PubMed Journals Articles About "HOST LOGIC" RSS

14:04 EST 11th December 2018 | BioPortfolio

HOST LOGIC PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest HOST LOGIC articles that have been published worldwide.

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Showing "HOST LOGIC" PubMed Articles 1–25 of 3,700+

Molecular engineering of logic gate types by module rearrangement in 'Pourbaix Sensors': the effect of excited-state electric fields.

Two types of fluorescent logic gates are accessed from two different arrangements of the same modular components, one as an AND logic gate (1) and the other as a PASS 0 logic gate (2). The logic gates were designed with an 'electron-donor-spacer1-fluorophore-spacer2-receptor' format and demonstrated in 1 : 1 (v/v) methanol/water. The molecules consist of ferrocene as the electron donor, 4-aminonaphthalimide as the fluorophore and a tertiary alkylamine as the receptor. In the presence of high H+ and Fe3+...

Heart disease diagnosis based on mediative fuzzy logic.

Mediative fuzzy logic is an approach able to deal with inconsistent information providing a solution when contradiction exists. The aim of this paper is to design an expert system based on this type of fuzzy logic in order to diagnose a possible heart disease for a patient. Our proposed system is an extension of the standard Mamdani fuzzy logic controller and contains 44 rules of the type single input-single output. The system works with 11 variables as inputs and one variable as output.

Integrated all-optical programmable logic array based on semiconductor optical amplifiers.

The all-optical programmable logic array (PLA) is one of the most important optical complex logic devices that can implement combinational logic functions. In this Letter, we propose and experimentally demonstrate an integrated all-optical PLA at the operation speed of 40 Gb/s. The PLA mainly consists of a delay interferometer (DI) and semiconductor optical amplifiers (SOAs) of different lengths. The DI is used to pre-code the input signals and improve the reconfigurability of the scheme. The longer SOAs a...

Logic circuit controlled multi-responsive branched DNA scaffolds.

A logic circuit controlled multi-responsive sensing platform built on a three-way DNA junction (TWJ) is reported. It enabled the construction of novel fluorescent sensing platforms responsive to any target out of HIV gene, ATP and pH value, and furthermore were logically regulated by two other targets and then behaved as different logic circuits, which consist of two tandem AND gates or cascaded NAND and INH gates by varying the positions of the fluorescent tags.

Recent Progress in Fluorescence Signal Design for DNA-based Logic Circuits.

DNA-based logic circuits, encoding algorithm in DNA and processing information, are leading molecular computer forward to frontier, owing to DNA's advantages of stability, accessibility, manipulability, and especially inherent biological significance and potential medical application. In recent years, numerous logic functions, from arithmetic to nonarithmetic, have been realized based on DNA. However, DNA can hardly provide detectable signal by itself, so that the DNA-based circuits have to depend on extrin...

Design of DNA-based Innovative Computing system of Digital Comparison.

Despite great potential and extensive interest in developing biomolecule-based computing, the development of even basic molecular logic gates is still in its infancy. Digital comparator (DC) is the basic unit in traditional electronic computers, but it is difficult to construct a system for achieving large-scale integration. Here, we construct, for the first time, a novel logic computing system of DCs that can compare whether two or more numbers are equal. Our approach is by taking advantage of facile prepa...

Hybrid mesoporous nanocarriers act by processing logic tasks: Toward the design of nanobots capable of reading information from the environment.

Here we present the design of smart nanodevices capable of reading molecular information from the environment and acting accordingly by processing boolean logic tasks. As proof of concept, we prepared Au-mesoporous silica (MS) nanoparticles functionalized with the enzyme glucose dehydrogenase (GDH) on the Au face and with supramolecular nanovalves as caps on the MS face, which is loaded with a cargo (dye or drug). The nanodevice acts as an AND logic gate and reads information from the solution (presence of ...

Learning to activate logic rules for textual reasoning.

Most current textual reasoning models cannotlearn human-like reasoning process, and thus lack interpretability and logical accuracy. To help address this issue, we propose a novel reasoning model which learns to activate logic rules explicitly via deep reinforcement learning. It takes the form of Memory Networks but features a special memory that stores relational tuples, mimicking the "Image Schema" in human cognitive activities. We redefine textual reasoning as a sequential decision-making process modifyi...

Review of Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery . By Christopher T. Walsh and Yi Tang. Royal Society of Chemistry Publishing . 2017 . xx + 765 pp. £89.00 (∼$119). ISBN 978-1-78801-076-4 .

Type-2 Fuzzy Logic-Based Linguistic Pursuing Strategy Design and Its Deployment to a Real-World Pursuit Evasion Game.

This paper presents a systematic and interpretable design approach to generate type-2 (T2) fuzzy logic-based linguistic pursuing strategies (PSs) and their deployment to a real-world pursuit-evasion game (PEG). First, we have developed a novel T2 fuzzy logic-based strategy planner (T2-FSP). Then, through detailed theoretical investigations on the input-output mapping of the T2-FSP, it has been shown that it is possible to design a linguistic PS which defines both pursuer's approaching behavior (aggressive, ...

A BODIPY derivative for colorimetric fluorescence sensing of Hg, Pb and Cu ions and its application in logic gates.

A BODIPY-based colorimetric and fluorescent chemosensor 1 anchored with dipyridylamino (DPA) receptor has been designed, synthesized and characterized. It exhibited a simultaneous sensitive recognition for Cu, Hg and Pb ions. With the addition of these three kinds of metal ions into 1 in CHCN, its initial absorption maximum displayed obvious blue shifts, and the color changes of the solution could be clearly observed by naked eyes. Besides, the fluorescence intensity was significantly enhanced accompanied w...

Reconfigurable logic in nanosecond Cu/GeTe/TiN filamentary memristors for energy-efficient in-memory computing.

