PubMed Journals Articles About "GRAIL" RSS

15:04 EDT 23rd March 2019 | BioPortfolio

GRAIL PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest GRAIL articles that have been published worldwide.

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Showing "GRAIL" PubMed Articles, all 22

Macrophage expression of E3 ubiquitin ligase Grail protects mice from lipopolysaccharide-induced hyperinflammation and organ injury.

Multiple organ dysfunction caused by hyperinflammation remains the major cause of mortality during sepsis. Excessive M1-macrophage activation leads to systemic inflammatory responses. Gene related to anergy in lymphocytes (Grail) is regarded as an important regulator of T cells that functions by diminishing cytokine production. However, its role in regulating macrophage activation and organ injury during sepsis remains unclear. Our aim was to examine the effects of Grail on macrophage reactivity and organ i...

Predicting which children have asthma: Are we any closer to finding the Holy Grail?

High-Flow Nasal Cannulae. The Quest for the Holy Grail in the Critical Respiratory Patient?

Can genetics predict risk for sudden cardiac death? The relentless search for the Holy Grail.

Early Diagnosis in Pulmonary Arterial Hypertension, the Search for the Holy Grail.

Chasing the 'Holy Grail' - Modulating Neutrophils in Inflammatory Lung Disease.

Magnetic Resonance Imaging-Based Prostate Cancer Screening: Is High-Value Care Achieved or Does the Holy Grail Remain Elusive?

Optimal Risk Prediction in Upper Gastrointestinal Bleeding - A Quest for the Holy Grail.

Platelets: the holy grail in cancer blood biomarker research?

We would like to promote the fact that platelets are increasingly emerging as a rich source of potential biomarkers for cancer. Blood platelets contain vast amounts of bioactive proteins, such as growth factors, chemokines, and cytokines. These proteins are either synthesized by the megakaryocytes that produce the platelets or are sequestered by the circulating platelets from the blood, in which case these proteins may originate from the tumor. Recent studies in patients have demonstrated that the presence ...

Early detection of microvascular dysfunction in hypertension: the holy grail of cardiovascular prevention and risk assessment?

In the Heart of Stiffness: Are Natural Heart Vibrations Reliable Enough to Assess Myocardial Stiffness, The New Holy Grail in Echocardiography?

Looking for the Holy Grail in Acute/Subacute Type B Dissection.

Combinatorial Screening of Nanoclay Reinforced Hydrogels: A Glimpse of the "Holy Grail" in Orthopedic Stem Cell Therapy?

Despite the promise of hydrogel-based stem cell therapies in orthopedics, a significant need still exists for development of injectable microenvironments capable of utilizing the complete regenerative potential of donor cells. Indeed, the quest for biomaterials that can direct stem cells into bone without any need of external factors has been the "Holy Grail" in orthopedic stem cell therapy for decades. To address this challenge, we have utilized a combinatorial approach to screen over 63 nanoengineered hyd...

Opportunities and Challenges in the Development of Cathode Materials for Rechargeable Mg Batteries.

Recent years have seen an intense and renewed interest in the Mg battery research, naming Mg-S the ≫Holy Grail≪ battery, and expectations that Mg battery system will be able to compete and surpass Li-ion batteries in a matter of years. Considerable progress has been achieved in the field of Mg electrolytes, where several new electrolytes with improved electrochemical performance and favorable chemical properties (non-corrosive, non-nucleophilic) were synthesized. Development in the field of cathodes rem...

Stress echo beyond coronary artery disease. is it the holy grail of cardiovascular imaging?

Stress echocardiography (SE) is a very useful method in clinical practice, since it offers important information both for patient's functional status and hemodynamic changes during stress. Therefore, SE provides strong diagnostic and prognostic data in a wide spectrum of cardiovascular diseases. This review summarizes the clinical applications of SE in conditions beyond coronary artery disease and highlights practical recommendations and key issues for each condition that need further investigation. SE is a...

Ex Vivo Expansion of Hematopoietic Stem Cells for Therapeutic Purposes: Lessons from Development and the Niche.

Expansion of hematopoietic stem cells (HSCs) for therapeutic purposes has been a "holy grail" in the field for many years. Ex vivo expansion of HSCs can help to overcome material shortage for transplantation purposes and genetic modification protocols. In this review, we summarize improved understanding in blood development, the effect of niche and conservative signaling pathways on HSCs in mice and humans, and also advances in ex vivo culturing protocols of human HSCs with cytokines or small molecule compo...

A 0.338cm , Artifact-Free, 64-Contact Neuromodulation Platform for Simultaneous Stimulation and Sensing.

Neuromodulation (NM) is the alteration of nervous tissue function through targeted delivery of a stimulus, such as electrical stimulation, into the affected neurological sites in the body. We present a "holy- grail" bi-directional NM interface that features 100mVpp linear input range and ability to sense data concurrent with stimulation (without blanking). The system includes a flexible 8-driver-to-64-contact custom waveform stimulator able to deliver up to 5.1mA per driver and a 64-contact sensing unit wit...

Coccidioidomycosis: What a long strange trip it's been.

The recorded history of coccidioidomycosis began in 1892 with the report of the illness of Domingo Escurra by Alejandro Posadas followed by a description of the first North American cases by Rixford and Gilchrist. Originally considered a protozoan, William Ophüls determined that Coccidioides was a fungus and that the lungs were the apparent initial site of infection. During the 1930s, both Gifford and Dickson determined that a self-limited illness, Valley Fever, was caused by the same fungus that caused th...

Blind source separation with mixture models - A hybrid approach to MR brain classification.

The development of automated segmentation approaches, which do not suffer from excessive computational burden and intra- and inter-observer variability, is the holy grail of multispectral MR image classification. A new segmentation approach to the data set of MR brain images using a combination of Independent Component Analysis (ICA) with a generalized version of the popular Gaussian Mixture Model (GMM) for unsupervised classification is proposed to be superior to conventional methods in this paper. We prop...

p73-Governed miRNA Networks: Translating Bioinformatics Approaches to Therapeutic Solutions for Cancer Metastasis.

The transcription factor p73 synthesizes a large number of isoforms and presents high structural and functional homology with p53, a well-known tumor suppressor and a famous "Holy Grail" of anticancer targeting. p73 has attracted increasing attention mainly because (a) unlike p53, p73 is rarely mutated in cancer, (b) some p73 isoforms can inhibit all hallmarks of cancer, and (c) it has the ability to mimic oncosuppressive functions of p53, even in p53-mutated cells. These attributes render p73 and its downs...

Wrinkled graphene cages as hosts for high capacity Li metal anodes shown by cryogenic electron microscopy.

Lithium (Li) metal has long been considered the "holy grail" of battery anode chemistry, but is plagued by its low efficiency and poor safety due to its high chemical reactivity and large volume fluctuation, respectively. Here we introduce a new host of wrinkled graphene cage (WGC) for Li metal. Different from recently reported amorphous carbon spheres, WGC shows highly improved mechanical stability, better Li ion conductivity and excellent solid electrolyte interphase (SEI) for continuous robust Li metal p...

Three-Dimensional Organoids in Cancer Research: The Search for the Holy Grail of Preclinical Cancer Modeling.

Most solid tumors become therapy resistant and will relapse, with no durable treatment option available. One major impediment to our understanding of cancer biology and finding innovative approaches to cancer treatment stems from the lack of better preclinical tumor models that address and explain tumor heterogeneity and person-to-person differences in therapeutic and toxic responses. Past cancer research has been driven by inadequate in vitro assays utilizing two-dimensional monolayers of cancer cells and ...

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