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Showing "HORIZON PHARMACETICALS CORPORATION" PubMed Articles 1–25 of 142

Horizon Hair of Extremal Black Holes and Measurements at Null Infinity.

It is shown that the conserved charges on the event horizon and the Cauchy horizon associated with scalar perturbations on extremal black holes are externally measurable from null infinity. This suggests that these charges have the potential to serve as an observational signature. The proof of this result is based on obtaining precise late-time asymptotics for the radiation field of outgoing perturbations.

"Reporting Time Horizons in Randomized Controlled Trials in Plastic Surgery: A Systematic Review."

Current guidelines for randomized controlled trial (RCT) reporting do not require authors to justify their choice of time horizon. This is concerning, as the time horizon when an outcome is assessed has important implications for the interpretation of study results, and resources allocated to an investigation. Therefore, this study seeks to examine the standards of time horizon reporting in the plastic surgery literature.

Decoding the Apparent Horizon: Coarse-Grained Holographic Entropy.

When a black hole forms from collapse in a holographic theory, the information in the black hole interior remains encoded in the boundary. We prove that the area of the black hole's apparent horizon is precisely the entropy associated with coarse graining over the information in its interior, subject to knowing the exterior geometry. This is the maximum holographic entanglement entropy that is compatible with all classical measurements conducted outside of the apparent horizon. We identify the boundary dual...

Searching for Near-Horizon Quantum Structures in the Binary Black-Hole Stochastic Gravitational-Wave Background.

Quantum gravity corrections have been speculated to lead to modifications to space-time geometry near black-hole horizons. Such structures may reflect gravitational waves, causing echoes that follow the main gravitational waves from binary black-hole coalescence. By studying two phenomenological models of the near-horizon structures under the Schwarzschild approximation, we show that such echoes, if they exist, will give rise to a stochastic gravitational-wave background, which is very substantial if the ne...

Association between Deepwater Horizon oil spill response and cleanup work experiences and lung function.

Oil spill response and cleanup (OSRC) workers had potentially stressful experiences during mitigation efforts following the 2010 Deepwater Horizon disaster. Smelling chemicals; skin or clothing contact with oil; heat stress; handling oily plants/wildlife or dead animal recovery; and/or being out of regular work may have posed a risk to worker respiratory health through psychological stress mechanisms.

Self-reported myocardial infarction and fatal coronary heart disease among oil spill workers and community members 5 years after Deepwater Horizon.

Chemical, physical and psychological stressors due to the 2010 Deepwater Horizon oil spill may impact coronary heart disease (CHD) among exposed populations. Using longitudinal information from two interviews in the Gulf Long Term Follow-up (GuLF) STUDY, we assessed CHD among oil spill workers and community members.

Oral GLP-1 Analog for Type 2 Diabetes on the Horizon.

Is hope on the horizon for premature ovarian insufficiency?

Seafinding revisited: how hatchling marine turtles respond to natural lighting at a nesting beach.

Hatchling marine turtles emerge at night from underground nests on oceanic beaches and then use visual cues to crawl from the nest site to the sea ("seafinding"). However, the light wavelengths (λ's) used to accomplish this orientation have not been thoroughly documented, nor do we understand why some λ's are favored over others. We measured nocturnal radiance on the horizon at 20 nm intervals between 340 and 600 nm at two nesting beach sites and then, under laboratory conditions, determined the lowest ...

Percutaneous Transcholecystic Management of Choledocholithiasis: A Next Horizon for Interventional Radiologists?

Gene-edited plants cross European event horizon.

Geosphere-biosphere circulation of chemical elements in soil and plant systems from a 100 km transect from southern central Norway.

Geochemical element separation is studied in 14 different sample media collected at 41 sites along an approximately 100-km long transect north of Oslo. At each site, soil C and O horizons and 12 plant materials (birch/spruce/cowberry/blueberry leaves/needles and twigs, horsetail, braken fern, pine bark and terrestrial moss) were sampled. The observed concentrations of 29 elements (K, Ca, P, Mg, Mn, S, Fe, Zn, Na, B, Cu, Mo, Co, Al, Ba, Rb, Sr, Ti, Ni, Pb, Cs, Cd, Ce, Sn, La, Tl, Y, Hg, Ag) were used to inve...

The role of hardpan formation on the reactivity of sulfidic mine tailings: A case study at Joutel mine (Québec).

The former Eagle and Telbel mine site (hereafter referred to as Joutel mine), located near the town of Joutel in the Nord-du-Québec (Canada) houses a tailings storage facility (TSF) that has been inactive since 1996. Fresh, unweathered tailings (beneath 10-30 cm of oxidized horizon) are characterized by an average sulfide content of 6-7 wt% and an average Fe-Mn-carbonate content of 20-40 wt%. The oxidation of Joutel's tailings under atmospheric conditions resulted in the precipitation of secondary ph...

Changes in microRNA-mRNA signatures agree with morphological, physiological, and behavioral changes in larval mahi-mahi treated with Deepwater Horizon oil.

In this study, we performed a systematic evaluation of global microRNA-mRNA interactions associated with the developmental toxicity of Deepwater Horizon oil using a combination of integrated mRNA and microRNA deep sequencing, expression profiling, gene ontology enrichment, and functional predictions by a series of advanced bioinformatic tools. After exposure to water accommodated fraction (WAF) of both weathered slick oil (0.5%, 1%, and 2%) and source oil (0.125%, 0.25%, and 0.5%) from the Deep Water Horizo...

