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PubMed Journals Articles About "GSK1120212B Standard DMSO Content GSK1120212B Lower DMSO Content" RSS

22:53 EST 15th December 2018 | BioPortfolio

GSK1120212B Standard DMSO Content GSK1120212B Lower DMSO Content PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest GSK1120212B Standard DMSO Content GSK1120212B Lower DMSO Content articles that have been published worldwide.

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Showing "GSK1120212B Standard DMSO content GSK1120212B Lower DMSO content" PubMed Articles 1–25 of 19,000+

The Development of an In Vitro Assay for the Prospective Determination of Aspirin Sensitivity.

Aspirin remains the standard for stroke prophylaxis. However, as many as 20%-25% of patients may fail to show a full response to aspirin. Ideally, patients who are resistant to aspirin could be identified, then receive an increased dose of aspirin or be changed to an alternative therapy more efficiently. We have developed an in vitro assay that may make this possible. Healthy volunteers (n = 13) between 18 and 50 years of age were tested for both ex vivo and in vivo responses to aspirin. Dimethyl sulfoxide ...


Solvent exchange and drug release characteristics of doxycycline hyclate-loaded bleached shellac in situ-forming gel and -microparticle.

Doxycycline hyclate (DX)-loaded bleached shellac (BS) in situ forming gel (isg) and in situ microparticle (ism) were prepared using dimethyl sulfoxide (DMSO), N-methyl pyrrolidone (NMP) and 2-pyrrolidone (PYR) as solvents. Solvent and drug release characteristics of them were investigated. Diffusion rate of solvent applied in formulation was as following: DMSO > NMP > PYR. In situ forming systems comprising PYR had the slowest release rate of solvent and drug while water flowed into system in rank o...

Molecular dynamics study of the influence of solvents on the structure and mechanical properties of poly(vinyl alcohol) gels.

Molecular dynamics (MD) simulations were employed to study the influence of solvents on the structure and mechanical properties of physically crosslinked poly(vinyl alcohol) (PVA) gels. Firstly, three kinds of PVA precursor gels were made by adding water, dimethyl sulfoxide (DMSO) and a mixture of DMSO and water (4:1 by weight), respectively. The solvents in the precursor gels were then exchanged with water to obtain three kinds of PVA hydrogels. Solvent in the precursor gel with a mixture of DMSO and water...


Evaluation of Novel Formulations of D-β-hydroxybutyrate and Melatonin in a Rat Model of Hemorrhagic Shock.

D-β-hydroxybutyrate and melatonin (BHB/MLT) infusion improves survival in hemorrhagic shock models. The original BHB/MLT formulation contains dimethyl sulfoxide (DMSO) to increase melatonin solubility. We formulated BHB/MLT solutions wherein DMSO was replaced either with 10% polyvinylpyrrolidone (BHB/MLT/PVP) or with 5% hydroxypropyl-β-cyclodextrin/2.5% PVP/2.5% polyethylene glycol 400 (BHB/MLT/CD). Safety and efficacy of the new and the original BHB/MLT solution were tested in a lethal rat hemorrhagic sh...

Changes of soluble sugars and ATP content during DMSO droplet freezing and PVS3 droplet vitrification of potato shoot tips.

The potato's great genetic diversity needs to be maintained for future agricultural applications and can be preserved at ultra-low temperatures. To decipher detailed physiological processes, the aim of the study was to analyze the regrowth in 28 gene bank accessions and to reveal metabolite changes in a subset of four accessions that showed pronounced differences after shoot tip cryopreservation using DMSO droplet freezing and PVS3 droplet vitrification. Regrowth varied in all 28 genotypes ranging from 5% (...

Polymorphism of crystalline complexes of V-amylose with fatty acids.

The crystallization of amylose from dilute solutions in the presence of a series of linear saturated fatty acids (C3 to C20) was investigated by varying the fatty acid concentration, crystallization temperature and solvent composition (DMSO:water in various ratios). The morphology and structure of the resulting model lamellar crystals were characterized by transmission electron microscopy as well as electron and X-ray diffraction. By adequately controlling the crystallization parameters, all fatty acids cou...

Diverse Surface Functional Groups and Electrochemical Behavior in Dimethyl Sulfoxide-Delaminated Ti3C2Tx MXene.

Functionalized groups in two-dimensional Ti3C2Tx MXene are considered to be an important factor influencing electrochemical performance in many applications involving energy storage, electrochemical sensors, and water purifications. However, after the dimethyl sulfoxide (DMSO) delamination, the effect on surface structures of Ti3C2Tx are still unclear and no systematical reports on capacitive behavior. Herein, we performed the experiments and theoretical calculations to confirm the relationship among differ...

Homo- and Heteroleptic Coordination Polymers and Oxido Clusters of Bismuth(III) Vinylsulfonates.