Owing to the capability of integrating the information storage and computing in the same physical location, in-memory computing with memristors has become a research hotspot as a promising route for non von Neumann architecture. However, it is still a challenge to develop high performance devices as well as optimized logic methodologies to realize energy-efficient computing. Herein, filamentary Cu/GeTe/TiN memristor is reported to show satisfactory properties with nanosecond switching speed (< 60 ns), lo...

Device-Level Photonic Memories and Logic Applications Using Phase-Change Materials.

Inspired by the great success of fiber optics in ultrafast data transmission, photonic computing is being extensively studied as an alternative to replace or hybridize electronic computers, which are reaching speed and bandwidth limitations. Mimicking and implementing basic computing elements on photonic devices is a first and essential step toward all-optical computers. Here, an optical pulse-width modulation (PWM) switching of phase-change materials on an integrated waveguide is developed, which allows pr...

Use of the logic model to develop and implement an interprofessional module for undergraduate healthcare students at a University in South Africa: A study protocol.

Interprofessional education and collaborative practice, supported by the World Health Organisation and the local Health Professions Council is not fully established at all universities and for all health professions in South Africa (HPCSA, 2014). In this study protocol, the logic model is proposed as a framework for the development of a module for final year healthcare students. The logic model will guide planning and implementation following the steps of situational analysis, input and processes, output a...

An enzymatic calculation system based on electrochemiluminescence and fluorescence of luminol and cyclic voltammetry of ferrocene methanol.

In this work, a biomolecular calculation system was developed based on electrochemiluminescence (ECL) and fluorescence emission (FL) of luminol and cyclic voltammetry (CV) of ferrocene methanol (FMA). When triethylamine (TEA) was added in luminol solution as a coreactant, a great ECL peak at 1.1 V was observed. While the further addition of enzymatic system, esterase/ethyl butyrate (EB), would significantly lower the ECL response. On the other hand, TEA could quench the FL signal of luminol at 430 nm, w...

Better Safe than Sorry: A Dual-Function Viral Protein Inhibiting Host Defense.

Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation.

The Terabase Search Engine: a large-scale relational database of short-read sequences.

DNA sequencing archives have grown to enormous scales in recent years, and thousands of human genomes have already been sequenced. The size of these data sets has made searching the raw read data infeasible without high-performance data-query technology. Additionally, it is challenging to search a repository of short-read data using relational logic and to apply that logic across samples from multiple whole-genome sequencing samples.

Malaria Makes the Most of Mealtimes.

Successive synchronized cycles of Plasmodium replication in the host's blood causes the symptoms of malaria and fuels disease transmission. In this issue of Cell Host & Microbe, Hirako et al. (2018) reveal that host circadian rhythms of inflammation and metabolism are responsible for the timing of cycles of parasite replication.

A generalized approach to predicting protein-protein interactions between virus and host.

Viral infection involves a large number of protein-protein interactions (PPIs) between virus and its host. These interactions range from the initial binding of viral coat proteins to host membrane receptor to the hijacking the host transcription machinery by viral proteins. Therefore, identifying PPIs between virus and its host helps understand the mechanism of viral infections and design antiviral drugs. Many computational methods have been developed to predict PPIs, but most of them are intended for PPIs ...

Generalist haemosporidian parasites are better adapted to a subset of host species in a multiple host community.

Parasites that can infect multiple host species are considered to be host generalists with low host specificity. However, whether generalist parasites are better adapted to a subset of their host species remains unknown. To elucidate this possibility, we compared the variation in prevalence and infection intensity among host species of three generalist parasite lineages belonging to the morphological species Haemoproteus majoris, in a natural bird community in southern Sweden. Prevalence in each host specie...

Host functions used by hepatitis B virus to complete its life cycle: Implications for developing host-targeting agents to treat chronic hepatitis B.

Similar to other mammalian viruses, the life cycle of hepatitis B virus (HBV) is heavily dependent upon and regulated by cellular (host) functions. These cellular functions can be generally placed in to two categories: (a) intrinsic host restriction factors and innate defenses, which must be evaded or repressed by the virus; and (b) gene products that provide functions necessary for the virus to complete its life cycle. Some of these functions may apply to all viruses, but some may be specific to HBV. In ce...

Host Response to Staphylococcus aureus Quorum Sensing Is NO.

Our understanding of the host mechanisms that protect against Staphylococcus aureus infection is incomplete. In this issue of Cell Host & Microbe, Urbano et al. (2018) report that nitric oxide (NO) targets the Agr quorum-sensing system to moderate S. aureus virulence.

Bacterial Prison Break: A Host Protein Mimic Paves the Way.

The intracellular pathogen Francisella secretes effector proteins inside host cells; however, their functions have remained unclear. In this issue of Cell Host & Microbe, Ledvina et al. (2018) elucidate the role of one such effector, OpiA, to be a bacterial phosphatidylinositol-3-kinase that alters phagosomal trafficking and can promote intracellular bacterial replication.

All Aboard! Enteric Viruses Travel Together.

Individual virus particles have long been accepted as the infectious unit during cellular infection and host-to-host transmission. In this issue of Cell Host & Microbe, Santiana et al. (2018) uncover vesicle-cloaked rotavirus and norovirus clusters in feces of infected hosts that are more infectious than free virus particles during fecal-oral transmission.

The Dermal Exposure Risk Management and Logic eTookit: Characterizing and managing dermal exposure during emergency management operations.

Emergency management and operations (EMO) personnel require up-to-date information to make informed decisions during natural and man-made disasters. However, information gaps present challenges for accessing human health risk assessment and risk management strategies for dermal exposure. This article describes the development of a decision support system, the Dermal Exposure Risk Management and Logic (DERMaL) eToolkit.

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