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PubMed Journals Articles About "Identification DRB1 Allele Risk Allele Japanese Moyamoya Disease" RSS

18:39 EDT 15th September 2019 | BioPortfolio

Identification DRB1 Allele Risk Allele Japanese Moyamoya Disease PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Identification DRB1 Allele Risk Allele Japanese Moyamoya Disease articles that have been published worldwide.

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Showing "Identification DRB1 allele risk allele Japanese moyamoya disease" PubMed Articles 1–25 of 41,000+

Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study.

Moyamoya disease (MMD) is a progressive cerebrovascular disease with unknown etiology. Growing evidence suggest its involvement of autoimmune and genetic mechanisms in the pathogenesis of MMD. This study aims to clarify the association between HLA allele and MMD.


The novel HLA-DRB1*04:01:10 allele detected in a Taiwanese individual.

One nucleotide substitution at residue 261 of HLA-DRB1*04:01:01:01 results in a new allele, HLA-DRB1*04:01:10. This article is protected by copyright. All rights reserved.

The HLA-DRB1*14:208 allele detected in a Taiwanese individual.

Nucleotide substitutions in exons 2 and 3 of HLA-DRB1*14:07:01 result in a new allele, HLA-DRB1*14:208. This article is protected by copyright. All rights reserved.


The association of rs703842 variants in CYP27B1 with multiple sclerosis susceptibility is influenced by the HLA-DRB1*15:01 allele in Slovaks.

In this study, we analysed the association of rs703842 in CYP27B1 gene with multiple sclerosis (MS) risk and disability progression in a group of 496 MS patients and 521 controls. For the first time in Central European Slovak population, we found the rs703842 allele C to be protective factor against MS development (p = 1.09 × 10). Moreover, the risky genotypes TT and TC were showed to be associated with an increased MS risk, and this was aggravated by the homozygous carriage of the HLA-DRB1*15:01 a...

Identification of a new allele, HLA-DRB1*01:01:01:02 discovered using Third-Generation Sequencing.

HLA-DRB1*01:01:01:02 is the first reported intronic variant of DRB1*01:01:01, differing by a single nucleotide substitution. This article is protected by copyright. All rights reserved.

Identification of the amino acids in the Major Histocompatibility Complex class II region of Scottish Blackface sheep that are associated with resistance to nematode infection.

Lambs with the Major Histocompatibility Complex (MHC) DRB1*1101 allele have been shown to produce fewer nematode eggs following natural and deliberate infection. These sheep also possess fewer adult Teladorsagia circumcincta than sheep with alternative alleles at the DRB1 locus. However, it is unclear if this allele is responsible for the reduced egg counts or merely acts as a marker for a linked gene. This study defined the MHC haplotypes in a population of naturally infected Scottish Blackface sheep by PC...

Identification of the new HLA-C*16:02:17 allele in a Brazilian candidate donor for bone marrow donation.

Identification of the novel HLA-C*16:02:17 allele that differs from HLA-C*16:02:01 in exon 2. This article is protected by copyright. All rights reserved.

Identification of the new HLA-A*24:02:131 allele in a Brazilian candidate donor for bone marrow donation.

Identification of the novel HLA-A*24:02:131 allele that differs from HLA-A*24:02:01:01 in exon 4. This article is protected by copyright. All rights reserved.

Identification of the new HLA-A*30:159 allele in a Brazilian candidate donor for bone marrow donation.

Identification of the novel HLA-A*30:159 allele that differs from HLA-A*30:01:01:01 in exon 3. This article is protected by copyright. All rights reserved.

HLA-A*01:01 in MHC is associated with psoriatic arthritis in Chinese Han population.

To verify whether PsA-associated HLA alleles proposed in other populations are also related to PsA in Chinese Han population, a study of PsA susceptible alleles in the HLA-A, HLA-B, HLA-C and HLA-DRB1 alleles was presented for Chinese Han population. Genotyping was performed by Illumina Miseq platform (Illumina, USA). 50 subtypes and 77 subtypes of HLA-A, HLA-B, HLA-C and HLA-DRB1 with minor allele frequency (MAF) > 1% were genotyped from two-digit and four-digit resolution analysis in 111 PsA and 207 HCs (...

Identification of the novel HLA-C*12:220 allele in a Chinese individual.

The new allele HLA-C*12:220 differs from HLA-C*12:03:01:01 by one nucleotide substitution in Exon 7. This article is protected by copyright. All rights reserved.

Characterization of a novel variant allele, HLA-C*08:125, identified in a Chinese Han individual.

The novel HLA-C*08:125 allele differs from the closest allele C*08:02:01:01 in exon 3. This article is protected by copyright. All rights reserved.

A novel HLA-A allele, HLA-A*68:01:42, identified by next-generation sequencing in a Chinese individual.

The novel HLA-A*68:01:42 allele differs from the closest matching allele, HLA-A*68:01:02:02 by one nucleotide substitution. This article is protected by copyright. All rights reserved.

High-resolution analysis of the HLA-A, HLA-B, HLA-C, and HLA-DRB1 alleles and national and regional haplotype frequencies based on 120,926 volunteers from the Italian Bone Marrow Donor Registry.

