stimuli-responsiveness of each compartment. Furthermore, colloidal self-assembly of ANPs via noncovalent interactions between compartments can create superstructures with additional functionality. In this study, ANPs with two compartments composed of oppositely charged and th...

How do biological stimuli modulate conformational changes of biomedical thermoresponsive polymer?

Continuing efforts to develop stimuli-responsive polymers (SRPs) as novel smart materials/biomaterials are anticipated to upgrade the quality life of humans. The details of the molecular, physico chemical and biophysical interactions between SRPs and proteins are not fully understood. Indeed, protein - polymer interactions play a major role in a wide range of biomedical/biomaterial applications. In this regard, we have demonstrated the influence of proteins (β-lactoglobulin (BLG) and stem bromelain (BM) as...

Non-Magnetic Injectable Implant for Magnetic Field-Driven Thermochemotherapy and Dual Stimuli-Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics.

Transformable liquid metal (LM)-based materials have attracted considerable research interest in biomedicine. However, the potential biomedical applications of LMs have not yet been fully explored. Herein, for the first trial, the inductive heating property of gallium-indium eutectic alloy (EGaIn) under alterative magnetic field is systematically investigated. By virtue of its inherent metallic nature, LM possesses excellent magnetic heating property as compared to the conventional magnetite nanoparticles, ...

Biomimetic Stimuli-Responsive Nanochannels and their Applications.

Biomimetic smart nanochannels have been studied extensively to achieve the precise ionic transport compared to biological ion channels. Similar to ion channels in living organisms, biomimetic smart nanochannels can respond to various stimuli, which allows for promising applications in many fields. In this review, we mainly summarize the recent advances in the design of biomimetic stimuli-responsive nanochannels and their potential applications including biosensors and drug delivery. Finally, an outlook on t...

Fabrication of thermo- and pH-sensitive cellulose nanofibrils-reinforced hydrogel with biomass nanoparticles.

Cellulose nanofibrils (CNFs) have been widely used as the reinforcing agent. However, there is still a challenge to control the mechanical properties of CNFs-reinforced hydrogels by changing the environmental variables. Here, we demonstrated a thermo- and multi-pH-responsive CNFs-reinforced hydrogel containing lignin nanoparticles as the functional dynamic cross-linkers in the polymeric network. The elastic and viscous modulus of the hydrogel can be tailored: (i) the modulus increases upon increasing pH fro...

Single-particle characterization of theranostic liposomes with stimulus sensing and controlled drug release properties.

Stimuli-responsive nanotheranostic systems, integrated with diagnosis and treatment features, have recently emerged and attracted much interest. However, most of the research mainly focuses on the novelty of nanomaterials, and undervalues the significance of single-particle characterization which can provide detailed physical and biochemical information for performance evaluation and heterogeneity assessment. Due to the small particle size and low content of functional modules, high throughput and multipara...

Fabrication of a Dual-Stimuli-Responsive Supramolecular Micelle from a Pillar5arene-Based Supramolecular Diblock Copolymer for Photodynamic Therapy.

A pH and thermo dual-responsive supramolecular diblock copolymer is constructed by host-guest recognition of pillar[5]arene and viologen salt. The host polymer, poly(N,N-dimethylaminoethyl methacrylate) bearing pillar[5]arene as the terminal group (P[5]A-PDMAEMA) is synthesized by atom transfer radical polymerization (ATRP). Guest polymer, ethyl viologen-ended poly(N-isopropylacrylamide) (EV-PNIPAM) is prepared by reversible addition-fragmentation chain transfer polymerization. The supramolecular diblock co...

Targeted and stimuli-responsive mesoporous silica nanoparticles for drug delivery and theranostic use.

For cancer therapy, the usefulness of mesoporous silica nanoparticles (MPSNPs) has been widely discussed, likely due to its inorganic nature and excellent structural features. The MPSNPs-based chemotherapeutics have been promisingly delivered to their target sites that help to minimize side effects and improve therapeutic effectiveness. A wide array of studies have been conducted to functionalize drug-loaded MPSNPs using targeting ligands and stimuli-sensitive substances. In addition, anticancer drugs have ...

To what extent do polymeric stabilizers affect nanoparticles characteristics?

Colloidal synthesis of nanoparticles using polymeric stabilizers as a template of a structure directing agent provided a plethora of opportunities in fabricating nanoparticles (NPs) with controlled size, shape, composition and structural characteristics. To understand the complete potency of polymeric stabilizers during the synthesis of nanoparticles, the relationship between polymer characteristics such as structure, molecular weight and concentration and nanoparticles characteristics is discussed in depth...