The synthesis and characterization of six homo- and heteroleptic coordination polymers and oxido clusters of bismuth(III) vinylsulfonates are reported. The solvent-mediated reaction of BiPh3 and vinylsulfonic acid in ethanol produces [Ph2Bi(O3SCH=CH2)]n (1), which crystallizes as a one-dimensional coordination polymer as a result of bridging sulfonato ligands accompanied by intermolecular Bi∙∙∙π(arene) London dispersion interactions. In solution, compound 1 equilibrates to give [PhBi(O3SCH=CH2)2]n (2...

The Influence of Dimethyl Sulfoxide on the Low-Temperature Behavior of Cholesterol-Loaded Palmitoyl-oleyl-phosphatidylcholine Membranes.

The properties of lipid membranes at low temperature are important for a number of biomedical and biotechnological applications and the success of these applications depends on understanding the effects of temperature changes on intermolecular lipid-lipid and lipid-water interactions. Here we use FTIR spectroscopy to study lipid suspensions in water/dimethyl sulfoxide (DMSO) solutions in the -60 °C to 30 °C range. DMSO is a cryo-preservative agent of cellular systems, and its action is largely related to ...

Cryosurvival after exposure of IVF-derived Nellore embryos to different cryoprotectants and exposure times during vitrification.

We evaluated the effects of the vitrification solution (i.e., ethylene glycol (EG) + dimethyl sulfoxide (DMSO) with or without propylene glycol (PG)) and of exposure time on the re-expansion and hatching rates of vitrified Bos indicus embryos. In vitro produced embryos (n = 1050) were divided into seven groups: control group (non-vitrified embryos) and six vitrification groups with different cryoprotectant concentrations and exposure times. After vitrification, embryos were cultured for determination of...

Changes of chemical composition and hemicelluloses structure in differently aged bamboo (Neosinocalamus affinis) culms.

To study the differences in chemical composition analysis and spatial distribution of young Neosinocalamus affinis bamboo, we used the method of standard of National Renewable Energy Laboratory and confocal Raman microscopy, respectively. It was found that the acid-soluble lignin and acid-insoluble lignin content showed an inverse relationship with the increasing bamboo age. Raman analysis revealed that Raman signal intensity of lignin both in the secondary cell wall (S) and the compound middle lamella (CML...

Storage stability of liposomes stored at elevated subzero temperatures in DMSO/sucrose mixtures.

Cryopreservation of biological materials is predominantly done using liquid nitrogen, and its application involves high maintenance costs and the need for periodical refilling of liquid nitrogen. Stable storage in mechanical freezers at -80°C would eliminate these issues and allow for shipment of frozen specimens using dry ice. In this work, the possibility of increasing the storage temperature of cryopreserved samples to -80°C by using combinations of DMSO and sucrose has been studied. Preservation effic...

Effects of different diluents, cryoprotective agents, and freezing rates on sperm cryopreservation in Epinephelus akaara.

We investigated various factors, including cryoprotective agents (CPAs), diluents, and freezing rates, to develop an optimal cryopreservation protocol for Epinephelus akaara sperm. In experiments using 10% dimethyl sulfoxide (DMSO), glycerol, and methanol with various diluents, 10% DMSO and 300 mM glucose yielded the highest post-thaw sperm motility. The combination of 10% glycerol and 300 mM sucrose yielded significantly higher post-thaw sperm motility than did combinations using other diluents. Glycer...

A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family.

The propensity for differentiation varies substantially across human pluripotent stem cell (hPSC) lines, greatly restricting the use of hPSCs for cell replacement therapy or disease modeling. Here, we investigate the underlying mechanisms and demonstrate that activation of the retinoblastoma (Rb) pathway in a transient manner is important for differentiation. In prior work, we demonstrated that pre-treating hPSCs with dimethylsulfoxide (DMSO) before directed differentiation enhanced differentiation potentia...

DMSO increases efficiency of genome editing at two non-coding loci.

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein-9 (Cas9) has become the tool of choice for genome editing. Despite the fact that it has evolved as a highly efficient means to edit/replace coding sequence, CRISPR/Cas9 efficiency for "clean" editing of non-coding DNA remains low. We set out to introduce a single base-pair substitution in two intronic SNPs at the FTO locus without altering nearby non-coding sequence. Substitution efficiency increased up to 10-fold b...

DMSO as switchable alkylating agent in heteroarene C-H functionalization.

Herein, we report a novel strategy for the activation of DMSO to act as a versatile alkylating agent in heteroarene C-H functionalization. This direct, simple, and mild switch between methylation/trideuteromethylation and methylthiomethylation of heteroarenes was achieved under reagent controlled photoredox catalysis conditions. The proposed mechanism is supported by both experimental and theoretical studies.

Stable, metal-free, visible-light-driven photocatalyst for efficient removal of pollutants: Mechanism of action.