HLA genes are highly polymorphic and structurally complex. They are located in the major histocompatibility complex (MHC) on chromosome 6, and the frequency of alleles and haplotypes varies widely among human populations. In this paper, we calculated the allele and haplotype frequencies using the HLA data of more than 120,000 Italian unrelated bone marrow donors enrolled in the national registry (IBMDR) and typed them with a high-resolution (HR) method for the HLA-A, -B, -C and -DRB1 alleles. The allele fre...

A Rapid Allele-Specific Assay for HLA-A*32:01 to Identify Patients at Risk for Vancomycin-Induced Drug Reaction with Eosinophilia and Systemic Symptoms.

Human leukocyte antigen (HLA) alleles have been implicated as risk factors for immune-mediated adverse drug reactions. We recently reported a strong association between HLA-A*32:01 and vancomycin-induced drug reaction with eosinophilia and systemic symptoms (DRESS). Identification of individuals with the risk allele prior to or shortly after the initiation of vancomycin therapy is of great clinical importance to prevent morbidity and mortality, improve drug safety and antibiotic treatment options. A prerequ...

Detection of a new allele variation in Chinese Han population at the STR locus SE33 (ACTBP2).

In order to apply a useful STR system in DNA database construction, we performed a population study in China. Allele and genotype frequencies for STR SE33 were obtained for a sample of 213 random Chinese in view of application in personal identification. And we observed a new structural variation of 21.2 allele at SE33 locus which is described here for the first time.

Correction: Allele-specific DNA methylation of disease susceptibility genes in Japanese patients with inflammatory bowel disease.

[This corrects the article DOI: 10.1371/journal.pone.0194036.].

Association between human leucocyte antigen alleles and risk of stroke in Iranian population.

Previous studies have demonstrated associations between human leucocyte antigen (HLA) and some types of ischaemic stroke. In the present study, we genotyped HLA-A,-B and -DRB1 alleles in 140 Iranian patients with history of ischaemic stroke and 140 age-/sex-matched healthy subjects. No significant difference has been found in the distribution of HLA-A and B alleles between cases and controls. The DRB1*16 allele was significantly over-represented in patient group compared with control group (Adjusted p value...

Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians.

Human leukocyte antigen (HLA) is a key genetic factor conferring risk of systemic lupus erythematosus (SLE), but precise independent localization of HLA effects is extremely challenging. As a result, the contribution of specific HLA alleles and amino-acid residues to the overall risk of SLE and to risk of specific autoantibodies are far from completely understood. Here, we dissected (a) overall SLE association signals across HLA, (b) HLA-peptide interaction, and (c) residue-autoantibody association. Classic...

Description of the novel KIR2DL4*00603 allele identified in a Chinese Hani individual.

The novel KIR2DL4*00603 allele differs from the closest allele KIR2DL4*00602 by a silent mutation. This article is protected by copyright. All rights reserved.

Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts.

Genome-wide association studies identified a single nucleotide polymorphism (SNP) in the MSRB3 gene encoding Methionine Sulfoxide Reductase-B3 (MsrB3) to be associated with the risk for low hippocampal volume and late onset Alzheimer's disease (AD). Subsequently, we identified AD-associated abnormal patterns of neuronal and vascular MsrB3 expression in postmortem hippocampi. The present study investigated the relationship between the MSRB3 SNP rs61921502, G (minor/risk allele) and MRI measures of brain inju...

Association between Apolipoprotein E Gene Polymorphism and Alzheimer's Disease in an Iranian Population: A Meta-Analysis.

The development of Alzheimer's disease (AD) has been strongly linked to the apolipoprotein E (APOE) polymorphism. A number studies have reported that the APOE ε4 allele is a genetic risk factor for developing AD, whereas the APOE ε2 and APOE ε3 alleles are considered to be neutral or even protective; however, there are conflicting data about these relationships in certain ethnic populations. Several meta-analyses have been performed to reduce the heterogeneity of results from different studies and estima...

Novel HLA Class I Alleles Outside the Extended DR3 Haplotype Are Protective against Autoimmune Hepatitis.

HLA class II allele, DRB1*03:01, is the most common genetic risk factor for autoimmune hepatitis (AIH), but other unrecognized HLA related risks exist.

ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients.

The objective of this case-control study was to evaluate the role of four single-nucleotide polymorphisms in the ERAP1 (rs2287987, rs30187, rs27044) and ERAP2 (rs2248374) genes and their haplotypes in predicting the risk for ankylosing spondylitis (AS) on a well-defined Polish population. Our study confirmed the strong association between the HLA-B*27 allele and the disease. For all tested ERAP1 SNPs we found significant differences in the minor allele and genotype distribution between patients and controls...

HLA class I allele lineages and haplotype frequencies in Arabs of the United Arab Emirates.

The high degree of polymorphism of the HLA system provides suitable genetic markers to study the diversity and migration of different world populations and is beneficial for forensic identification, anthropology, transplantation and disease associations. Although the United Arab Emirates (UAE) population of about nine million people is heterogeneous, information is limited for the HLA class I allele and haplotype frequencies of the Bedouin ethnic group. We performed low-resolution PCR-SSP genotyping of thre...


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