Evaluation of NO emissions of a retrofitted Euro 5 passenger car for the Horizon prize "Engine retrofit".

The Horizon 2020 prize for the "Engine Retrofit for Clean Air" aims at reducing the pollution in cities by spurring the development of retrofit technology for diesel engines. A Euro 5 passenger car was retrofitted with an under-floor SCR (Selective Catalytic Reduction) for NO catalyst in combination with a solid ammonia based dosing system as the NO reductant. The vehicle was tested both on the road and on the chassis dynamometer under various test cycles and ambient temperatures. The NO emissions were redu...

Soft-Hair-Enhanced Entanglement Beyond Page Curves in a Black Hole Evaporation Qubit Model.

We propose a model with multiple qubits that reproduces the thermal properties of four-dimensional Schwarzschild black holes (BHs) by simultaneously taking account of the emission of Hawking particles and the zero-energy soft-hair evaporation at the horizon. The results verify that the entanglement entropy between a qubit and other subsystems, including emitted radiation, is much larger than the BH entropy analogue of the qubit, as opposed to the Page curve prediction. Our result suggests that early Hawking...

Functional Nonlinear Model Predictive Control Based on Adaptive Dynamic Programming.

This paper presents a functional model predictive control (MPC) approach based on an adaptive dynamic programming (ADP) algorithm with the abilities of handling control constraints and disturbances for the optimal control of nonlinear discrete-time systems. In the proposed ADP-based nonlinear MPC (NMPC) structure, a neural-network-based identification is established first to reconstruct the unknown system dynamics. Then, the actor-critic scheme is adopted with a critic network to estimate the index performa...

Receding horizon control strategy for an electric vehicle with dual-motor coupling system in consideration of stochastic vehicle mass.

Additional degrees of freedom existed in dual-motor coupling system bring considerable challenge to the optimal control of electric vehicles. Moreover, the stochastic characteristic of vehicle mass can further increase this challenge. A receding horizon control (RHC) strategy in consideration of stochastic vehicle mass is proposed in this study to respond to this challenge. Aiming at an electric vehicle with dual-motor coupling, a Markov chain is firstly deployed to predict future driving conditions by a fo...

Combined effects of hypoxia or elevated temperature and Deepwater Horizon crude oil exposure on juvenile mahi-mahi swimming performance.

This study examined potential interactive effects of co-exposure to Deepwater Horizon (DWH) crude oil (∼30 μg L ΣPAHs) for 24 h and either hypoxia (2.5 mg O L; 40% O saturation) or elevated temperature (30 °C) on the swimming performance of juvenile mahi-mahi (Coryphaena hippurus). Additionally, effects of shorter duration exposures to equal or higher doses of oil alone either prior to swimming or during the actual swim trial itself were examined. Only exposure to hypoxia alone or combined wi...

On Building Online Visualization Maps for News Data Streams by Means of Mathematical Optimization.

In this article we develop a novel online framework to visualize news data over a time horizon. First, we perform a Natural Language Processing analysis, wherein the words are extracted, and their attributes, namely the importance and the relatedness, are calculated. Second, we present a Mathematical Optimization model for the visualization problem and a numerical optimization approach. The model represents the words using circles, the time-varying area of which displays the importance of the words in each ...

Changes on the Horizon for Drug Repurposing, Rescue, and Repositioning at ASSAY.

Finite-Horizon Optimal Consensus Control for Unknown Multiagent State-Delay Systems.

This paper investigates finite-horizon optimal consensus control problem for unknown multiagent systems with state delays. It is well known that optimal consensus control is the solutions to the coupled Hamilton-Jacobi-Bellman (HJB) equations. An off-policy reinforcement learning (RL) algorithm is developed to learn the two-stage optimal consensus solutions to the coupled time-varying HJB equations using the measurable state data instead of the knowledge of the state-delayed system dynamics. Subsequently, f...

Soil organic carbon depletion and degradation in surface soil after long-term non-growing season warming in High Arctic Svalbard.

Arctic tundra active-layer soils are at risk of soil organic carbon (SOC) depletion and degradation upon global climate warming because they are in a stage of relatively early decomposition. Non-growing season (NGS) warming is particularly pronounced, and observed increases of CO emissions during experimentally warmed NGSs give concern for great SOC losses to the atmosphere. Here, we used snow fences in Arctic Spitsbergen dwarf shrub tundra to simulate 1.86 °C NGS warming for 9 consecutive years, while g...

Mobile Robot Networks for Environmental Monitoring: A Cooperative Receding Horizon Temporal Logic Control Approach.

This paper deals with the problem of environmental monitoring by designing and analyzing a cooperative receding horizon temporal logic (CRH-TL) control approach for mobile robot networks. First, a radial basis function network is used to model the distribution of environmental attributes in the monitored environment. On the basis of the established environment model, the problem of environmental monitoring can be formulated as a dynamical optimization problem. Second, an acceptable node set is obtained by e...

Deepwater Horizon oil alone and in conjunction with Vibrio anguillarum exposure modulates immune response and growth in red snapper (Lutjanus campechanus).

This study examined the impacts of Macondo oil from the Deepwater Horizon oil spill, both alone and in conjunction with exposure to the known fish pathogen Vibrio anguillarum, on the expression of five immune-related gene transcripts of red snapper (il8, il10, tnfa, il1b, and igm). In order to elucidate this impact, six different test conditions were used: one Control group (No oil/No pathogen), one Low oil/No pathogen group (tPAH50 = 0.563 μg/L), one High oil/No pathogen group (tPAH50 = 17.084...

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