H2O2-responsive organosilica-doxorubicin nanoparticles for targeted imaging and killing of cancer cells based on key intermediate Si-PBA.

Doxorubicin (Dox) is a widely used fluorescent chemotherapy drug. Its primary delivery systems based on physical adsorption of silica nanoparticles may lead to low drug loading content. Direct loading of Dox through covalent bonds during the formation of silica nanoparticles has never been reported. In this work, we designed a key intermediate Si-PBA, which contains not only alkoxysilane moieties to form organosilica nanoparticles but also phenylboronic acid moieties to react with diol-containing compounds....

ROS-responsive "smart" polymeric conjugate: synthesis, characterization and proof-of-concept study.

New approaches integrating stimuli-responsive linkers into prodrugs are currently emerging. These "smart" prodrugs can enhance the effectivity of conventional prodrugs with promising clinical applicability. Oxidative stress is central to several diseases, including cancer. Therefore, the design of prodrugs that respond to ROS stimulus, allowing a selective drug release in this condition, is fairly encouraging. Aiming to investigate the ROS-responsiveness of prodrugs containing the ROS-cleavable moiety, Thio...

Rationally designed DNA-based nanocarriers.

Nanomaterials employed for enhanced drug delivery and therapeutic effects have been extensively investigated in the past decade. The outcome of current anticancer treatments based on conventional nanoparticles is suboptimal, due to the lack of biocompatibility, the deficient tumor targeting, the limited drug accumulation in the diseased region, etc. Alternatively, DNA-based nanocarriers have emerged as a novel and versatile platform to integrate the advantages of nanotechnologies and biological sciences, wh...

Molecularly Imprinted Nanoparticles for Biomedical Applications.

Molecularly imprinted polymers (MIPs) are synthetic receptors with tailor-made recognition sites for target molecules. Their high affinity and selectivity, excellent stability, easy preparation, and low cost make them promising substitutes to biological receptors in many applications where molecular recognition is important. In particular, spherical MIP nanoparticles (or nanoMIPs) with diameters typically below 200 nm have drawn great attention because of their high surface-area-to-volume ratio, easy remova...

pH-Dependent aggregation and pH-independent cell membrane adhesion of monolayer-protected mixed charged gold nanoparticles.

Design of pH-responsive monolayer-protected gold nanoparticles (AuNPs) that are mixed charged, with the ability to switch their net surface charge, based on the stimuli of environmental pH is a promising technique in nanomedicine. However, understanding of pH-responsive mixed charged AuNP behavior in terms of their stability and cellular interaction are still limited. In this work, we study the aggregation of pH-responsive AuNPs and their interaction with model lipid bilayers by adopting Martini coarse-grai...

Multifunctional hyaluronate - Nanoparticle hybrid systems for diagnostic, therapeutic and theranostic applications.

Diagnostic and therapeutic nanoparticles have been actively investigated for the last few decades as new platforms for biomedical applications. Despite their great versatility and potency, nanoparticles have generally required further modification with biocompatible materials such as biopolymers and synthetic polymers for in vivo administration to improve their biological functions, stability, and biocompatibility. Among a variety of natural and synthetic biomaterials, hyaluronate (HA) has been considered a...

Novel biocompatible poly(acrylamide)-grafted-dextran hydrogels: Synthesis, characterization and biomedical applications.

An electro-responsive PAAm-g-Dxt copolymer was synthesized and characterized by H NMR & FTIR spectroscopy, neutralization equivalent, elemental and thermogravimetric analysis to ascertain the grafting reaction. Further, we developed an electro-responsive transdermal drug delivery system (ETDS) utilizing PAAm-g-Dxt copolymer for rivastigmine tartarate delivery through skin. The ETDS were developed using drug-loaded PAAm-g-Dxt hydrogel as the reservoir, and cross-linked dextran-poly(vinyl alcohol) blend films...

Selective acetylene hydrogenation over single-atom alloy nanoparticles by kinetic Monte Carlo.

Single-atom alloys, which are prepared by embedding isolated metal sites in host metals, are promising systems for improved catalyst selectivity. For technical applications, catalysts based on nanoparticles are preferred, thanks to a large surface area. Herein, we investigate acetylene to ethylene hydrogenation using kinetic Monte Carlo simulations based on density functional theory, and compare the performance of Pd/Cu nanoparticles with Pd(111) and Pd/Cu(111). We find that embedding Pd in Cu systems stron...


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