A low-cost and metal-free semiconductor-based photocatalyst driven by visible light has attracted great interest for water remediation. A relatively larger-surface area carbon nitride consisting of thin nanosheets is synthesized, firstly adopting melamine (M), cyanuric acid (C), urea (U) and dimethyl sulfoxide (DMSO) as the starting materials to form the supramolecular carbon nitride MCU(DMSO)-CN. Physical, chemical, and optical properties of the resulting samples were characterized. The photocatalytic perf...

Low molecular-weight hyaluronan as a cryoprotectant for the storage of microencapsulated cells.

The low-temperature storage of therapeutic cell-based products plays a crucial role in their clinical translation for the treatment of diverse diseases. Although dimethylsulfoxide (DMSO) is the most successful cryoprotectant in slow freezing of microencapsulated cells, it has shown adverse effects after cryopreserved cell-based products implantation. Therefore, the search of alternative non-toxic cryoprotectants for encapsulated cells is continuously investigated to move from bench to the clinic. In this wo...

Effects of cryoprotectants and cryoprotectant combinations on viability and maturation rates of Camelus dromedaries oocytes vitrified at germinal vesicle stage.

Camel fertility faces many problems that could be solved by assisted reproductive technologies (ART). The experiment designed to explore the effect of different cryoprotectant concentrations and combinations on viability and maturation rates of vitrified-warmed camel oocytes. Ovaries collected directly after slaughtering from local abattoir and transported to laboratory in a thermo flask contain normal physiological saline. Oocytes aspirated from follicles (2 - 8 mm) in diameter and washed three times in TC...

DAY/NIGHT MELATONIN CONTENT IN CEREBRAL PALSY.

Changes in the sleep-wake cycle are frequent and may impair quality of life in individuals with cerebral palsy (CP). To investigate if a lack of a day/night variation of melatonin content could be related with sleep disorders (SD), the SD were evaluated with a Sleep Questionnaire and the melatonin content using ELISA in 33 individuals with CP and 24 controls. The indicative of SD were present in 47% of CP group, and the most frequent was the indicative of sleep breathing disorder. The CP group showed higher...

Transition Metal Free Approach for the Synthesis of 4-Aryl-quinolines from Alkynes and Anilines.

An efficient and transition metal-free approach for the synthesis of 4-arylquinolines from readily available anilines and alkynes in the presence of K2S2O8 and DMSO has been developed. A variety of alkynes and anilines having diverse range of substitution patterns can undergo the one pot cascade process successfully. Effectively, this method uses DMSO as one carbon source, thus providing a highly atom economical and environmentally benign approach for the synthesis of 4-arylquinolines.

Trehalose to cryopreserve human pluripotent stem cells.

The successful exploitation of human pluripotent stem cells (hPSCs) for research, translational or commercial reasons requires the implementation of a simple and efficient cryopreservation method. Cryopreservation is usually performed with dimethylsulphoxide (DMSO), in addition to animal proteins. However, even at sub-toxic levels, DMSO diminishes the pluripotency capacity of hPSCs and affects their epigenetic system by acting on the three DNA methyltransferases (Dnmts) and histone modification enzymes. Our...

Synergistic Catalysis-Enabled Thia-Aza-Prins Cyclization with DMSO and Disulfides: Entry to Sulfenylated 1,3-Oxazinanes and Oxazolidines.

A novel synergistically catalyzed thia-aza-Prins cyclization of alkenylamines with disulfides is reported, rendering the first synthesis of sulfenylated 1,3-oxazinanes and oxazolidines in good to high yields. Importantly, DMSO serves simultaneously as a reaction medium and a surrogate for formaldehyde. Mechanistic studies provide evidence that actions of CuBr and in situ formed sulfinic acids as a Lewis acid and Brønsted acid catalyst, respectively, synergistically catalyze these cyclization processes.

Water-Soluble Ruthenium(II) Carbonyls with 1,3,5-Triaza-7-phosphoadamantane.

As a continuation of our strategy for preparing new Ru(II) precursors with improved water solubility through the introduction of highly water-soluble 1,3,5-triaza-7-phosphoadamantane (PTA) supporting ligands in the coordination sphere, in this work, we address the largely unexplored preparation of Ru(II)-PTA carbonyls. Two complementary synthetic approaches were used: (1) the treatment of a series of neutral Ru(II)-CO-dmso compounds of general formula RuCl(CO) (dmso) ( n = 1-3, 1-5) with PTA; (2) the reacti...

Differences between porcine longissimus thoracis and semitendinosus intramuscular fat content and the regulation of their preadipocytes during adipogenic differentiation.

Intramuscular fat (IMF) plays an important role in pork quality. However, differences in the adipogenic regulation of IMF content between pig longissimus thoracis (LT) and semitendinosus (ST) remain unclear. Here, we found that IMF content of 180-day-old pig LT was greater than that of pig ST. Furthermore, lipid accumulation was earlier and greater in LT intramuscular preadipocytes (L-IMA) than in ST intramuscular preadipocytes (S-IMA) during differentiation. Interestingly, glucose consumption was lower in ...


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